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Protein

Vesicular integral-membrane protein VIP36

Gene

Lman2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981CarbohydratePROSITE-ProRule annotation
Binding sitei133 – 1331CarbohydratePROSITE-ProRule annotation
Metal bindingi164 – 1641CalciumPROSITE-ProRule annotation
Metal bindingi166 – 1661Calcium; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi168 – 1681CalciumPROSITE-ProRule annotation
Binding sitei192 – 1921CarbohydratePROSITE-ProRule annotation
Metal bindingi195 – 1951CalciumPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • positive regulation of phagocytosis Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular integral-membrane protein VIP36
Alternative name(s):
Lectin mannose-binding 2
Vesicular integral-membrane protein 36
Short name:
VIP36
Gene namesi
Name:Lman2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914140. Lman2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini47 – 324278LumenalSequence analysisAdd
BLAST
Transmembranei325 – 34723HelicalSequence analysisAdd
BLAST
Topological domaini348 – 35811CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646Sequence analysisAdd
BLAST
Chaini47 – 358312Vesicular integral-membrane protein VIP36PRO_0000017667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Disulfide bondi204 ↔ 241PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9DBH5.
MaxQBiQ9DBH5.
PaxDbiQ9DBH5.
PeptideAtlasiQ9DBH5.
PRIDEiQ9DBH5.
TopDownProteomicsiQ9DBH5.

PTM databases

PhosphoSiteiQ9DBH5.
SwissPalmiQ9DBH5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021484.
CleanExiMM_LMAN2.
GenevisibleiQ9DBH5. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9DBH5. 5 interactions.
MINTiMINT-1858792.
STRINGi10090.ENSMUSP00000021940.

Structurei

3D structure databases

ProteinModelPortaliQ9DBH5.
SMRiQ9DBH5. Positions 53-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 278225L-type lectin-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1683Carbohydrate bindingPROSITE-ProRule annotation
Regioni262 – 2643Carbohydrate bindingPROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 L-type lectin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3839. Eukaryota.
ENOG410YH8V. LUCA.
GeneTreeiENSGT00530000062977.
HOGENOMiHOG000164540.
HOVERGENiHBG052334.
InParanoidiQ9DBH5.
KOiK10082.
OMAiRNEWKSC.
OrthoDBiEOG091G0AZ1.
TreeFamiTF313311.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR005052. Lectin_leg.
[Graphical view]
PfamiPF03388. Lectin_leg-like. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51328. L_LECTIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEAWLWRW GWGWGQRCPG RPGLPGPGPS PTTFLHLLLL LGPVAADITD
60 70 80 90 100
GNSEHLKREH SLIKPYQGVG SSSMPLWDFQ GSTMLTSQYV RLTPDERSKE
110 120 130 140 150
GSIWNHQPCF LKDWEMHVHF KVHGTGKKNL HGDGIALWYT RDRLVPGPVF
160 170 180 190 200
GSKDNFHGLA IFLDTYPNDE TTERVFPYIS VMVNNGSLSY DHSKDGRWSE
210 220 230 240 250
LAGCTADFRN RDHDTFLAVR YSRGRLTVMT DLEDKNEWKN CIDITGVRLP
260 270 280 290 300
TGYYFGASAG TGDLSDNHDI ISIKLFQLTV ERTPEEESID WTKIEPGVNF
310 320 330 340 350
LKSPKDNVDD PTGNFRNGPL TGWRVFLLLL CALLGVVVCA VVGAVVFQKR

QERNKRFY
Length:358
Mass (Da):40,430
Last modified:July 27, 2011 - v2
Checksum:i14FB29BF3FDD3B54
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191V → L in BAB29313 (PubMed:16141072).Curated
Sequence conflicti328 – 3281L → V in BAB23695 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004952 mRNA. Translation: BAB23695.1.
AK014384 mRNA. Translation: BAB29313.1.
AK083442 mRNA. Translation: BAC38916.1.
AK150383 mRNA. Translation: BAE29514.1.
AK166953 mRNA. Translation: BAE39136.1.
AK169401 mRNA. Translation: BAE41147.1.
CH466546 Genomic DNA. Translation: EDL41187.1.
BC049221 mRNA. Translation: AAH49221.1.
BC055327 mRNA. Translation: AAH55327.1.
CCDSiCCDS26544.1.
RefSeqiNP_080104.2. NM_025828.3.
UniGeneiMm.38868.

Genome annotation databases

EnsembliENSMUST00000021940; ENSMUSP00000021940; ENSMUSG00000021484.
GeneIDi66890.
KEGGimmu:66890.
UCSCiuc007qqo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004952 mRNA. Translation: BAB23695.1.
AK014384 mRNA. Translation: BAB29313.1.
AK083442 mRNA. Translation: BAC38916.1.
AK150383 mRNA. Translation: BAE29514.1.
AK166953 mRNA. Translation: BAE39136.1.
AK169401 mRNA. Translation: BAE41147.1.
CH466546 Genomic DNA. Translation: EDL41187.1.
BC049221 mRNA. Translation: AAH49221.1.
BC055327 mRNA. Translation: AAH55327.1.
CCDSiCCDS26544.1.
RefSeqiNP_080104.2. NM_025828.3.
UniGeneiMm.38868.

3D structure databases

ProteinModelPortaliQ9DBH5.
SMRiQ9DBH5. Positions 53-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBH5. 5 interactions.
MINTiMINT-1858792.
STRINGi10090.ENSMUSP00000021940.

PTM databases

PhosphoSiteiQ9DBH5.
SwissPalmiQ9DBH5.

Proteomic databases

EPDiQ9DBH5.
MaxQBiQ9DBH5.
PaxDbiQ9DBH5.
PeptideAtlasiQ9DBH5.
PRIDEiQ9DBH5.
TopDownProteomicsiQ9DBH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021940; ENSMUSP00000021940; ENSMUSG00000021484.
GeneIDi66890.
KEGGimmu:66890.
UCSCiuc007qqo.1. mouse.

Organism-specific databases

CTDi10960.
MGIiMGI:1914140. Lman2.

Phylogenomic databases

eggNOGiKOG3839. Eukaryota.
ENOG410YH8V. LUCA.
GeneTreeiENSGT00530000062977.
HOGENOMiHOG000164540.
HOVERGENiHBG052334.
InParanoidiQ9DBH5.
KOiK10082.
OMAiRNEWKSC.
OrthoDBiEOG091G0AZ1.
TreeFamiTF313311.

Miscellaneous databases

ChiTaRSiLman2. mouse.
PROiQ9DBH5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021484.
CleanExiMM_LMAN2.
GenevisibleiQ9DBH5. MM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR005052. Lectin_leg.
[Graphical view]
PfamiPF03388. Lectin_leg-like. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51328. L_LECTIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMAN2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBH5
Secondary accession number(s): Q8BJL4, Q9CXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.