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Protein
Submitted name:

Nuclear factor of activated T-cells c1 isoform IB-VIII

Gene

Nfatc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-4086398. Ca2+ pathway.
R-MMU-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of activated T-cells c1 isoform IB-VIIIImported
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 1Imported
Gene namesi
Name:Nfatc1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:102469. Nfatc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ9DBQ6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129001.

Structurei

3D structure databases

SMRiQ9DBQ6. Positions 398-682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini397 – 579183RHD (Rel-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IHFR. Eukaryota.
ENOG41105U2. LUCA.
GeneTreeiENSGT00550000074562.
HOVERGENiHBG069754.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamiPF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLEQDPEF DFDFLFEFDQ SGGGAAAAEH YSYVSPSVTS TLPLPTAHSA
60 70 80 90 100
LPAACHDLQT STPGISAVPS ANHPPSYGGA VDSGPSGYFL SSGNTRPNGA
110 120 130 140 150
PTLESPRIEI TSYLGLHHGS GQFFHDVEVE DVLPSCKRSP STATLHLPSL
160 170 180 190 200
EAYRDPSCLS PASSLSSRSC NSEASSYESN YSYPYASPQT SPWQSPCVSP
210 220 230 240 250
KTTDPEEGFP RSLGACHLLG SPRHSPSTSP RASITEESWL GARGSRPTSP
260 270 280 290 300
CNKRKYSLNG RQPSCSPHHS PTPSPHGSPR VSVTEDTWLG NTTQYTSSAI
310 320 330 340 350
VAAINALTTD STLDLGDGVP IKSRKTALEH APSVALKVEP AGEDLGTTPP
360 370 380 390 400
TSDFPPEEYT FQHLRKGAFC EQYLSVPQAS YQWAKPKSLS PTSYMSPSLP
410 420 430 440 450
ALDWQLPSHS GPYELRIEVQ PKSHHRAHYE TEGSRGAVKA SAGGHPIVQL
460 470 480 490 500
HGYLENEPLT LQLFIGTADD RLLRPHAFYQ VHRITGKTVS TTSHEIILSN
510 520 530 540 550
TKVLEIPLLP ENNMRAIIDC AGILKLRNSD IELRKGETDI GRKNTRVRLV
560 570 580 590 600
FRVHIPQPNG RTLSLQVASN PIECSQRSAQ ELPLVEKQST DSYPVIGGKK
610 620 630 640 650
MVLSGHNFLQ DSKVIFVEKA PDGHHVWEME AKTDRDLCKP NSLVVEIPPF
660 670 680 690 700
RNQRITSPVQ VSFYVCNGKR KRSQYQRFTY LPANGNSVFL TLSSESELRG

GFY
Length:703
Mass (Da):76,692
Last modified:June 1, 2001 - v1
Checksum:iD737C9B86E280C7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123818 Genomic DNA. No translation available.
AC149054 Genomic DNA. No translation available.
EU887571 mRNA. Translation: ACG55591.1.
AK004810 mRNA. Translation: BAB23581.1.
RefSeqiNP_058071.2. NM_016791.4.
UniGeneiMm.329560.

Genome annotation databases

EnsembliENSMUST00000035800; ENSMUSP00000046312; ENSMUSG00000033016.
GeneIDi18018.
UCSCiuc008ftf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123818 Genomic DNA. No translation available.
AC149054 Genomic DNA. No translation available.
EU887571 mRNA. Translation: ACG55591.1.
AK004810 mRNA. Translation: BAB23581.1.
RefSeqiNP_058071.2. NM_016791.4.
UniGeneiMm.329560.

3D structure databases

SMRiQ9DBQ6. Positions 398-682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035800; ENSMUSP00000046312; ENSMUSG00000033016.
GeneIDi18018.
UCSCiuc008ftf.2. mouse.

Organism-specific databases

CTDi4772.
MGIiMGI:102469. Nfatc1.

Phylogenomic databases

eggNOGiENOG410IHFR. Eukaryota.
ENOG41105U2. LUCA.
GeneTreeiENSGT00550000074562.
HOVERGENiHBG069754.

Enzyme and pathway databases

ReactomeiR-MMU-2871809. FCERI mediated Ca+2 mobilization.
R-MMU-4086398. Ca2+ pathway.
R-MMU-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ9DBQ6. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamiPF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  9. "Alternative splicing and expression of human and mouse NFAT genes."
    Vihma H., Pruunsild P., Timmusk T.
    Genomics 0:0-0(2008)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9DBQ6_MOUSE
AccessioniPrimary (citable) accession number: Q9DBQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.