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Protein

Amyloid beta A4 precursor protein-binding family B member 2

Gene

Apbb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein.By similarity

GO - Molecular functioni

  • beta-amyloid binding Source: GO_Central
  • histone acetyltransferase binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • axon guidance Source: MGI
  • cell cycle arrest Source: UniProtKB
  • extracellular matrix organization Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell growth Source: UniProtKB
  • neuron migration Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • protein stabilization Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 2
Gene namesi
Name:Apbb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108405. Apbb2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Amyloid beta A4 precursor protein-binding family B member 2PRO_0000076053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei334 – 3341PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBR4.
PaxDbiQ9DBR4.
PRIDEiQ9DBR4.

PTM databases

PhosphoSiteiQ9DBR4.

Expressioni

Gene expression databases

BgeeiQ9DBR4.
ExpressionAtlasiQ9DBR4. baseline and differential.
GenevestigatoriQ9DBR4.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein.By similarity

Protein-protein interaction databases

BioGridi198142. 4 interactions.
IntActiQ9DBR4. 1 interaction.

Structurei

Secondary structure

1
760
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi592 – 60110Combined sources
Beta strandi603 – 6053Combined sources
Helixi609 – 62012Combined sources
Turni624 – 6263Combined sources
Beta strandi629 – 6357Combined sources
Beta strandi638 – 6425Combined sources
Beta strandi650 – 6556Combined sources
Turni656 – 6583Combined sources
Beta strandi659 – 6646Combined sources
Beta strandi671 – 6766Combined sources
Beta strandi678 – 6803Combined sources
Beta strandi682 – 6887Combined sources
Helixi694 – 70411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortaliQ9DBR4.
SMRiQ9DBR4. Positions 291-320, 417-704.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBR4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 32233WWPROSITE-ProRule annotationAdd
BLAST
Domaini413 – 580168PID 1PROSITE-ProRule annotationAdd
BLAST
Domaini586 – 738153PID 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PID domains.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG76544.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ9DBR4.
KOiK04530.
OMAiTKNSTPP.
OrthoDBiEOG79W94P.
PhylomeDBiQ9DBR4.
TreeFamiTF314331.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN
60 70 80 90 100
AEIKHSDAKN STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV
110 120 130 140 150
KNGENQLRKA AEQGQQDPNK NLSPAAVINL TSEKLEVKDP HPQESSGCEI
160 170 180 190 200
LPSQPRRTKS FLNYYADLET SARELGQNLG PCQGVGEEKA QPGPGQAPVV
210 220 230 240 250
IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI
260 270 280 290 300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN
310 320 330 340 350
DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP
360 370 380 390 400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP
410 420 430 440 450
HGDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL
460 470 480 490 500
SYCKNDIRDT VGIWGEGKDM YLSLENDMLS LVDPMDRSVL HSQPIVNIRV
510 520 530 540 550
WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA TSLHEICSKI
560 570 580 590 600
MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML
610 620 630 640 650
PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV
660 670 680 690 700
LVECRVRFLS FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV
710 720 730 740 750
QAACMLRYQK CLVARPPSQK VRPPPPPADS VTRRVTTNVK RGVLSLIDTL
760
KQKRPVTETP
Length:760
Mass (Da):83,201
Last modified:March 1, 2003 - v2
Checksum:i9E66E34489F4D736
GO
Isoform 2 (identifier: Q9DBR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.

Show »
Length:739
Mass (Da):80,815
Checksum:i5821BB835A62868C
GO
Isoform 3 (identifier: Q9DBR4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     509-510: Missing.

Show »
Length:737
Mass (Da):80,530
Checksum:i2A8C34E8176E223C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei348 – 36821Missing in isoform 2 and isoform 3. 1 PublicationVSP_011661Add
BLAST
Alternative sequencei509 – 5102Missing in isoform 3. 1 PublicationVSP_011662

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004792 mRNA. Translation: BAB23568.2.
BC076587 mRNA. Translation: AAH76587.1.
CCDSiCCDS51510.1. [Q9DBR4-1]
CCDS57344.1. [Q9DBR4-3]
RefSeqiNP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1. [Q9DBR4-3]
NP_033816.1. NM_009686.2. [Q9DBR4-1]
UniGeneiMm.5159.

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207. [Q9DBR4-1]
ENSMUST00000160870; ENSMUSP00000123978; ENSMUSG00000029207. [Q9DBR4-3]
GeneIDi11787.
KEGGimmu:11787.
UCSCiuc008xox.2. mouse. [Q9DBR4-1]
uc008xpb.2. mouse. [Q9DBR4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004792 mRNA. Translation: BAB23568.2.
BC076587 mRNA. Translation: AAH76587.1.
CCDSiCCDS51510.1. [Q9DBR4-1]
CCDS57344.1. [Q9DBR4-3]
RefSeqiNP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1. [Q9DBR4-3]
NP_033816.1. NM_009686.2. [Q9DBR4-1]
UniGeneiMm.5159.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortaliQ9DBR4.
SMRiQ9DBR4. Positions 291-320, 417-704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198142. 4 interactions.
IntActiQ9DBR4. 1 interaction.

PTM databases

PhosphoSiteiQ9DBR4.

Proteomic databases

MaxQBiQ9DBR4.
PaxDbiQ9DBR4.
PRIDEiQ9DBR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207. [Q9DBR4-1]
ENSMUST00000160870; ENSMUSP00000123978; ENSMUSG00000029207. [Q9DBR4-3]
GeneIDi11787.
KEGGimmu:11787.
UCSCiuc008xox.2. mouse. [Q9DBR4-1]
uc008xpb.2. mouse. [Q9DBR4-3]

Organism-specific databases

CTDi323.
MGIiMGI:108405. Apbb2.

Phylogenomic databases

eggNOGiNOG76544.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ9DBR4.
KOiK04530.
OMAiTKNSTPP.
OrthoDBiEOG79W94P.
PhylomeDBiQ9DBR4.
TreeFamiTF314331.

Miscellaneous databases

ChiTaRSiApbb2. mouse.
EvolutionaryTraceiQ9DBR4.
NextBioi279605.
PROiQ9DBR4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBR4.
ExpressionAtlasiQ9DBR4. baseline and differential.
GenevestigatoriQ9DBR4.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Eye.
  3. "Solution structure of the C-terminal phosphotyrosine interaction domain of APBB2 from mouse."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 582-704.

Entry informationi

Entry nameiAPBB2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBR4
Secondary accession number(s): Q6DFX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.