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Protein

Amyloid beta A4 precursor protein-binding family B member 2

Gene

Apbb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein.By similarity

GO - Molecular functioni

  • beta-amyloid binding Source: GO_Central
  • histone acetyltransferase binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • axon guidance Source: MGI
  • cell cycle arrest Source: UniProtKB
  • extracellular matrix organization Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell growth Source: UniProtKB
  • neuron migration Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • protein stabilization Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 2
Gene namesi
Name:Apbb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108405. Apbb2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760531 – 760Amyloid beta A4 precursor protein-binding family B member 2Add BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DBR4.
PRIDEiQ9DBR4.

PTM databases

iPTMnetiQ9DBR4.
PhosphoSitePlusiQ9DBR4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029207.
ExpressionAtlasiQ9DBR4. baseline and differential.
GenevisibleiQ9DBR4. MM.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein.By similarity

GO - Molecular functioni

  • histone acetyltransferase binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198142. 4 interactors.
IntActiQ9DBR4. 1 interactor.
STRINGi10090.ENSMUSP00000125211.

Structurei

Secondary structure

1760
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi592 – 601Combined sources10
Beta strandi603 – 605Combined sources3
Helixi609 – 620Combined sources12
Turni624 – 626Combined sources3
Beta strandi629 – 635Combined sources7
Beta strandi638 – 642Combined sources5
Beta strandi650 – 655Combined sources6
Turni656 – 658Combined sources3
Beta strandi659 – 664Combined sources6
Beta strandi671 – 676Combined sources6
Beta strandi678 – 680Combined sources3
Beta strandi682 – 688Combined sources7
Helixi694 – 704Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortaliQ9DBR4.
SMRiQ9DBR4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBR4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 322WWPROSITE-ProRule annotationAdd BLAST33
Domaini413 – 580PID 1PROSITE-ProRule annotationAdd BLAST168
Domaini586 – 738PID 2PROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Contains 2 PID domains.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ9DBR4.
KOiK04530.
OMAiTKNSTPP.
PhylomeDBiQ9DBR4.
TreeFamiTF314331.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 2 hits.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN
60 70 80 90 100
AEIKHSDAKN STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV
110 120 130 140 150
KNGENQLRKA AEQGQQDPNK NLSPAAVINL TSEKLEVKDP HPQESSGCEI
160 170 180 190 200
LPSQPRRTKS FLNYYADLET SARELGQNLG PCQGVGEEKA QPGPGQAPVV
210 220 230 240 250
IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI
260 270 280 290 300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN
310 320 330 340 350
DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP
360 370 380 390 400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP
410 420 430 440 450
HGDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL
460 470 480 490 500
SYCKNDIRDT VGIWGEGKDM YLSLENDMLS LVDPMDRSVL HSQPIVNIRV
510 520 530 540 550
WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA TSLHEICSKI
560 570 580 590 600
MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML
610 620 630 640 650
PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV
660 670 680 690 700
LVECRVRFLS FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV
710 720 730 740 750
QAACMLRYQK CLVARPPSQK VRPPPPPADS VTRRVTTNVK RGVLSLIDTL
760
KQKRPVTETP
Length:760
Mass (Da):83,201
Last modified:March 1, 2003 - v2
Checksum:i9E66E34489F4D736
GO
Isoform 2 (identifier: Q9DBR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.

Show »
Length:739
Mass (Da):80,815
Checksum:i5821BB835A62868C
GO
Isoform 3 (identifier: Q9DBR4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     509-510: Missing.

Show »
Length:737
Mass (Da):80,530
Checksum:i2A8C34E8176E223C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011661348 – 368Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011662509 – 510Missing in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004792 mRNA. Translation: BAB23568.2.
BC076587 mRNA. Translation: AAH76587.1.
CCDSiCCDS51510.1. [Q9DBR4-1]
CCDS57344.1. [Q9DBR4-3]
RefSeqiNP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1. [Q9DBR4-3]
NP_033816.1. NM_009686.2. [Q9DBR4-1]
UniGeneiMm.5159.

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207. [Q9DBR4-3]
ENSMUST00000162349; ENSMUSP00000123752; ENSMUSG00000029207. [Q9DBR4-1]
GeneIDi11787.
KEGGimmu:11787.
UCSCiuc008xpb.2. mouse. [Q9DBR4-3]
uc033ijy.1. mouse. [Q9DBR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004792 mRNA. Translation: BAB23568.2.
BC076587 mRNA. Translation: AAH76587.1.
CCDSiCCDS51510.1. [Q9DBR4-1]
CCDS57344.1. [Q9DBR4-3]
RefSeqiNP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1. [Q9DBR4-3]
NP_033816.1. NM_009686.2. [Q9DBR4-1]
UniGeneiMm.5159.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortaliQ9DBR4.
SMRiQ9DBR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198142. 4 interactors.
IntActiQ9DBR4. 1 interactor.
STRINGi10090.ENSMUSP00000125211.

PTM databases

iPTMnetiQ9DBR4.
PhosphoSitePlusiQ9DBR4.

Proteomic databases

PaxDbiQ9DBR4.
PRIDEiQ9DBR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207. [Q9DBR4-3]
ENSMUST00000162349; ENSMUSP00000123752; ENSMUSG00000029207. [Q9DBR4-1]
GeneIDi11787.
KEGGimmu:11787.
UCSCiuc008xpb.2. mouse. [Q9DBR4-3]
uc033ijy.1. mouse. [Q9DBR4-1]

Organism-specific databases

CTDi323.
MGIiMGI:108405. Apbb2.

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ9DBR4.
KOiK04530.
OMAiTKNSTPP.
PhylomeDBiQ9DBR4.
TreeFamiTF314331.

Miscellaneous databases

ChiTaRSiApbb2. mouse.
EvolutionaryTraceiQ9DBR4.
PROiQ9DBR4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029207.
ExpressionAtlasiQ9DBR4. baseline and differential.
GenevisibleiQ9DBR4. MM.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 2 hits.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPBB2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBR4
Secondary accession number(s): Q6DFX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.