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Q9DBG5

- PLIN3_MOUSE

UniProt

Q9DBG5 - PLIN3_MOUSE

Protein

Perilipin-3

Gene

Plin3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.By similarity

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Perilipin-3
    Alternative name(s):
    Cargo selection protein TIP47
    Mannose-6-phosphate receptor-binding protein 1
    Gene namesi
    Name:Plin3
    Synonyms:M6prbp1, Tip47
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1914155. Plin3.

    Subcellular locationi

    Cytoplasm By similarity. Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Lipid droplet By similarity
    Note: Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails By similarity.By similarity

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. lipid particle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Lipid droplet, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 437436Perilipin-3PRO_0000099891Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei65 – 651N6-acetyllysine1 Publication
    Modified residuei130 – 1301PhosphoserineBy similarity
    Modified residuei174 – 1741PhosphothreonineBy similarity
    Modified residuei179 – 1791PhosphoserineBy similarity
    Modified residuei183 – 1831PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9DBG5.
    PaxDbiQ9DBG5.
    PRIDEiQ9DBG5.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00319270.

    PTM databases

    PhosphoSiteiQ9DBG5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9DBG5.
    BgeeiQ9DBG5.
    CleanExiMM_M6PRBP1.
    GenevestigatoriQ9DBG5.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain) By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9DBG5. 2 interactions.
    MINTiMINT-1748486.
    STRINGi10090.ENSMUSP00000019726.

    Structurei

    Secondary structure

    1
    437
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi207 – 2104
    Helixi212 – 2165
    Helixi227 – 2359
    Beta strandi239 – 2424
    Helixi243 – 2453
    Helixi248 – 28740
    Helixi324 – 35027
    Turni351 – 3544
    Helixi357 – 37620
    Helixi377 – 3793
    Helixi383 – 3853
    Helixi388 – 41326
    Beta strandi421 – 4277

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SZIX-ray2.80A191-437[»]
    ProteinModelPortaliQ9DBG5.
    SMRiQ9DBG5. Positions 206-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9DBG5.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili251 – 28434Sequence AnalysisAdd
    BLAST
    Coiled coili357 – 41054Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the perilipin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG81115.
    GeneTreeiENSGT00500000044795.
    HOGENOMiHOG000033816.
    HOVERGENiHBG002935.
    InParanoidiQ9DBG5.
    OMAiQEQSYFV.
    OrthoDBiEOG7SN8CD.
    PhylomeDBiQ9DBG5.
    TreeFamiTF328397.

    Family and domain databases

    InterProiIPR004279. Perilipin.
    [Graphical view]
    PANTHERiPTHR14024. PTHR14024. 1 hit.
    PfamiPF03036. Perilipin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036881. PAT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DBG5-1 [UniParc]FASTAAdd to Basket

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    MSSNGTDAPA EAQAAMEEPV VQPSVVDRVA GLPLISSTYG MVSAAYTSTK    50
    ENYPHVRTVC DVAEKGVKTL TTAAVSTAQP ILSKLEPQIA TASEYAHRGL 100
    DRLQESLPIL QQPTEKVLAD TKELVSSTVS GAQEMVSSSV SSAKETVATR 150
    VTGAVDVTLG AVQNSVDKTK SAMTSGVQSV MGSRVGQMVI SGVDRVLVKS 200
    EAWADNRLPL TEAELALIAT PPEDSDMASL QQQRQEQNYF VRLGSLSERL 250
    RNHAYEHSLG KLQNARQKAQ ETLQQLTSVL GLMESVKQGV DQRLGEGQEK 300
    LHQMWLSWNQ KTPQDAEKDP AKPEQVEARA LSMFRDITQQ LQSMCVALGA 350
    SIQGLPSHVR EQAQQARSQV NDLQATFSGI HSFQDLSAGV LAQTRERIAR 400
    AREALDNTVE YVAQNTPAMW LVGPFAPGIT EKTPEGK 437
    Length:437
    Mass (Da):47,262
    Last modified:June 1, 2001 - v1
    Checksum:iF7CDD3A754A5C04D
    GO

