SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9DBG5

- PLIN3_MOUSE

UniProt

Q9DBG5 - PLIN3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Perilipin-3
Gene
Plin3, M6prbp1, Tip47
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network By similarity.

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-3
Alternative name(s):
Cargo selection protein TIP47
Mannose-6-phosphate receptor-binding protein 1
Gene namesi
Name:Plin3
Synonyms:M6prbp1, Tip47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1914155. Plin3.

Subcellular locationi

Cytoplasm By similarity. Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Lipid droplet By similarity
Note: Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails By similarity.

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. lipid particle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 437436Perilipin-3
PRO_0000099891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei65 – 651N6-acetyllysine1 Publication
Modified residuei130 – 1301Phosphoserine By similarity
Modified residuei174 – 1741Phosphothreonine By similarity
Modified residuei179 – 1791Phosphoserine By similarity
Modified residuei183 – 1831Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9DBG5.
PaxDbiQ9DBG5.
PRIDEiQ9DBG5.

2D gel databases

REPRODUCTION-2DPAGEIPI00319270.

PTM databases

PhosphoSiteiQ9DBG5.

Expressioni

Gene expression databases

ArrayExpressiQ9DBG5.
BgeeiQ9DBG5.
CleanExiMM_M6PRBP1.
GenevestigatoriQ9DBG5.

Interactioni

Subunit structurei

Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain) By similarity.

Protein-protein interaction databases

IntActiQ9DBG5. 2 interactions.
MINTiMINT-1748486.
STRINGi10090.ENSMUSP00000019726.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi207 – 2104
Helixi212 – 2165
Helixi227 – 2359
Beta strandi239 – 2424
Helixi243 – 2453
Helixi248 – 28740
Helixi324 – 35027
Turni351 – 3544
Helixi357 – 37620
Helixi377 – 3793
Helixi383 – 3853
Helixi388 – 41326
Beta strandi421 – 4277

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SZIX-ray2.80A191-437[»]
ProteinModelPortaliQ9DBG5.
SMRiQ9DBG5. Positions 206-431.

Miscellaneous databases

EvolutionaryTraceiQ9DBG5.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili251 – 28434 Reviewed prediction
Add
BLAST
Coiled coili357 – 41054 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the perilipin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG81115.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ9DBG5.
OMAiQEQSYFV.
OrthoDBiEOG7SN8CD.
PhylomeDBiQ9DBG5.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBG5-1 [UniParc]FASTAAdd to Basket

« Hide

MSSNGTDAPA EAQAAMEEPV VQPSVVDRVA GLPLISSTYG MVSAAYTSTK    50
ENYPHVRTVC DVAEKGVKTL TTAAVSTAQP ILSKLEPQIA TASEYAHRGL 100
DRLQESLPIL QQPTEKVLAD TKELVSSTVS GAQEMVSSSV SSAKETVATR 150
VTGAVDVTLG AVQNSVDKTK SAMTSGVQSV MGSRVGQMVI SGVDRVLVKS 200
EAWADNRLPL TEAELALIAT PPEDSDMASL QQQRQEQNYF VRLGSLSERL 250
RNHAYEHSLG KLQNARQKAQ ETLQQLTSVL GLMESVKQGV DQRLGEGQEK 300
LHQMWLSWNQ KTPQDAEKDP AKPEQVEARA LSMFRDITQQ LQSMCVALGA 350
SIQGLPSHVR EQAQQARSQV NDLQATFSGI HSFQDLSAGV LAQTRERIAR 400
AREALDNTVE YVAQNTPAMW LVGPFAPGIT EKTPEGK 437
Length:437
Mass (Da):47,262
Last modified:June 1, 2001 - v1
Checksum:iF7CDD3A754A5C04D
GO

Sequence cautioni

The sequence BAC33798.1 differs from that shown. Reason: Frameshift at position 400.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004970 mRNA. Translation: BAB23708.1.
AK012517 mRNA. Translation: BAB28291.1.
AK049537 mRNA. Translation: BAC33798.1. Frameshift.
AK050140 mRNA. Translation: BAC34089.1.
AK132313 mRNA. Translation: BAE21098.1.
AK167214 mRNA. Translation: BAE39340.1.
BC011116 mRNA. Translation: AAH11116.1.
CCDSiCCDS28901.1.
RefSeqiNP_080112.1. NM_025836.3.
UniGeneiMm.311696.

Genome annotation databases

EnsembliENSMUST00000019726; ENSMUSP00000019726; ENSMUSG00000024197.
GeneIDi66905.
KEGGimmu:66905.
UCSCiuc008dbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004970 mRNA. Translation: BAB23708.1 .
AK012517 mRNA. Translation: BAB28291.1 .
AK049537 mRNA. Translation: BAC33798.1 . Frameshift.
AK050140 mRNA. Translation: BAC34089.1 .
AK132313 mRNA. Translation: BAE21098.1 .
AK167214 mRNA. Translation: BAE39340.1 .
BC011116 mRNA. Translation: AAH11116.1 .
CCDSi CCDS28901.1.
RefSeqi NP_080112.1. NM_025836.3.
UniGenei Mm.311696.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SZI X-ray 2.80 A 191-437 [» ]
ProteinModelPortali Q9DBG5.
SMRi Q9DBG5. Positions 206-431.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DBG5. 2 interactions.
MINTi MINT-1748486.
STRINGi 10090.ENSMUSP00000019726.

PTM databases

PhosphoSitei Q9DBG5.

2D gel databases

REPRODUCTION-2DPAGE IPI00319270.

Proteomic databases

MaxQBi Q9DBG5.
PaxDbi Q9DBG5.
PRIDEi Q9DBG5.

Protocols and materials databases

DNASUi 66905.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019726 ; ENSMUSP00000019726 ; ENSMUSG00000024197 .
GeneIDi 66905.
KEGGi mmu:66905.
UCSCi uc008dbn.1. mouse.

Organism-specific databases

CTDi 10226.
MGIi MGI:1914155. Plin3.

Phylogenomic databases

eggNOGi NOG81115.
GeneTreei ENSGT00500000044795.
HOGENOMi HOG000033816.
HOVERGENi HBG002935.
InParanoidi Q9DBG5.
OMAi QEQSYFV.
OrthoDBi EOG7SN8CD.
PhylomeDBi Q9DBG5.
TreeFami TF328397.

Miscellaneous databases

EvolutionaryTracei Q9DBG5.
NextBioi 322981.
PROi Q9DBG5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9DBG5.
Bgeei Q9DBG5.
CleanExi MM_M6PRBP1.
Genevestigatori Q9DBG5.

Family and domain databases

InterProi IPR004279. Perilipin.
[Graphical view ]
PANTHERi PTHR14024. PTHR14024. 1 hit.
Pfami PF03036. Perilipin. 1 hit.
[Graphical view ]
PIRSFi PIRSF036881. PAT. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Head and Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  4. "Structure of a lipid droplet protein; the PAT family member TIP47."
    Hickenbottom S.J., Kimmel A.R., Londos C., Hurley J.H.
    Structure 12:1199-1207(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 191-437.

Entry informationi

Entry nameiPLIN3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBG5
Secondary accession number(s): Q3TK05, Q8BKV9, Q9CZK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi