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Protein

Bardet-Biedl syndrome 10 protein homolog

Gene

Bbs10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 10 protein homolog
Gene namesi
Name:Bbs10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919019. Bbs10.

Subcellular locationi

  • Cell projectioncilium By similarity

  • Note: Located within the basal body of the primary cilium of differentiating preadipocytes.By similarity

GO - Cellular componenti

  • cilium Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352731 – 713Bardet-Biedl syndrome 10 protein homologAdd BLAST713

Proteomic databases

PaxDbiQ9DBI2.
PeptideAtlasiQ9DBI2.
PRIDEiQ9DBI2.

PTM databases

iPTMnetiQ9DBI2.
PhosphoSitePlusiQ9DBI2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035759.
CleanExiMM_BBS10.
GenevisibleiQ9DBI2. MM.

Interactioni

Subunit structurei

Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60356N.
IntActiQ9DBI2. 4 interactors.
STRINGi10090.ENSMUSP00000049387.

Structurei

3D structure databases

ProteinModelPortaliQ9DBI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00390000002417.
HOGENOMiHOG000050242.
HOVERGENiHBG055802.
InParanoidiQ9DBI2.
KOiK19401.
OMAiAKTFIIF.
OrthoDBiEOG091G0H6P.
PhylomeDBiQ9DBI2.
TreeFamiTF335867.

Family and domain databases

Gene3Di1.10.560.10. 1 hit.
InterProiView protein in InterPro
IPR002423. Cpn60/TCP-1.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9DBI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQGSVTAA LRVAEVLESI ANRCVGPEGG QVLCTKPTGE VLLSRDGGCL
60 70 80 90 100
LEALHLEHPL ARMIVACVSS HLKKTGDGAK TFIIFLCHLL RGLHAIGEKG
110 120 130 140 150
KDSFTSENIQ SHERHWKNCC QWKSISQALQ TFQTQTLGCI VDRSLSRHYL
160 170 180 190 200
SVFSSSTEGR KLCRHSLELL LEAYFCGRVG RNNHRFISQL MCDYVFKCMA
210 220 230 240 250
CESGVEVFEL LDHCFAELNV GVTGLPVSDS RIIDGLVLPR DFSMYCPADG
260 270 280 290 300
DIRMVIVTEI LQPQFSSAGS EFVLNSETQF QASQCWITDR TKTVMNHLRG
310 320 330 340 350
QNVKLLLTSV KQPDLVIYCA RLNSISVVEC LSAEEVSLVQ RITGLSPCVL
360 370 380 390 400
PEVASQCEIS DSTLVKFCKP LILRSKRYVH LGLISTCAFI PHSMVLCGPV
410 420 430 440 450
LGLVEQHERA FHGAFKMLRQ LFTDLDLNYI IQTKQQCNPS PLAYDNSRER
460 470 480 490 500
NHSPETDKYQ DIVAKSKNKL ETQTHLEVYS GLGASDTELR AGKPWSAHKK
510 520 530 540 550
TPIAPSQTDE MLKCLPPERS GIIDNCDLSI ENHSTGNPTA EDTGTEISFE
560 570 580 590 600
HLQVSDNAGK GYTLPVMRKS LDTCTCQGYC SSTVPAGCVL PVGGSFEILM
610 620 630 640 650
SYYLLSYAKQ CRQSDETVIS MLIADALLGI PKILYKPKKG KDSFPHIYMR
660 670 680 690 700
SLHALQASQP MVSGQSGFES VAGKYQLLTS VLQCLMKILT IDLIINIKRQ
710
PQKTADQESE DEF
Length:713
Mass (Da):78,924
Last modified:May 16, 2006 - v2
Checksum:iAEEBC611994FDB84
GO

Sequence cautioni

The sequence BAB23682 differs from that shown. Intron retention. Several introns.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004937 mRNA. Translation: BAB23682.1. Sequence problems.
CCDSiCCDS48689.1.
RefSeqiNP_082190.1. NM_027914.1.
UniGeneiMm.45256.

Genome annotation databases

EnsembliENSMUST00000040454; ENSMUSP00000049387; ENSMUSG00000035759.
GeneIDi71769.
KEGGimmu:71769.
UCSCiuc011xnf.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBBS10_MOUSE
AccessioniPrimary (citable) accession number: Q9DBI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: June 7, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families