    Sequence cautioni

    The sequence BAC33798.1 differs from that shown. Reason: Frameshift at position 400.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004970 mRNA. Translation: BAB23708.1.
    AK012517 mRNA. Translation: BAB28291.1.
    AK049537 mRNA. Translation: BAC33798.1. Frameshift.
    AK050140 mRNA. Translation: BAC34089.1.
    AK132313 mRNA. Translation: BAE21098.1.
    AK167214 mRNA. Translation: BAE39340.1.
    BC011116 mRNA. Translation: AAH11116.1.
    CCDSiCCDS28901.1.
    RefSeqiNP_080112.1. NM_025836.3.
    UniGeneiMm.311696.

    Genome annotation databases

    EnsembliENSMUST00000019726; ENSMUSP00000019726; ENSMUSG00000024197.
    GeneIDi66905.
    KEGGimmu:66905.
    UCSCiuc008dbn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004970 mRNA. Translation: BAB23708.1 .
    AK012517 mRNA. Translation: BAB28291.1 .
    AK049537 mRNA. Translation: BAC33798.1 . Frameshift.
    AK050140 mRNA. Translation: BAC34089.1 .
    AK132313 mRNA. Translation: BAE21098.1 .
    AK167214 mRNA. Translation: BAE39340.1 .
    BC011116 mRNA. Translation: AAH11116.1 .
    CCDSi CCDS28901.1.
    RefSeqi NP_080112.1. NM_025836.3.
    UniGenei Mm.311696.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SZI X-ray 2.80 A 191-437 [» ]
    ProteinModelPortali Q9DBG5.
    SMRi Q9DBG5. Positions 206-431.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DBG5. 2 interactions.
    MINTi MINT-1748486.
    STRINGi 10090.ENSMUSP00000019726.

    PTM databases

    PhosphoSitei Q9DBG5.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00319270.

    Proteomic databases

    MaxQBi Q9DBG5.
    PaxDbi Q9DBG5.
    PRIDEi Q9DBG5.

    Protocols and materials databases

    DNASUi 66905.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019726 ; ENSMUSP00000019726 ; ENSMUSG00000024197 .
    GeneIDi 66905.
    KEGGi mmu:66905.
    UCSCi uc008dbn.1. mouse.

    Organism-specific databases

    CTDi 10226.
    MGIi MGI:1914155. Plin3.

    Phylogenomic databases

    eggNOGi NOG81115.
    GeneTreei ENSGT00500000044795.
    HOGENOMi HOG000033816.
    HOVERGENi HBG002935.
    InParanoidi Q9DBG5.
    OMAi QEQSYFV.
    OrthoDBi EOG7SN8CD.
    PhylomeDBi Q9DBG5.
    TreeFami TF328397.

    Miscellaneous databases

    EvolutionaryTracei Q9DBG5.
    NextBioi 322981.
    PROi Q9DBG5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DBG5.
    Bgeei Q9DBG5.
    CleanExi MM_M6PRBP1.
    Genevestigatori Q9DBG5.

    Family and domain databases

    InterProi IPR004279. Perilipin.
    [Graphical view ]
    PANTHERi PTHR14024. PTHR14024. 1 hit.
    Pfami PF03036. Perilipin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036881. PAT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Head and Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    4. "Structure of a lipid droplet protein; the PAT family member TIP47."
      Hickenbottom S.J., Kimmel A.R., Londos C., Hurley J.H.
      Structure 12:1199-1207(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 191-437.

    Entry informationi

    Entry nameiPLIN3_MOUSE
    AccessioniPrimary (citable) accession number: Q9DBG5
    Secondary accession number(s): Q3TK05, Q8BKV9, Q9CZK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3