Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

Aldh7a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity).By similarity

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Alpha-aminoadipic semialdehyde dehydrogenase (Aldh7a1)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei195Transition state stabilizerBy similarity1
Active sitei296Proton acceptorPROSITE-ProRule annotation1
Active sitei330NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi274 – 279NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.3. 3474.
1.2.1.31. 3474.
ReactomeiR-MMU-6798163. Choline catabolism.
R-MMU-71064. Lysine catabolism.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
Short name:
Alpha-AASA dehydrogenase
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
Antiquitin-1
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Delta1-piperideine-6-carboxylate dehydrogenase
Short name:
P6c dehydrogenase
Gene namesi
Name:Aldh7a1
Synonyms:Ald7a1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:108186. Aldh7a1.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity
Isoform 1 :
  • Mitochondrion By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000005649127 – 539Alpha-aminoadipic semialdehyde dehydrogenaseAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86N6-acetyllysine; alternateCombined sources1
Modified residuei86N6-succinyllysine; alternateCombined sources1
Modified residuei94N6-acetyllysine; alternateCombined sources1
Modified residuei94N6-succinyllysine; alternateCombined sources1
Modified residuei97N6-acetyllysine; alternateCombined sources1
Modified residuei97N6-succinyllysine; alternateCombined sources1
Modified residuei462N6-acetyllysineCombined sources1
Modified residuei500N6-acetyllysineCombined sources1
Modified residuei537N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9DBF1.
PeptideAtlasiQ9DBF1.
PRIDEiQ9DBF1.

2D gel databases

REPRODUCTION-2DPAGEQ9DBF1.

PTM databases

iPTMnetiQ9DBF1.
PhosphoSitePlusiQ9DBF1.
SwissPalmiQ9DBF1.

Expressioni

Tissue specificityi

Present in liver, kidney, brain and pancreas, and at lower levels in jejunum, duodenum, stomach and testes (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000053644.
CleanExiMM_ALDH7A1.
ExpressionAtlasiQ9DBF1. baseline and differential.
GenevisibleiQ9DBF1. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9DBF1. 4 interactors.
MINTiMINT-1859388.
STRINGi10090.ENSMUSP00000065089.

Structurei

3D structure databases

ProteinModelPortaliQ9DBF1.
SMRiQ9DBF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2453. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271511.
HOVERGENiHBG050485.
InParanoidiQ9DBF1.
KOiK14085.
OMAiEGYESGC.
OrthoDBiEOG091G058Y.
PhylomeDBiQ9DBF1.
TreeFamiTF300388.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBF1-1) [UniParc]FASTAAdd to basket
Also known as: mALDH7A1_v21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRVPRRLCV QSVKTSKLSG PWSRPAAHMS TLLIHHPQYA WLQDLGLRED
60 70 80 90 100
NEGVYNGSWG GRGEVITTYC PANNEPIARV RQASLKDYEE TIGKAKKAWN
110 120 130 140 150
IWADIPAPKR GEIVRKIGDA FREKIQLLGR LVSLEMGKIL VEGIGEVQEY
160 170 180 190 200
VDVCDYAAGL SRMIGGPTLP SERPGHALIE MWNPLGLVGI ITAFNFPVAV
210 220 230 240 250
FGWNNAIALI TGNVCLWKGA PTTSLVSVAV TKIIAQVLED NLLPGAICSL
260 270 280 290 300
VCGGADIGTT MARDERVNLL SFTGSTQVGK EVALMVQERF GKSLLELGGN
310 320 330 340 350
NAIIAFEDAD LSLVVPSVLF AAVGTAGQRC TTVRRLFLHE SIHNEVVDRL
360 370 380 390 400
RSAYSQIRVG NPWDPNILYG PLHTKQAVSM FVRAVEEAKK QGGTVVYGGK
410 420 430 440 450
VMDHPGNYVE PTIVTGLAHD APIVHQETFA PILYVFKFQD EEEVFEWNNE
460 470 480 490 500
VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK
510 520 530
HTGGGRESGS DAWKQYMRRS TCTINYSTSL PLAQGIKFQ
Length:539
Mass (Da):58,861
Last modified:April 20, 2010 - v4
Checksum:i7591EE5652F2577E
GO
Isoform 2 (identifier: Q9DBF1-2) [UniParc]FASTAAdd to basket
Also known as: mALDH7A1_v11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:511
Mass (Da):55,645
Checksum:i37952CEC7C5F3A85
GO

Sequence cautioni

The sequence AAH12407 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE26715 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164I → M in BAE26715 (PubMed:16141072).Curated1
Sequence conflicti467I → V in BAE35641 (PubMed:16141072).Curated1
Sequence conflicti491E → G in BAE35641 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0389891 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004991 mRNA. Translation: BAB23726.1.
AK145873 mRNA. Translation: BAE26715.1. Different initiation.
AK160117 mRNA. Translation: BAE35641.1.
AK169195 mRNA. Translation: BAE40971.1.
BC012407 mRNA. Translation: AAH12407.1. Different initiation.
CCDSiCCDS29258.2. [Q9DBF1-1]
CCDS50291.1. [Q9DBF1-2]
RefSeqiNP_001120810.1. NM_001127338.1. [Q9DBF1-2]
NP_613066.2. NM_138600.4. [Q9DBF1-1]
UniGeneiMm.30250.

Genome annotation databases

EnsembliENSMUST00000066208; ENSMUSP00000065089; ENSMUSG00000053644. [Q9DBF1-1]
ENSMUST00000174518; ENSMUSP00000133372; ENSMUSG00000053644. [Q9DBF1-2]
GeneIDi110695.
KEGGimmu:110695.
UCSCiuc008eyn.2. mouse. [Q9DBF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004991 mRNA. Translation: BAB23726.1.
AK145873 mRNA. Translation: BAE26715.1. Different initiation.
AK160117 mRNA. Translation: BAE35641.1.
AK169195 mRNA. Translation: BAE40971.1.
BC012407 mRNA. Translation: AAH12407.1. Different initiation.
CCDSiCCDS29258.2. [Q9DBF1-1]
CCDS50291.1. [Q9DBF1-2]
RefSeqiNP_001120810.1. NM_001127338.1. [Q9DBF1-2]
NP_613066.2. NM_138600.4. [Q9DBF1-1]
UniGeneiMm.30250.

3D structure databases

ProteinModelPortaliQ9DBF1.
SMRiQ9DBF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBF1. 4 interactors.
MINTiMINT-1859388.
STRINGi10090.ENSMUSP00000065089.

PTM databases

iPTMnetiQ9DBF1.
PhosphoSitePlusiQ9DBF1.
SwissPalmiQ9DBF1.

2D gel databases

REPRODUCTION-2DPAGEQ9DBF1.

Proteomic databases

PaxDbiQ9DBF1.
PeptideAtlasiQ9DBF1.
PRIDEiQ9DBF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066208; ENSMUSP00000065089; ENSMUSG00000053644. [Q9DBF1-1]
ENSMUST00000174518; ENSMUSP00000133372; ENSMUSG00000053644. [Q9DBF1-2]
GeneIDi110695.
KEGGimmu:110695.
UCSCiuc008eyn.2. mouse. [Q9DBF1-1]

Organism-specific databases

CTDi501.
MGIiMGI:108186. Aldh7a1.

Phylogenomic databases

eggNOGiKOG2453. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271511.
HOVERGENiHBG050485.
InParanoidiQ9DBF1.
KOiK14085.
OMAiEGYESGC.
OrthoDBiEOG091G058Y.
PhylomeDBiQ9DBF1.
TreeFamiTF300388.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.
BRENDAi1.2.1.3. 3474.
1.2.1.31. 3474.
ReactomeiR-MMU-6798163. Choline catabolism.
R-MMU-71064. Lysine catabolism.

Miscellaneous databases

PROiQ9DBF1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053644.
CleanExiMM_ALDH7A1.
ExpressionAtlasiQ9DBF1. baseline and differential.
GenevisibleiQ9DBF1. MM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL7A1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBF1
Secondary accession number(s): Q3TFC7, Q3TVH7, Q3UKT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.