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Q9DBN9

- DDX59_MOUSE

UniProt

Q9DBN9 - DDX59_MOUSE

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Protein
Probable ATP-dependent RNA helicase DDX59
Gene
Ddx59
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri104 – 13330HIT-type
Add
BLAST
Nucleotide bindingi247 – 2548ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX59 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 59
Gene namesi
Name:Ddx59
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1915247. Ddx59.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Probable ATP-dependent RNA helicase DDX59
PRO_0000282714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Phosphoserine By similarity
Modified residuei160 – 1601Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBN9.
PRIDEiQ9DBN9.

PTM databases

PhosphoSiteiQ9DBN9.

Expressioni

Developmental stagei

AT 11.5 dpc, expressed in the developing snout region, eye and limb buds. At 13.5 dpc, highly enriched in the lips, palatal shelves (secondary palate), and developing limb buds.1 Publication

Gene expression databases

BgeeiQ9DBN9.
CleanExiMM_DDX59.
GenevestigatoriQ9DBN9.

Structurei

3D structure databases

ProteinModelPortaliQ9DBN9.
SMRiQ9DBN9. Positions 96-143, 168-583.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 405172Helicase ATP-binding
Add
BLAST
Domaini416 – 579164Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi203 – 23129Q motif
Add
BLAST
Motifi353 – 3564DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG0513.
GeneTreeiENSGT00740000115519.
HOGENOMiHOG000006599.
HOVERGENiHBG106120.
InParanoidiQ9DBN9.
OMAiEHPFILN.
OrthoDBiEOG7B8S3D.
PhylomeDBiQ9DBN9.
TreeFamiTF330866.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
IPR007529. Znf_HIT.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04438. zf-HIT. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9DBN9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFVPRSLKIK RSSNDDLKSG EAKKSKPEAG GLQVEGDRDT PVHTSVTEEA    50
VTADKPGHAS STNSPSCQLA EVSSTGPDEG VKDSHPSEEP VKSFSKTQRW 100
PEPGEPVCVV CGRYGEYICD KTDEDVCSLE CKAKHLLQVK EGEGSLRPSS 150
PQRVAAEPES PLDAFYVYKE HPFIVTLKED QIETLKQQLG ISVQGQDVAR 200
PIIDFEHCGF PETLNQNLKK SGYEVPTPIQ MQMIPVGLLG RDILASADTG 250
SGKTAAFLLP VIIRAFSEDK TPSALILTPT RELAIQIERQ AKELMSGLPR 300
MKTVLLVGGL PLPPQLYRLR QHVKVIIATP GRLLDIIKQS SVSLSGIKIV 350
VVDEADTMLK MGFQQQVLDV LEHTPGDCQT ILVSATIPDS IEQLTDQLLH 400
NPVRIITGDK NLPCASVRQI ILWVEDPAKK KKLFEILNDQ KLFKPPVLVF 450
VDCKLGADLL SEAVQKITGL NSTSIHSEKS QVERRDILKG LLEGDYEVVV 500
STGVLGRGLD LVNVKLVVNF DMPSSMDEYV HQVGRVGRLG QNGTAITFIN 550
NNSKRLFWDV AKRVKPTGSI LPPQLLNSPY LHEQKRKEQQ KDRQTQNSLV 600
TGANLMDIIR KHEKSSSQK 619
Length:619
Mass (Da):68,234
Last modified:June 1, 2001 - v1
Checksum:iE4FE6E723D125697
GO
Isoform 2 (identifier: Q9DBN9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-292: DKTPSALILTPTRELAIQIERQAK → VIYQSDMSSSLKQTRDLPSFIVCN
     293-619: Missing.

Note: No experimental confirmation available.

Show »
Length:292
Mass (Da):31,851
Checksum:iB178BF6B8DCA3B90
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei269 – 29224DKTPS…ERQAK → VIYQSDMSSSLKQTRDLPSF IVCN in isoform 2.
VSP_026429Add
BLAST
Alternative sequencei293 – 619327Missing in isoform 2.
VSP_026430Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081C → S in BAB28694. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004833 mRNA. Translation: BAB23601.1.
AK013179 mRNA. Translation: BAB28694.1.
AK076462 mRNA. Translation: BAC36354.1.
BC023840 mRNA. Translation: AAH23840.1.
CCDSiCCDS15326.1. [Q9DBN9-1]
RefSeqiNP_080776.1. NM_026500.3. [Q9DBN9-1]
UniGeneiMm.385462.
Mm.486546.

Genome annotation databases

EnsembliENSMUST00000027655; ENSMUSP00000027655; ENSMUSG00000026404. [Q9DBN9-1]
GeneIDi67997.
KEGGimmu:67997.
UCSCiuc007cut.1. mouse. [Q9DBN9-2]
uc007cuu.2. mouse. [Q9DBN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004833 mRNA. Translation: BAB23601.1 .
AK013179 mRNA. Translation: BAB28694.1 .
AK076462 mRNA. Translation: BAC36354.1 .
BC023840 mRNA. Translation: AAH23840.1 .
CCDSi CCDS15326.1. [Q9DBN9-1 ]
RefSeqi NP_080776.1. NM_026500.3. [Q9DBN9-1 ]
UniGenei Mm.385462.
Mm.486546.

3D structure databases

ProteinModelPortali Q9DBN9.
SMRi Q9DBN9. Positions 96-143, 168-583.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9DBN9.

Proteomic databases

MaxQBi Q9DBN9.
PRIDEi Q9DBN9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027655 ; ENSMUSP00000027655 ; ENSMUSG00000026404 . [Q9DBN9-1 ]
GeneIDi 67997.
KEGGi mmu:67997.
UCSCi uc007cut.1. mouse. [Q9DBN9-2 ]
uc007cuu.2. mouse. [Q9DBN9-1 ]

Organism-specific databases

CTDi 83479.
MGIi MGI:1915247. Ddx59.

Phylogenomic databases

eggNOGi COG0513.
GeneTreei ENSGT00740000115519.
HOGENOMi HOG000006599.
HOVERGENi HBG106120.
InParanoidi Q9DBN9.
OMAi EHPFILN.
OrthoDBi EOG7B8S3D.
PhylomeDBi Q9DBN9.
TreeFami TF330866.

Miscellaneous databases

ChiTaRSi DDX59. mouse.
NextBioi 326168.
PROi Q9DBN9.
SOURCEi Search...

Gene expression databases

Bgeei Q9DBN9.
CleanExi MM_DDX59.
Genevestigatori Q9DBN9.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
IPR007529. Znf_HIT.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04438. zf-HIT. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Head and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome."
    Shamseldin H.E., Rajab A., Alhashem A., Shaheen R., Al-Shidi T., Alamro R., Al Harassi S., Alkuraya F.S.
    Am. J. Hum. Genet. 93:555-560(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDDX59_MOUSE
AccessioniPrimary (citable) accession number: Q9DBN9
Secondary accession number(s): Q8C667, Q9CSD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi