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Q9DBJ3 (BI2L1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Short name=BAI1-associated protein 2-like protein 1
Alternative name(s):
Insulin receptor tyrosine kinase substrate
Gene names
Name:Baiap2l1
Synonyms:Irtks
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection By similarity.

Subunit structure

Interacts with RAC1. Binds to F-actin. Interacts with FASLG By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Note: Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites By similarity.

Tissue specificity

Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level). Ref.5

Domain

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation By similarity.

Post-translational modification

Phosphorylated on tyrosine in response to insulin By similarity.

Sequence similarities

Contains 1 IMD (IRSp53/MIM homology) domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
PRO_0000247855

Regions

Domain1 – 249249IMD
Domain340 – 40364SH3
Region486 – 51429Binds F-actin By similarity
Coiled coil115 – 14834 Potential

Amino acid modifications

Modified residue2481Phosphothreonine By similarity
Modified residue2571Phosphothreonine By similarity
Modified residue2611Phosphoserine Ref.3
Modified residue2811Phosphoserine By similarity
Modified residue3321Phosphoserine By similarity
Modified residue4111Phosphothreonine By similarity
Modified residue4211Phosphoserine Ref.3

Secondary structure

............. 514
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9DBJ3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AF9974A0696812EC

FASTA51457,188
        10         20         30         40         50         60 
MSRGPEEVNR LTENTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA YYDGVAKIGE 

        70         80         90        100        110        120 
IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKDI IHELEKKTEL DVKYMNATLK 

       130        140        150        160        170        180 
RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG RNALKYEHKE IEYVETVTSR QSEIQKFIAD 

       190        200        210        220        230        240 
GCKEALLEEK RRFCFLVDKH CSFASHIHYY HMQSAELLNS KLPRWQETCC DATKVPEKIM 

       250        260        270        280        290        300 
NMIEEIKTPI STPVSGTPQP SPMIERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM 

       310        320        330        340        350        360 
FNNPATAAQS SEKTNNSTAN TGEDPSLQRS VSVATGLNMM KKQKVKTIFP HTAGNNKTLL 

       370        380        390        400        410        420 
SFAQGDVLTL LIPEEKDGWL YGEHDTTKAR GWFPSSYTKL LEENEAMSVP TPSPAPVRSI 

       430        440        450        460        470        480 
STVDLTEKSS VVIPPPDYLE CLSMGATSDK KAGAPKVPSA STFRAPVSRP DATSTSPSDA 

       490        500        510 
NGTAKPPFLS GENPFATVKL RPTVTNDRSA PIIR 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261 AND SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"Solution structure of RSGI RUH-010, an SH3 domain from mouse cDNA."
RIKEN structural genomics initiative (RSGI)
Submitted (SEP-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 343-401.
[5]"Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties."
Millard T.H., Dawson J., Machesky L.M.
J. Cell Sci. 120:1663-1672(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004918 mRNA. Translation: BAB23669.1.
BC015459 mRNA. Translation: AAH15459.1.
RefSeqNP_080109.1. NM_025833.3.
UniGeneMm.18814.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SPKNMR-A343-401[»]
ProteinModelPortalQ9DBJ3.
SMRQ9DBJ3. Positions 6-227, 343-401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9DBJ3. 2 interactions.
MINTMINT-4128274.
STRING10090.ENSMUSP00000053129.

PTM databases

PhosphoSiteQ9DBJ3.

Proteomic databases

PaxDbQ9DBJ3.
PRIDEQ9DBJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055190; ENSMUSP00000053129; ENSMUSG00000038859.
GeneID66898.
KEGGmmu:66898.
UCSCuc009alq.1. mouse.

Organism-specific databases

CTD55971.
MGIMGI:1914148. Baiap2l1.

Phylogenomic databases

eggNOGNOG71665.
GeneTreeENSGT00390000005995.
HOGENOMHOG000038005.
HOVERGENHBG054462.
InParanoidQ9DBJ3.
OMAYRNVMEQ.
OrthoDBEOG7N0C3W.
PhylomeDBQ9DBJ3.
TreeFamTF325648.

Gene expression databases

BgeeQ9DBJ3.
CleanExMM_BAIAP2L1.
GenevestigatorQ9DBJ3.

Family and domain databases

InterProIPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR14206. PTHR14206. 1 hit.
PfamPF08397. IMD. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9DBJ3.
NextBio322961.
PROQ9DBJ3.
SOURCESearch...

Entry information

Entry nameBI2L1_MOUSE
AccessionPrimary (citable) accession number: Q9DBJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot