Reviewed, UniProtKB/Swiss-Prot Q9DBF1 (AL7A1_MOUSE)

Names and origin

Protein names

Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase
      Short name=Alpha-AASA dehydrogenase
    EC=1.2.1.31
Alternative name(s):
    Delta1-piperideine-6-carboxylate dehydrogenease
      Short name=P6c dehydrogenase
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1

Gene names

Name:	Aldh7a1
Synonyms:	Ald7a1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
Subunit structure	Homotetramer By similarity. UniProtKB P83402
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P83402
	Chain	2 – 511	510	Alpha-aminoadipic semialdehyde dehydrogenase		PRO_0000056491
Regions
	Nucleotide binding	246 – 251	6	NAD By similarity UniProtKB Q56694
Sites
	Active site	268	1	Proton acceptor By similarity UniProtKB Q56694
	Active site	302	1	Nucleophile By similarity UniProtKB Q56694
	Site	167	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9DBF1-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 37952CEC7C5F3A85	FASTA	511	55,645
	10 20 30 40 50 60 MSTLLIHHPQ YAWLQDLGLR EDNEGVYNGS WGGRGEVITT YCPANNEPIA RVRQASLKDY 70 80 90 100 110 120 EETIGKAKKA WNIWADIPAP KRGEIVRKIG DAFREKIQLL GRLVSLEMGK ILVEGIGEVQ 130 140 150 160 170 180 EYVDVCDYAA GLSRMIGGPT LPSERPGHAL IEMWNPLGLV GIITAFNFPV AVFGWNNAIA 190 200 210 220 230 240 LITGNVCLWK GAPTTSLVSV AVTKIIAQVL EDNLLPGAIC SLVCGGADIG TTMARDERVN 250 260 270 280 290 300 LLSFTGSTQV GKEVALMVQE RFGKSLLELG GNNAIIAFED ADLSLVVPSV LFAAVGTAGQ 310 320 330 340 350 360 RCTTVRRLFL HESIHNEVVD RLRSAYSQIR VGNPWDPNIL YGPLHTKQAV SMFVRAVEEA 370 380 390 400 410 420 KKQGGTVVYG GKVMDHPGNY VEPTIVTGLA HDAPIVHQET FAPILYVFKF QDEEEVFEWN 430 440 450 460 470 480 NEVKQGLSSS IFTKDLGRIF RWLGPKGSDC GIVNVNIPTS GAEIGGAFGG EKHTGGGRES 490 500 510 GSDAWKQYMR RSTCTINYST SLPLAQGIKF Q

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK004991 mRNA. Translation: BAB23726.1. BC012407 mRNA. Translation: AAH12407.1.
IPI	IPI00890092.
RefSeq	NP_001120810.1. NP_613066.2.
UniGene	Mm.30250
3D structure databases
SMR	Q9DBF1. Positions 2-499.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9DBF1.
2-D gel databases
REPRODUCTION-2DPAGE	Q9DBF1.
Proteomic databases
PRIDE	Q9DBF1.
Genome annotation databases
Ensembl	ENSMUST00000066208; ENSMUSP00000065089; ENSMUSG00000053644; Mus musculus. [Genome view] ENSMUST00000116635; ENSMUSP00000112334; ENSMUSG00000053644; Mus musculus. [Genome view]
GeneID	110695.
KEGG	mmu:110695.
NMPDR	fig|10090.3.peg.4006.
UCSC	uc008eyo.1. mouse.
Organism-specific databases
CTD	110695.
MGI	MGI:108186. Aldh7a1.
Phylogenomic databases
HOVERGEN	Q9DBF1.
InParanoid	Q9DBF1.
OMA	WNPLGVV.
OrthoDB	EOG99KJ9G.
PhylomeDB	Q9DBF1.
Enzyme and pathway databases
BRENDA	1.2.1.31. 244.
Gene expression databases
ArrayExpress	Q9DBF1.
Bgee	Q9DBF1.
CleanEx	MM_ALDH7A1.
Genevestigator	Q9DBF1.
GermOnline	ENSMUSG00000053644. Mus musculus.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	364487.
SOURCE	Search...

Entry information

Entry name

AL7A1_MOUSE

Accession

Primary (citable) accession number: Q9DBF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)