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Q9DBR4

- APBB2_MOUSE

UniProt

Q9DBR4 - APBB2_MOUSE

Protein

Amyloid beta A4 precursor protein-binding family B member 2

Gene

Apbb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May modulate the internalization of beta-amyloid precursor protein.By similarity

    GO - Molecular functioni

    1. histone acetyltransferase binding Source: UniProtKB
    2. protein binding Source: MGI
    3. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. actin filament-based movement Source: UniProtKB
    2. axon guidance Source: MGI
    3. cell cycle arrest Source: UniProtKB
    4. extracellular matrix organization Source: MGI
    5. negative regulation of apoptotic process Source: MGI
    6. negative regulation of cell growth Source: UniProtKB
    7. neuron migration Source: MGI
    8. positive regulation of apoptotic process Source: MGI
    9. protein stabilization Source: UniProtKB
    10. regulation of transcription, DNA-templated Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 2
    Gene namesi
    Name:Apbb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:108405. Apbb2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760Amyloid beta A4 precursor protein-binding family B member 2PRO_0000076053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9DBR4.
    PaxDbiQ9DBR4.
    PRIDEiQ9DBR4.

    PTM databases

    PhosphoSiteiQ9DBR4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9DBR4.
    BgeeiQ9DBR4.
    GenevestigatoriQ9DBR4.

    Interactioni

    Subunit structurei

    Binds to the intracellular domain of the beta-amyloid precursor protein.By similarity

    Protein-protein interaction databases

    BioGridi198142. 4 interactions.
    IntActiQ9DBR4. 1 interaction.

    Structurei

    Secondary structure

    1
    760
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi592 – 60110
    Beta strandi603 – 6053
    Helixi609 – 62012
    Turni624 – 6263
    Beta strandi629 – 6357
    Beta strandi638 – 6425
    Beta strandi650 – 6556
    Turni656 – 6583
    Beta strandi659 – 6646
    Beta strandi671 – 6766
    Beta strandi678 – 6803
    Beta strandi682 – 6887
    Helixi694 – 70411

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WGUNMR-A582-704[»]
    2ROZNMR-B582-704[»]
    2YSZNMR-A582-704[»]
    2YT0NMR-A582-704[»]
    2YT1NMR-A582-704[»]
    ProteinModelPortaliQ9DBR4.
    SMRiQ9DBR4. Positions 291-320, 417-553, 582-704.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9DBR4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 32233WWPROSITE-ProRule annotationAdd
    BLAST
    Domaini413 – 580168PID 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini586 – 738153PID 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PID domains.PROSITE-ProRule annotation
    Contains 1 WW domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG76544.
    GeneTreeiENSGT00390000000002.
    HOGENOMiHOG000033983.
    HOVERGENiHBG050524.
    InParanoidiQ9DBR4.
    KOiK04530.
    OMAiTKNSTPP.
    OrthoDBiEOG79W94P.
    PhylomeDBiQ9DBR4.
    TreeFamiTF314331.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00640. PID. 2 hits.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 2 hits.
    SM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS01179. PID. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9DBR4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN    50
    AEIKHSDAKN STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV 100
    KNGENQLRKA AEQGQQDPNK NLSPAAVINL TSEKLEVKDP HPQESSGCEI 150
    LPSQPRRTKS FLNYYADLET SARELGQNLG PCQGVGEEKA QPGPGQAPVV 200
    IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI 250
    QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN 300
    DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP 350
    WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP 400
    HGDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL 450
    SYCKNDIRDT VGIWGEGKDM YLSLENDMLS LVDPMDRSVL HSQPIVNIRV 500
    WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA TSLHEICSKI 550
    MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML 600
    PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV 650
    LVECRVRFLS FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV 700
    QAACMLRYQK CLVARPPSQK VRPPPPPADS VTRRVTTNVK RGVLSLIDTL 750
    KQKRPVTETP 760
    Length:760
    Mass (Da):83,201
    Last modified:March 1, 2003 - v2
    Checksum:i9E66E34489F4D736
    GO
    Isoform 2 (identifier: Q9DBR4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         348-368: Missing.

