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Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

Aldh7a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity).By similarity

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Alpha-aminoadipic semialdehyde dehydrogenase (Aldh7a1)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei195Transition state stabilizerBy similarity1
Active sitei296Proton acceptorPROSITE-ProRule annotation1
Active sitei330NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi274 – 279NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.2.1.3 3474
1.2.1.31 3474
ReactomeiR-MMU-6798163 Choline catabolism
R-MMU-71064 Lysine catabolism
UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
Short name:
Alpha-AASA dehydrogenase
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
Antiquitin-1
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Delta1-piperideine-6-carboxylate dehydrogenase
Short name:
P6c dehydrogenase
Gene namesi
Name:Aldh7a1
Synonyms:Ald7a1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:108186 Aldh7a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000005649127 – 539Alpha-aminoadipic semialdehyde dehydrogenaseAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86N6-acetyllysine; alternateCombined sources1
Modified residuei86N6-succinyllysine; alternateCombined sources1
Modified residuei94N6-acetyllysine; alternateCombined sources1
Modified residuei94N6-succinyllysine; alternateCombined sources1
Modified residuei97N6-acetyllysine; alternateCombined sources1
Modified residuei97N6-succinyllysine; alternateCombined sources1
Modified residuei462N6-acetyllysineCombined sources1
Modified residuei500N6-acetyllysineCombined sources1
Modified residuei537N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9DBF1
PeptideAtlasiQ9DBF1
PRIDEiQ9DBF1

2D gel databases

REPRODUCTION-2DPAGEQ9DBF1

PTM databases

iPTMnetiQ9DBF1
PhosphoSitePlusiQ9DBF1
SwissPalmiQ9DBF1

Expressioni

Tissue specificityi

Present in liver, kidney, brain and pancreas, and at lower levels in jejunum, duodenum, stomach and testes (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000053644
CleanExiMM_ALDH7A1
ExpressionAtlasiQ9DBF1 baseline and differential
GenevisibleiQ9DBF1 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9DBF1, 4 interactors
MINTiQ9DBF1
STRINGi10090.ENSMUSP00000065089

Structurei

3D structure databases

ProteinModelPortaliQ9DBF1
SMRiQ9DBF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2453 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000271511
HOVERGENiHBG050485
InParanoidiQ9DBF1
KOiK14085
OMAiDAWKVYM
OrthoDBiEOG091G058Y
PhylomeDBiQ9DBF1
TreeFamiTF300388

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBF1-1) [UniParc]FASTAAdd to basket
Also known as: mALDH7A1_v21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRVPRRLCV QSVKTSKLSG PWSRPAAHMS TLLIHHPQYA WLQDLGLRED
60 70 80 90 100
NEGVYNGSWG GRGEVITTYC PANNEPIARV RQASLKDYEE TIGKAKKAWN
110 120 130 140 150
IWADIPAPKR GEIVRKIGDA FREKIQLLGR LVSLEMGKIL VEGIGEVQEY
160 170 180 190 200
VDVCDYAAGL SRMIGGPTLP SERPGHALIE MWNPLGLVGI ITAFNFPVAV
210 220 230 240 250
FGWNNAIALI TGNVCLWKGA PTTSLVSVAV TKIIAQVLED NLLPGAICSL
260 270 280 290 300
VCGGADIGTT MARDERVNLL SFTGSTQVGK EVALMVQERF GKSLLELGGN
310 320 330 340 350
NAIIAFEDAD LSLVVPSVLF AAVGTAGQRC TTVRRLFLHE SIHNEVVDRL
360 370 380 390 400
RSAYSQIRVG NPWDPNILYG PLHTKQAVSM FVRAVEEAKK QGGTVVYGGK
410 420 430 440 450
VMDHPGNYVE PTIVTGLAHD APIVHQETFA PILYVFKFQD EEEVFEWNNE
460 470 480 490 500
VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK
510 520 530
HTGGGRESGS DAWKQYMRRS TCTINYSTSL PLAQGIKFQ
Length:539
Mass (Da):58,861
Last modified:April 20, 2010 - v4
Checksum:i7591EE5652F2577E
GO
Isoform 2 (identifier: Q9DBF1-2) [UniParc]FASTAAdd to basket
Also known as: mALDH7A1_v11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:511
Mass (Da):55,645
Checksum:i37952CEC7C5F3A85
GO

Sequence cautioni

The sequence AAH12407 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE26715 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164I → M in BAE26715 (PubMed:16141072).Curated1
Sequence conflicti467I → V in BAE35641 (PubMed:16141072).Curated1
Sequence conflicti491E → G in BAE35641 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0389891 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004991 mRNA Translation: BAB23726.1
AK145873 mRNA Translation: BAE26715.1 Different initiation.
AK160117 mRNA Translation: BAE35641.1
AK169195 mRNA Translation: BAE40971.1
BC012407 mRNA Translation: AAH12407.1 Different initiation.
CCDSiCCDS29258.2 [Q9DBF1-1]
CCDS50291.1 [Q9DBF1-2]
RefSeqiNP_001120810.1, NM_001127338.1 [Q9DBF1-2]
NP_613066.2, NM_138600.4 [Q9DBF1-1]
UniGeneiMm.30250

Genome annotation databases

EnsembliENSMUST00000066208; ENSMUSP00000065089; ENSMUSG00000053644 [Q9DBF1-1]
ENSMUST00000174518; ENSMUSP00000133372; ENSMUSG00000053644 [Q9DBF1-2]
GeneIDi110695
KEGGimmu:110695
UCSCiuc008eyn.2 mouse [Q9DBF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAL7A1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBF1
Secondary accession number(s): Q3TFC7, Q3TVH7, Q3UKT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 143 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health