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Q9DBP5 (KCY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UMP-CMP kinase

EC=2.7.4.14
Alternative name(s):
Cytidine monophosphate kinase
Cytidylate kinase
Deoxycytidylate kinase
Uridine monophosphate kinase
Uridine monophosphate/cytidine monophosphate kinase
Short name=UMP/CMP kinase
Short name=UMP/CMPK
Gene names
Name:Cmpk1
Synonyms:Cmk, Cmpk, Uck, Umk, Umpk
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes specific phosphoryl transfer from ATP to UMP and CMP By similarity.

Catalytic activity

ATP + (d)CMP = ADP + (d)CDP.

ATP + UMP = ADP + UDP.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the adenylate kinase family.

Sequence caution

The sequence AAH17684.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB22163.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC36852.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE27170.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE29352.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE36771.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAM19996.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196UMP-CMP kinase
PRO_0000158950

Regions

Nucleotide binding10 – 189ATP By similarity

Amino acid modifications

Modified residue551N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9DBP5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7972B629D7542294

FASTA19622,165
        10         20         30         40         50         60 
MKPLVVFVLG GPGAGKGTQC ARIVEKYGYT HLSAGELLRD ERKNPDSQYG ELIEKYIKEG 

        70         80         90        100        110        120 
KIVPVEITIS LLKREMDQTM AANAQKNKFL IDGFPRNQDN LQGWNKTMDG KADVSFVLFF 

       130        140        150        160        170        180 
DCNNEICIER CLERGKSSGR SDDNRESLEK RIQTYLESTK PIIDLYEEMG KVKKIDASKS 

       190 
VDEVFGEVVK IFDKEG 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
[4]Lubec G., Klug S., Yang J.W., Zigmond M.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-16; 27-39; 62-73 AND 89-96, MASS SPECTROMETRY.
Tissue: Brain and Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK077534 mRNA. Translation: BAC36852.1. Different initiation.
AK002526 mRNA. Translation: BAB22163.1. Different initiation.
AL670035 Genomic DNA. Translation: CAM19996.1. Different initiation.
AK162173 mRNA. Translation: BAE36771.1. Different initiation.
AK150162 mRNA. Translation: BAE29352.1. Different initiation.
AK146436 mRNA. Translation: BAE27170.1. Different initiation.
AK004827 mRNA. Translation: BAB23595.1.
BC017684 mRNA. Translation: AAH17684.1. Different initiation.
IPIIPI00331146.
RefSeqNP_079923.3. NM_025647.3.
UniGeneMm.294159.

3D structure databases

ProteinModelPortalQ9DBP5.
SMRQ9DBP5. Positions 3-196.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9DBP5. 1 interaction.
STRINGQ9DBP5.

PTM databases

PhosphoSiteQ9DBP5.

2D gel databases

REPRODUCTION-2DPAGEIPI00331146.
Q9DBP5.
UCD-2DPAGEQ9DBP5.

Proteomic databases

PRIDEQ9DBP5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030491; ENSMUSP00000030491; ENSMUSG00000028719.
GeneID66588.
KEGGmmu:66588.
UCSCuc008ueg.2. mouse.

Organism-specific databases

CTD51727.
MGIMGI:1913838. Cmpk1.

Phylogenomic databases

eggNOGroNOG15473.
GeneTreeENSGT00390000016215.
HOGENOMHBG630208.
HOVERGENHBG108060.
InParanoidQ9DBP5.
OrthoDBEOG4F1X45.

Gene expression databases

ArrayExpressQ9DBP5.
BgeeQ9DBP5.
CleanExMM_CMPK1.
GenevestigatorQ9DBP5.
GermOnlineENSMUSG00000028719. Mus musculus.

Family and domain databases

InterProIPR000850. Adenylate_kin.
IPR006266. UMP_CMP_kinase.
[Graphical view]
KOK13800.
PANTHERPTHR23359. Adenylate_kin. 1 hit.
PfamPF00406. ADK. 1 hit.
[Graphical view]
PRINTSPR00094. ADENYLTKNASE.
TIGRFAMsTIGR01359. UMP_CMP_kin_fam. 1 hit.
PROSITEPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio322084.
SOURCESearch...

Entry information

Entry nameKCY_MOUSE
AccessionPrimary (citable) accession number: Q9DBP5
Secondary accession number(s): Q8BK17, Q8VD05, Q9DCS7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: December 14, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families