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Q9DBR4

- APBB2_MOUSE

UniProt

Q9DBR4 - APBB2_MOUSE

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Protein
Amyloid beta A4 precursor protein-binding family B member 2
Gene
Apbb2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein By similarity.

GO - Molecular functioni

  1. histone acetyltransferase binding Source: UniProtKB
  2. protein binding Source: MGI
  3. transcription factor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. actin filament-based movement Source: UniProtKB
  2. axon guidance Source: MGI
  3. cell cycle arrest Source: UniProtKB
  4. extracellular matrix organization Source: MGI
  5. negative regulation of apoptotic process Source: MGI
  6. negative regulation of cell growth Source: UniProtKB
  7. neuron migration Source: MGI
  8. positive regulation of apoptotic process Source: MGI
  9. protein stabilization Source: UniProtKB
  10. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 2
Gene namesi
Name:Apbb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:108405. Apbb2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Amyloid beta A4 precursor protein-binding family B member 2
PRO_0000076053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBR4.
PaxDbiQ9DBR4.
PRIDEiQ9DBR4.

PTM databases

PhosphoSiteiQ9DBR4.

Expressioni

Gene expression databases

ArrayExpressiQ9DBR4.
BgeeiQ9DBR4.
GenevestigatoriQ9DBR4.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein By similarity.

Protein-protein interaction databases

BioGridi198142. 4 interactions.
IntActiQ9DBR4. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi592 – 60110
Beta strandi603 – 6053
Helixi609 – 62012
Turni624 – 6263
Beta strandi629 – 6357
Beta strandi638 – 6425
Beta strandi650 – 6556
Turni656 – 6583
Beta strandi659 – 6646
Beta strandi671 – 6766
Beta strandi678 – 6803
Beta strandi682 – 6887
Helixi694 – 70411

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortaliQ9DBR4.
SMRiQ9DBR4. Positions 291-320, 417-553, 582-704.

Miscellaneous databases

EvolutionaryTraceiQ9DBR4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 32233WW
Add
BLAST
Domaini413 – 580168PID 1
Add
BLAST
Domaini586 – 738153PID 2
Add
BLAST

Sequence similaritiesi

Contains 2 PID domains.
Contains 1 WW domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG76544.
GeneTreeiENSGT00390000000002.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiQ9DBR4.
KOiK04530.
OMAiTKNSTPP.
OrthoDBiEOG79W94P.
PhylomeDBiQ9DBR4.
TreeFamiTF314331.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9DBR4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN    50
AEIKHSDAKN STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV 100
KNGENQLRKA AEQGQQDPNK NLSPAAVINL TSEKLEVKDP HPQESSGCEI 150
LPSQPRRTKS FLNYYADLET SARELGQNLG PCQGVGEEKA QPGPGQAPVV 200
IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI 250
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN 300
DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP 350
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP 400
HGDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL 450
SYCKNDIRDT VGIWGEGKDM YLSLENDMLS LVDPMDRSVL HSQPIVNIRV 500
WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA TSLHEICSKI 550
MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML 600
PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV 650
LVECRVRFLS FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV 700
QAACMLRYQK CLVARPPSQK VRPPPPPADS VTRRVTTNVK RGVLSLIDTL 750
KQKRPVTETP 760
Length:760
Mass (Da):83,201
Last modified:March 1, 2003 - v2
Checksum:i9E66E34489F4D736
GO
Isoform 2 (identifier: Q9DBR4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.

Show »
Length:739
Mass (Da):80,815
Checksum:i5821BB835A62868C
GO
Isoform 3 (identifier: Q9DBR4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     509-510: Missing.

Show »
Length:737
Mass (Da):80,530
Checksum:i2A8C34E8176E223C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei348 – 36821Missing in isoform 2 and isoform 3.
VSP_011661Add
BLAST
Alternative sequencei509 – 5102Missing in isoform 3.
VSP_011662

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004792 mRNA. Translation: BAB23568.2.
BC076587 mRNA. Translation: AAH76587.1.
CCDSiCCDS51510.1. [Q9DBR4-1]
CCDS57344.1. [Q9DBR4-3]
RefSeqiNP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1. [Q9DBR4-3]
NP_033816.1. NM_009686.2. [Q9DBR4-1]
UniGeneiMm.5159.

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207. [Q9DBR4-1]
ENSMUST00000160870; ENSMUSP00000123978; ENSMUSG00000029207. [Q9DBR4-3]
GeneIDi11787.
KEGGimmu:11787.
UCSCiuc008xox.2. mouse. [Q9DBR4-1]
uc008xpb.2. mouse. [Q9DBR4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004792 mRNA. Translation: BAB23568.2 .
BC076587 mRNA. Translation: AAH76587.1 .
CCDSi CCDS51510.1. [Q9DBR4-1 ]
CCDS57344.1. [Q9DBR4-3 ]
RefSeqi NP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1. [Q9DBR4-3 ]
NP_033816.1. NM_009686.2. [Q9DBR4-1 ]
UniGenei Mm.5159.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WGU NMR - A 582-704 [» ]
2ROZ NMR - B 582-704 [» ]
2YSZ NMR - A 582-704 [» ]
2YT0 NMR - A 582-704 [» ]
2YT1 NMR - A 582-704 [» ]
ProteinModelPortali Q9DBR4.
SMRi Q9DBR4. Positions 291-320, 417-553, 582-704.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198142. 4 interactions.
IntActi Q9DBR4. 1 interaction.

PTM databases

PhosphoSitei Q9DBR4.

Proteomic databases

MaxQBi Q9DBR4.
PaxDbi Q9DBR4.
PRIDEi Q9DBR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000159786 ; ENSMUSP00000125211 ; ENSMUSG00000029207 . [Q9DBR4-1 ]
ENSMUST00000160870 ; ENSMUSP00000123978 ; ENSMUSG00000029207 . [Q9DBR4-3 ]
GeneIDi 11787.
KEGGi mmu:11787.
UCSCi uc008xox.2. mouse. [Q9DBR4-1 ]
uc008xpb.2. mouse. [Q9DBR4-3 ]

Organism-specific databases

CTDi 323.
MGIi MGI:108405. Apbb2.

Phylogenomic databases

eggNOGi NOG76544.
GeneTreei ENSGT00390000000002.
HOGENOMi HOG000033983.
HOVERGENi HBG050524.
InParanoidi Q9DBR4.
KOi K04530.
OMAi TKNSTPP.
OrthoDBi EOG79W94P.
PhylomeDBi Q9DBR4.
TreeFami TF314331.

Miscellaneous databases

ChiTaRSi APBB2. mouse.
EvolutionaryTracei Q9DBR4.
NextBioi 279605.
PROi Q9DBR4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9DBR4.
Bgeei Q9DBR4.
Genevestigatori Q9DBR4.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF51045. SSF51045. 1 hit.
PROSITEi PS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Eye.
  3. "Solution structure of the C-terminal phosphotyrosine interaction domain of APBB2 from mouse."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 582-704.

Entry informationi

Entry nameiAPBB2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBR4
Secondary accession number(s): Q6DFX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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