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Q9DBR4 (APBB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amyloid beta A4 precursor protein-binding family B member 2
Gene names
Name:Apbb2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May modulate the internalization of beta-amyloid precursor protein By similarity.

Subunit structure

Binds to the intracellular domain of the beta-amyloid precursor protein By similarity.

Sequence similarities

Contains 2 PID domains.

Contains 1 WW domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament-based movement

Non-traceable author statement PubMed 12089154. Source: UniProtKB

axon guidance

Inferred from genetic interaction PubMed 16407979. Source: MGI

cell cycle arrest

Inferred from direct assay PubMed 12089154. Source: UniProtKB

extracellular matrix organization

Inferred from genetic interaction PubMed 16407979. Source: MGI

negative regulation of apoptotic process

Inferred from genetic interaction PubMed 15629131. Source: MGI

negative regulation of cell growth

Inferred from direct assay PubMed 12089154. Source: UniProtKB

neuron migration

Inferred from genetic interaction PubMed 16407979. Source: MGI

positive regulation of apoptotic process

Inferred from direct assay PubMed 15629131. Source: MGI

protein stabilization

Non-traceable author statement PubMed 11544248. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12089154. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15629131. Source: MGI

nucleus

Inferred from direct assay PubMed 12089154. Source: UniProtKB

   Molecular_functionhistone acetyltransferase binding

Non-traceable author statement PubMed 12089154. Source: UniProtKB

transcription factor binding

Inferred from direct assay PubMed 12089154. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9DBR4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9DBR4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
Isoform 3 (identifier: Q9DBR4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     509-510: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 760760Amyloid beta A4 precursor protein-binding family B member 2
PRO_0000076053

Regions

Domain290 – 32233WW
Domain413 – 580168PID 1
Domain586 – 738153PID 2

Amino acid modifications

Modified residue1231Phosphoserine By similarity

Natural variations

Alternative sequence348 – 36821Missing in isoform 2 and isoform 3.
VSP_011661
Alternative sequence509 – 5102Missing in isoform 3.
VSP_011662

Secondary structure

......................... 760
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 2.
Checksum: 9E66E34489F4D736

FASTA76083,201
        10         20         30         40         50         60 
MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN AEIKHSDAKN 

        70         80         90        100        110        120 
STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 

       130        140        150        160        170        180 
NLSPAAVINL TSEKLEVKDP HPQESSGCEI LPSQPRRTKS FLNYYADLET SARELGQNLG 

       190        200        210        220        230        240 
PCQGVGEEKA QPGPGQAPVV IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG 

       250        260        270        280        290        300 
AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN 

       310        320        330        340        350        360 
DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP WSDFAVLNGG 

       370        380        390        400        410        420 
KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP HGDDDDSCSI NSDPEAKCFA 

       430        440        450        460        470        480 
VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL SYCKNDIRDT VGIWGEGKDM YLSLENDMLS 

       490        500        510        520        530        540 
LVDPMDRSVL HSQPIVNIRV WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA 

       550        560        570        580        590        600 
TSLHEICSKI MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML 

       610        620        630        640        650        660 
PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV LVECRVRFLS 

       670        680        690        700        710        720 
FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV QAACMLRYQK CLVARPPSQK 

       730        740        750        760 
VRPPPPPADS VTRRVTTNVK RGVLSLIDTL KQKRPVTETP 

« Hide

Isoform 2 [UniParc].

Checksum: 5821BB835A62868C
Show »

FASTA73980,815
Isoform 3 [UniParc].

Checksum: 2A8C34E8176E223C
Show »

FASTA73780,530

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6.
Tissue: Eye.
[3]"Solution structure of the C-terminal phosphotyrosine interaction domain of APBB2 from mouse."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 582-704.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004792 mRNA. Translation: BAB23568.2.
BC076587 mRNA. Translation: AAH76587.1.
RefSeqNP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1.
NP_033816.1. NM_009686.2.
UniGeneMm.5159.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortalQ9DBR4.
SMRQ9DBR4. Positions 291-320, 417-704.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198142. 4 interactions.
IntActQ9DBR4. 1 interaction.

PTM databases

PhosphoSiteQ9DBR4.

Proteomic databases

PaxDbQ9DBR4.
PRIDEQ9DBR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207. [Q9DBR4-1]
ENSMUST00000160870; ENSMUSP00000123978; ENSMUSG00000029207. [Q9DBR4-3]
GeneID11787.
KEGGmmu:11787.
UCSCuc008xox.2. mouse. [Q9DBR4-1]
uc008xpb.2. mouse. [Q9DBR4-3]

Organism-specific databases

CTD323.
MGIMGI:108405. Apbb2.

Phylogenomic databases

eggNOGNOG76544.
GeneTreeENSGT00390000000002.
HOGENOMHOG000033983.
HOVERGENHBG050524.
InParanoidQ9DBR4.
KOK04530.
OMATKNSTPP.
OrthoDBEOG79W94P.
PhylomeDBQ9DBR4.
TreeFamTF314331.

Gene expression databases

ArrayExpressQ9DBR4.
BgeeQ9DBR4.
GenevestigatorQ9DBR4.

Family and domain databases

Gene3D2.30.29.30. 2 hits.
InterProIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF51045. SSF51045. 1 hit.
PROSITEPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPBB2. mouse.
EvolutionaryTraceQ9DBR4.
NextBio279605.
PROQ9DBR4.
SOURCESearch...

Entry information

Entry nameAPBB2_MOUSE
AccessionPrimary (citable) accession number: Q9DBR4
Secondary accession number(s): Q6DFX8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot