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Q9DBK0

- ACO12_MOUSE

UniProt

Q9DBK0 - ACO12_MOUSE

Protein

Acyl-coenzyme A thioesterase 12

Gene

Acot12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Hydrolyzes acetyl-CoA to acetate and CoA.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O = CoA + acetate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei145 – 1451Coenzyme ABy similarity

    GO - Molecular functioni

    1. acetyl-CoA hydrolase activity Source: MGI
    2. ATP binding Source: MGI
    3. lipid binding Source: InterPro

    GO - Biological processi

    1. acetyl-CoA metabolic process Source: MGI
    2. fatty acid metabolic process Source: MGI
    3. pyruvate metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00231.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-coenzyme A thioesterase 12 (EC:3.1.2.1)
    Short name:
    Acyl-CoA thioesterase 12
    Alternative name(s):
    Acyl-CoA thioester hydrolase 12
    Cytoplasmic acetyl-CoA hydrolase 1
    Short name:
    CACH-1
    Short name:
    mCACH-1
    Gene namesi
    Name:Acot12
    Synonyms:Cach, Cach1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1921406. Acot12.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Acyl-coenzyme A thioesterase 12PRO_0000053810Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-succinyllysine1 Publication
    Modified residuei97 – 971N6-succinyllysine1 Publication
    Modified residuei160 – 1601N6-succinyllysine1 Publication
    Modified residuei229 – 2291N6-succinyllysine1 Publication

    Proteomic databases

    MaxQBiQ9DBK0.
    PaxDbiQ9DBK0.
    PRIDEiQ9DBK0.

    PTM databases

    PhosphoSiteiQ9DBK0.

    Expressioni

    Gene expression databases

    BgeeiQ9DBK0.
    CleanExiMM_ACOT12.
    GenevestigatoriQ9DBK0.

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.By similarity

    Protein-protein interaction databases

    IntActiQ9DBK0. 3 interactions.
    MINTiMINT-4089645.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DBK0.
    SMRiQ9DBK0. Positions 8-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 128128Acyl coenzyme A hydrolase 1Add
    BLAST
    Domaini162 – 302141Acyl coenzyme A hydrolase 2Add
    BLAST
    Domaini327 – 536210STARTPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 563Coenzyme A bindingBy similarity
    Regioni83 – 853Coenzyme A bindingBy similarity
    Regioni235 – 2373Coenzyme A bindingBy similarity

    Sequence similaritiesi

    Contains 1 START domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1607.
    GeneTreeiENSGT00750000117709.
    HOGENOMiHOG000232032.
    HOVERGENiHBG023847.
    InParanoidiQ9DBK0.
    KOiK01067.
    OMAiPLWDPHY.
    OrthoDBiEOG70CR6C.
    PhylomeDBiQ9DBK0.
    TreeFamiTF328368.

