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Protein

Sodium-dependent phosphate transport protein 2B

Gene

Slc34a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

GO - Molecular functioni

GO - Biological processi

  • cellular phosphate ion homeostasis Source: MGI
  • in utero embryonic development Source: MGI
  • phosphate ion transport Source: MGI
  • response to estrogen Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-427589. Type II Na+/Pi cotransporters.
R-MMU-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2B
Short name:
Sodium-phosphate transport protein 2B
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2B
Sodium/phosphate cotransporter 2B
Short name:
Na(+)/Pi cotransporter 2B
Short name:
NaPi-2b
Solute carrier family 34 member 2
Gene namesi
Name:Slc34a2
Synonyms:Npt2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1342284. Slc34a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 91CytoplasmicSequence analysisAdd BLAST91
Transmembranei92 – 112Helical; Name=M1Sequence analysisAdd BLAST21
Topological domaini113 – 136ExtracellularSequence analysisAdd BLAST24
Transmembranei137 – 157Helical; Name=M2Sequence analysisAdd BLAST21
Topological domaini158 – 213CytoplasmicSequence analysisAdd BLAST56
Transmembranei214 – 234Helical; Name=M3Sequence analysisAdd BLAST21
Topological domaini235 – 363ExtracellularSequence analysisAdd BLAST129
Transmembranei364 – 384Helical; Name=M4Sequence analysisAdd BLAST21
Topological domaini385 – 408CytoplasmicSequence analysisAdd BLAST24
Transmembranei409 – 429Helical; Name=M5Sequence analysisAdd BLAST21
Topological domaini430 – 486ExtracellularSequence analysisAdd BLAST57
Transmembranei487 – 507Helical; Name=M6Sequence analysisAdd BLAST21
Topological domaini508 – 526CytoplasmicSequence analysisAdd BLAST19
Transmembranei527 – 547Helical; Name=M7Sequence analysisAdd BLAST21
Topological domaini548 – 551ExtracellularSequence analysis4
Transmembranei552 – 572Helical; Name=M8Sequence analysisAdd BLAST21
Topological domaini573 – 696CytoplasmicSequence analysisAdd BLAST124

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • brush border Source: MGI
  • cytoplasm Source: GO_Central
  • integral component of membrane Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686141 – 697Sodium-dependent phosphate transport protein 2BAdd BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi303 ↔ 350By similarity
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9DBP0.
PaxDbiQ9DBP0.
PRIDEiQ9DBP0.

PTM databases

iPTMnetiQ9DBP0.
PhosphoSitePlusiQ9DBP0.

Expressioni

Tissue specificityi

Highly abundant in the ileum of small intestine, whereas it is almost absent in the duodenum and in the jejunum.1 Publication

Inductioni

Up-regulated in the entire small intestine by low-phosphate diet. Up-regulated by metabolic acidosis.2 Publications

Gene expression databases

BgeeiENSMUSG00000029188.
ExpressionAtlasiQ9DBP0. baseline and differential.
GenevisibleiQ9DBP0. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998123.
STRINGi10090.ENSMUSP00000092380.

Structurei

3D structure databases

ProteinModelPortaliQ9DBP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi465 – 468Poly-Thr4
Compositional biasi535 – 538Poly-Phe4
Compositional biasi564 – 572Poly-Leu9
Compositional biasi613 – 644Cys-richAdd BLAST32
Compositional biasi649 – 655Poly-Glu7

Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8P. Eukaryota.
COG1283. LUCA.
GeneTreeiENSGT00390000005032.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ9DBP0.
KOiK14683.
OMAiATERNEF.
OrthoDBiEOG091G0DR5.
PhylomeDBiQ9DBP0.
TreeFamiTF313981.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029852. Na/Pi_transpt_2B.
[Graphical view]
PANTHERiPTHR10010:SF23. PTHR10010:SF23. 2 hits.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DBP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPWPELENA QPNPGKFIEG ASGPQSSIPA KDKEASKTND NGTPVAKTEL
60 70 80 90 100
LPSYSALVLI EEHPEGTDPW DLPELQDTGI KWSERDTKGK TLCIFQGVGK
110 120 130 140 150
FILLLGFLYL FVCSLDVLSS AFQLVGGKVA GQFFSNNSIM SNPVAGLVIG
160 170 180 190 200
VLVTVMVQSS STSSSIIVSM VASSLLTVRA AIPIIMGANI GTSITNTIVA
210 220 230 240 250
LMQAGDRNEF RRAFAGATVH DFFNWLSVFV LLPLEAATHY LEILTNLVLE
260 270 280 290 300
TFKFQNGEDA PDILKVITDP FTKLIIQLDK KVIQQIAMGD SAAQNKSLIK
310 320 330 340 350
IWCKSITNVT EMNVTVPSTD NCTSPSYCWT DGIQTWTIQN VTQKENIAKC
360 370 380 390 400
QHIFVNFSLP DLAVGIILLT VSLVVLCGCL IMIVKLLGSV LRGQVATVIK
410 420 430 440 450
KTLNTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAM TPLIGIGVIS
460 470 480 490 500
IERAYPLTLG SNIGTTTTAI LAALASPGNT LRSSLQIALC HFFFNISGIL
510 520 530 540 550
LWYPIPFTRL PIRLAKGLGN ISAKYRWFAV FYLIFFFFVT PLTVFGLSLA
560 570 580 590 600
GWPVLVGVGV PIILLLLLVL CLRMLQFRCP RILPLKLRDW NFLPLWMHSL
610 620 630 640 650
KPWDNVISLA TTCFQRRCCC CCRVCCRVCC MVCGCKCCRC SKCCRDQGEE
660 670 680 690
EEEKEQDIPV KASGAFDNAA MSKECQDEGK GQVEVLSMKA LSNTTVF
Length:697
Mass (Da):76,245
Last modified:June 1, 2001 - v1
Checksum:i2A7B9384857EF16F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81K → R in AAC80007 (PubMed:9826740).Curated1
Sequence conflicti155V → L in AAC80007 (PubMed:9826740).Curated1
Sequence conflicti622Missing (PubMed:9826740).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081499 mRNA. Translation: AAC80007.1.
AK004832 mRNA. Translation: BAB23600.1.
AK145599 mRNA. Translation: BAE26533.1.
BC096369 mRNA. Translation: AAH96369.1.
CCDSiCCDS19291.1.
RefSeqiNP_035532.2. NM_011402.3.
UniGeneiMm.284891.

Genome annotation databases

EnsembliENSMUST00000094787; ENSMUSP00000092380; ENSMUSG00000029188.
GeneIDi20531.
KEGGimmu:20531.
UCSCiuc008xla.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081499 mRNA. Translation: AAC80007.1.
AK004832 mRNA. Translation: BAB23600.1.
AK145599 mRNA. Translation: BAE26533.1.
BC096369 mRNA. Translation: AAH96369.1.
CCDSiCCDS19291.1.
RefSeqiNP_035532.2. NM_011402.3.
UniGeneiMm.284891.

3D structure databases

ProteinModelPortaliQ9DBP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998123.
STRINGi10090.ENSMUSP00000092380.

PTM databases

iPTMnetiQ9DBP0.
PhosphoSitePlusiQ9DBP0.

Proteomic databases

MaxQBiQ9DBP0.
PaxDbiQ9DBP0.
PRIDEiQ9DBP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094787; ENSMUSP00000092380; ENSMUSG00000029188.
GeneIDi20531.
KEGGimmu:20531.
UCSCiuc008xla.2. mouse.

Organism-specific databases

CTDi10568.
MGIiMGI:1342284. Slc34a2.

Phylogenomic databases

eggNOGiENOG410IE8P. Eukaryota.
COG1283. LUCA.
GeneTreeiENSGT00390000005032.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ9DBP0.
KOiK14683.
OMAiATERNEF.
OrthoDBiEOG091G0DR5.
PhylomeDBiQ9DBP0.
TreeFamiTF313981.

Enzyme and pathway databases

ReactomeiR-MMU-427589. Type II Na+/Pi cotransporters.
R-MMU-5683826. Surfactant metabolism.

Miscellaneous databases

PROiQ9DBP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029188.
ExpressionAtlasiQ9DBP0. baseline and differential.
GenevisibleiQ9DBP0. MM.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029852. Na/Pi_transpt_2B.
[Graphical view]
PANTHERiPTHR10010:SF23. PTHR10010:SF23. 2 hits.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPT2B_MOUSE
AccessioniPrimary (citable) accession number: Q9DBP0
Secondary accession number(s): Q9Z290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.