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Q9DBP0

- NPT2B_MOUSE

UniProt

Q9DBP0 - NPT2B_MOUSE

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Protein
Sodium-dependent phosphate transport protein 2B
Gene
Slc34a2, Npt2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

GO - Molecular functioni

  1. phosphate ion binding Source: Ensembl
  2. sodium ion binding Source: Ensembl
  3. sodium-dependent phosphate transmembrane transporter activity Source: MGI
  4. sodium:phosphate symporter activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular phosphate ion homeostasis Source: Ensembl
  3. in utero embryonic development Source: MGI
  4. phosphate ion transport Source: MGI
  5. response to estradiol Source: Ensembl
  6. response to fructose Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2B
Short name:
Sodium-phosphate transport protein 2B
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2B
Sodium/phosphate cotransporter 2B
Short name:
Na(+)/Pi cotransporter 2B
Short name:
NaPi-2b
Solute carrier family 34 member 2
Gene namesi
Name:Slc34a2
Synonyms:Npt2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1342284. Slc34a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9191Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei92 – 11221Helical; Name=M1; Reviewed prediction
Add
BLAST
Topological domaini113 – 13624Extracellular Reviewed prediction
Add
BLAST
Transmembranei137 – 15721Helical; Name=M2; Reviewed prediction
Add
BLAST
Topological domaini158 – 21356Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Name=M3; Reviewed prediction
Add
BLAST
Topological domaini235 – 363129Extracellular Reviewed prediction
Add
BLAST
Transmembranei364 – 38421Helical; Name=M4; Reviewed prediction
Add
BLAST
Topological domaini385 – 40824Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei409 – 42921Helical; Name=M5; Reviewed prediction
Add
BLAST
Topological domaini430 – 48657Extracellular Reviewed prediction
Add
BLAST
Transmembranei487 – 50721Helical; Name=M6; Reviewed prediction
Add
BLAST
Topological domaini508 – 52619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei527 – 54721Helical; Name=M7; Reviewed prediction
Add
BLAST
Topological domaini548 – 5514Extracellular Reviewed prediction
Transmembranei552 – 57221Helical; Name=M8; Reviewed prediction
Add
BLAST
Topological domaini573 – 696124Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. brush border Source: MGI
  3. brush border membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Sodium-dependent phosphate transport protein 2B
PRO_0000068614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi303 ↔ 350 By similarity
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DBP0.
PRIDEiQ9DBP0.

PTM databases

PhosphoSiteiQ9DBP0.

Expressioni

Tissue specificityi

Highly abundant in the ileum of small intestine, whereas it is almost absent in the duodenum and in the jejunum.1 Publication

Inductioni

Up-regulated in the entire small intestine by low-phosphate diet. Up-regulated by metabolic acidosis.2 Publications

Gene expression databases

BgeeiQ9DBP0.
GenevestigatoriQ9DBP0.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998123.
STRINGi10090.ENSMUSP00000092380.

Structurei

3D structure databases

ProteinModelPortaliQ9DBP0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi465 – 4684Poly-Thr
Compositional biasi535 – 5384Poly-Phe
Compositional biasi564 – 5729Poly-Leu
Compositional biasi613 – 64432Cys-rich
Add
BLAST
Compositional biasi649 – 6557Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1283.
GeneTreeiENSGT00390000005032.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ9DBP0.
KOiK14683.
OMAiYSHESTD.
OrthoDBiEOG72ZCDP.
PhylomeDBiQ9DBP0.
TreeFamiTF313981.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
[Graphical view]
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DBP0-1 [UniParc]FASTAAdd to Basket