    Family and domain databases

    Gene3Di3.10.129.10. 2 hits.
    3.30.530.20. 1 hit.
    InterProiIPR029069. HotDog_dom.
    IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    IPR006683. Thioestr_supf.
    [Graphical view]
    PfamiPF03061. 4HBT. 2 hits.
    PF01852. START. 1 hit.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 2 hits.
    PROSITEiPS50848. START. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DBK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESMVAPGEV LMSQAIQPAH ADSRGELSAG QLLKWMDTTA CLAAEKHAGI    50
    SCVTASMDDI LFEDTARIGQ IITIRAKVTR AFSTSMEISI KVIVQDKFTG 100
    IQKLLCVAFS TFVAKPVGKE KVHLKPVLLQ TEQEQVEHNL ASERRKVRLQ 150
    HENTFNNIMK ESSRFSDSIC NEEEGTATTM GTSVQSIELV LPPHANHHGN 200
    TFGGQIMAWM ETVATISASR LCHGHPFLKS VDMFKFRGPS TVGDRLVFSA 250
    IVNNTFQNSV EVGVRVEAFD CQEWAEGQGR HINSAFLIYN AVDDQEKLIT 300
    FPRIQPISKD DFRRYQGAIA RRRIRLGRKY VISHKKEVPL SAQWDISKKG 350
    SLSNTNVEAL KNLASKSGWE ITTTLEKIKI YTLEEQDAIS VKVEKLVGSP 400
    AHIAYHLLSD LTKRPLWDPH YISCEVIDQV SEDDQIYYIT CSVVNGDKPK 450
    DFVVLVSRRK PLKDNNTYTV ALRSVVLPSV PSSPQYIRSE VICAGFLIQA 500
    VDSNSCTVTY LNQMSDSILP YFAGNIGGWS KSIEEAAASC IKFIENATPD 550
    GLKSVL 556
    Length:556
    Mass (Da):61,762
    Last modified:June 1, 2001 - v1
    Checksum:i9FE9C487BBCBB812
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078618 mRNA. Translation: BAB84021.1.
    AK004905 mRNA. Translation: BAB23658.1.
    AK034622 mRNA. Translation: BAC28775.1.
    BC025852 mRNA. Translation: AAH25852.1.
    CCDSiCCDS26678.1.
    RefSeqiNP_083066.1. NM_028790.3.
    UniGeneiMm.275963.

    Genome annotation databases

    EnsembliENSMUST00000022120; ENSMUSP00000022120; ENSMUSG00000021620.
    GeneIDi74156.
    KEGGimmu:74156.
    UCSCiuc007rka.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB078618 mRNA. Translation: BAB84021.1 .
    AK004905 mRNA. Translation: BAB23658.1 .
    AK034622 mRNA. Translation: BAC28775.1 .
    BC025852 mRNA. Translation: AAH25852.1 .
    CCDSi CCDS26678.1.
    RefSeqi NP_083066.1. NM_028790.3.
    UniGenei Mm.275963.

    3D structure databases

    ProteinModelPortali Q9DBK0.
    SMRi Q9DBK0. Positions 8-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DBK0. 3 interactions.
    MINTi MINT-4089645.

    PTM databases

    PhosphoSitei Q9DBK0.

    Proteomic databases

    MaxQBi Q9DBK0.
    PaxDbi Q9DBK0.
    PRIDEi Q9DBK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022120 ; ENSMUSP00000022120 ; ENSMUSG00000021620 .
    GeneIDi 74156.
    KEGGi mmu:74156.
    UCSCi uc007rka.1. mouse.

    Organism-specific databases

    CTDi 134526.
    MGIi MGI:1921406. Acot12.

    Phylogenomic databases

    eggNOGi COG1607.
    GeneTreei ENSGT00750000117709.
    HOGENOMi HOG000232032.
    HOVERGENi HBG023847.
    InParanoidi Q9DBK0.
    KOi K01067.
    OMAi PLWDPHY.
    OrthoDBi EOG70CR6C.
    PhylomeDBi Q9DBK0.
    TreeFami TF328368.

    Enzyme and pathway databases

    UniPathwayi UPA00231 .

    Miscellaneous databases

    NextBioi 339934.
    PROi Q9DBK0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DBK0.
    CleanExi MM_ACOT12.
    Genevestigatori Q9DBK0.

    Family and domain databases

    Gene3Di 3.10.129.10. 2 hits.
    3.30.530.20. 1 hit.
    InterProi IPR029069. HotDog_dom.
    IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    IPR006683. Thioestr_supf.
    [Graphical view ]
    Pfami PF03061. 4HBT. 2 hits.
    PF01852. START. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 2 hits.
    PROSITEi PS50848. START. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key enzyme involved in fat metabolism: cDNA cloning, sequencing and functional expression."
      Suematsu N., Okamoto K., Isohashi F.
      Acta Biochim. Pol. 49:937-945(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-556.
      Tissue: Liver.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-34; LYS-97; LYS-160 AND LYS-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiACO12_MOUSE
    AccessioniPrimary (citable) accession number: Q9DBK0
    Secondary accession number(s): Q544M5, Q8R108
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3