Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal recognition particle receptor subunit alpha

Gene

Srpra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi423 – 430GTPBy similarity8
Nucleotide bindingi518 – 522GTPBy similarity5
Nucleotide bindingi586 – 589GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:SrpraBy similarity
Synonyms:Srpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914648 Srpr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012141 – 636Signal recognition particle receptor subunit alphaAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineBy similarity1
Modified residuei283PhosphothreonineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei576PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DBG7
MaxQBiQ9DBG7
PaxDbiQ9DBG7
PeptideAtlasiQ9DBG7
PRIDEiQ9DBG7

PTM databases

iPTMnetiQ9DBG7
PhosphoSitePlusiQ9DBG7
SwissPalmiQ9DBG7

Expressioni

Gene expression databases

BgeeiENSMUSG00000032042
ExpressionAtlasiQ9DBG7 baseline and differential
GenevisibleiQ9DBG7 MM

Interactioni

Subunit structurei

Heterodimer with SRPRB.By similarity

Protein-protein interaction databases

IntActiQ9DBG7, 1 interactor
MINTiQ9DBG7
STRINGi10090.ENSMUSP00000034541

Structurei

3D structure databases

ProteinModelPortaliQ9DBG7
SMRiQ9DBG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

eggNOGiKOG0781 Eukaryota
COG0552 LUCA
GeneTreeiENSGT00550000074936
HOGENOMiHOG000201671
HOVERGENiHBG047566
InParanoidiQ9DBG7
KOiK13431
OMAiVSMVHAT
OrthoDBiEOG091G05TG
PhylomeDBiQ9DBG7
TreeFamiTF106189

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011012 Longin-like_dom_sf
IPR027417 P-loop_NTPase
IPR007222 Sig_recog_particle_rcpt_asu_N
IPR013822 Signal_recog_particl_SRP54_hlx
IPR036225 SRP/SRP_N
IPR000897 SRP54_GTPase_dom
PfamiView protein in Pfam
PF04086 SRP-alpha_N, 1 hit
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF52540 SSF52540, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE
60 70 80 90 100
ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ
110 120 130 140 150
QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR
160 170 180 190 200
SMIETRGEKT KEKAKNNKKR GAKKEGSDGT LATSKTAPAE KSGLSAGPEN
210 220 230 240 250
GELSKEELIR RKREEFIQKH GKGLDKSSKS TKSDTPKEKG KKAPRVWELG
260 270 280 290 300
GCANKEVLDY STPTTNGTPE AALSEDINLI RGTGPGGQLQ DLDCSSSDDE
310 320 330 340 350
GATQNTKPSA TKGTLGGMFG MLKGLVGSKS LSREDMESVL DKMRDHLIAK
360 370 380 390 400
NVAADIAVQL CESVANKLEG KVMGTFSTVT STVKQALQES LVQILQPQRR
410 420 430 440 450
VDMLRDIMDA QRRQRPYVVT FCGVNGVGKS TNLAKISFWL LENGFSVLIA
460 470 480 490 500
ACDTFRAGAV EQLRTHTRRL TALHPPEKHG GRTMVQLFEK GYGKDAAGIA
510 520 530 540 550
MEAIAFARNQ GFDVVLVDTA GRMQDNAPLM TALAKLITVN TPDLVLFVGE
560 570 580 590 600
ALVGNEAVDQ LVKFNRALAD HSMAQTPRLI DGIVLTKFDT IDDKVGAAIS
610 620 630
MTYITSKPIV FVGTGQTYCD LRSLNAKAVV AALMKA
Length:636
Mass (Da):69,623
Last modified:June 1, 2001 - v1
Checksum:i19C7D33196CBE410
GO

Sequence cautioni

The sequence AAH12512 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104L → S in AAH21839 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004967 mRNA Translation: BAB23706.1
AK038017 mRNA Translation: BAC29922.1
BC012512 mRNA Translation: AAH12512.1 Different initiation.
BC021839 mRNA Translation: AAH21839.1
CCDSiCCDS22959.1
RefSeqiNP_080406.1, NM_026130.1
UniGeneiMm.284688

Genome annotation databases

EnsembliENSMUST00000034541; ENSMUSP00000034541; ENSMUSG00000032042
GeneIDi67398
KEGGimmu:67398
UCSCiuc009osy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSRPRA_MOUSE
AccessioniPrimary (citable) accession number: Q9DBG7
Secondary accession number(s): Q8VC45, Q921H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health