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Protein

Signal recognition particle receptor subunit alpha

Gene

Srpra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi423 – 430GTPBy similarity8
Nucleotide bindingi518 – 522GTPBy similarity5
Nucleotide bindingi586 – 589GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:SrpraBy similarity
Synonyms:Srpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914648. Srpr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012141 – 636Signal recognition particle receptor subunit alphaAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineBy similarity1
Modified residuei283PhosphothreonineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei576PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DBG7.
MaxQBiQ9DBG7.
PaxDbiQ9DBG7.
PeptideAtlasiQ9DBG7.
PRIDEiQ9DBG7.

PTM databases

iPTMnetiQ9DBG7.
PhosphoSitePlusiQ9DBG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032042.
ExpressionAtlasiQ9DBG7. baseline and differential.
GenevisibleiQ9DBG7. MM.

Interactioni

Subunit structurei

Heterodimer with SRPRB.By similarity

Protein-protein interaction databases

IntActiQ9DBG7. 1 interactor.
MINTiMINT-1853595.
STRINGi10090.ENSMUSP00000034541.

Structurei

3D structure databases

ProteinModelPortaliQ9DBG7.
SMRiQ9DBG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

eggNOGiKOG0781. Eukaryota.
COG0552. LUCA.
GeneTreeiENSGT00550000074936.
HOGENOMiHOG000201671.
HOVERGENiHBG047566.
InParanoidiQ9DBG7.
KOiK13431.
OMAiIFVELYG.
OrthoDBiEOG091G05TG.
PhylomeDBiQ9DBG7.
TreeFamiTF106189.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 1 hit.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE
60 70 80 90 100
ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ
110 120 130 140 150
QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR
160 170 180 190 200
SMIETRGEKT KEKAKNNKKR GAKKEGSDGT LATSKTAPAE KSGLSAGPEN
210 220 230 240 250
GELSKEELIR RKREEFIQKH GKGLDKSSKS TKSDTPKEKG KKAPRVWELG
260 270 280 290 300
GCANKEVLDY STPTTNGTPE AALSEDINLI RGTGPGGQLQ DLDCSSSDDE
310 320 330 340 350
GATQNTKPSA TKGTLGGMFG MLKGLVGSKS LSREDMESVL DKMRDHLIAK
360 370 380 390 400
NVAADIAVQL CESVANKLEG KVMGTFSTVT STVKQALQES LVQILQPQRR
410 420 430 440 450
VDMLRDIMDA QRRQRPYVVT FCGVNGVGKS TNLAKISFWL LENGFSVLIA
460 470 480 490 500
ACDTFRAGAV EQLRTHTRRL TALHPPEKHG GRTMVQLFEK GYGKDAAGIA
510 520 530 540 550
MEAIAFARNQ GFDVVLVDTA GRMQDNAPLM TALAKLITVN TPDLVLFVGE
560 570 580 590 600
ALVGNEAVDQ LVKFNRALAD HSMAQTPRLI DGIVLTKFDT IDDKVGAAIS
610 620 630
MTYITSKPIV FVGTGQTYCD LRSLNAKAVV AALMKA
Length:636
Mass (Da):69,623
Last modified:June 1, 2001 - v1
Checksum:i19C7D33196CBE410
GO

Sequence cautioni

The sequence AAH12512 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104L → S in AAH21839 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004967 mRNA. Translation: BAB23706.1.
AK038017 mRNA. Translation: BAC29922.1.
BC012512 mRNA. Translation: AAH12512.1. Different initiation.
BC021839 mRNA. Translation: AAH21839.1.
CCDSiCCDS22959.1.
RefSeqiNP_080406.1. NM_026130.1.
UniGeneiMm.284688.

Genome annotation databases

EnsembliENSMUST00000034541; ENSMUSP00000034541; ENSMUSG00000032042.
GeneIDi67398.
KEGGimmu:67398.
UCSCiuc009osy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004967 mRNA. Translation: BAB23706.1.
AK038017 mRNA. Translation: BAC29922.1.
BC012512 mRNA. Translation: AAH12512.1. Different initiation.
BC021839 mRNA. Translation: AAH21839.1.
CCDSiCCDS22959.1.
RefSeqiNP_080406.1. NM_026130.1.
UniGeneiMm.284688.

3D structure databases

ProteinModelPortaliQ9DBG7.
SMRiQ9DBG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBG7. 1 interactor.
MINTiMINT-1853595.
STRINGi10090.ENSMUSP00000034541.

PTM databases

iPTMnetiQ9DBG7.
PhosphoSitePlusiQ9DBG7.

Proteomic databases

EPDiQ9DBG7.
MaxQBiQ9DBG7.
PaxDbiQ9DBG7.
PeptideAtlasiQ9DBG7.
PRIDEiQ9DBG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034541; ENSMUSP00000034541; ENSMUSG00000032042.
GeneIDi67398.
KEGGimmu:67398.
UCSCiuc009osy.1. mouse.

Organism-specific databases

CTDi67398.
MGIiMGI:1914648. Srpr.

Phylogenomic databases

eggNOGiKOG0781. Eukaryota.
COG0552. LUCA.
GeneTreeiENSGT00550000074936.
HOGENOMiHOG000201671.
HOVERGENiHBG047566.
InParanoidiQ9DBG7.
KOiK13431.
OMAiIFVELYG.
OrthoDBiEOG091G05TG.
PhylomeDBiQ9DBG7.
TreeFamiTF106189.

Miscellaneous databases

PROiQ9DBG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032042.
ExpressionAtlasiQ9DBG7. baseline and differential.
GenevisibleiQ9DBG7. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 1 hit.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRPRA_MOUSE
AccessioniPrimary (citable) accession number: Q9DBG7
Secondary accession number(s): Q8VC45, Q921H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.