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Protein

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

Acadsb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity).By similarity

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+.

Cofactori

FADBy similarity

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183Substrate; via carbonyl oxygenBy similarity1
Binding sitei283SubstrateBy similarity1
Binding sitei319FAD; shared with dimeric partnerBy similarity1
Binding sitei330FAD; shared with dimeric partnerBy similarity1
Active sitei414Proton acceptorBy similarity1
Binding sitei415Substrate; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi174 – 183FADBy similarity10
Nucleotide bindingi207 – 209FADBy similarity3
Nucleotide bindingi387 – 391FAD; shared with dimeric partnerBy similarity5
Nucleotide bindingi416 – 418FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-70895 Branched-chain amino acid catabolism
UniPathwayiUPA00660

Names & Taxonomyi

Protein namesi
Recommended name:
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.5)
Short name:
SBCAD
Alternative name(s):
2-methyl branched chain acyl-CoA dehydrogenase
Short name:
2-MEBCAD
2-methylbutyryl-coenzyme A dehydrogenase
Short name:
2-methylbutyryl-CoA dehydrogenase
Gene namesi
Name:Acadsb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914135 Acadsb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionBy similarityAdd BLAST33
ChainiPRO_000000052034 – 432Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70N6-acetyllysine; alternateCombined sources1
Modified residuei70N6-succinyllysine; alternateCombined sources1
Modified residuei183PhosphoserineBy similarity1
Modified residuei278N6-succinyllysineCombined sources1
Modified residuei284N6-acetyllysine; alternateCombined sources1
Modified residuei284N6-succinyllysine; alternateCombined sources1
Modified residuei426N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DBL1
MaxQBiQ9DBL1
PaxDbiQ9DBL1
PeptideAtlasiQ9DBL1
PRIDEiQ9DBL1

PTM databases

iPTMnetiQ9DBL1
PhosphoSitePlusiQ9DBL1
SwissPalmiQ9DBL1

Expressioni

Gene expression databases

BgeeiENSMUSG00000030861
ExpressionAtlasiQ9DBL1 baseline and differential
GenevisibleiQ9DBL1 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9DBL1, 2 interactors
MINTiQ9DBL1
STRINGi10090.ENSMUSP00000015829

Structurei

3D structure databases

ProteinModelPortaliQ9DBL1
SMRiQ9DBL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 230Substrate bindingBy similarity2
Regioni291 – 294Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0139 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131659
HOVERGENiHBG000224
InParanoidiQ9DBL1
KOiK09478
PhylomeDBiQ9DBL1
TreeFamiTF105055

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSALQLWR MGGLLRRRFP TCLSPWKIPP RVLKSSQPEA LVSLTNNAVA
60 70 80 90 100
FAPLQTLTDE EIMMKQTVKK FAQEHVAPLV SSMDENSKME KSVIQGLFQQ
110 120 130 140 150
GLMGIEVEAQ YGGTEASFFC SVLVIEELAK VDASVALLCD IQNTIINNLF
160 170 180 190 200
RKHASEEQKA TYLPKLVTEK LGSFCLSEAG AGSDSFAMKT RADKSGNYYV
210 220 230 240 250
LNGSKMWISH AEHAELFLVF ANVDPSSGYR GITCFLVDRD TEGFQIGKRE
260 270 280 290 300
NKMGIRASST CQLTFENVKV PETNILGKIG HGYKYAIGSL NEGRIGIAAQ
310 320 330 340 350
MLGLAQGCFD YTIPYIKERM QFGKRIFDFQ GLQHQVAQVA TQLEATRLLT
360 370 380 390 400
YNAARLVEAG RPFIKEASMA KYYASEVAGL TTSKCIEWMG GVGYTKDYPV
410 420 430
EKFFRDAKIG TIYEGASNIQ LNTIAKHIDA EY
Length:432
Mass (Da):47,874
Last modified:June 1, 2001 - v1
Checksum:i0272723CE36BCC46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004889 mRNA Translation: BAB23646.1
CCDSiCCDS21916.1
RefSeqiNP_080102.1, NM_025826.4
UniGeneiMm.334274
Mm.487956

Genome annotation databases

EnsembliENSMUST00000015829; ENSMUSP00000015829; ENSMUSG00000030861
GeneIDi66885
KEGGimmu:66885
UCSCiuc009kbm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiACDSB_MOUSE
AccessioniPrimary (citable) accession number: Q9DBL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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