Q9DBG9 (TX1B3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tax1-binding protein 3

Alternative name(s):
Tax interaction protein 1
Short name=TIP-1

Gene names

Name:

Tax1bp3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the Rho signaling pathway By similarity. May act as an inhibitor of the Wnt signaling pathway. Ref.4 UniProtKB O14907
Subunit structure	Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via PDZ domain) with ARHGEF16 By similarity. Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Ref.4
Subcellular location	Cytoplasm. Nucleus Ref.4.
Sequence similarities	Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Rho protein signal transduction Inferred from sequence or structural similarity. Source: UniProtKB Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of Wnt receptor signaling pathway Inferred from direct assay Ref.4. Source: UniProtKB negative regulation of cell proliferation Inferred from direct assay Ref.4. Source: MGI negative regulation of protein localization at cell surface Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay Ref.4. Source: MGI nucleus Inferred from direct assay Ref.4. Source: MGI
Molecular function	beta-catenin binding Inferred from physical interaction Ref.4. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ctnnb1	Q02248	6	EBI-1161647,EBI-397872

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 124

124

Tax1-binding protein 3

PRO_0000233944

Regions

Domain

15 – 112

98

PDZ

Amino acid modifications

Modified residue

61

1

Phosphoserine By similarity

Secondary structure

1

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124

Helix Strand Turn

Details...

Beta strand

14 – 19

6

Helix

41 – 43

3

Turn

66 – 68

3

Beta strand

76 – 80

5

Helix

90 – 97

8

Beta strand

103 – 110

8

Helix

112 – 115

4

Helix

116 – 122

7

Sequences

	Sequence		Length	Mass (Da)
	Q9DBG9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F3FBD0F475F69FCD	FASTA	124	13,723
	10 20 30 40 50 60 MSYTPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV 70 80 90 100 110 120 SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ SMLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Bone marrow, Heart and Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and NMRI. Tissue: Brain and Mammary gland.
[4]	"The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells." Kanamori M., Sandy P., Marzinotto S., Benetti R., Kai C., Hayashizaki Y., Schneider C., Suzuki H. J. Biol. Chem. 278:38758-38764(2003) [PubMed: 12874278] [Abstract] Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK004963 mRNA. Translation: BAB23703.1.
AK150816 mRNA. Translation: BAE29879.1.
AK168533 mRNA. Translation: BAE40411.1.
AK170485 mRNA. Translation: BAE41827.1.
AL670399 Genomic DNA. Translation: CAI24794.1.
BC008166 mRNA. Translation: AAH08166.1.
BC094314 mRNA. Translation: AAH94314.1.

IPI

IPI00119696.

RefSeq

NP_083840.1. NM_029564.2.

UniGene

Mm.371656.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DIW	X-ray	2.10	A/B	1-124	[»]
3DJ1	X-ray	1.80	A/B	1-124	[»]
3DJ3	X-ray	2.40	A/B/C/D	1-112	[»]

ProteinModelPortal

Q9DBG9.

SMR

Q9DBG9. Positions 9-123.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9DBG9. 3 interactions.

STRING

Q9DBG9.

PTM databases

PhosphoSite

Q9DBG9.

Proteomic databases

PRIDE

Q9DBG9.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000040687; ENSMUSP00000047410; ENSMUSG00000040158.

GeneID

76281.

KEGG

mmu:76281.

Organism-specific databases

CTD

30851.

MGI

MGI:1923531. Tax1bp3.

Phylogenomic databases

eggNOG

maNOG22760.

GeneTree

ENSGT00390000002877.

HOGENOM

HBG382462.

HOVERGEN

HBG052814.

InParanoid

Q9DBG9.

OMA

LRQGDNL.

OrthoDB

EOG4MKNHP.

PhylomeDB

Q9DBG9.

Gene expression databases

Bgee

Q9DBG9.

Genevestigator

Q9DBG9.

GermOnline

ENSMUSG00000040158. Mus musculus.
ENSMUSG00000075312. Mus musculus.

Family and domain databases

InterPro

IPR001478. PDZ/DHR/GLGF.
IPR017268. Tax1-binding_p3.
[Graphical view]

Pfam

PF00595. PDZ. 1 hit.
[Graphical view]

PIRSF

PIRSF037712. Tax1-binding_p3. 1 hit.

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

447003.

SOURCE

Search...

Entry information

Entry name

TX1B3_MOUSE

Accession

Primary (citable) accession number: Q9DBG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	June 1, 2001
Last modified:	September 21, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program