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Protein

Carboxypeptidase N subunit 2

Gene

Cpn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase N subunit 2
Alternative name(s):
Carboxypeptidase N 83 kDa chain
Carboxypeptidase N large subunit
Carboxypeptidase N polypeptide 2
Carboxypeptidase N regulatory subunit
Gene namesi
Name:Cpn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1919006. Cpn2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002099022 – 547Carboxypeptidase N subunit 2Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)2 Publications1
Glycosylationi111N-linked (GlcNAc...)1 Publication1
Glycosylationi119N-linked (GlcNAc...)1 Publication1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Glycosylationi348N-linked (GlcNAc...)1 Publication1
Glycosylationi359N-linked (GlcNAc...)1 Publication1
Glycosylationi367N-linked (GlcNAc...)1 Publication1
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9DBB9.
PaxDbiQ9DBB9.
PeptideAtlasiQ9DBB9.
PRIDEiQ9DBB9.

PTM databases

PhosphoSitePlusiQ9DBB9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023176.
CleanExiMM_CPN2.
GenevisibleiQ9DBB9. MM.

Interactioni

Subunit structurei

Tetramer of two catalytic chains and two glycosylated inactive chains.By similarity

Protein-protein interaction databases

IntActiQ9DBB9. 1 interactor.
MINTiMINT-4090020.
STRINGi10090.ENSMUSP00000069318.

Structurei

3D structure databases

ProteinModelPortaliQ9DBB9.
SMRiQ9DBB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 49LRRNTAdd BLAST28
Repeati98 – 119LRR 1Add BLAST22
Repeati122 – 143LRR 2Add BLAST22
Repeati146 – 167LRR 3Add BLAST22
Repeati170 – 191LRR 4Add BLAST22
Repeati194 – 215LRR 5Add BLAST22
Repeati218 – 239LRR 6Add BLAST22
Repeati242 – 263LRR 7Add BLAST22
Repeati266 – 287LRR 8Add BLAST22
Repeati290 – 311LRR 9Add BLAST22
Repeati314 – 335LRR 10Add BLAST22
Repeati338 – 359LRR 11Add BLAST22
Repeati362 – 383LRR 12Add BLAST22
Domaini395 – 447LRRCTAdd BLAST53

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000294123.
HOVERGENiHBG050814.
InParanoidiQ9DBB9.
KOiK13023.
OMAiWQCDCHL.
OrthoDBiEOG091G057B.
PhylomeDBiQ9DBB9.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPGAWLCWV SLLLLARLTQ PCPVGCDCFG REVFCSDEQL ADIPPDIPPH
60 70 80 90 100
ITDIVFVETA FTTVRTRAFS GSPNLTKVVF LNTQVRHLEP DAFGGLPRLQ
110 120 130 140 150
DLEITGSPVS NLSAHIFSNL SSLEKLTLDF DRLAGLPEDL FCHMDILESL
160 170 180 190 200
QLQGNQLRTL PGRLFQSLRD LRTLNLAQNL LTQLPKGAFQ SLTGLQMLKL
210 220 230 240 250
SNNMLARLPE GALGSLSSLQ ELFLDGNAIT ELSPHLFSQL FSLEMLWLQH
260 270 280 290 300
NAICHLPVSL FSSLHNLTFL SLKDNALRTL PEGLFAHNQG LLHLSLSYNQ
310 320 330 340 350
LETIPEGAFT NLSRLVSLTL SHNAITDLPE HVFRNLEQLV KLSLDSNNLT
360 370 380 390 400
ALHPALFHNL SRLQLLNLSR NQLTTLPGGI FDTNYDLFNL ALLGNPWQCD
410 420 430 440 450
CHLSYLTSWL RLYNNQISNT HTFCAGPAYL KGQLVPNLKQ EQLICPVNPG
460 470 480 490 500
HLSFRALGLD EGEPAGSWDL TVEGRAAHSQ CAYSNPEGTV LLACEESRCR
510 520 530 540
WLNIQLSSRD GSDSAAMVYN SSQEWGLRSS CGLLRVTVSI EAPAAGP
Length:547
Mass (Da):60,479
Last modified:September 27, 2004 - v2
Checksum:i89437E8F32DA1453
GO

Sequence cautioni

The sequence AAH25836 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB23775 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005049 mRNA. Translation: BAB23775.1. Different initiation.
BC025836 mRNA. Translation: AAH25836.1. Different initiation.
BC138287 mRNA. Translation: AAI38288.1.
BC138288 mRNA. Translation: AAI38289.1.
CCDSiCCDS49819.1.
RefSeqiNP_082180.2. NM_027904.3.
XP_006522648.1. XM_006522585.1.
UniGeneiMm.290614.

Genome annotation databases

EnsembliENSMUST00000064856; ENSMUSP00000069318; ENSMUSG00000023176.
GeneIDi71756.
KEGGimmu:71756.
UCSCiuc007ywm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005049 mRNA. Translation: BAB23775.1. Different initiation.
BC025836 mRNA. Translation: AAH25836.1. Different initiation.
BC138287 mRNA. Translation: AAI38288.1.
BC138288 mRNA. Translation: AAI38289.1.
CCDSiCCDS49819.1.
RefSeqiNP_082180.2. NM_027904.3.
XP_006522648.1. XM_006522585.1.
UniGeneiMm.290614.

3D structure databases

ProteinModelPortaliQ9DBB9.
SMRiQ9DBB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBB9. 1 interactor.
MINTiMINT-4090020.
STRINGi10090.ENSMUSP00000069318.

PTM databases

PhosphoSitePlusiQ9DBB9.

Proteomic databases

MaxQBiQ9DBB9.
PaxDbiQ9DBB9.
PeptideAtlasiQ9DBB9.
PRIDEiQ9DBB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064856; ENSMUSP00000069318; ENSMUSG00000023176.
GeneIDi71756.
KEGGimmu:71756.
UCSCiuc007ywm.1. mouse.

Organism-specific databases

CTDi1370.
MGIiMGI:1919006. Cpn2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000294123.
HOVERGENiHBG050814.
InParanoidiQ9DBB9.
KOiK13023.
OMAiWQCDCHL.
OrthoDBiEOG091G057B.
PhylomeDBiQ9DBB9.
TreeFamiTF351124.

Miscellaneous databases

PROiQ9DBB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023176.
CleanExiMM_CPN2.
GenevisibleiQ9DBB9. MM.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPN2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBB9
Secondary accession number(s): B2RR89, Q8R113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.