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Protein

Perilipin-3

Gene

Plin3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-3
Alternative name(s):
Cargo selection protein TIP47
Mannose-6-phosphate receptor-binding protein 1
Gene namesi
Name:Plin3
Synonyms:M6prbp1, Tip47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914155. Plin3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000998912 – 437Perilipin-3Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei65N6-acetyllysineCombined sources1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei130PhosphoserineBy similarity1
Modified residuei174PhosphothreonineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei220PhosphothreonineBy similarity1
Modified residuei245PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9DBG5.
MaxQBiQ9DBG5.
PaxDbiQ9DBG5.
PeptideAtlasiQ9DBG5.
PRIDEiQ9DBG5.

2D gel databases

REPRODUCTION-2DPAGEIPI00319270.

PTM databases

iPTMnetiQ9DBG5.
PhosphoSitePlusiQ9DBG5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024197.
CleanExiMM_M6PRBP1.
GenevisibleiQ9DBG5. MM.

Interactioni

Subunit structurei

Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211801. 1 interactor.
DIPiDIP-49514N.
IntActiQ9DBG5. 2 interactors.
MINTiMINT-1748486.
STRINGi10090.ENSMUSP00000019726.

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi207 – 210Combined sources4
Helixi212 – 216Combined sources5
Helixi227 – 235Combined sources9
Beta strandi239 – 242Combined sources4
Helixi243 – 245Combined sources3
Helixi248 – 287Combined sources40
Helixi324 – 350Combined sources27
Turni351 – 354Combined sources4
Helixi357 – 376Combined sources20
Helixi377 – 379Combined sources3
Helixi383 – 385Combined sources3
Helixi388 – 413Combined sources26
Beta strandi421 – 427Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZIX-ray2.80A191-437[»]
ProteinModelPortaliQ9DBG5.
SMRiQ9DBG5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBG5.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili251 – 284Sequence analysisAdd BLAST34
Coiled coili357 – 410Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJG1. Eukaryota.
ENOG410XTQ5. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ9DBG5.
KOiK20287.
OMAiWADNHLP.
OrthoDBiEOG091G0D6Q.
PhylomeDBiQ9DBG5.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNGTDAPA EAQAAMEEPV VQPSVVDRVA GLPLISSTYG MVSAAYTSTK
60 70 80 90 100
ENYPHVRTVC DVAEKGVKTL TTAAVSTAQP ILSKLEPQIA TASEYAHRGL
110 120 130 140 150
DRLQESLPIL QQPTEKVLAD TKELVSSTVS GAQEMVSSSV SSAKETVATR
160 170 180 190 200
VTGAVDVTLG AVQNSVDKTK SAMTSGVQSV MGSRVGQMVI SGVDRVLVKS
210 220 230 240 250
EAWADNRLPL TEAELALIAT PPEDSDMASL QQQRQEQNYF VRLGSLSERL
260 270 280 290 300
RNHAYEHSLG KLQNARQKAQ ETLQQLTSVL GLMESVKQGV DQRLGEGQEK
310 320 330 340 350
LHQMWLSWNQ KTPQDAEKDP AKPEQVEARA LSMFRDITQQ LQSMCVALGA
360 370 380 390 400
SIQGLPSHVR EQAQQARSQV NDLQATFSGI HSFQDLSAGV LAQTRERIAR
410 420 430
AREALDNTVE YVAQNTPAMW LVGPFAPGIT EKTPEGK
Length:437
Mass (Da):47,262
Last modified:June 1, 2001 - v1
Checksum:iF7CDD3A754A5C04D
GO

Sequence cautioni

The sequence BAC33798 differs from that shown. Reason: Frameshift at position 400.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004970 mRNA. Translation: BAB23708.1.
AK012517 mRNA. Translation: BAB28291.1.
AK049537 mRNA. Translation: BAC33798.1. Frameshift.
AK050140 mRNA. Translation: BAC34089.1.
AK132313 mRNA. Translation: BAE21098.1.
AK167214 mRNA. Translation: BAE39340.1.
BC011116 mRNA. Translation: AAH11116.1.
CCDSiCCDS28901.1.
RefSeqiNP_080112.1. NM_025836.3.
UniGeneiMm.311696.

Genome annotation databases

EnsembliENSMUST00000019726; ENSMUSP00000019726; ENSMUSG00000024197.
GeneIDi66905.
KEGGimmu:66905.
UCSCiuc008dbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004970 mRNA. Translation: BAB23708.1.
AK012517 mRNA. Translation: BAB28291.1.
AK049537 mRNA. Translation: BAC33798.1. Frameshift.
AK050140 mRNA. Translation: BAC34089.1.
AK132313 mRNA. Translation: BAE21098.1.
AK167214 mRNA. Translation: BAE39340.1.
BC011116 mRNA. Translation: AAH11116.1.
CCDSiCCDS28901.1.
RefSeqiNP_080112.1. NM_025836.3.
UniGeneiMm.311696.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZIX-ray2.80A191-437[»]
ProteinModelPortaliQ9DBG5.
SMRiQ9DBG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211801. 1 interactor.
DIPiDIP-49514N.
IntActiQ9DBG5. 2 interactors.
MINTiMINT-1748486.
STRINGi10090.ENSMUSP00000019726.

PTM databases

iPTMnetiQ9DBG5.
PhosphoSitePlusiQ9DBG5.

2D gel databases

REPRODUCTION-2DPAGEIPI00319270.

Proteomic databases

EPDiQ9DBG5.
MaxQBiQ9DBG5.
PaxDbiQ9DBG5.
PeptideAtlasiQ9DBG5.
PRIDEiQ9DBG5.

Protocols and materials databases

DNASUi66905.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019726; ENSMUSP00000019726; ENSMUSG00000024197.
GeneIDi66905.
KEGGimmu:66905.
UCSCiuc008dbn.1. mouse.

Organism-specific databases

CTDi10226.
MGIiMGI:1914155. Plin3.

Phylogenomic databases

eggNOGiENOG410IJG1. Eukaryota.
ENOG410XTQ5. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ9DBG5.
KOiK20287.
OMAiWADNHLP.
OrthoDBiEOG091G0D6Q.
PhylomeDBiQ9DBG5.
TreeFamiTF328397.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

EvolutionaryTraceiQ9DBG5.
PROiQ9DBG5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024197.
CleanExiMM_M6PRBP1.
GenevisibleiQ9DBG5. MM.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBG5
Secondary accession number(s): Q3TK05, Q8BKV9, Q9CZK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.