ID   AL7A1_MOUSE             Reviewed;         511 AA.
AC   Q9DBF1;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 68.
DE   RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase;
DE            Short=Alpha-AASA dehydrogenase;
DE            EC=1.2.1.31;
DE   AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenease;
DE            Short=P6c dehydrogenase;
DE   AltName: Full=Aldehyde dehydrogenase family 7 member A1;
DE   AltName: Full=Antiquitin-1;
GN   Name=Aldh7a1; Synonyms=Ald7a1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Liver;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: L-2-aminoadipate 6-semialdehyde + NAD(P)(+) +
CC       H(2)O = L-2-aminoadipate + NAD(P)H.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AK004991; BAB23726.1; -; mRNA.
DR   EMBL; BC012407; AAH12407.1; -; mRNA.
DR   IPI; IPI00890092; -.
DR   RefSeq; NP_001120810.1; -.
DR   UniGene; Mm.30250; -.
DR   SMR; Q9DBF1; 2-499.
DR   PhosphoSite; Q9DBF1; -.
DR   REPRODUCTION-2DPAGE; Q9DBF1; -.
DR   PRIDE; Q9DBF1; -.
DR   Ensembl; ENSMUSG00000053644; Mus musculus.
DR   GeneID; 110695; -.
DR   KEGG; mmu:110695; -.
DR   NMPDR; fig|10090.3.peg.4006; -.
DR   MGI; MGI:108186; Aldh7a1.
DR   HOVERGEN; Q9DBF1; -.
DR   OMA; Q9DBF1; WNPLGVV.
DR   BRENDA; 1.2.1.31; 244.
DR   NextBio; 364487; -.
DR   ArrayExpress; Q9DBF1; -.
DR   Bgee; Q9DBF1; -.
DR   CleanEx; MM_ALDH7A1; -.
DR   GermOnline; ENSMUSG00000053644; Mus musculus.
DR   GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR   GO; GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase a...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   NAD; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    511       Alpha-aminoadipic semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000056491.
FT   NP_BIND     246    251       NAD (By similarity).
FT   ACT_SITE    268    268       Proton acceptor (By similarity).
FT   ACT_SITE    302    302       Nucleophile (By similarity).
FT   SITE        167    167       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   511 AA;  55645 MW;  37952CEC7C5F3A85 CRC64;
     MSTLLIHHPQ YAWLQDLGLR EDNEGVYNGS WGGRGEVITT YCPANNEPIA RVRQASLKDY
     EETIGKAKKA WNIWADIPAP KRGEIVRKIG DAFREKIQLL GRLVSLEMGK ILVEGIGEVQ
     EYVDVCDYAA GLSRMIGGPT LPSERPGHAL IEMWNPLGLV GIITAFNFPV AVFGWNNAIA
     LITGNVCLWK GAPTTSLVSV AVTKIIAQVL EDNLLPGAIC SLVCGGADIG TTMARDERVN
     LLSFTGSTQV GKEVALMVQE RFGKSLLELG GNNAIIAFED ADLSLVVPSV LFAAVGTAGQ
     RCTTVRRLFL HESIHNEVVD RLRSAYSQIR VGNPWDPNIL YGPLHTKQAV SMFVRAVEEA
     KKQGGTVVYG GKVMDHPGNY VEPTIVTGLA HDAPIVHQET FAPILYVFKF QDEEEVFEWN
     NEVKQGLSSS IFTKDLGRIF RWLGPKGSDC GIVNVNIPTS GAEIGGAFGG EKHTGGGRES
     GSDAWKQYMR RSTCTINYST SLPLAQGIKF Q
//