Q9DBP5 (KCY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UMP-CMP kinase
EC=2.7.4.14

Alternative name(s):
Cytidine monophosphate kinase
Cytidylate kinase
Deoxycytidylate kinase
Uridine monophosphate kinase
Uridine monophosphate/cytidine monophosphate kinase
Short name=UMP/CMP kinase
Short name=UMP/CMPK

Gene names

Name:	Cmpk1
Synonyms:	Cmk, Cmpk, Uck, Umk, Umpk

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes specific phosphoryl transfer from ATP to UMP and CMP By similarity.
Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. ATP + UMP = ADP + UDP.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Sequence similarities	Belongs to the adenylate kinase family.
Sequence caution	The sequence AAH17684.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB22163.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC36852.1 differs from that shown. Reason: Erroneous initiation. The sequence BAE27170.1 differs from that shown. Reason: Erroneous initiation. The sequence BAE29352.1 differs from that shown. Reason: Erroneous initiation. The sequence BAE36771.1 differs from that shown. Reason: Erroneous initiation. The sequence CAM19996.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: EC phosphotransferase activity, phosphate group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	UMP-CMP kinase		PRO_0000158950
Regions
	Nucleotide binding	10 – 18	9	ATP By similarity
Amino acid modifications
	Modified residue	55	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9DBP5 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7972B629D7542294	FASTA	196	22,165
	10 20 30 40 50 60 MKPLVVFVLG GPGAGKGTQC ARIVEKYGYT HLSAGELLRD ERKNPDSQYG ELIEKYIKEG 70 80 90 100 110 120 KIVPVEITIS LLKREMDQTM AANAQKNKFL IDGFPRNQDN LQGWNKTMDG KADVSFVLFF 130 140 150 160 170 180 DCNNEICIER CLERGKSSGR SDDNRESLEK RIQTYLESTK PIIDLYEEMG KVKKIDASKS 190 VDEVFGEVVK IFDKEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Lung.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
[4]	Lubec G., Klug S., Yang J.W., Zigmond M. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-16; 27-39; 62-73 AND 89-96, MASS SPECTROMETRY. Tissue: Brain and Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK077534 mRNA. Translation: BAC36852.1. Different initiation. AK002526 mRNA. Translation: BAB22163.1. Different initiation. AL670035 Genomic DNA. Translation: CAM19996.1. Different initiation. AK162173 mRNA. Translation: BAE36771.1. Different initiation. AK150162 mRNA. Translation: BAE29352.1. Different initiation. AK146436 mRNA. Translation: BAE27170.1. Different initiation. AK004827 mRNA. Translation: BAB23595.1. BC017684 mRNA. Translation: AAH17684.1. Different initiation.
IPI	IPI00331146.
RefSeq	NP_079923.3. NM_025647.3.
UniGene	Mm.294159.
3D structure databases
ProteinModelPortal	Q9DBP5.
SMR	Q9DBP5. Positions 3-196.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9DBP5. 1 interaction.
STRING	Q9DBP5.
PTM databases
PhosphoSite	Q9DBP5.
2D gel databases
REPRODUCTION-2DPAGE	IPI00331146. Q9DBP5.
UCD-2DPAGE	Q9DBP5.
Proteomic databases
PRIDE	Q9DBP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030491; ENSMUSP00000030491; ENSMUSG00000028719.
GeneID	66588.
KEGG	mmu:66588.
UCSC	uc008ueg.2. mouse.
Organism-specific databases
CTD	51727.
MGI	MGI:1913838. Cmpk1.
Phylogenomic databases
eggNOG	roNOG15473.
GeneTree	ENSGT00390000016215.
HOGENOM	HBG630208.
HOVERGEN	HBG108060.
InParanoid	Q9DBP5.
OrthoDB	EOG4F1X45.
Gene expression databases
ArrayExpress	Q9DBP5.
Bgee	Q9DBP5.
CleanEx	MM_CMPK1.
Genevestigator	Q9DBP5.
GermOnline	ENSMUSG00000028719. Mus musculus.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR006266. UMP_CMP_kinase. [Graphical view]
KO	K13800.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01359. UMP_CMP_kin_fam. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	322084.
SOURCE	Search...

Entry information

Entry name

KCY_MOUSE

Accession

Primary (citable) accession number: Q9DBP5
Secondary accession number(s): Q8BK17, Q8VD05, Q9DCS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program