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Protein

Bardet-Biedl syndrome 10 protein homolog

Gene

Bbs10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II repressing transcription factor binding Source: MGI

GO - Biological processi

  1. cellular protein metabolic process Source: InterPro
  2. chaperone-mediated protein complex assembly Source: MGI
  3. nonmotile primary cilium assembly Source: MGI
  4. photoreceptor cell maintenance Source: MGI
  5. regulation of protein complex assembly Source: MGI
  6. retina homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 10 protein homolog
Gene namesi
Name:Bbs10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1919019. Bbs10.

Subcellular locationi

Cell projectioncilium By similarity
Note: Located within the basal body of the primary cilium of differentiating preadipocytes.By similarity

GO - Cellular componenti

  1. cilium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Bardet-Biedl syndrome 10 protein homologPRO_0000235273Add
BLAST

Proteomic databases

PRIDEiQ9DBI2.

PTM databases

PhosphoSiteiQ9DBI2.

Expressioni

Gene expression databases

BgeeiQ9DBI2.
CleanExiMM_BBS10.
GenevestigatoriQ9DBI2.

Interactioni

Subunit structurei

Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.By similarity

Protein-protein interaction databases

DIPiDIP-60356N.
IntActiQ9DBI2. 4 interactions.
STRINGi10090.ENSMUSP00000049387.

Structurei

3D structure databases

ProteinModelPortaliQ9DBI2.
SMRiQ9DBI2. Positions 9-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360.
GeneTreeiENSGT00390000002417.
HOGENOMiHOG000050242.
HOVERGENiHBG055802.
InParanoidiQ9DBI2.
OMAiCVLPVGG.
OrthoDBiEOG7SXW5J.
PhylomeDBiQ9DBI2.
TreeFamiTF335867.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
InterProiIPR002423. Cpn60/TCP-1.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 2 hits.
[Graphical view]
SUPFAMiSSF48592. SSF48592. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9DBI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQGSVTAA LRVAEVLESI ANRCVGPEGG QVLCTKPTGE VLLSRDGGCL
60 70 80 90 100
LEALHLEHPL ARMIVACVSS HLKKTGDGAK TFIIFLCHLL RGLHAIGEKG
110 120 130 140 150
KDSFTSENIQ SHERHWKNCC QWKSISQALQ TFQTQTLGCI VDRSLSRHYL
160 170 180 190 200
SVFSSSTEGR KLCRHSLELL LEAYFCGRVG RNNHRFISQL MCDYVFKCMA
210 220 230 240 250
CESGVEVFEL LDHCFAELNV GVTGLPVSDS RIIDGLVLPR DFSMYCPADG
260 270 280 290 300
DIRMVIVTEI LQPQFSSAGS EFVLNSETQF QASQCWITDR TKTVMNHLRG
310 320 330 340 350
QNVKLLLTSV KQPDLVIYCA RLNSISVVEC LSAEEVSLVQ RITGLSPCVL
360 370 380 390 400
PEVASQCEIS DSTLVKFCKP LILRSKRYVH LGLISTCAFI PHSMVLCGPV
410 420 430 440 450
LGLVEQHERA FHGAFKMLRQ LFTDLDLNYI IQTKQQCNPS PLAYDNSRER
460 470 480 490 500
NHSPETDKYQ DIVAKSKNKL ETQTHLEVYS GLGASDTELR AGKPWSAHKK
510 520 530 540 550
TPIAPSQTDE MLKCLPPERS GIIDNCDLSI ENHSTGNPTA EDTGTEISFE
560 570 580 590 600
HLQVSDNAGK GYTLPVMRKS LDTCTCQGYC SSTVPAGCVL PVGGSFEILM
610 620 630 640 650
SYYLLSYAKQ CRQSDETVIS MLIADALLGI PKILYKPKKG KDSFPHIYMR
660 670 680 690 700
SLHALQASQP MVSGQSGFES VAGKYQLLTS VLQCLMKILT IDLIINIKRQ
710
PQKTADQESE DEF
Length:713
Mass (Da):78,924
Last modified:May 16, 2006 - v2
Checksum:iAEEBC611994FDB84
GO

Sequence cautioni

The sequence BAB23682.1 differs from that shown.Intron retention. Several introns.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004937 mRNA. Translation: BAB23682.1. Sequence problems.
CCDSiCCDS48689.1.
RefSeqiNP_082190.1. NM_027914.1.
UniGeneiMm.45256.

Genome annotation databases

EnsembliENSMUST00000040454; ENSMUSP00000049387; ENSMUSG00000035759.
GeneIDi71769.
KEGGimmu:71769.
UCSCiuc011xnf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004937 mRNA. Translation: BAB23682.1. Sequence problems.
CCDSiCCDS48689.1.
RefSeqiNP_082190.1. NM_027914.1.
UniGeneiMm.45256.

3D structure databases

ProteinModelPortaliQ9DBI2.
SMRiQ9DBI2. Positions 9-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60356N.
IntActiQ9DBI2. 4 interactions.
STRINGi10090.ENSMUSP00000049387.

PTM databases

PhosphoSiteiQ9DBI2.

Proteomic databases

PRIDEiQ9DBI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040454; ENSMUSP00000049387; ENSMUSG00000035759.
GeneIDi71769.
KEGGimmu:71769.
UCSCiuc011xnf.1. mouse.

Organism-specific databases

CTDi79738.
MGIiMGI:1919019. Bbs10.

Phylogenomic databases

eggNOGiKOG0360.
GeneTreeiENSGT00390000002417.
HOGENOMiHOG000050242.
HOVERGENiHBG055802.
InParanoidiQ9DBI2.
OMAiCVLPVGG.
OrthoDBiEOG7SXW5J.
PhylomeDBiQ9DBI2.
TreeFamiTF335867.

Miscellaneous databases

ChiTaRSiBbs10. mouse.
NextBioi334461.
PROiQ9DBI2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBI2.
CleanExiMM_BBS10.
GenevestigatoriQ9DBI2.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
InterProiIPR002423. Cpn60/TCP-1.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 2 hits.
[Graphical view]
SUPFAMiSSF48592. SSF48592. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.

Entry informationi

Entry nameiBBS10_MOUSE
AccessioniPrimary (citable) accession number: Q9DBI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: February 4, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.