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Q9DBI2 (BBS10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bardet-Biedl syndrome 10 protein homolog
Gene names
Name:Bbs10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length713 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation By similarity.

Subunit structure

Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 By similarity.

Subcellular location

Cell projectioncilium By similarity. Note: Located within the basal body of the primary cilium of differentiating preadipocytes By similarity.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

Sequence caution

The sequence BAB23682.1 differs from that shown. Reason: Intron retention. Several introns.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 713713Bardet-Biedl syndrome 10 protein homolog
PRO_0000235273

Sequences

Sequence LengthMass (Da)Tools
Q9DBI2 [UniParc].

Last modified May 16, 2006. Version 2.
Checksum: AEEBC611994FDB84

FASTA71378,924
        10         20         30         40         50         60 
MASQGSVTAA LRVAEVLESI ANRCVGPEGG QVLCTKPTGE VLLSRDGGCL LEALHLEHPL 

        70         80         90        100        110        120 
ARMIVACVSS HLKKTGDGAK TFIIFLCHLL RGLHAIGEKG KDSFTSENIQ SHERHWKNCC 

       130        140        150        160        170        180 
QWKSISQALQ TFQTQTLGCI VDRSLSRHYL SVFSSSTEGR KLCRHSLELL LEAYFCGRVG 

       190        200        210        220        230        240 
RNNHRFISQL MCDYVFKCMA CESGVEVFEL LDHCFAELNV GVTGLPVSDS RIIDGLVLPR 

       250        260        270        280        290        300 
DFSMYCPADG DIRMVIVTEI LQPQFSSAGS EFVLNSETQF QASQCWITDR TKTVMNHLRG 

       310        320        330        340        350        360 
QNVKLLLTSV KQPDLVIYCA RLNSISVVEC LSAEEVSLVQ RITGLSPCVL PEVASQCEIS 

       370        380        390        400        410        420 
DSTLVKFCKP LILRSKRYVH LGLISTCAFI PHSMVLCGPV LGLVEQHERA FHGAFKMLRQ 

       430        440        450        460        470        480 
LFTDLDLNYI IQTKQQCNPS PLAYDNSRER NHSPETDKYQ DIVAKSKNKL ETQTHLEVYS 

       490        500        510        520        530        540 
GLGASDTELR AGKPWSAHKK TPIAPSQTDE MLKCLPPERS GIIDNCDLSI ENHSTGNPTA 

       550        560        570        580        590        600 
EDTGTEISFE HLQVSDNAGK GYTLPVMRKS LDTCTCQGYC SSTVPAGCVL PVGGSFEILM 

       610        620        630        640        650        660 
SYYLLSYAKQ CRQSDETVIS MLIADALLGI PKILYKPKKG KDSFPHIYMR SLHALQASQP 

       670        680        690        700        710 
MVSGQSGFES VAGKYQLLTS VLQCLMKILT IDLIINIKRQ PQKTADQESE DEF 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004937 mRNA. Translation: BAB23682.1. Sequence problems.
CCDSCCDS48689.1.
RefSeqNP_082190.1. NM_027914.1.
UniGeneMm.45256.

3D structure databases

ProteinModelPortalQ9DBI2.
SMRQ9DBI2. Positions 9-100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60356N.
IntActQ9DBI2. 4 interactions.
STRING10090.ENSMUSP00000049387.

PTM databases

PhosphoSiteQ9DBI2.

Proteomic databases

PRIDEQ9DBI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040454; ENSMUSP00000049387; ENSMUSG00000035759.
GeneID71769.
KEGGmmu:71769.
UCSCuc011xnf.1. mouse.

Organism-specific databases

CTD79738.
MGIMGI:1919019. Bbs10.

Phylogenomic databases

eggNOGKOG0360.
GeneTreeENSGT00390000002417.
HOGENOMHOG000050242.
HOVERGENHBG055802.
InParanoidQ9DBI2.
OMACVLPVGG.
OrthoDBEOG7SXW5J.
PhylomeDBQ9DBI2.
TreeFamTF335867.

Gene expression databases

BgeeQ9DBI2.
CleanExMM_BBS10.
GenevestigatorQ9DBI2.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
InterProIPR002423. Cpn60/TCP-1.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamPF00118. Cpn60_TCP1. 2 hits.
[Graphical view]
SUPFAMSSF48592. SSF48592. 2 hits.
ProtoNetSearch...

Other

NextBio334461.
PROQ9DBI2.
SOURCESearch...

Entry information

Entry nameBBS10_MOUSE
AccessionPrimary (citable) accession number: Q9DBI2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot