Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inhibitor of carbonic anhydrase

Gene

Ica

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions.2 Publications

GO - Molecular functioni

  • enzyme inhibitor activity Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiS60.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of carbonic anhydrase
Gene namesi
Name:Ica
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1919025. 1300017J02Rik.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi143W → R: Confers ability to bind ferric iron and carbonate; when associated with Y-207. 1 Publication1
Mutagenesisi207S → Y: Confers ability to bind ferric iron and carbonate; when associated with R-143. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041537620 – 700Inhibitor of carbonic anhydraseAdd BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 67PROSITE-ProRule annotation1 Publication
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation1 Publication
Modified residuei42Dimethylated arginineBy similarity1
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation1 Publication
Disulfide bondi172 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi175 ↔ 198PROSITE-ProRule annotation1 Publication
Disulfide bondi185 ↔ 196PROSITE-ProRule annotation1 Publication
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation1 Publication
Disulfide bondi358 ↔ 390PROSITE-ProRule annotation1 Publication
Disulfide bondi368 ↔ 381PROSITE-ProRule annotation1 Publication
Disulfide bondi415 ↔ 695PROSITE-ProRule annotation1 Publication
Disulfide bondi438 ↔ 658PROSITE-ProRule annotation1 Publication
Disulfide bondi470 ↔ 545PROSITE-ProRule annotation1 Publication
Disulfide bondi494 ↔ 686PROSITE-ProRule annotation1 Publication
Disulfide bondi504 ↔ 518PROSITE-ProRule annotation1 Publication
Disulfide bondi515 ↔ 528PROSITE-ProRule annotation1 Publication
Disulfide bondi585 ↔ 599PROSITE-ProRule annotation1 Publication
Glycosylationi664N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

MaxQBiQ9DBD0.
PaxDbiQ9DBD0.
PeptideAtlasiQ9DBD0.
PRIDEiQ9DBD0.

PTM databases

iPTMnetiQ9DBD0.
PhosphoSitePlusiQ9DBD0.
SwissPalmiQ9DBD0.

Expressioni

Tissue specificityi

Detected in blood plasma, heart, kidney, liver, colon, lung, spleen, pancreas and testis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000033688.
ExpressionAtlasiQ9DBD0. baseline and differential.
GenevisibleiQ9DBD0. MM.

Interactioni

Subunit structurei

Monomer. Interacts (via transferrin-like domain 2) with CA2.2 Publications

Protein-protein interaction databases

IntActiQ9DBD0. 2 interactors.
MINTiMINT-4128179.
STRINGi10090.ENSMUSP00000035163.

Structurei

Secondary structure

1700
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 29Combined sources5
Helixi33 – 48Combined sources16
Beta strandi50 – 53Combined sources4
Beta strandi56 – 60Combined sources5
Helixi64 – 72Combined sources9
Beta strandi78 – 81Combined sources4
Helixi85 – 87Combined sources3
Beta strandi96 – 105Combined sources10
Beta strandi107 – 111Combined sources5
Beta strandi113 – 121Combined sources9
Turni122 – 124Combined sources3
Turni128 – 133Combined sources6
Beta strandi135 – 139Combined sources5
Turni144 – 147Combined sources4
Helixi148 – 153Combined sources6
Beta strandi161 – 163Combined sources3
Helixi164 – 167Combined sources4
Beta strandi168 – 172Combined sources5
Turni178 – 180Combined sources3
Helixi182 – 184Combined sources3
Beta strandi185 – 187Combined sources3
Beta strandi202 – 204Combined sources3
Helixi206 – 209Combined sources4
Helixi212 – 215Combined sources4
Beta strandi220 – 225Combined sources6
Helixi226 – 229Combined sources4
Helixi238 – 240Combined sources3
Beta strandi242 – 245Combined sources4
Beta strandi251 – 253Combined sources3
Helixi257 – 259Combined sources3
Beta strandi262 – 266Combined sources5
Beta strandi269 – 277Combined sources9
Helixi279 – 292Combined sources14
Beta strandi293 – 300Combined sources8
Beta strandi307 – 311Combined sources5
Beta strandi320 – 323Combined sources4
Helixi330 – 345Combined sources16
Beta strandi355 – 362Combined sources8
Helixi363 – 374Combined sources12
Turni375 – 377Combined sources3
Beta strandi378 – 386Combined sources9
Helixi387 – 396Combined sources10
Beta strandi401 – 404Combined sources4
Helixi406 – 414Combined sources9
Beta strandi418 – 422Combined sources5
Beta strandi446 – 455Combined sources10
Beta strandi469 – 472Combined sources4
Helixi477 – 481Combined sources5
Helixi483 – 488Combined sources6
Helixi496 – 499Combined sources4
Beta strandi500 – 504Combined sources5
Beta strandi515 – 517Combined sources3
Beta strandi530 – 534Combined sources5
Helixi538 – 548Combined sources11
Beta strandi551 – 555Combined sources5
Turni561 – 563Combined sources3
Helixi571 – 573Combined sources3
Turni578 – 580Combined sources3
Beta strandi581 – 584Combined sources4
Beta strandi586 – 588Combined sources3
Beta strandi590 – 592Combined sources3
Turni596 – 598Combined sources3
Beta strandi601 – 604Combined sources4
Beta strandi608 – 611Combined sources4
Beta strandi613 – 615Combined sources3
Helixi616 – 630Combined sources15
Beta strandi636 – 639Combined sources4
Beta strandi646 – 648Combined sources3
Beta strandi650 – 652Combined sources3
Helixi668 – 679Combined sources12
Helixi684 – 686Combined sources3
Helixi690 – 695Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MC2X-ray2.40A/B/C/D20-700[»]
ProteinModelPortaliQ9DBD0.
SMRiQ9DBD0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBD0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 347Transferrin-like 1PROSITE-ProRule annotationAdd BLAST323
Domaini355 – 685Transferrin-like 2PROSITE-ProRule annotationAdd BLAST331

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
GeneTreeiENSGT00390000001619.
HOVERGENiHBG000055.
InParanoidiQ9DBD0.
KOiK14736.
OMAiEYRMFQM.
OrthoDBiEOG091G0242.
PhylomeDBiQ9DBD0.
TreeFamiTF324013.

Family and domain databases

InterProiIPR029785. ICA.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PANTHERiPTHR11485:SF20. PTHR11485:SF20. 1 hit.
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 1 hit.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLICALLC LGTLGLCLAL PEKTIRWCVV SDHEATKCSS FRDNMKKVLP
60 70 80 90 100
AGGPAVTCVR KMSHPECIRD ISANKVDAVT VDGALVAEAD LPHHSLKPIM
110 120 130 140 150
AEYYGSKDDP KTHYYVVAMA KKGTGFQLNQ LRGKKSCHTG LGWSAGWYVP
160 170 180 190 200
LSTLLPSGSR ETAAATFFSS SCVPCADGKM FPSLCQLCAG KGTDKCACSS
210 220 230 240 250
REPYFGSWGA LKCLQDGTAD VSFVKHLTVF EAMPTKADRD QYELLCMDNT
260 270 280 290 300
RRPVEEYEQC YLARVPSHVV VARSVDGKED SIQELLRVAQ EHFGKDKSSP
310 320 330 340 350
FQLFGSPHGE DLLFTDAAHG LLRVPRKIDI SLYLGYEFLS AFRNLKRGLE
360 370 380 390 400
DSQRVKWCAV GQQERTKCDQ WSAVSGGALA CATEETPEDC IAATMKGEAD
410 420 430 440 450
AMSLDGGFAY VAGHCGLVPV LAENYLSTHS SGRLGSKCVN APLEGYYVVA
460 470 480 490 500
VVKKSDVGIT WKSLQGKKSC HTAVGTSEGW NVPMGLIYNQ TGSCKFDAFF
510 520 530 540 550
SRSCAPGSDP DSPLCALCVG GNNPAHMCAA NNAEGYHGSS GALRCLVEKG
560 570 580 590 600
DVAFMKHPTV LQNTDGKNPE PWAKGLKHED FELLCLDGTR KPVTEAQSCH
610 620 630 640 650
LARVPNRAVF SRKDKADFVR RILFNQQELF GRNGFEYMMF QMFESSAKDL
660 670 680 690 700
LFSDDTECLS NLQNKTTYKT YLGPQYLTLM DNFRQCLSSE LLDACTFHKY
Length:700
Mass (Da):76,766
Last modified:June 1, 2001 - v1
Checksum:i38C991D1021AE548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122747 Genomic DNA. No translation available.
AK005035 mRNA. Translation: BAB23762.1.
CCDSiCCDS23452.1.
RefSeqiNP_082194.1. NM_027918.2.
UniGeneiMm.18802.

Genome annotation databases

EnsembliENSMUST00000035163; ENSMUSP00000035163; ENSMUSG00000033688.
GeneIDi71775.
KEGGimmu:71775.
UCSCiuc009rgk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122747 Genomic DNA. No translation available.
AK005035 mRNA. Translation: BAB23762.1.
CCDSiCCDS23452.1.
RefSeqiNP_082194.1. NM_027918.2.
UniGeneiMm.18802.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MC2X-ray2.40A/B/C/D20-700[»]
ProteinModelPortaliQ9DBD0.
SMRiQ9DBD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBD0. 2 interactors.
MINTiMINT-4128179.
STRINGi10090.ENSMUSP00000035163.

Protein family/group databases

MEROPSiS60.977.

PTM databases

iPTMnetiQ9DBD0.
PhosphoSitePlusiQ9DBD0.
SwissPalmiQ9DBD0.

Proteomic databases

MaxQBiQ9DBD0.
PaxDbiQ9DBD0.
PeptideAtlasiQ9DBD0.
PRIDEiQ9DBD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035163; ENSMUSP00000035163; ENSMUSG00000033688.
GeneIDi71775.
KEGGimmu:71775.
UCSCiuc009rgk.1. mouse.

Organism-specific databases

MGIiMGI:1919025. 1300017J02Rik.

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
GeneTreeiENSGT00390000001619.
HOVERGENiHBG000055.
InParanoidiQ9DBD0.
KOiK14736.
OMAiEYRMFQM.
OrthoDBiEOG091G0242.
PhylomeDBiQ9DBD0.
TreeFamiTF324013.

Miscellaneous databases

EvolutionaryTraceiQ9DBD0.
PROiQ9DBD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033688.
ExpressionAtlasiQ9DBD0. baseline and differential.
GenevisibleiQ9DBD0. MM.

Family and domain databases

InterProiIPR029785. ICA.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PANTHERiPTHR11485:SF20. PTHR11485:SF20. 1 hit.
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 1 hit.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICA_MOUSE
AccessioniPrimary (citable) accession number: Q9DBD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.