    Show »
    Length:739
    Mass (Da):80,815
    Checksum:i5821BB835A62868C
    GO
    Isoform 3 (identifier: Q9DBR4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         348-368: Missing.
         509-510: Missing.

    Show »
    Length:737
    Mass (Da):80,530
    Checksum:i2A8C34E8176E223C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei348 – 36821Missing in isoform 2 and isoform 3. 1 PublicationVSP_011661Add
    BLAST
    Alternative sequencei509 – 5102Missing in isoform 3. 1 PublicationVSP_011662

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004792 mRNA. Translation: BAB23568.2.
    BC076587 mRNA. Translation: AAH76587.1.
    CCDSiCCDS51510.1. [Q9DBR4-1]
    CCDS57344.1. [Q9DBR4-3]
    RefSeqiNP_001188343.1. NM_001201414.1.
    NP_001188344.1. NM_001201415.1. [Q9DBR4-3]
    NP_033816.1. NM_009686.2. [Q9DBR4-1]
    UniGeneiMm.5159.

    Genome annotation databases

    EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207. [Q9DBR4-1]
    ENSMUST00000160870; ENSMUSP00000123978; ENSMUSG00000029207. [Q9DBR4-3]
    GeneIDi11787.
    KEGGimmu:11787.
    UCSCiuc008xox.2. mouse. [Q9DBR4-1]
    uc008xpb.2. mouse. [Q9DBR4-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004792 mRNA. Translation: BAB23568.2 .
    BC076587 mRNA. Translation: AAH76587.1 .
    CCDSi CCDS51510.1. [Q9DBR4-1 ]
    CCDS57344.1. [Q9DBR4-3 ]
    RefSeqi NP_001188343.1. NM_001201414.1.
    NP_001188344.1. NM_001201415.1. [Q9DBR4-3 ]
    NP_033816.1. NM_009686.2. [Q9DBR4-1 ]
    UniGenei Mm.5159.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WGU NMR - A 582-704 [» ]
    2ROZ NMR - B 582-704 [» ]
    2YSZ NMR - A 582-704 [» ]
    2YT0 NMR - A 582-704 [» ]
    2YT1 NMR - A 582-704 [» ]
    ProteinModelPortali Q9DBR4.
    SMRi Q9DBR4. Positions 291-320, 417-553, 582-704.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198142. 4 interactions.
    IntActi Q9DBR4. 1 interaction.

    PTM databases

    PhosphoSitei Q9DBR4.

    Proteomic databases

    MaxQBi Q9DBR4.
    PaxDbi Q9DBR4.
    PRIDEi Q9DBR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000159786 ; ENSMUSP00000125211 ; ENSMUSG00000029207 . [Q9DBR4-1 ]
    ENSMUST00000160870 ; ENSMUSP00000123978 ; ENSMUSG00000029207 . [Q9DBR4-3 ]
    GeneIDi 11787.
    KEGGi mmu:11787.
    UCSCi uc008xox.2. mouse. [Q9DBR4-1 ]
    uc008xpb.2. mouse. [Q9DBR4-3 ]

    Organism-specific databases

    CTDi 323.
    MGIi MGI:108405. Apbb2.

    Phylogenomic databases

    eggNOGi NOG76544.
    GeneTreei ENSGT00390000000002.
    HOGENOMi HOG000033983.
    HOVERGENi HBG050524.
    InParanoidi Q9DBR4.
    KOi K04530.
    OMAi TKNSTPP.
    OrthoDBi EOG79W94P.
    PhylomeDBi Q9DBR4.
    TreeFami TF314331.

    Miscellaneous databases

    ChiTaRSi APBB2. mouse.
    EvolutionaryTracei Q9DBR4.
    NextBioi 279605.
    PROi Q9DBR4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DBR4.
    Bgeei Q9DBR4.
    Genevestigatori Q9DBR4.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00640. PID. 2 hits.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 2 hits.
    SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS01179. PID. 2 hits.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6.
      Tissue: Eye.
    3. "Solution structure of the C-terminal phosphotyrosine interaction domain of APBB2 from mouse."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 582-704.

    Entry informationi

    Entry nameiAPBB2_MOUSE
    AccessioniPrimary (citable) accession number: Q9DBR4
    Secondary accession number(s): Q6DFX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3