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Protein

Proline-, glutamic acid- and leucine-rich protein 1

Gene

Pelp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K (By similarity). Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-, glutamic acid- and leucine-rich protein 1
Alternative name(s):
Modulator of non-genomic activity of estrogen receptor
Gene namesi
Name:Pelp1
Synonyms:Mnar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1922523. Pelp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002521372 – 1123Proline-, glutamic acid- and leucine-rich protein 1Add BLAST1122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei478PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei751PhosphothreonineBy similarity1
Modified residuei755PhosphoserineCombined sources1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1039PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DBD5.
MaxQBiQ9DBD5.
PaxDbiQ9DBD5.
PeptideAtlasiQ9DBD5.
PRIDEiQ9DBD5.

PTM databases

iPTMnetiQ9DBD5.
PhosphoSitePlusiQ9DBD5.

Expressioni

Tissue specificityi

Widely expressed with high levels in testis, ovary, uterus and pituitary gland.1 Publication

Gene expression databases

BgeeiENSMUSG00000018921.
CleanExiMM_PELP1.
ExpressionAtlasiQ9DBD5. baseline and differential.
GenevisibleiQ9DBD5. MM.

Interactioni

Subunit structurei

Interacts with BCAS3, HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol. Interacts with CREBBP, EP300, AR and NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and the other with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr4a1P128133EBI-6909114,EBI-10896863

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217350. 3 interactors.
IntActiQ9DBD5. 2 interactors.
MINTiMINT-4128201.
STRINGi10090.ENSMUSP00000019065.

Structurei

3D structure databases

ProteinModelPortaliQ9DBD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 37LXXLL motif 15
Motifi69 – 73LXXLL motif 25
Motifi111 – 115LXXLL motif 35
Motifi155 – 159LXXLL motif 45
Motifi177 – 181LXXLL motif 55
Motifi264 – 268LXXLL motif 65
Motifi271 – 275LXXLL motif 75
Motifi365 – 369LXXLL motif 85
Motifi460 – 464LXXLL motif 95
Motifi580 – 584LXXLL motif 105
Motifi585 – 589LXXLL motif 115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 407Leu-richAdd BLAST375
Compositional biasi634 – 876Pro-richAdd BLAST243
Compositional biasi893 – 1094Glu-richAdd BLAST202
Compositional biasi974 – 1121Pro-richAdd BLAST148

Domaini

The Glu-rich region mediates histones interaction.By similarity
The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ4S. Eukaryota.
ENOG4110K7C. LUCA.
GeneTreeiENSGT00730000111225.
HOGENOMiHOG000115494.
HOVERGENiHBG080634.
InParanoidiQ9DBD5.
KOiK16913.
OMAiYAILELW.
OrthoDBiEOG091G039A.
TreeFamiTF331332.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR031193. PELP1.
IPR012583. RIX1_N.
IPR012980. Uncharacterised_NUC202.
[Graphical view]
PANTHERiPTHR24023:SF429. PTHR24023:SF429. 3 hits.
PfamiPF08166. NUC202. 2 hits.
PF08167. RIX1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVLSGAS AGSPAGAPGG PGGLSAVGSG PRLRLLLLES ISGLLQPRTA
60 70 80 90 100
SPVAPVHPPI QWAPHLPGLM CLLRLHGTAG GAQNLSALGA LVNLSNAHLG
110 120 130 140 150
SIKTRFEGLC LLSLLIGESP TELFQQHCVS WLRSIQQVLQ SQDSPSTMEL
160 170 180 190 200
AVAVLRDLLR HASQLPTLFR DISTNHLPGL LTSLLGLRPE CEQSALEGMK
210 220 230 240 250
ACVTYFPRAC GSLKGKLASF FLSRLDSLNP QLQQLACECY SRLPSLGAGF
260 270 280 290 300
SQGLKHTENW EQELHSLLTS LHSLLGSLFE ETEPAPVQSE GPGIEMLLSH
310 320 330 340 350
SEDGNTHVLL QLRQRFSGLA RCLGLMLSSE FGAPVSVPVQ EILDLICRIL
360 370 380 390 400
GISSKNINLL GDGPLRLLLL PSLHLEALDL LSALILACGS RLLRFGALIS
410 420 430 440 450
RLLPQVLNAW STGRDTLAPG QERPYSTIRT KVYAILELWV QVCGASAGML
460 470 480 490 500
QGGASGEALL THLLSDISPP ADALKLCSTR GSSDGGLQSG KPSAPKKLKL
510 520 530 540 550
DMGEALAPPS QRKGDRNANS DVCAAALRGL SRTILMCGPL IKEETHRRLH
560 570 580 590 600
DLVLPLVMSV QQGEVLGSSP YNSSCCRLGL YRLLLALLLA PSPRCPPPLA
610 620 630 640 650
CALKAFSLGQ WEDSLEVSSF CSEALVTCAA LTHPRVPPLQ SSGPACPTPA
660 670 680 690 700
PVPPPEAPSS FRAPAFHPPG PMPSIGAVPS TGPLPSAGPI PTVGSMASTG
710 720 730 740 750
QVPSRPGPPA TANHLGLSVP GLVSVPPRLL PGPENHRAGS GEDPVLAPSG
760 770 780 790 800
TPPPSIPPDE TFGGRVPRPA FVHYDKEEAS DVEISLESDS DDSVVIVPEG
810 820 830 840 850
LPSLPPAPPS GTPPPAAPAG PPTASPPVPA KEDSEELPAT PGPPPPPPPP
860 870 880 890 900
PPPASGPVTL PPPQLVPEGT PGGGGPTAME EDLTVININS SDEEEEEEEE
910 920 930 940 950
EEEEDEDEEE EDFEEEEEDE EEYFEEEEEE EEFEEEFEEE EGELEEEEEE
960 970 980 990 1000
EEEELDEVED VEFGSAGEVE EGGPPPPTLP PALPPSDSPK VQPEAEPEPG
1010 1020 1030 1040 1050
LLLEVEEPGP EEVPGPETAP TLAPEVLPSQ EEGEQEVGSP AAGPPQELVE
1060 1070 1080 1090 1100
ESSAPPALLE EGTEGGGDKV PPPPETPAEE METEAEVPAP QEKEQDDTAA
1110 1120
MLADFIDCPP DDEKPPPATE PDS
Length:1,123
Mass (Da):118,069
Last modified:October 17, 2006 - v2
Checksum:i571BF1BD6A705067
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti566L → P in AAH16444 (PubMed:15489334).Curated1
Sequence conflicti566L → P in AAH57987 (PubMed:15489334).Curated1
Sequence conflicti864Q → L in BAB23754 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005027 mRNA. Translation: BAB23754.1.
AL596096 Genomic DNA. Translation: CAI51981.1.
BC016444 mRNA. Translation: AAH16444.1.
BC057987 mRNA. Translation: AAH57987.1.
BC090620 mRNA. Translation: AAH90620.1.
CCDSiCCDS24945.1.
RefSeqiNP_083507.3. NM_029231.4.
UniGeneiMm.340601.

Genome annotation databases

EnsembliENSMUST00000019065; ENSMUSP00000019065; ENSMUSG00000018921.
GeneIDi75273.
KEGGimmu:75273.
UCSCiuc007jup.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005027 mRNA. Translation: BAB23754.1.
AL596096 Genomic DNA. Translation: CAI51981.1.
BC016444 mRNA. Translation: AAH16444.1.
BC057987 mRNA. Translation: AAH57987.1.
BC090620 mRNA. Translation: AAH90620.1.
CCDSiCCDS24945.1.
RefSeqiNP_083507.3. NM_029231.4.
UniGeneiMm.340601.

3D structure databases

ProteinModelPortaliQ9DBD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217350. 3 interactors.
IntActiQ9DBD5. 2 interactors.
MINTiMINT-4128201.
STRINGi10090.ENSMUSP00000019065.

PTM databases

iPTMnetiQ9DBD5.
PhosphoSitePlusiQ9DBD5.

Proteomic databases

EPDiQ9DBD5.
MaxQBiQ9DBD5.
PaxDbiQ9DBD5.
PeptideAtlasiQ9DBD5.
PRIDEiQ9DBD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019065; ENSMUSP00000019065; ENSMUSG00000018921.
GeneIDi75273.
KEGGimmu:75273.
UCSCiuc007jup.2. mouse.

Organism-specific databases

CTDi27043.
MGIiMGI:1922523. Pelp1.

Phylogenomic databases

eggNOGiENOG410IJ4S. Eukaryota.
ENOG4110K7C. LUCA.
GeneTreeiENSGT00730000111225.
HOGENOMiHOG000115494.
HOVERGENiHBG080634.
InParanoidiQ9DBD5.
KOiK16913.
OMAiYAILELW.
OrthoDBiEOG091G039A.
TreeFamiTF331332.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiPelp1. mouse.
PROiQ9DBD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018921.
CleanExiMM_PELP1.
ExpressionAtlasiQ9DBD5. baseline and differential.
GenevisibleiQ9DBD5. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR031193. PELP1.
IPR012583. RIX1_N.
IPR012980. Uncharacterised_NUC202.
[Graphical view]
PANTHERiPTHR24023:SF429. PTHR24023:SF429. 3 hits.
PfamiPF08166. NUC202. 2 hits.
PF08167. RIX1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPELP1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBD5
Secondary accession number(s): Q5F2E2, Q6PEM0, Q91YM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.