Reviewed, UniProtKB/Swiss-Prot Q9DBG9 (TX1B3_MOUSE)

Names and origin

Protein names

Recommended name:
    Tax1-binding protein 3
Alternative name(s):
    Tax interaction protein 1
      Short name=TIP-1

Gene names

Name:

Tax1bp3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the Rho signaling pathway By similarity. May act as an inhibitor of the Wnt signaling pathway. Ref.4 UniProtKB O14907
Subunit structure	Interacts via its PDZ domain with GLS2. Interacts via its PDZ domain with the C-terminal region of RTKN. This interaction facilitates Rho-mediated activation of the FOS serum response element (SRE) By similarity. Interacts via its PDZ domain with CTNNB1. This interaction inhibits the transcriptional activity of CTNNB1. Ref.4
Subcellular location	Cytoplasm. Nucleus Ref.4.
Sequence similarities	Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	Rho protein signal transduction Inferred from sequence or structural similarity. Source: UniProtKB Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of Wnt receptor signaling pathway Ref.4 Inferred from direct assay. Source: UniProtKB negative regulation of cell proliferation Ref.4 Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Ref.4 Inferred from direct assay. Source: MGI nucleus Ref.4 Inferred from direct assay. Source: MGI
Molecular function	beta-catenin binding Ref.4 Inferred from physical interaction. Source: MGI transcription regulator activity Ref.4 Inferred from mutant phenotype. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ctnnb1	Q02248	4	EBI-1161647,EBI-397872
Rtkn	Q8C6B2	1	EBI-1161647,EBI-1162441
tax	Q82235	1	EBI-1161647,EBI-1162486	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 124

124

Tax1-binding protein 3

PRO_0000233944

Regions

Domain

15 – 112

98

PDZ

Amino acid modifications

Modified residue

61

1

Phosphoserine By similarity

Secondary structure

1

.

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.

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.

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.

.

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.

.

124

Helix Strand Turn

Details...

Beta strand

14 – 19

6

Helix

41 – 43

3

Turn

66 – 68

3

Beta strand

76 – 80

5

Helix

90 – 97

8

Beta strand

103 – 110

8

Helix

112 – 115

4

Helix

116 – 122

7

Sequences

	Sequence		Length	Mass (Da)
	Q9DBG9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F3FBD0F475F69FCD	FASTA	124	13,723
	10 20 30 40 50 60 MSYTPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV 70 80 90 100 110 120 SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ SMLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Bone marrow, Heart and Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and NMRI. Tissue: Brain and Mammary gland.
[4]	"The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells." Kanamori M., Sandy P., Marzinotto S., Benetti R., Kai C., Hayashizaki Y., Schneider C., Suzuki H. J. Biol. Chem. 278:38758-38764(2003) [PubMed: 12874278] [Abstract] Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK004963 mRNA. Translation: BAB23703.1.
AK150816 mRNA. Translation: BAE29879.1.
AK168533 mRNA. Translation: BAE40411.1.
AK170485 mRNA. Translation: BAE41827.1.
AL670399 Genomic DNA. Translation: CAI24794.1.
BC008166 mRNA. Translation: AAH08166.1.
BC094314 mRNA. Translation: AAH94314.1.

IPI

IPI00119696.

RefSeq

NP_083840.1.
XP_001473359.1.
XP_001475087.1.

UniGene

Mm.186
Mm.371656

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DIW	X-ray	2.10	A/B	1-124	[»]
3DJ1	X-ray	1.80	A/B	1-124	[»]
3DJ3	X-ray	2.40	A/B/C/D	1-112	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9DBG9. 3 interactions.

STRING

Q9DBG9.

Proteomic databases

PRIDE

Q9DBG9.

Genome annotation databases

Ensembl

ENSMUST00000040687; ENSMUSP00000047410; ENSMUSG00000040158; Mus musculus. [Genome view]

GeneID

100039683.
76281.

KEGG

mmu:100039683.
mmu:100045937.
mmu:76281.

UCSC

uc007kac.1. mouse.

Organism-specific databases

CTD

76281.

MGI

MGI:1923531. Tax1bp3.

Phylogenomic databases

eggNOG

maNOG22760.

HOGENOM

HBG382462.

HOVERGEN

Q9DBG9.

InParanoid

Q9DBG9.

OMA

DNLILGF.

OrthoDB

EOG97WR89.

PhylomeDB

Q9DBG9.

Gene expression databases

Genevestigator

Q9DBG9.

GermOnline

ENSMUSG00000040158. Mus musculus.
ENSMUSG00000075312. Mus musculus.

Family and domain databases

InterPro

IPR001478. PDZ/DHR/GLGF.
IPR017268. Tax1-binding_p3.
[Graphical view]

Pfam

PF00595. PDZ. 1 hit.
[Graphical view]

PIRSF

PIRSF037712. Tax1-binding_p3. 1 hit.

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

447003.

SOURCE

Search...

Entry information

Entry name

TX1B3_MOUSE

Accession

Primary (citable) accession number: Q9DBG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	June 1, 2001
Last modified:	January 19, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)