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Protein

Transmembrane protease serine 6

Gene

Tmprss6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei617 – 6171Charge relay systemBy similarity
Active sitei668 – 6681Charge relay systemBy similarity
Active sitei762 – 7621Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: BHF-UCL
  • fibrinolysis Source: UniProtKB
  • iron ion homeostasis Source: MGI
  • membrane protein proteolysis Source: UniProtKB
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • proteolysis Source: UniProtKB
  • self proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.109. 3474.

Protein family/group databases

MEROPSiS01.308.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 6 (EC:3.4.21.-)
Alternative name(s):
Matriptase-2
Gene namesi
Name:Tmprss6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1919003. Tmprss6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959CytoplasmicSequence analysisAdd
BLAST
Transmembranei60 – 8021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini81 – 811731ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display the phenotype named mask, characterized by progressive loss of body (but not facial) hair, microcytic anemia and female infertility, all reversible by dietary iron supplementation. The mask phenotype results from reduced absorption of dietary iron caused by high levels of hepcidin.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi762 – 7621S → A: Protease-dead. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Transmembrane protease serine 6PRO_0000088697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi335 ↔ 366By similarity
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi458 ↔ 470By similarity
Disulfide bondi464 ↔ 480By similarity
Disulfide bondi474 ↔ 489By similarity
Disulfide bondi491 ↔ 503By similarity
Disulfide bondi497 ↔ 516By similarity
Disulfide bondi510 ↔ 525By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi531 ↔ 543By similarity
Disulfide bondi538 ↔ 557By similarity
Disulfide bondi551 ↔ 566By similarity
Disulfide bondi602 ↔ 618By similarity
Disulfide bondi702 ↔ 768By similarity
Disulfide bondi733 ↔ 747By similarity
Disulfide bondi758 ↔ 787By similarity

Post-translational modificationi

The single-chain zymogen undergoes autoproteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9DBI0.
PRIDEiQ9DBI0.

Expressioni

Tissue specificityi

Expressed at highest levels in adult mice liver, kidney and uterus. Also strongly expressed within the nasal cavity by olfactory epithelial cells. A weak, but detectable, signal in adult mice tissues analyzed including brain, lung, heart, kidney, spleen, muscle, intestine, thymus and pancreas. No signal in residual embryonic yolk sac, developing kidney tubules or in embryonic tissues analyzed including lung, heart, gastrointestinal tract and epithelium of the oral cavity.1 Publication

Developmental stagei

Expressed at higher levels from 12.5 dpc to 15.5 dpc with a peak at 13.5 dpc. Expressed in the developing liver and at lower levels in developing pharyngo-tympanic tubes.1 Publication

Gene expression databases

BgeeiQ9DBI0.
CleanExiMM_TMPRSS6.
GenevisibleiQ9DBI0. MM.

Interactioni

Subunit structurei

Interacts with HFE2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017086.

Structurei

3D structure databases

ProteinModelPortaliQ9DBI0.
SMRiQ9DBI0. Positions 460-810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 209124SEAPROSITE-ProRule annotationAdd
BLAST
Domaini213 – 336124CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini323 – 440118CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini445 – 47733LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini478 – 51437LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST
Domaini518 – 55538LDL-receptor class A 3PROSITE-ProRule annotationAdd
BLAST
Domaini577 – 811235Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Domaini

Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).1 Publication

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 3 LDL-receptor class A domains.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00840000129691.
HOGENOMiHOG000136851.
HOVERGENiHBG108590.
InParanoidiQ9DBI0.
KOiK09637.
OMAiQGQWIIQ.
OrthoDBiEOG75B84T.
PhylomeDBiQ9DBI0.
TreeFamiTF330647.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
3.30.70.960. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR000859. CUB_dom.
IPR002172. LDrepeatLR_classA_rpt.
IPR017118. Pept_S1A_matriptase-2.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
PF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037135. Matriptase-2. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00192. LDLa. 3 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF57424. SSF57424. 3 hits.
SSF82671. SSF82671. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 3 hits.
PS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRCFQLPCS TRMPTTEVPQ AADGQGDAGD GEEAAEPEGK FKPPKNTKRK
60 70 80 90 100
NRDYVRFTPL LLVLAALVSA GVMLWYFLGY KAEVTVSQVY SGSLRVLNRH
110 120 130 140 150
FSQDLGRRES IAFRSESAKA QKMLQELVAS TRLGTYYNSS SVYSFGEGPL
160 170 180 190 200
TCFFWFILDI PEYQRLTLSP EVVRELLVDE LLSNSSTLAS YKTEYEVDPE
210 220 230 240 250
GLVILEASVN DIVVLNSTLG CYRYSYVNPG QVLPLKGPDQ QTTSCLWHLQ
260 270 280 290 300
GPEDLMIKVR LEWTRVDCRD RVAMYDAAGP LEKRLITSVY GCSRQEPVME
310 320 330 340 350
VLASGSVMAV VWKKGMHSYY DPFLLSVKSV AFQDCQVNLT LEGRLDTQGF
360 370 380 390 400
LRTPYYPSYY SPSTHCSWHL TVPSLDYGLA LWFDAYALRR QKYNRLCTQG
410 420 430 440 450
QWMIQNRRLC GFRTLQPYAE RIPMVASDGV TINFTSQISL TGPGVQVYYS
460 470 480 490 500
LYNQSDPCPG EFLCSVNGLC VPACDGIKDC PNGLDERNCV CRAMFQCQED
510 520 530 540 550
STCISLPRVC DRQPDCLNGS DEEQCQEGVP CGTFTFQCED RSCVKKPNPE
560 570 580 590 600
CDGQSDCRDG SDEQHCDCGL QGLSSRIVGG TVSSEGEWPW QASLQIRGRH
610 620 630 640 650
ICGGALIADR WVITAAHCFQ EDSMASPKLW TVFLGKMRQN SRWPGEVSFK
660 670 680 690 700
VSRLFLHPYH EEDSHDYDVA LLQLDHPVVY SATVRPVCLP ARSHFFEPGQ
710 720 730 740 750
HCWITGWGAQ REGGPVSNTL QKVDVQLVPQ DLCSEAYRYQ VSPRMLCAGY
760 770 780 790 800
RKGKKDACQG DSGGPLVCRE PSGRWFLAGL VSWGLGCGRP NFFGVYTRVT
810
RVINWIQQVL T
Length:811
Mass (Da):90,978
Last modified:October 14, 2008 - v4
Checksum:i32EB3E7C3127801B
GO
Isoform 2 (identifier: Q9DBI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-594: DCGLQGLSSRIVGGTVSSEGEWPWQASL → AWPPRSCGPCSWERCGRTRAGQARCPSR
     595-811: Missing.

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):66,733
Checksum:i036E77DA7D7DA21D
GO
Isoform 3 (identifier: Q9DBI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-581: DCGLQGLSSRIVGGT → GPLQPYCGRDRVLRG
     582-811: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):65,287
Checksum:iDE658EC33C9B1E03
GO

Sequence cautioni

The sequence AAH57674.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti690 – 6901P → PP in BAB23684 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei567 – 59428DCGLQ…WQASL → AWPPRSCGPCSWERCGRTRA GQARCPSR in isoform 2. 1 PublicationVSP_035564Add
BLAST
Alternative sequencei567 – 58115DCGLQ…IVGGT → GPLQPYCGRDRVLRG in isoform 3. 1 PublicationVSP_035565Add
BLAST
Alternative sequencei582 – 811230Missing in isoform 3. 1 PublicationVSP_035566Add
BLAST
Alternative sequencei595 – 811217Missing in isoform 2. 1 PublicationVSP_035567Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY240929 mRNA. Translation: AAP69827.1.
EU190436 mRNA. Translation: ABW38782.1.
EU190437 mRNA. Translation: ABW38783.1.
AK004939 mRNA. Translation: BAB23684.2.
AL590144 Genomic DNA. No translation available.
BC029645 mRNA. Translation: AAH29645.2.
BC057674 mRNA. Translation: AAH57674.1. Different initiation.
BK000520 Genomic DNA. Translation: DAA00246.1.
CCDSiCCDS37133.1. [Q9DBI0-1]
RefSeqiNP_082178.2. NM_027902.2. [Q9DBI0-1]
XP_006521479.1. XM_006521416.1.
UniGeneiMm.34056.

