Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

Baiap2l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Short name:
BAI1-associated protein 2-like protein 1
Alternative name(s):
Insulin receptor tyrosine kinase substrate
Gene namesi
Name:Baiap2l1
Synonyms:Irtks
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914148. Baiap2l1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478551 – 514Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphothreonineCombined sources1
Modified residuei257PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1
Modified residuei411PhosphothreonineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei421PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine in response to insulin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBJ3.
PaxDbiQ9DBJ3.
PeptideAtlasiQ9DBJ3.
PRIDEiQ9DBJ3.

PTM databases

iPTMnetiQ9DBJ3.
PhosphoSitePlusiQ9DBJ3.

Expressioni

Tissue specificityi

Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000038859.
CleanExiMM_BAIAP2L1.
GenevisibleiQ9DBJ3. MM.

Interactioni

Subunit structurei

Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9DBJ3. 2 interactors.
MINTiMINT-4128274.
STRINGi10090.ENSMUSP00000053129.

Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi344 – 346Combined sources3
Beta strandi357 – 359Combined sources3
Beta strandi367 – 370Combined sources4
Beta strandi379 – 384Combined sources6
Turni385 – 387Combined sources3
Beta strandi390 – 394Combined sources5
Helixi395 – 397Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SPKNMR-A343-401[»]
ProteinModelPortaliQ9DBJ3.
SMRiQ9DBJ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBJ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249IMDPROSITE-ProRule annotationAdd BLAST249
Domaini340 – 403SH3PROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni486 – 514Binds F-actinBy similarityAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 148Sequence analysisAdd BLAST34

Domaini

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IGQC. Eukaryota.
ENOG410Y6FF. LUCA.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ9DBJ3.
KOiK20127.
OMAiYRNVMEQ.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ9DBJ3.
TreeFamiTF325648.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030060. IRTKS.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF4. PTHR14206:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGPEEVNR LTENTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA
60 70 80 90 100
YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKDI
110 120 130 140 150
IHELEKKTEL DVKYMNATLK RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG
160 170 180 190 200
RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH
210 220 230 240 250
CSFASHIHYY HMQSAELLNS KLPRWQETCC DATKVPEKIM NMIEEIKTPI
260 270 280 290 300
STPVSGTPQP SPMIERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM
310 320 330 340 350
FNNPATAAQS SEKTNNSTAN TGEDPSLQRS VSVATGLNMM KKQKVKTIFP
360 370 380 390 400
HTAGNNKTLL SFAQGDVLTL LIPEEKDGWL YGEHDTTKAR GWFPSSYTKL
410 420 430 440 450
LEENEAMSVP TPSPAPVRSI STVDLTEKSS VVIPPPDYLE CLSMGATSDK
460 470 480 490 500
KAGAPKVPSA STFRAPVSRP DATSTSPSDA NGTAKPPFLS GENPFATVKL
510
RPTVTNDRSA PIIR
Length:514
Mass (Da):57,188
Last modified:June 1, 2001 - v1
Checksum:iAF9974A0696812EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004918 mRNA. Translation: BAB23669.1.
BC015459 mRNA. Translation: AAH15459.1.
CCDSiCCDS39378.1.
RefSeqiNP_080109.1. NM_025833.3.
UniGeneiMm.18814.

Genome annotation databases

EnsembliENSMUST00000055190; ENSMUSP00000053129; ENSMUSG00000038859.
GeneIDi66898.
KEGGimmu:66898.
UCSCiuc009alq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004918 mRNA. Translation: BAB23669.1.
BC015459 mRNA. Translation: AAH15459.1.
CCDSiCCDS39378.1.
RefSeqiNP_080109.1. NM_025833.3.
UniGeneiMm.18814.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SPKNMR-A343-401[»]
ProteinModelPortaliQ9DBJ3.
SMRiQ9DBJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBJ3. 2 interactors.
MINTiMINT-4128274.
STRINGi10090.ENSMUSP00000053129.

PTM databases

iPTMnetiQ9DBJ3.
PhosphoSitePlusiQ9DBJ3.

Proteomic databases

MaxQBiQ9DBJ3.
PaxDbiQ9DBJ3.
PeptideAtlasiQ9DBJ3.
PRIDEiQ9DBJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055190; ENSMUSP00000053129; ENSMUSG00000038859.
GeneIDi66898.
KEGGimmu:66898.
UCSCiuc009alq.1. mouse.

Organism-specific databases

CTDi55971.
MGIiMGI:1914148. Baiap2l1.

Phylogenomic databases

eggNOGiENOG410IGQC. Eukaryota.
ENOG410Y6FF. LUCA.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ9DBJ3.
KOiK20127.
OMAiYRNVMEQ.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ9DBJ3.
TreeFamiTF325648.

Miscellaneous databases

EvolutionaryTraceiQ9DBJ3.
PROiQ9DBJ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038859.
CleanExiMM_BAIAP2L1.
GenevisibleiQ9DBJ3. MM.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030060. IRTKS.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF4. PTHR14206:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBI2L1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.