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Protein

Probable ATP-dependent RNA helicase DDX59

Gene

Ddx59

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri104 – 133HIT-typeAdd BLAST30
Nucleotide bindingi247 – 254ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX59 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 59
Gene namesi
Name:Ddx59
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915247. Ddx59.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002827141 – 619Probable ATP-dependent RNA helicase DDX59Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DBN9.
PeptideAtlasiQ9DBN9.
PRIDEiQ9DBN9.

PTM databases

iPTMnetiQ9DBN9.
PhosphoSitePlusiQ9DBN9.

Expressioni

Developmental stagei

AT 11.5 dpc, expressed in the developing snout region, eye and limb buds. At 13.5 dpc, highly enriched in the lips, palatal shelves (secondary palate), and developing limb buds.1 Publication

Gene expression databases

BgeeiENSMUSG00000026404.
CleanExiMM_DDX59.
GenevisibleiQ9DBN9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027655.

Structurei

3D structure databases

ProteinModelPortaliQ9DBN9.
SMRiQ9DBN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 405Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST172
Domaini416 – 579Helicase C-terminalPROSITE-ProRule annotationAdd BLAST164

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi203 – 231Q motifAdd BLAST29
Motifi353 – 356DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HIT-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri104 – 133HIT-typeAdd BLAST30

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00820000127023.
HOGENOMiHOG000006599.
HOVERGENiHBG106120.
InParanoidiQ9DBN9.
KOiK19466.
OMAiVDTMLKM.
OrthoDBiEOG091G04X9.
PhylomeDBiQ9DBN9.
TreeFamiTF330866.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
IPR007529. Znf_HIT.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04438. zf-HIT. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVPRSLKIK RSSNDDLKSG EAKKSKPEAG GLQVEGDRDT PVHTSVTEEA
60 70 80 90 100
VTADKPGHAS STNSPSCQLA EVSSTGPDEG VKDSHPSEEP VKSFSKTQRW
110 120 130 140 150
PEPGEPVCVV CGRYGEYICD KTDEDVCSLE CKAKHLLQVK EGEGSLRPSS
160 170 180 190 200
PQRVAAEPES PLDAFYVYKE HPFIVTLKED QIETLKQQLG ISVQGQDVAR
210 220 230 240 250
PIIDFEHCGF PETLNQNLKK SGYEVPTPIQ MQMIPVGLLG RDILASADTG
260 270 280 290 300
SGKTAAFLLP VIIRAFSEDK TPSALILTPT RELAIQIERQ AKELMSGLPR
310 320 330 340 350
MKTVLLVGGL PLPPQLYRLR QHVKVIIATP GRLLDIIKQS SVSLSGIKIV
360 370 380 390 400
VVDEADTMLK MGFQQQVLDV LEHTPGDCQT ILVSATIPDS IEQLTDQLLH
410 420 430 440 450
NPVRIITGDK NLPCASVRQI ILWVEDPAKK KKLFEILNDQ KLFKPPVLVF
460 470 480 490 500
VDCKLGADLL SEAVQKITGL NSTSIHSEKS QVERRDILKG LLEGDYEVVV
510 520 530 540 550
STGVLGRGLD LVNVKLVVNF DMPSSMDEYV HQVGRVGRLG QNGTAITFIN
560 570 580 590 600
NNSKRLFWDV AKRVKPTGSI LPPQLLNSPY LHEQKRKEQQ KDRQTQNSLV
610
TGANLMDIIR KHEKSSSQK
Length:619
Mass (Da):68,234
Last modified:June 1, 2001 - v1
Checksum:iE4FE6E723D125697
GO
Isoform 2 (identifier: Q9DBN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-292: DKTPSALILTPTRELAIQIERQAK → VIYQSDMSSSLKQTRDLPSFIVCN
     293-619: Missing.

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):31,851
Checksum:iB178BF6B8DCA3B90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208C → S in BAB28694 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026429269 – 292DKTPS…ERQAK → VIYQSDMSSSLKQTRDLPSF IVCN in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_026430293 – 619Missing in isoform 2. 1 PublicationAdd BLAST327

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004833 mRNA. Translation: BAB23601.1.
AK013179 mRNA. Translation: BAB28694.1.
AK076462 mRNA. Translation: BAC36354.1.
BC023840 mRNA. Translation: AAH23840.1.
CCDSiCCDS15326.1. [Q9DBN9-1]
RefSeqiNP_080776.1. NM_026500.3. [Q9DBN9-1]
UniGeneiMm.385462.
Mm.486546.

Genome annotation databases

EnsembliENSMUST00000027655; ENSMUSP00000027655; ENSMUSG00000026404. [Q9DBN9-1]
GeneIDi67997.
KEGGimmu:67997.
UCSCiuc007cut.1. mouse. [Q9DBN9-2]
uc007cuu.2. mouse. [Q9DBN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004833 mRNA. Translation: BAB23601.1.
AK013179 mRNA. Translation: BAB28694.1.
AK076462 mRNA. Translation: BAC36354.1.
BC023840 mRNA. Translation: AAH23840.1.
CCDSiCCDS15326.1. [Q9DBN9-1]
RefSeqiNP_080776.1. NM_026500.3. [Q9DBN9-1]
UniGeneiMm.385462.
Mm.486546.

3D structure databases

ProteinModelPortaliQ9DBN9.
SMRiQ9DBN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027655.

PTM databases

iPTMnetiQ9DBN9.
PhosphoSitePlusiQ9DBN9.

Proteomic databases

PaxDbiQ9DBN9.
PeptideAtlasiQ9DBN9.
PRIDEiQ9DBN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027655; ENSMUSP00000027655; ENSMUSG00000026404. [Q9DBN9-1]
GeneIDi67997.
KEGGimmu:67997.
UCSCiuc007cut.1. mouse. [Q9DBN9-2]
uc007cuu.2. mouse. [Q9DBN9-1]

Organism-specific databases

CTDi83479.
MGIiMGI:1915247. Ddx59.

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00820000127023.
HOGENOMiHOG000006599.
HOVERGENiHBG106120.
InParanoidiQ9DBN9.
KOiK19466.
OMAiVDTMLKM.
OrthoDBiEOG091G04X9.
PhylomeDBiQ9DBN9.
TreeFamiTF330866.

Miscellaneous databases

ChiTaRSiDdx59. mouse.
PROiQ9DBN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026404.
CleanExiMM_DDX59.
GenevisibleiQ9DBN9. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
IPR007529. Znf_HIT.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04438. zf-HIT. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX59_MOUSE
AccessioniPrimary (citable) accession number: Q9DBN9
Secondary accession number(s): Q8C667, Q9CSD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.