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Protein

Protein-associating with the carboxyl-terminal domain of ezrin

Gene

Scyl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulating cell adhesion/migration complexes in migrating cells.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-associating with the carboxyl-terminal domain of ezrin
Alternative name(s):
Ezrin-binding protein PACE-1
SCY1-like protein 3
Gene namesi
Name:Scyl3
Synonyms:Pace1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921385. Scyl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000581682 – 735Protein-associating with the carboxyl-terminal domain of ezrinAdd BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei439PhosphoserineCombined sources1
Modified residuei701PhosphoserineBy similarity1

Post-translational modificationi

May be myristoylated; myristoylation may target it to Golgi compartment.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ9DBQ7.
PeptideAtlasiQ9DBQ7.
PRIDEiQ9DBQ7.

PTM databases

iPTMnetiQ9DBQ7.
PhosphoSitePlusiQ9DBQ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026584.
CleanExiMM_SCYL3.
ExpressionAtlasiQ9DBQ7. baseline and differential.
GenevisibleiQ9DBQ7. MM.

Interactioni

Subunit structurei

Interacts with EZR/VIL2 C-terminal domain.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027876.

Structurei

3D structure databases

ProteinModelPortaliQ9DBQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 245Protein kinasePROSITE-ProRule annotationAdd BLAST244
Repeati194 – 249HEAT 1Add BLAST56
Repeati285 – 323HEAT 2Add BLAST39
Repeati333 – 370HEAT 3Add BLAST38
Repeati372 – 409HEAT 4Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni547 – 735Interaction with EZRBy similarityAdd BLAST189

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 4 HEAT repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
GeneTreeiENSGT00860000133812.
HOGENOMiHOG000115424.
HOVERGENiHBG053485.
InParanoidiQ9DBQ7.
KOiK17542.
OMAiQFSSKFA.
OrthoDBiEOG091G0B8M.
PhylomeDBiQ9DBQ7.
TreeFamiTF313435.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSENSALKS YTLRESPFTL PSGLAVYPAI LQDGKCASVF VYKRENEDKV
60 70 80 90 100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSPAEV
110 120 130 140 150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCQVP
160 170 180 190 200
QATPEFLRNI QSVRDPASIP PEEMSPEFSG LPESHGHARD AYAFGALVDS
210 220 230 240 250
LLPIFNEQVS ADVLSSFLQI LHSALLNPMP ECRPALSTLL SHDFFRNDFL
260 270 280 290 300
EVVNFLKSLT LKSEDEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF
310 320 330 340 350
AEPVAVKSFL PYLLGPKKEN APGETPCLLS PALFQSRVIP VLLRLFEVHE
360 370 380 390 400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSN SIVAITLRSL
410 420 430 440 450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK TSDLSPEGSP MHVVCSQQSR
460 470 480 490 500
VSKVLEDPSS NVFPKWLSGN VPSSSRKRIQ EECYSSLSQT GDQFSHTIKF
510 520 530 540 550
PMNGLSDVKN TSEDNGSFPA GSNKPEEWPD WSEPEEPEQQ PASIHRWPRE
560 570 580 590 600
PCDVAESQHT NLTAEEVTWD DGEASFGTEI NSTATASAPV PVTSGGQSTS
610 620 630 640 650
AALVPLTEES KPLQSSPSSK TSHRQHEEVK PPQVSQERPL KAPSGLGLGE
660 670 680 690 700
EFTIQVKKKP VQDPELDWFA DMIPEIKPSG TFLILPELRT EVMVPDKDNV
710 720 730
SSLMQFSSKF AATEMTEGEA EGWEGEELAW EDNNW
Length:735
Mass (Da):81,333
Last modified:January 23, 2007 - v3
Checksum:i13E6652AE93A4424
GO
Isoform 2 (identifier: Q9DBQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-99: HLKTLRHPCL...VALETLSPAE → MAFTSSLREC...LLSSFMTEDI
     100-735: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:99
Mass (Da):11,283
Checksum:i562162FBD40B9AF9
GO
Isoform 3 (identifier: Q9DBQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-331: Missing.

Note: No experimental confirmation available.
Show »
Length:722
Mass (Da):80,024
Checksum:i1E536A38605B2A07
GO

Sequence cautioni

The sequence BAC31777 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BC066800 differs from that shown. Reason: Erroneous termination at position 613. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93E → Q in BAE37123 (PubMed:16141072).Curated1
Sequence conflicti226L → Q in BC066800 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03798556 – 99HLKTL…LSPAE → MAFTSSLRECSLWKWPWKPC LLQKSVLESMTYCWLLSSFM TEDI in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_013126100 – 735Missing in isoform 2. 1 PublicationAdd BLAST636
Alternative sequenceiVSP_027369319 – 331Missing in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004809 mRNA. Translation: BAB23580.1.
AK044100 mRNA. Translation: BAC31777.1. Sequence problems.
AK050999 mRNA. Translation: BAC34492.1.
AK162937 mRNA. Translation: BAE37123.1.
BC043085 mRNA. Translation: AAH43085.1.
BC066800 mRNA. No translation available.
CCDSiCCDS15430.1. [Q9DBQ7-1]
CCDS69967.1. [Q9DBQ7-3]
RefSeqiNP_001272931.1. NM_001286002.1. [Q9DBQ7-3]
NP_001272932.1. NM_001286003.1.
NP_083052.1. NM_028776.5. [Q9DBQ7-1]
XP_006496912.1. XM_006496849.1.
XP_017176061.1. XM_017320572.1.
UniGeneiMm.389213.

Genome annotation databases

EnsembliENSMUST00000027876; ENSMUSP00000027876; ENSMUSG00000026584. [Q9DBQ7-1]
ENSMUST00000161908; ENSMUSP00000125735; ENSMUSG00000026584. [Q9DBQ7-3]
ENSMUST00000162234; ENSMUSP00000123704; ENSMUSG00000026584. [Q9DBQ7-2]
ENSMUST00000170359; ENSMUSP00000132109; ENSMUSG00000026584. [Q9DBQ7-3]
GeneIDi240880.
KEGGimmu:240880.
UCSCiuc007dhq.2. mouse. [Q9DBQ7-1]
uc011wuu.1. mouse. [Q9DBQ7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004809 mRNA. Translation: BAB23580.1.
AK044100 mRNA. Translation: BAC31777.1. Sequence problems.
AK050999 mRNA. Translation: BAC34492.1.
AK162937 mRNA. Translation: BAE37123.1.
BC043085 mRNA. Translation: AAH43085.1.
BC066800 mRNA. No translation available.
CCDSiCCDS15430.1. [Q9DBQ7-1]
CCDS69967.1. [Q9DBQ7-3]
RefSeqiNP_001272931.1. NM_001286002.1. [Q9DBQ7-3]
NP_001272932.1. NM_001286003.1.
NP_083052.1. NM_028776.5. [Q9DBQ7-1]
XP_006496912.1. XM_006496849.1.
XP_017176061.1. XM_017320572.1.
UniGeneiMm.389213.

3D structure databases

ProteinModelPortaliQ9DBQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027876.

PTM databases

iPTMnetiQ9DBQ7.
PhosphoSitePlusiQ9DBQ7.

Proteomic databases

PaxDbiQ9DBQ7.
PeptideAtlasiQ9DBQ7.
PRIDEiQ9DBQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027876; ENSMUSP00000027876; ENSMUSG00000026584. [Q9DBQ7-1]
ENSMUST00000161908; ENSMUSP00000125735; ENSMUSG00000026584. [Q9DBQ7-3]
ENSMUST00000162234; ENSMUSP00000123704; ENSMUSG00000026584. [Q9DBQ7-2]
ENSMUST00000170359; ENSMUSP00000132109; ENSMUSG00000026584. [Q9DBQ7-3]
GeneIDi240880.
KEGGimmu:240880.
UCSCiuc007dhq.2. mouse. [Q9DBQ7-1]
uc011wuu.1. mouse. [Q9DBQ7-3]

Organism-specific databases

CTDi57147.
MGIiMGI:1921385. Scyl3.

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
GeneTreeiENSGT00860000133812.
HOGENOMiHOG000115424.
HOVERGENiHBG053485.
InParanoidiQ9DBQ7.
KOiK17542.
OMAiQFSSKFA.
OrthoDBiEOG091G0B8M.
PhylomeDBiQ9DBQ7.
TreeFamiTF313435.

Miscellaneous databases

PROiQ9DBQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026584.
CleanExiMM_SCYL3.
ExpressionAtlasiQ9DBQ7. baseline and differential.
GenevisibleiQ9DBQ7. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPACE1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBQ7
Secondary accession number(s): Q3TRA7
, Q6NY01, Q8BQC9, Q8BRJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.