Q9DBR4 (APBB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amyloid beta A4 precursor protein-binding family B member 2

Gene names

Name:

Apbb2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	760 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May modulate the internalization of beta-amyloid precursor protein By similarity.
Subunit structure	Binds to the intracellular domain of the beta-amyloid precursor protein By similarity.
Sequence similarities	Contains 2 PID domains. Contains 1 WW domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament-based movement Non-traceable author statement PubMed 12089154. Source: UniProtKB axon guidance Inferred from genetic interaction PubMed 16407979. Source: MGI cell cycle arrest Inferred from direct assay PubMed 12089154. Source: UniProtKB extracellular matrix organization Inferred from genetic interaction PubMed 16407979. Source: MGI negative regulation of S phase of mitotic cell cycle Inferred from direct assay PubMed 12089154. Source: UniProtKB negative regulation of apoptotic process Inferred from genetic interaction PubMed 15629131. Source: MGI negative regulation of cell growth Inferred from direct assay PubMed 12089154. Source: UniProtKB neuron migration Inferred from genetic interaction PubMed 16407979. Source: MGI positive regulation of apoptotic process Inferred from direct assay PubMed 15629131. Source: MGI protein stabilization Non-traceable author statement PubMed 11544248. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from direct assay PubMed 12089154. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay PubMed 15629131. Source: MGI nucleus Inferred from direct assay PubMed 12089154. Source: UniProtKB
Molecular_function	histone acetyltransferase binding Non-traceable author statement PubMed 12089154. Source: UniProtKB transcription factor binding Inferred from direct assay PubMed 12089154. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9DBR4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9DBR4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.

Isoform 3 (identifier: Q9DBR4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     509-510: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 760

760

Amyloid beta A4 precursor protein-binding family B member 2

PRO_0000076053

Regions

Domain

290 – 322

33

WW

Domain

413 – 580

168

PID 1

Domain

586 – 738

153

PID 2

Amino acid modifications

Modified residue

123

1

Phosphoserine By similarity

Natural variations

Alternative sequence

348 – 368

21

Missing in isoform 2 and isoform 3.

VSP_011661

Alternative sequence

509 – 510

2

Missing in isoform 3.

VSP_011662

Secondary structure

1

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760

Helix Strand Turn

Details...

Beta strand

592 – 601

10

Beta strand

603 – 605

3

Helix

609 – 620

12

Turn

624 – 626

3

Beta strand

629 – 635

7

Beta strand

638 – 642

5

Beta strand

650 – 655

6

Turn

656 – 658

3

Beta strand

659 – 664

6

Beta strand

671 – 676

6

Beta strand

678 – 680

3

Beta strand

682 – 688

7

Helix

694 – 704

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: 9E66E34489F4D736	FASTA	760	83,201
	10 20 30 40 50 60 MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN AEIKHSDAKN 70 80 90 100 110 120 STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 130 140 150 160 170 180 NLSPAAVINL TSEKLEVKDP HPQESSGCEI LPSQPRRTKS FLNYYADLET SARELGQNLG 190 200 210 220 230 240 PCQGVGEEKA QPGPGQAPVV IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG 250 260 270 280 290 300 AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN 310 320 330 340 350 360 DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP WSDFAVLNGG 370 380 390 400 410 420 KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP HGDDDDSCSI NSDPEAKCFA 430 440 450 460 470 480 VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL SYCKNDIRDT VGIWGEGKDM YLSLENDMLS 490 500 510 520 530 540 LVDPMDRSVL HSQPIVNIRV WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA 550 560 570 580 590 600 TSLHEICSKI MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML 610 620 630 640 650 660 PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV LVECRVRFLS 670 680 690 700 710 720 FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV QAACMLRYQK CLVARPPSQK 730 740 750 760 VRPPPPPADS VTRRVTTNVK RGVLSLIDTL KQKRPVTETP
	Isoform 2 [UniParc]. Checksum: 5821BB835A62868C	FASTA	739	80,815
	10 20 30 40 50 60 MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN AEIKHSDAKN 70 80 90 100 110 120 STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 130 140 150 160 170 180 NLSPAAVINL TSEKLEVKDP HPQESSGCEI LPSQPRRTKS FLNYYADLET SARELGQNLG 190 200 210 220 230 240 PCQGVGEEKA QPGPGQAPVV IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG 250 260 270 280 290 300 AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN 310 320 330 340 350 360 DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEDLH AATVNPDPSL 370 380 390 400 410 420 KEFEGATLRY ASLKLRNAPH GDDDDSCSIN SDPEAKCFAV RSLGWVEMAE EDLAPGKSSV 430 440 450 460 470 480 AVNNCIRQLS YCKNDIRDTV GIWGEGKDMY LSLENDMLSL VDPMDRSVLH SQPIVNIRVW 490 500 510 520 530 540 GVGRDNGRER DFAYVARDKD TRILKCHVFR CDTPAKAIAT SLHEICSKIM AERKNAKALA 550 560 570 580 590 600 CSSLQERTNM SLDVPLQVDF PTPKTELVQK FRVQYLGMLP VDRPVGMDTL NSAIENLMTS 610 620 630 640 650 660 SSKEDWPSVN MNVADATVTV ISEKNEEEVL VECRVRFLSF MGVGKDVHTF AFIMDTGNQR 670 680 690 700 710 720 FECHVFWCEP NAANVSEAVQ AACMLRYQKC LVARPPSQKV RPPPPPADSV TRRVTTNVKR 730 GVLSLIDTLK QKRPVTETP
	Isoform 3 [UniParc]. Checksum: 2A8C34E8176E223C	FASTA	737	80,530
	10 20 30 40 50 60 MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN AEIKHSDAKN 70 80 90 100 110 120 STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 130 140 150 160 170 180 NLSPAAVINL TSEKLEVKDP HPQESSGCEI LPSQPRRTKS FLNYYADLET SARELGQNLG 190 200 210 220 230 240 PCQGVGEEKA QPGPGQAPVV IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG 250 260 270 280 290 300 AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN 310 320 330 340 350 360 DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEDLH AATVNPDPSL 370 380 390 400 410 420 KEFEGATLRY ASLKLRNAPH GDDDDSCSIN SDPEAKCFAV RSLGWVEMAE EDLAPGKSSV 430 440 450 460 470 480 AVNNCIRQLS YCKNDIRDTV GIWGEGKDMY LSLENDMLSL VDPMDRSVLH SQPIVNIRVW 490 500 510 520 530 540 GVGRDNGRDF AYVARDKDTR ILKCHVFRCD TPAKAIATSL HEICSKIMAE RKNAKALACS 550 560 570 580 590 600 SLQERTNMSL DVPLQVDFPT PKTELVQKFR VQYLGMLPVD RPVGMDTLNS AIENLMTSSS 610 620 630 640 650 660 KEDWPSVNMN VADATVTVIS EKNEEEVLVE CRVRFLSFMG VGKDVHTFAF IMDTGNQRFE 670 680 690 700 710 720 CHVFWCEPNA ANVSEAVQAA CMLRYQKCLV ARPPSQKVRP PPPPADSVTR RVTTNVKRGV 730 LSLIDTLKQK RPVTETP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: C57BL/6. Tissue: Eye.
[3]	"Solution structure of the C-terminal phosphotyrosine interaction domain of APBB2 from mouse." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 582-704.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK004792 mRNA. Translation: BAB23568.2.
BC076587 mRNA. Translation: AAH76587.1.

IPI

IPI00187397.
IPI00471423.
IPI00471424.

RefSeq

NP_001188343.1. NM_001201414.1.
NP_001188344.1. NM_001201415.1.
NP_033816.1. NM_009686.1.

UniGene

Mm.5159.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WGU	NMR	-	A	582-704	[»]
2ROZ	NMR	-	B	582-704	[»]
2YSZ	NMR	-	A	582-704	[»]
2YT0	NMR	-	A	582-704	[»]
2YT1	NMR	-	A	582-704	[»]

ProteinModelPortal

Q9DBR4.

SMR

Q9DBR4. Positions 291-320, 417-553, 582-704.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9DBR4. 1 interaction.

PTM databases

PhosphoSite

Q9DBR4.

Proteomic databases

PaxDb

Q9DBR4.

PRIDE

Q9DBR4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207.
ENSMUST00000160870; ENSMUSP00000123978; ENSMUSG00000029207.

GeneID

11787.

KEGG

mmu:11787.

UCSC

uc008xox.2. mouse.
uc008xpb.2. mouse.

Organism-specific databases

CTD

323.

MGI

MGI:108405. Apbb2.

Phylogenomic databases

eggNOG

NOG76544.

GeneTree

ENSGT00390000000002.

HOGENOM

HOG000033983.

HOVERGEN

HBG050524.

InParanoid

Q9DBR4.

KO

K04530.

OMA

TKNSTPP.

OrthoDB

EOG43XV35.

Gene expression databases

ArrayExpress

Q9DBR4.

Bgee

Q9DBR4.

Genevestigator

Q9DBR4.

GermOnline

ENSMUSG00000029207. Mus musculus.

Family and domain databases

Gene3D

2.30.29.30. 2 hits.

InterPro

IPR011993. PH_like_dom.
IPR006020. PTyr_interaction_dom.
IPR001202. WW_dom.
[Graphical view]

Pfam

PF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]

SMART

SM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]

SUPFAM

SSF51045. WW_Rsp5_WWP. 1 hit.

PROSITE

PS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

APBB2. mouse.

EvolutionaryTrace

Q9DBR4.

NextBio

279605.

SOURCE

Search...

Entry information

Entry name

APBB2_MOUSE

Accession

Primary (citable) accession number: Q9DBR4
Secondary accession number(s): Q6DFX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program