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Protein

Amyloid-beta A4 precursor protein-binding family B member 2

Gene

Apbb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate the internalization of amyloid-beta precursor protein.By similarity

GO - Molecular functioni

  • amyloid-beta binding Source: GO_Central
  • histone acetyltransferase binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • axon guidance Source: MGI
  • cell cycle arrest Source: UniProtKB
  • extracellular matrix organization Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell growth Source: UniProtKB
  • neuron migration Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • protein stabilization Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family B member 2
Gene namesi
Name:Apbb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108405 Apbb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760531 – 760Amyloid-beta A4 precursor protein-binding family B member 2Add BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DBR4
PRIDEiQ9DBR4

PTM databases

iPTMnetiQ9DBR4
PhosphoSitePlusiQ9DBR4

Expressioni

Gene expression databases

BgeeiENSMUSG00000029207
ExpressionAtlasiQ9DBR4 baseline and differential
GenevisibleiQ9DBR4 MM

Interactioni

Subunit structurei

Binds to the intracellular domain of the amyloid-beta precursor protein.By similarity

GO - Molecular functioni

  • histone acetyltransferase binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi1981424 interactors.
ELMiQ9DBR4
IntActiQ9DBR4 1 interactor.
MINTiQ9DBR4
STRINGi10090.ENSMUSP00000125211

Structurei

Secondary structure

1760
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi592 – 601Combined sources10
Beta strandi603 – 605Combined sources3
Helixi609 – 620Combined sources12
Turni624 – 626Combined sources3
Beta strandi629 – 635Combined sources7
Beta strandi638 – 642Combined sources5
Beta strandi650 – 655Combined sources6
Turni656 – 658Combined sources3
Beta strandi659 – 664Combined sources6
Beta strandi671 – 676Combined sources6
Beta strandi678 – 680Combined sources3
Beta strandi682 – 688Combined sources7
Helixi694 – 704Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortaliQ9DBR4
SMRiQ9DBR4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBR4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 322WWPROSITE-ProRule annotationAdd BLAST33
Domaini413 – 580PID 1PROSITE-ProRule annotationAdd BLAST168
Domaini586 – 738PID 2PROSITE-ProRule annotationAdd BLAST153

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA Eukaryota
ENOG410YEVS LUCA
GeneTreeiENSGT00390000000002
HOGENOMiHOG000033983
HOVERGENiHBG050524
InParanoidiQ9DBR4
KOiK04530
OMAiTKNSTPP
PhylomeDBiQ9DBR4
TreeFamiTF314331

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di2.30.29.302 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00640 PID, 2 hits
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN
60 70 80 90 100
AEIKHSDAKN STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV
110 120 130 140 150
KNGENQLRKA AEQGQQDPNK NLSPAAVINL TSEKLEVKDP HPQESSGCEI
160 170 180 190 200
LPSQPRRTKS FLNYYADLET SARELGQNLG PCQGVGEEKA QPGPGQAPVV
210 220 230 240 250
IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI
260 270 280 290 300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN
310 320 330 340 350
DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP
360 370 380 390 400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP
410 420 430 440 450
HGDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL
460 470 480 490 500
SYCKNDIRDT VGIWGEGKDM YLSLENDMLS LVDPMDRSVL HSQPIVNIRV
510 520 530 540 550
WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA TSLHEICSKI
560 570 580 590 600
MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML
610 620 630 640 650
PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV
660 670 680 690 700
LVECRVRFLS FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV
710 720 730 740 750
QAACMLRYQK CLVARPPSQK VRPPPPPADS VTRRVTTNVK RGVLSLIDTL
760
KQKRPVTETP
Length:760
Mass (Da):83,201
Last modified:March 1, 2003 - v2
Checksum:i9E66E34489F4D736
GO
Isoform 2 (identifier: Q9DBR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.

Show »
Length:739
Mass (Da):80,815
Checksum:i5821BB835A62868C
GO
Isoform 3 (identifier: Q9DBR4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     509-510: Missing.

Show »
Length:737
Mass (Da):80,530
Checksum:i2A8C34E8176E223C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011661348 – 368Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011662509 – 510Missing in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004792 mRNA Translation: BAB23568.2
BC076587 mRNA Translation: AAH76587.1
CCDSiCCDS51510.1 [Q9DBR4-1]
CCDS57344.1 [Q9DBR4-3]
RefSeqiNP_001188343.1, NM_001201414.1
NP_001188344.1, NM_001201415.1 [Q9DBR4-3]
NP_033816.1, NM_009686.2 [Q9DBR4-1]
UniGeneiMm.5159

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207 [Q9DBR4-3]
ENSMUST00000162349; ENSMUSP00000123752; ENSMUSG00000029207 [Q9DBR4-1]
GeneIDi11787
KEGGimmu:11787
UCSCiuc008xpb.2 mouse [Q9DBR4-3]
uc033ijy.1 mouse [Q9DBR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAPBB2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBR4
Secondary accession number(s): Q6DFX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome