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Q9DBJ3

- BI2L1_MOUSE

UniProt

Q9DBJ3 - BI2L1_MOUSE

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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

Baiap2l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity).By similarity

GO - Molecular functioni

  1. proline-rich region binding Source: UniProtKB

GO - Biological processi

  1. filopodium assembly Source: InterPro
  2. positive regulation of actin cytoskeleton reorganization Source: UniProtKB
  3. positive regulation of actin filament polymerization Source: UniProtKB
  4. response to bacterium Source: UniProtKB
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Short name:
BAI1-associated protein 2-like protein 1
Alternative name(s):
Insulin receptor tyrosine kinase substrate
Gene namesi
Name:Baiap2l1
Synonyms:Irtks
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1914148. Baiap2l1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity
Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. cytosol Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1PRO_0000247855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphothreonineBy similarity
Modified residuei257 – 2571PhosphothreonineBy similarity
Modified residuei261 – 2611Phosphoserine1 Publication
Modified residuei281 – 2811PhosphoserineBy similarity
Modified residuei332 – 3321PhosphoserineBy similarity
Modified residuei411 – 4111PhosphothreonineBy similarity
Modified residuei421 – 4211Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine in response to insulin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBJ3.
PaxDbiQ9DBJ3.
PRIDEiQ9DBJ3.

PTM databases

PhosphoSiteiQ9DBJ3.

Expressioni

Tissue specificityi

Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiQ9DBJ3.
CleanExiMM_BAIAP2L1.
GenevestigatoriQ9DBJ3.

Interactioni

Subunit structurei

Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9DBJ3. 2 interactions.
MINTiMINT-4128274.
STRINGi10090.ENSMUSP00000053129.

Structurei

Secondary structure

1
514
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi344 – 3463Combined sources
Beta strandi357 – 3593Combined sources
Beta strandi367 – 3704Combined sources
Beta strandi379 – 3846Combined sources
Turni385 – 3873Combined sources
Beta strandi390 – 3945Combined sources
Helixi395 – 3973Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SPKNMR-A343-401[»]
ProteinModelPortaliQ9DBJ3.
SMRiQ9DBJ3. Positions 6-227, 343-401.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBJ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 249249IMDPROSITE-ProRule annotationAdd
BLAST
Domaini340 – 40364SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni486 – 51429Binds F-actinBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili115 – 14834Sequence AnalysisAdd
BLAST

Domaini

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG71665.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ9DBJ3.
OMAiYRNVMEQ.
OrthoDBiEOG7N0C3W.
PhylomeDBiQ9DBJ3.
TreeFamiTF325648.

Family and domain databases

InterProiIPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRGPEEVNR LTENTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA
60 70 80 90 100
YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKDI
110 120 130 140 150
IHELEKKTEL DVKYMNATLK RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG
160 170 180 190 200
RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH
210 220 230 240 250
CSFASHIHYY HMQSAELLNS KLPRWQETCC DATKVPEKIM NMIEEIKTPI
260 270 280 290 300
STPVSGTPQP SPMIERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM
310 320 330 340 350
FNNPATAAQS SEKTNNSTAN TGEDPSLQRS VSVATGLNMM KKQKVKTIFP
360 370 380 390 400
HTAGNNKTLL SFAQGDVLTL LIPEEKDGWL YGEHDTTKAR GWFPSSYTKL
410 420 430 440 450
LEENEAMSVP TPSPAPVRSI STVDLTEKSS VVIPPPDYLE CLSMGATSDK
460 470 480 490 500
KAGAPKVPSA STFRAPVSRP DATSTSPSDA NGTAKPPFLS GENPFATVKL
510
RPTVTNDRSA PIIR
Length:514
Mass (Da):57,188
Last modified:June 1, 2001 - v1
Checksum:iAF9974A0696812EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004918 mRNA. Translation: BAB23669.1.
BC015459 mRNA. Translation: AAH15459.1.
CCDSiCCDS39378.1.
RefSeqiNP_080109.1. NM_025833.3.
UniGeneiMm.18814.

Genome annotation databases

EnsembliENSMUST00000055190; ENSMUSP00000053129; ENSMUSG00000038859.
GeneIDi66898.
KEGGimmu:66898.
UCSCiuc009alq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004918 mRNA. Translation: BAB23669.1 .
BC015459 mRNA. Translation: AAH15459.1 .
CCDSi CCDS39378.1.
RefSeqi NP_080109.1. NM_025833.3.
UniGenei Mm.18814.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SPK NMR - A 343-401 [» ]
ProteinModelPortali Q9DBJ3.
SMRi Q9DBJ3. Positions 6-227, 343-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DBJ3. 2 interactions.
MINTi MINT-4128274.
STRINGi 10090.ENSMUSP00000053129.

PTM databases

PhosphoSitei Q9DBJ3.

Proteomic databases

MaxQBi Q9DBJ3.
PaxDbi Q9DBJ3.
PRIDEi Q9DBJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055190 ; ENSMUSP00000053129 ; ENSMUSG00000038859 .
GeneIDi 66898.
KEGGi mmu:66898.
UCSCi uc009alq.1. mouse.

Organism-specific databases

CTDi 55971.
MGIi MGI:1914148. Baiap2l1.

Phylogenomic databases

eggNOGi NOG71665.
GeneTreei ENSGT00390000005995.
HOGENOMi HOG000038005.
HOVERGENi HBG054462.
InParanoidi Q9DBJ3.
OMAi YRNVMEQ.
OrthoDBi EOG7N0C3W.
PhylomeDBi Q9DBJ3.
TreeFami TF325648.

Miscellaneous databases

EvolutionaryTracei Q9DBJ3.
NextBioi 322961.
PROi Q9DBJ3.
SOURCEi Search...

Gene expression databases

Bgeei Q9DBJ3.
CleanExi MM_BAIAP2L1.
Genevestigatori Q9DBJ3.

Family and domain databases

InterProi IPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR14206. PTHR14206. 1 hit.
Pfami PF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261 AND SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Solution structure of RSGI RUH-010, an SH3 domain from mouse cDNA."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 343-401.
  5. "Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties."
    Millard T.H., Dawson J., Machesky L.M.
    J. Cell Sci. 120:1663-1672(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiBI2L1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3