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Q9DBM0

- ABCG8_MOUSE

UniProt

Q9DBM0 - ABCG8_MOUSE

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Protein

ATP-binding cassette sub-family G member 8

Gene
Abcg8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

GO - Molecular functioni

  1. ATPase activity Source: Ensembl
  2. ATP binding Source: Ensembl
  3. cholesterol transporter activity Source: Ensembl

GO - Biological processi

  1. cholesterol efflux Source: BHF-UCL
  2. cholesterol homeostasis Source: MGI
  3. excretion Source: BHF-UCL
  4. intestinal cholesterol absorption Source: BHF-UCL
  5. negative regulation of intestinal cholesterol absorption Source: Ensembl
  6. negative regulation of intestinal phytosterol absorption Source: Ensembl
  7. phospholipid transport Source: MGI
  8. response to drug Source: Ensembl
  9. response to nutrient Source: Ensembl
  10. sterol homeostasis Source: MGI
  11. sterol transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 8
Alternative name(s):
Sterolin-2
Gene namesi
Name:Abcg8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1914720. Abcg8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 413413Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei414 – 43421Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini435 – 44713Extracellular Reviewed predictionAdd
BLAST
Transmembranei448 – 46821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini469 – 49628Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei497 – 51721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini518 – 5269Extracellular Reviewed prediction
Transmembranei527 – 54721Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini548 – 56922Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei570 – 59021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini591 – 63949Extracellular Reviewed predictionAdd
BLAST
Transmembranei640 – 66021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini661 – 67313Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673ATP-binding cassette sub-family G member 8PRO_0000093397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi619 – 6191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9DBM0.

PTM databases

PhosphoSiteiQ9DBM0.

Expressioni

Tissue specificityi

Expressed in the intestine and, at lower level, in the liver.1 Publication

Inductioni

Up-regulated by cholesterol feeding. Possibly mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Endotoxin (LPS) significantly decreased mRNA levels in the liver but not in the small intestine.2 Publications

Gene expression databases

BgeeiQ9DBM0.
GenevestigatoriQ9DBM0.

Interactioni

Subunit structurei

May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9DBM0.
SMRiQ9DBM0. Positions 46-323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 314267ABC transporterAdd
BLAST
Domaini411 – 665255ABC transmembrane type-2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00740000114855.
HOGENOMiHOG000033764.
HOVERGENiHBG050444.
InParanoidiQ9DBM0.
KOiK05684.
OMAiKCHSERS.
PhylomeDBiQ9DBM0.
TreeFamiTF105212.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9DBM0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEKTKEETQ LWNGTVLQDA SQGLQDSLFS SESDNSLYFT YSGQSNTLEV    50
RDLTYQVDIA SQVPWFEQLA QFKIPWRSHS SQDSCELGIR NLSFKVRSGQ 100
MLAIIGSSGC GRASLLDVIT GRGHGGKMKS GQIWINGQPS TPQLVRKCVA 150
HVRQHDQLLP NLTVRETLAF IAQMRLPRTF SQAQRDKRVE DVIAELRLRQ 200
CANTRVGNTY VRGVSGGERR RVSIGVQLLW NPGILILDEP TSGLDSFTAH 250
NLVTTLSRLA KGNRLVLISL HQPRSDIFRL FDLVLLMTSG TPIYLGAAQQ 300
MVQYFTSIGH PCPRYSNPAD FYVDLTSIDR RSKEREVATV EKAQSLAALF 350
LEKVQGFDDF LWKAEAKELN TSTHTVSLTL TQDTDCGTAV ELPGMIEQFS 400
TLIRRQISND FRDLPTLLIH GSEACLMSLI IGFLYYGHGA KQLSFMDTAA 450
LLFMIGALIP FNVILDVVSK CHSERSMLYY ELEDGLYTAG PYFFAKILGE 500
LPEHCAYVII YAMPIYWLTN LRPVPELFLL HFLLVWLVVF CCRTMALAAS 550
AMLPTFHMSS FFCNALYNSF YLTAGFMINL DNLWIVPAWI SKLSFLRWCF 600
SGLMQIQFNG HLYTTQIGNF TFSILGDTMI SAMDLNSHPL YAIYLIVIGI 650
SYGFLFLYYL SLKLIKQKSI QDW 673
Length:673
Mass (Da):75,996
Last modified:June 1, 2001 - v1
Checksum:i78012611A5DF2589
GO
Isoform 2 (identifier: Q9DBM0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-377: Missing.

Note: No experimental confirmation available.

Show »
Length:672
Mass (Da):75,909
Checksum:iFC57D60AB2D79D1F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei377 – 3771Missing in isoform 2. VSP_000053

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF324495 mRNA. Translation: AAK84079.1.
AK004871 mRNA. Translation: BAB23630.1.
CCDSiCCDS29002.1. [Q9DBM0-1]
RefSeqiNP_001272934.1. NM_001286005.1.
NP_080456.1. NM_026180.3. [Q9DBM0-1]
UniGeneiMm.26581.

Genome annotation databases

EnsembliENSMUST00000045714; ENSMUSP00000035246; ENSMUSG00000024254. [Q9DBM0-1]
GeneIDi67470.
KEGGimmu:67470.
UCSCiuc008dta.1. mouse. [Q9DBM0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF324495 mRNA. Translation: AAK84079.1 .
AK004871 mRNA. Translation: BAB23630.1 .
CCDSi CCDS29002.1. [Q9DBM0-1 ]
RefSeqi NP_001272934.1. NM_001286005.1.
NP_080456.1. NM_026180.3. [Q9DBM0-1 ]
UniGenei Mm.26581.

3D structure databases

ProteinModelPortali Q9DBM0.
SMRi Q9DBM0. Positions 46-323.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9DBM0.

Proteomic databases

PRIDEi Q9DBM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045714 ; ENSMUSP00000035246 ; ENSMUSG00000024254 . [Q9DBM0-1 ]
GeneIDi 67470.
KEGGi mmu:67470.
UCSCi uc008dta.1. mouse. [Q9DBM0-1 ]

Organism-specific databases

CTDi 64241.
MGIi MGI:1914720. Abcg8.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00740000114855.
HOGENOMi HOG000033764.
HOVERGENi HBG050444.
InParanoidi Q9DBM0.
KOi K05684.
OMAi KCHSERS.
PhylomeDBi Q9DBM0.
TreeFami TF105212.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

NextBioi 324674.
PROi Q9DBM0.
SOURCEi Search...

Gene expression databases

Bgeei Q9DBM0.
Genevestigatori Q9DBM0.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively."
    Lu K., Lee M.-H., Hazard S., Brooks-Wilson A., Hidaka H., Kojima H., Ose L., Stalenhoef A.F.H., Mietinnen T., Bjorkhem I., Bruckert E., Pandya A., Brewer H.B. Jr., Salen G., Dean M., Srivastava A.K., Patel S.B.
    Am. J. Hum. Genet. 69:278-290(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters."
    Berge K.E., Tian H., Graf G.A., Yu L., Grishin N.V., Schultz J., Kwiterovich P., Shan B., Barnes R., Hobbs H.H.
    Science 290:1771-1775(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  4. "Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR."
    Khovidhunkit W., Moser A.H., Shigenaga J.K., Grunfeld C., Feingold K.R.
    J. Lipid Res. 44:1728-1736(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOWN-REGULATION BY ENDOTOXIN.

Entry informationi

Entry nameiABCG8_MOUSE
AccessioniPrimary (citable) accession number: Q9DBM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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