Genome annotation databases

EnsembliENSMUST00000017086; ENSMUSP00000017086; ENSMUSG00000016942. [Q9DBI0-1]
GeneIDi71753.
KEGGimmu:71753.
UCSCiuc007wpi.1. mouse. [Q9DBI0-1]
uc011zvt.1. mouse. [Q9DBI0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY240929 mRNA. Translation: AAP69827.1.
EU190436 mRNA. Translation: ABW38782.1.
EU190437 mRNA. Translation: ABW38783.1.
AK004939 mRNA. Translation: BAB23684.2.
AL590144 Genomic DNA. No translation available.
BC029645 mRNA. Translation: AAH29645.2.
BC057674 mRNA. Translation: AAH57674.1. Different initiation.
BK000520 Genomic DNA. Translation: DAA00246.1.
CCDSiCCDS37133.1. [Q9DBI0-1]
RefSeqiNP_082178.2. NM_027902.2. [Q9DBI0-1]
XP_006521479.1. XM_006521416.1.
UniGeneiMm.34056.

3D structure databases

ProteinModelPortaliQ9DBI0.
SMRiQ9DBI0. Positions 460-810.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017086.

Protein family/group databases

MEROPSiS01.308.

Proteomic databases

PaxDbiQ9DBI0.
PRIDEiQ9DBI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017086; ENSMUSP00000017086; ENSMUSG00000016942. [Q9DBI0-1]
GeneIDi71753.
KEGGimmu:71753.
UCSCiuc007wpi.1. mouse. [Q9DBI0-1]
uc011zvt.1. mouse. [Q9DBI0-2]

Organism-specific databases

CTDi164656.
MGIiMGI:1919003. Tmprss6.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00840000129691.
HOGENOMiHOG000136851.
HOVERGENiHBG108590.
InParanoidiQ9DBI0.
KOiK09637.
OMAiQGQWIIQ.
OrthoDBiEOG75B84T.
PhylomeDBiQ9DBI0.
TreeFamiTF330647.

Enzyme and pathway databases

BRENDAi3.4.21.109. 3474.

Miscellaneous databases

ChiTaRSiTmprss6. mouse.
PROiQ9DBI0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBI0.
CleanExiMM_TMPRSS6.
GenevisibleiQ9DBI0. MM.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
3.30.70.960. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR000859. CUB_dom.
IPR002172. LDrepeatLR_classA_rpt.
IPR017118. Pept_S1A_matriptase-2.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
PF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037135. Matriptase-2. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00192. LDLa. 3 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF57424. SSF57424. 3 hits.
SSF82671. SSF82671. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 3 hits.
PS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues."
    Hooper J.D., Campagnolo L., Goodarzi G., Truong T.N., Stuhlmann H., Quigley J.P.
    Biochem. J. 373:689-702(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, DOMAIN, MUTAGENESIS OF SER-762, DISRUPTION PHENOTYPE.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver.
  6. "Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer."
    Netzel-Arnett S., Hooper J.D., Szabo R., Madison E.L., Quigley J.P., Bugge T.H., Antalis T.M.
    Cancer Metastasis Rev. 22:237-258(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "The type II transmembrane serine protease matriptase-2 --identification, structural features, enzymology, expression pattern and potential roles."
    Ramsay A.J., Reid J.C., Velasco G., Quigley J.P., Hooper J.D.
    Front. Biosci. 13:569-579(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTMPS6_MOUSE
AccessioniPrimary (citable) accession number: Q9DBI0
Secondary accession number(s): A8W478
, A8W479, Q3KN88, Q6PF94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 14, 2008
Last modified: June 8, 2016
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.