« Hide

MAPWPELENA QPNPGKFIEG ASGPQSSIPA KDKEASKTND NGTPVAKTEL    50
LPSYSALVLI EEHPEGTDPW DLPELQDTGI KWSERDTKGK TLCIFQGVGK 100
FILLLGFLYL FVCSLDVLSS AFQLVGGKVA GQFFSNNSIM SNPVAGLVIG 150
VLVTVMVQSS STSSSIIVSM VASSLLTVRA AIPIIMGANI GTSITNTIVA 200
LMQAGDRNEF RRAFAGATVH DFFNWLSVFV LLPLEAATHY LEILTNLVLE 250
TFKFQNGEDA PDILKVITDP FTKLIIQLDK KVIQQIAMGD SAAQNKSLIK 300
IWCKSITNVT EMNVTVPSTD NCTSPSYCWT DGIQTWTIQN VTQKENIAKC 350
QHIFVNFSLP DLAVGIILLT VSLVVLCGCL IMIVKLLGSV LRGQVATVIK 400
KTLNTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAM TPLIGIGVIS 450
IERAYPLTLG SNIGTTTTAI LAALASPGNT LRSSLQIALC HFFFNISGIL 500
LWYPIPFTRL PIRLAKGLGN ISAKYRWFAV FYLIFFFFVT PLTVFGLSLA 550
GWPVLVGVGV PIILLLLLVL CLRMLQFRCP RILPLKLRDW NFLPLWMHSL 600
KPWDNVISLA TTCFQRRCCC CCRVCCRVCC MVCGCKCCRC SKCCRDQGEE 650
EEEKEQDIPV KASGAFDNAA MSKECQDEGK GQVEVLSMKA LSNTTVF 697
Length:697
Mass (Da):76,245
Last modified:June 1, 2001 - v1
Checksum:i2A7B9384857EF16F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811K → R in AAC80007. 1 Publication
Sequence conflicti155 – 1551V → L in AAC80007. 1 Publication
Sequence conflicti622 – 6221Missing1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081499 mRNA. Translation: AAC80007.1.
AK004832 mRNA. Translation: BAB23600.1.
AK145599 mRNA. Translation: BAE26533.1.
BC096369 mRNA. Translation: AAH96369.1.
CCDSiCCDS19291.1.
RefSeqiNP_035532.2. NM_011402.3.
UniGeneiMm.284891.

Genome annotation databases

EnsembliENSMUST00000094787; ENSMUSP00000092380; ENSMUSG00000029188.
GeneIDi20531.
KEGGimmu:20531.
UCSCiuc008xla.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081499 mRNA. Translation: AAC80007.1 .
AK004832 mRNA. Translation: BAB23600.1 .
AK145599 mRNA. Translation: BAE26533.1 .
BC096369 mRNA. Translation: AAH96369.1 .
CCDSi CCDS19291.1.
RefSeqi NP_035532.2. NM_011402.3.
UniGenei Mm.284891.

3D structure databases

ProteinModelPortali Q9DBP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4998123.
STRINGi 10090.ENSMUSP00000092380.

PTM databases

PhosphoSitei Q9DBP0.

Proteomic databases

PaxDbi Q9DBP0.
PRIDEi Q9DBP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094787 ; ENSMUSP00000092380 ; ENSMUSG00000029188 .
GeneIDi 20531.
KEGGi mmu:20531.
UCSCi uc008xla.2. mouse.

Organism-specific databases

CTDi 10568.
MGIi MGI:1342284. Slc34a2.

Phylogenomic databases

eggNOGi COG1283.
GeneTreei ENSGT00390000005032.
HOGENOMi HOG000006550.
HOVERGENi HBG006527.
InParanoidi Q9DBP0.
KOi K14683.
OMAi YSHESTD.
OrthoDBi EOG72ZCDP.
PhylomeDBi Q9DBP0.
TreeFami TF313981.

Miscellaneous databases

NextBioi 298787.
PROi Q9DBP0.
SOURCEi Search...

Gene expression databases

Bgeei Q9DBP0.
Genevestigatori Q9DBP0.

Family and domain databases

InterProi IPR003841. Na/Pi_transpt.
[Graphical view ]
Pfami PF02690. Na_Pi_cotrans. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01013. 2a58. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine."
    Hilfiker H., Hattenhauer O., Traebert M., Forster I.C., Murer H., Biber J.
    Proc. Natl. Acad. Sci. U.S.A. 95:14564-14569(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
    Tissue: Small intestine.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine."
    Radanovic T., Wagner C.A., Murer H., Biber J.
    Am. J. Physiol. 288:G496-G500(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.
    Strain: NMRI.
  5. "Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine."
    Stauber A., Radanovic T., Stange G., Murer H., Wagner C.A., Biber J.
    Am. J. Physiol. 288:G501-G506(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiNPT2B_MOUSE
AccessioniPrimary (citable) accession number: Q9DBP0
Secondary accession number(s): Q9Z290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi