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Protein

Tax1-binding protein 3

Gene

Tax1bp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity).By similarity1 Publication

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • protein C-terminus binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 3
Alternative name(s):
Tax interaction protein 1
Short name:
TIP-1
Gene namesi
Name:Tax1bp3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923531. Tax1bp3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002339442 – 124Tax1-binding protein 3Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei61PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DBG9.
MaxQBiQ9DBG9.
PaxDbiQ9DBG9.
PeptideAtlasiQ9DBG9.
PRIDEiQ9DBG9.

PTM databases

iPTMnetiQ9DBG9.
PhosphoSitePlusiQ9DBG9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040158.
ExpressionAtlasiQ9DBG9. baseline and differential.
GenevisibleiQ9DBG9. MM.

Interactioni

Subunit structurei

Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding (By similarity). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Interacts with ADGRB2 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ctnnb1Q022486EBI-1161647,EBI-397872

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • protein C-terminus binding Source: MGI

Protein-protein interaction databases

BioGridi218059. 1 interactor.
IntActiQ9DBG9. 3 interactors.
STRINGi10090.ENSMUSP00000047410.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 19Combined sources6
Beta strandi21 – 23Combined sources3
Beta strandi26 – 28Combined sources3
Beta strandi30 – 35Combined sources6
Helixi41 – 43Combined sources3
Beta strandi48 – 51Combined sources4
Beta strandi55 – 60Combined sources6
Helixi65 – 69Combined sources5
Beta strandi76 – 80Combined sources5
Helixi90 – 97Combined sources8
Beta strandi103 – 110Combined sources8
Helixi112 – 115Combined sources4
Helixi116 – 122Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DIWX-ray2.10A/B1-124[»]
3DJ1X-ray1.80A/B1-124[»]
3DJ3X-ray2.40A/B/C/D1-112[»]
ProteinModelPortaliQ9DBG9.
SMRiQ9DBG9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBG9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 112PDZPROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3553. Eukaryota.
ENOG4111IK0. LUCA.
GeneTreeiENSGT00390000002877.
HOGENOMiHOG000015753.
HOVERGENiHBG052814.
InParanoidiQ9DBG9.
OMAiDPTQNPF.
OrthoDBiEOG091G0UZR.
PhylomeDBiQ9DBG9.
TreeFamiTF318964.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017268. Tax1-binding_p3.
[Graphical view]
PANTHERiPTHR23136. PTHR23136. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF037712. Tax1-binding_p3. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK
60 70 80 90 100
TDKGIYVTRV SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR
110 120
SEEVVRLLVT RQSLQKAVQQ SMLS
Length:124
Mass (Da):13,723
Last modified:June 1, 2001 - v1
Checksum:iF3FBD0F475F69FCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004963 mRNA. Translation: BAB23703.1.
AK150816 mRNA. Translation: BAE29879.1.
AK168533 mRNA. Translation: BAE40411.1.
AK170485 mRNA. Translation: BAE41827.1.
AL670399 Genomic DNA. Translation: CAI24794.1.
BC008166 mRNA. Translation: AAH08166.1.
BC094314 mRNA. Translation: AAH94314.1.
CCDSiCCDS25000.1.
RefSeqiNP_083840.1. NM_029564.2.
UniGeneiMm.371656.

Genome annotation databases

EnsembliENSMUST00000040687; ENSMUSP00000047410; ENSMUSG00000040158.
GeneIDi76281.
KEGGimmu:76281.
UCSCiuc007kac.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004963 mRNA. Translation: BAB23703.1.
AK150816 mRNA. Translation: BAE29879.1.
AK168533 mRNA. Translation: BAE40411.1.
AK170485 mRNA. Translation: BAE41827.1.
AL670399 Genomic DNA. Translation: CAI24794.1.
BC008166 mRNA. Translation: AAH08166.1.
BC094314 mRNA. Translation: AAH94314.1.
CCDSiCCDS25000.1.
RefSeqiNP_083840.1. NM_029564.2.
UniGeneiMm.371656.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DIWX-ray2.10A/B1-124[»]
3DJ1X-ray1.80A/B1-124[»]
3DJ3X-ray2.40A/B/C/D1-112[»]
ProteinModelPortaliQ9DBG9.
SMRiQ9DBG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218059. 1 interactor.
IntActiQ9DBG9. 3 interactors.
STRINGi10090.ENSMUSP00000047410.

PTM databases

iPTMnetiQ9DBG9.
PhosphoSitePlusiQ9DBG9.

Proteomic databases

EPDiQ9DBG9.
MaxQBiQ9DBG9.
PaxDbiQ9DBG9.
PeptideAtlasiQ9DBG9.
PRIDEiQ9DBG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040687; ENSMUSP00000047410; ENSMUSG00000040158.
GeneIDi76281.
KEGGimmu:76281.
UCSCiuc007kac.1. mouse.

Organism-specific databases

CTDi30851.
MGIiMGI:1923531. Tax1bp3.

Phylogenomic databases

eggNOGiKOG3553. Eukaryota.
ENOG4111IK0. LUCA.
GeneTreeiENSGT00390000002877.
HOGENOMiHOG000015753.
HOVERGENiHBG052814.
InParanoidiQ9DBG9.
OMAiDPTQNPF.
OrthoDBiEOG091G0UZR.
PhylomeDBiQ9DBG9.
TreeFamiTF318964.

Enzyme and pathway databases

ReactomeiR-MMU-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

EvolutionaryTraceiQ9DBG9.
PROiQ9DBG9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040158.
ExpressionAtlasiQ9DBG9. baseline and differential.
GenevisibleiQ9DBG9. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017268. Tax1-binding_p3.
[Graphical view]
PANTHERiPTHR23136. PTHR23136. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF037712. Tax1-binding_p3. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTX1B3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.