Reviewed,
UniProtKB/Swiss-Prot Q9DBK0 (ACO12_MOUSE)
Last modified
January 19, 2010.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acyl-coenzyme A thioesterase 12 Short name=Acyl-CoA thioesterase 12 EC=3.1.2.1 Alternative name(s): Acyl-CoA thioester hydrolase 12 Cytoplasmic acetyl-CoA hydrolase 1 Short name=mCACH-1 Short name=CACH-1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 556 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Hydrolyzes acetyl-CoA to acetate and CoA By similarity. |
| Catalytic activity | Acetyl-CoA + H2O = CoA + acetate. |
| Pathway | |
| Subunit structure | Homodimer or homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Contains 2 acyl coenzyme A hydrolase domains. Contains 1 START domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid metabolism Lipid metabolism |
| Cellular component | Cytoplasm |
| Domain | Repeat |
| Molecular function | Hydrolase Serine esterase |
| Gene Ontology (GO) | |
| Biological process | acetyl-CoA metabolic process Ref.1 Inferred from direct assay. Source: MGI |
| Cellular component | cytosol Ref.1 Traceable author statement. Source: MGI |
| Molecular function | ATP binding Ref.1 Inferred from direct assay. Source: MGI acetyl-CoA hydrolase activity Ref.1Inferred from direct assay. Source: MGI carboxylesterase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 556 | 556 | Acyl-coenzyme A thioesterase 12 | PRO_0000053810 | |||||
Regions | |||||||||
| Domain | 1 – 128 | 128 | Acyl coenzyme A hydrolase 1 | ||||||
| Domain | 162 – 302 | 141 | Acyl coenzyme A hydrolase 2 | ||||||
| Domain | 327 – 536 | 210 | START | ||||||
| Region | 54 – 56 | 3 | Coenzyme A binding By similarity | ||||||
| Region | 83 – 85 | 3 | Coenzyme A binding By similarity | ||||||
| Region | 235 – 237 | 3 | Coenzyme A binding By similarity | ||||||
Sites | |||||||||
| Binding site | 145 | 1 | Coenzyme A By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key enzyme involved in fat metabolism: cDNA cloning, sequencing and functional expression." Suematsu N., Okamoto K., Isohashi F. Acta Biochim. Pol. 49:937-945(2002) [PubMed: 12545200] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Liver. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Liver. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-556. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB078618 mRNA. Translation: BAB84021.1. AK004905 mRNA. Translation: BAB23658.1. AK034622 mRNA. Translation: BAC28775.1. BC025852 mRNA. Translation: AAH25852.1. |
| IPI | IPI00119810. |
| RefSeq | NP_083066.1. |
| UniGene | Mm.275963 |
3D structure databases | |
| SMR | Q9DBK0. Positions 8-299, 182-331, 355-529. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9DBK0. |
Proteomic databases | |
| PRIDE | Q9DBK0. |
Genome annotation databases | |
| Ensembl | ENSMUST00000022120; ENSMUSP00000022120; ENSMUSG00000021620; Mus musculus. [Genome view] |
| GeneID | 74156. |
| KEGG | mmu:74156. |
| UCSC | uc007rka.1. mouse. |
Organism-specific databases | |
| CTD | 74156. |
| MGI | MGI:1921406. Acot12. |
Phylogenomic databases | |
| HOGENOM | HBG443629. |
| HOVERGEN | Q9DBK0. |
| InParanoid | Q9DBK0. |
| OMA | PYFAGNL. |
| OrthoDB | EOG9CJZ2N. |
| PhylomeDB | Q9DBK0. |
Enzyme and pathway databases | |
| BRENDA | 3.1.2.1. 244. |
Gene expression databases | |
| ArrayExpress | Q9DBK0. |
| Bgee | Q9DBK0. |
| CleanEx | MM_ACOT12. |
| Genevestigator | Q9DBK0. |
| GermOnline | ENSMUSG00000021620. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002913. START_lipid_bd. IPR006683. Thioestr_supf. [Graphical view] |
| Pfam | PF03061. 4HBT. 2 hits. PF01852. START. 1 hit. [Graphical view] |
| PROSITE | PS50848. START. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 339934. |
| SOURCE | Search... |
Entry information
| Entry name | ACO12_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9DBK0 Secondary accession number(s): Q544M5, Q8R108 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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