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Protein

Lon protease homolog 2, peroxisomal

Gene

Lonp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei743UniRule annotation1
Active sitei786UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 382ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 2, peroxisomalUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
Lon protease-like protein 2UniRule annotation
Short name:
Lon protease 2UniRule annotation
Peroxisomal Lon proteaseUniRule annotation
Gene namesi
Name:Lonp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914137 Lonp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002876412 – 852Lon protease homolog 2, peroxisomalAdd BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DBN5
PaxDbiQ9DBN5
PeptideAtlasiQ9DBN5
PRIDEiQ9DBN5

PTM databases

iPTMnetiQ9DBN5
PhosphoSitePlusiQ9DBN5
SwissPalmiQ9DBN5

Expressioni

Gene expression databases

BgeeiENSMUSG00000047866
CleanExiMM_LONP2
ExpressionAtlasiQ9DBN5 baseline and differential
GenevisibleiQ9DBN5 MM

Interactioni

Subunit structurei

Interacts with PEX5. Interacts with TYSND1 (By similarity). May interact with enzymes involved in beta-oxidation of fatty acids, including ACOX1/AOX (By similarity).UniRule annotationBy similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211789, 2 interactors
IntActiQ9DBN5, 1 interactor
MINTiQ9DBN5
STRINGi10090.ENSMUSP00000034141

Structurei

3D structure databases

ProteinModelPortaliQ9DBN5
SMRiQ9DBN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 220Lon N-terminalPROSITE-ProRule annotationAdd BLAST208
Domaini651 – 837Lon proteolyticPROSITE-ProRule annotationAdd BLAST187

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi850 – 852Microbody targeting signalUniRule annotation3

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2004 Eukaryota
COG0466 LUCA
GeneTreeiENSGT00530000063553
HOGENOMiHOG000261408
HOVERGENiHBG000798
InParanoidiQ9DBN5
KOiK01338
OMAiPILCLYG
OrthoDBiEOG091G02SC
PhylomeDBiQ9DBN5
TreeFamiTF317215

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_03121 lonp2_euk, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR004815 Lon_bac/euk-typ
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR003111 Lon_substr-bd
IPR027501 Lonp2_euk
IPR027417 P-loop_NTPase
IPR008268 Peptidase_S16_AS
IPR015947 PUA-like_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10046 PTHR10046, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF05362 Lon_C, 1 hit
PF02190 LON_substr_bdg, 1 hit
PIRSFiPIRSF001174 Lon_proteas, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00464 LON, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00763 lon, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS51786 LON_PROTEOLYTIC, 1 hit
PS01046 LON_SER, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSVSPIQIP SRLPLLLTHE SVLLPGSTMR TSVDTARNLQ LVRSRLLKGT
60 70 80 90 100
SLQSTILGVI PNTPDPASDT QDLPPLHRIG TAALAVQVVG SNWPKPHYTL
110 120 130 140 150
LITGLCRFQI VQVLKEKPYP VAEVEQLDRL EEFPNICKSR EELGELSEQF
160 170 180 190 200
YRYAVQLVEM LDMSVPAVAK LRRLLDNLPR EALPDILTSI IRTSNKEKLQ
210 220 230 240 250
ILDAVSLEDR FKMTIPLLVR QIEGLKLLQK TRKPKQDDDK RVIAIRPIRR
260 270 280 290 300
IPHIPGTLED EEEEEDNDDI VMLEKKIRTS SMPEQAHKVC VKEIKRLKKM
310 320 330 340 350
PQSMPEYALT RNYLELMVEL PWNKSTTDRL DIRAARILLD NDHYAMEKLK
360 370 380 390 400
RRVLEYLAVR QLKNNLKGPI LCFVGPPGVG KTSVGRSVAK TLGREFHRIA
410 420 430 440 450
LGGVCDQSDI RGHRRTYVGS MPGRIINGLK TVGVNNPVFL LDEVDKLGKS
460 470 480 490 500
LQGDPAAALL EVLDPEQNHN FTDHYLNVAF DLSQVLFIAT ANTTATIPPA
510 520 530 540 550
LLDRMEIIQV PGYTQEEKIE IAHRHLIPKQ LEQHGLTPQQ IQIPQHTTLA
560 570 580 590 600
IITRYTREAG VRSLDRKFGA ICRAVAVKVA EGQHKEAKLD RSDVADGEGC
610 620 630 640 650
KEHVLEDAKP ESISDTADLA LPPEMPILID SHALKDILGP PLYELEVSER
660 670 680 690 700
LSQPGVAIGL AWTPLGGKIM FVEASRMDGE GQLTLTGQLG DVMKESAHLA
710 720 730 740 750
ISWLRSNAKK YHLTNAFGSF DLLDNTDIHL HFPAGAVTKD GPSAGVTIVT
760 770 780 790 800
CLASLFSGRL VRSDVAMTGE ITLRGLVLPV GGIKDKVLAA HRAGLKQIII
810 820 830 840 850
PQRNEKDLEE IPSNVRQDLS FVTASCLDEV LNAAFDGGFP VKTRPGLIDS

KL
Length:852
Mass (Da):94,526
Last modified:June 1, 2001 - v1
Checksum:i890BD7E654D04DC7
GO
Isoform 2 (identifier: Q9DBN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-659: SERLSQPGVAIG → MILISMFTLVLA
     660-852: Missing.

Note: No experimental confirmation available.
Show »
Length:659
Mass (Da):73,989
Checksum:iEC4B4E725B6D87F3
GO
Isoform 3 (identifier: Q9DBN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-319: Missing.

Note: No experimental confirmation available.
Show »
Length:710
Mass (Da):77,891
Checksum:i7A67CC6266AFB55E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87Q → P in BAE30373 (PubMed:16141072).Curated1
Sequence conflicti348K → E in BAE40624 (PubMed:16141072).Curated1
Sequence conflicti348K → E in BAE40762 (PubMed:16141072).Curated1
Sequence conflicti740D → V in BAE30373 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025576178 – 319Missing in isoform 3. 1 PublicationAdd BLAST142
Alternative sequenceiVSP_025577648 – 659SERLS…GVAIG → MILISMFTLVLA in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_025578660 – 852Missing in isoform 2. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004843 mRNA Translation: BAB23609.1
AK050231 mRNA Translation: BAC34137.1
AK151103 mRNA Translation: BAE30113.1
AK151406 mRNA Translation: BAE30373.1
AK168791 mRNA Translation: BAE40624.1
AK168628 mRNA Translation: BAE40488.1
AK168956 mRNA Translation: BAE40762.1
AK169656 mRNA Translation: BAE41280.1
BC049090 mRNA Translation: AAH49090.1
CCDSiCCDS22503.1 [Q9DBN5-1]
RefSeqiNP_001162063.1, NM_001168591.1
NP_080103.1, NM_025827.3 [Q9DBN5-1]
UniGeneiMm.324550

Genome annotation databases

EnsembliENSMUST00000034141; ENSMUSP00000034141; ENSMUSG00000047866 [Q9DBN5-1]
ENSMUST00000122188; ENSMUSP00000113834; ENSMUSG00000047866 [Q9DBN5-3]
ENSMUST00000155433; ENSMUSP00000118737; ENSMUSG00000047866 [Q9DBN5-2]
GeneIDi66887
KEGGimmu:66887
UCSCiuc009mqm.3 mouse [Q9DBN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLONP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBN5
Secondary accession number(s): Q3TEG8
, Q3TFY6, Q3TGR0, Q3UAE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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