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Q9DBP0

- NPT2B_MOUSE

UniProt

Q9DBP0 - NPT2B_MOUSE

Protein

Sodium-dependent phosphate transport protein 2B

Gene

Slc34a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

    GO - Molecular functioni

    1. phosphate ion binding Source: Ensembl
    2. sodium:phosphate symporter activity Source: Ensembl
    3. sodium-dependent phosphate transmembrane transporter activity Source: MGI
    4. sodium ion binding Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular phosphate ion homeostasis Source: Ensembl
    3. in utero embryonic development Source: MGI
    4. phosphate ion transport Source: MGI
    5. response to estradiol Source: Ensembl
    6. response to fructose Source: Ensembl

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transport protein 2B
    Short name:
    Sodium-phosphate transport protein 2B
    Alternative name(s):
    Na(+)-dependent phosphate cotransporter 2B
    Sodium/phosphate cotransporter 2B
    Short name:
    Na(+)/Pi cotransporter 2B
    Short name:
    NaPi-2b
    Solute carrier family 34 member 2
    Gene namesi
    Name:Slc34a2
    Synonyms:Npt2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1342284. Slc34a2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. brush border Source: MGI
    3. brush border membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. microvillus membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Sodium-dependent phosphate transport protein 2BPRO_0000068614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi303 ↔ 350By similarity
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9DBP0.
    PRIDEiQ9DBP0.

    PTM databases

    PhosphoSiteiQ9DBP0.

    Expressioni

    Tissue specificityi

    Highly abundant in the ileum of small intestine, whereas it is almost absent in the duodenum and in the jejunum.1 Publication

    Inductioni

    Up-regulated in the entire small intestine by low-phosphate diet. Up-regulated by metabolic acidosis.2 Publications

    Gene expression databases

    BgeeiQ9DBP0.
    GenevestigatoriQ9DBP0.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4998123.
    STRINGi10090.ENSMUSP00000092380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DBP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9191CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini113 – 13624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini158 – 21356CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini235 – 363129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini385 – 40824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini430 – 48657ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini508 – 52619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini548 – 5514ExtracellularSequence Analysis
    Topological domaini573 – 696124CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei92 – 11221Helical; Name=M1Sequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721Helical; Name=M2Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421Helical; Name=M3Sequence AnalysisAdd
    BLAST
    Transmembranei364 – 38421Helical; Name=M4Sequence AnalysisAdd
    BLAST
    Transmembranei409 – 42921Helical; Name=M5Sequence AnalysisAdd
    BLAST
    Transmembranei487 – 50721Helical; Name=M6Sequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721Helical; Name=M7Sequence AnalysisAdd
    BLAST
    Transmembranei552 – 57221Helical; Name=M8Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi465 – 4684Poly-Thr
    Compositional biasi535 – 5384Poly-Phe
    Compositional biasi564 – 5729Poly-Leu
    Compositional biasi613 – 64432Cys-richAdd
    BLAST
    Compositional biasi649 – 6557Poly-Glu

    Sequence similaritiesi

    Belongs to the SLC34A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1283.
    GeneTreeiENSGT00390000005032.
    HOGENOMiHOG000006550.
    HOVERGENiHBG006527.
    InParanoidiQ9DBP0.
    KOiK14683.
    OMAiYSHESTD.
    OrthoDBiEOG72ZCDP.
    PhylomeDBiQ9DBP0.
    TreeFamiTF313981.

    Family and domain databases

    InterProiIPR003841. Na/Pi_transpt.
    [Graphical view]
    PfamiPF02690. Na_Pi_cotrans. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01013. 2a58. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9DBP0-1 [UniParc]FASTAAdd to Basket

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    MAPWPELENA QPNPGKFIEG ASGPQSSIPA KDKEASKTND NGTPVAKTEL    50
    LPSYSALVLI EEHPEGTDPW DLPELQDTGI KWSERDTKGK TLCIFQGVGK 100
    FILLLGFLYL FVCSLDVLSS AFQLVGGKVA GQFFSNNSIM SNPVAGLVIG 150
    VLVTVMVQSS STSSSIIVSM VASSLLTVRA AIPIIMGANI GTSITNTIVA 200
    LMQAGDRNEF RRAFAGATVH DFFNWLSVFV LLPLEAATHY LEILTNLVLE 250
    TFKFQNGEDA PDILKVITDP FTKLIIQLDK KVIQQIAMGD SAAQNKSLIK 300
    IWCKSITNVT EMNVTVPSTD NCTSPSYCWT DGIQTWTIQN VTQKENIAKC 350
    QHIFVNFSLP DLAVGIILLT VSLVVLCGCL IMIVKLLGSV LRGQVATVIK 400
    KTLNTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAM TPLIGIGVIS 450
    IERAYPLTLG SNIGTTTTAI LAALASPGNT LRSSLQIALC HFFFNISGIL 500
    LWYPIPFTRL PIRLAKGLGN ISAKYRWFAV FYLIFFFFVT PLTVFGLSLA 550
    GWPVLVGVGV PIILLLLLVL CLRMLQFRCP RILPLKLRDW NFLPLWMHSL 600
    KPWDNVISLA TTCFQRRCCC CCRVCCRVCC MVCGCKCCRC SKCCRDQGEE 650
    EEEKEQDIPV KASGAFDNAA MSKECQDEGK GQVEVLSMKA LSNTTVF 697
    Length:697
    Mass (Da):76,245
    Last modified:June 1, 2001 - v1
    Checksum:i2A7B9384857EF16F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811K → R in AAC80007. (PubMed:9826740)Curated
    Sequence conflicti155 – 1551V → L in AAC80007. (PubMed:9826740)Curated
    Sequence conflicti622 – 6221Missing(PubMed:9826740)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081499 mRNA. Translation: AAC80007.1.
    AK004832 mRNA. Translation: BAB23600.1.
    AK145599 mRNA. Translation: BAE26533.1.
    BC096369 mRNA. Translation: AAH96369.1.
    CCDSiCCDS19291.1.
    RefSeqiNP_035532.2. NM_011402.3.
    UniGeneiMm.284891.

    Genome annotation databases

    EnsembliENSMUST00000094787; ENSMUSP00000092380; ENSMUSG00000029188.
    GeneIDi20531.
    KEGGimmu:20531.
    UCSCiuc008xla.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081499 mRNA. Translation: AAC80007.1 .
    AK004832 mRNA. Translation: BAB23600.1 .
    AK145599 mRNA. Translation: BAE26533.1 .
    BC096369 mRNA. Translation: AAH96369.1 .
    CCDSi CCDS19291.1.
    RefSeqi NP_035532.2. NM_011402.3.
    UniGenei Mm.284891.

    3D structure databases

    ProteinModelPortali Q9DBP0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4998123.
    STRINGi 10090.ENSMUSP00000092380.

    PTM databases

    PhosphoSitei Q9DBP0.

    Proteomic databases

    PaxDbi Q9DBP0.
    PRIDEi Q9DBP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094787 ; ENSMUSP00000092380 ; ENSMUSG00000029188 .
    GeneIDi 20531.
    KEGGi mmu:20531.
    UCSCi uc008xla.2. mouse.

    Organism-specific databases

    CTDi 10568.
    MGIi MGI:1342284. Slc34a2.

    Phylogenomic databases

    eggNOGi COG1283.
    GeneTreei ENSGT00390000005032.
    HOGENOMi HOG000006550.
    HOVERGENi HBG006527.
    InParanoidi Q9DBP0.
    KOi K14683.
    OMAi YSHESTD.
    OrthoDBi EOG72ZCDP.
    PhylomeDBi Q9DBP0.
    TreeFami TF313981.

    Miscellaneous databases

    NextBioi 298787.
    PROi Q9DBP0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DBP0.
    Genevestigatori Q9DBP0.

    Family and domain databases

    InterProi IPR003841. Na/Pi_transpt.
    [Graphical view ]
    Pfami PF02690. Na_Pi_cotrans. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01013. 2a58. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine."
      Hilfiker H., Hattenhauer O., Traebert M., Forster I.C., Murer H., Biber J.
      Proc. Natl. Acad. Sci. U.S.A. 95:14564-14569(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NMRI.
      Tissue: Small intestine.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine."
      Radanovic T., Wagner C.A., Murer H., Biber J.
      Am. J. Physiol. 288:G496-G500(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, TISSUE SPECIFICITY.
      Strain: NMRI.
    5. "Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine."
      Stauber A., Radanovic T., Stange G., Murer H., Wagner C.A., Biber J.
      Am. J. Physiol. 288:G501-G506(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiNPT2B_MOUSE
    AccessioniPrimary (citable) accession number: Q9DBP0
    Secondary accession number(s): Q9Z290
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3