Reviewed, UniProtKB/Swiss-Prot Q9DBB8 (DHDH_MOUSE)

Names and origin

Protein names

Recommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    EC=1.3.1.20
Alternative name(s):
    Dimeric dihydrodiol dehydrogenase
    D-xylose-NADP dehydrogenase
    EC=1.1.1.179
    D-xylose 1-dehydrogenase

Gene names

Name:

Dhdh

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-xylose 1-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase		PRO_0000315364
Sites
	Site	71	1	May play an important role in coenzyme binding By similarity
	Site	79	1	May play an important role in coenzyme binding By similarity
	Site	97	1	May play an important role in coenzyme binding By similarity
	Site	176	1	May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
	Site	180	1	May play an important role in catalytic activity By similarity
Experimental info
	Sequence conflict	115	1	S → F in AAI16415. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9DBB8-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 24CCCB8DB0423074	FASTA	333	36,301
	10 20 30 40 50 60 MALRWGIVSA GLIANDFTTV LSSLPSSEHQ VVAVAARDLN RAEEFAQKFN IPKAYGSYEE 70 80 90 100 110 120 LAKDPNVEVA YIATQHPQHK PAVLLCLAAG KAVLCEKPMG VNAAEVREMV AKARSQGVFL 130 140 150 160 170 180 MEAIWSRFFP AMEALREVLV QGTIGDLRVA RAEFGFDLSH IPRATDWNQA GGGLLDLGIY 190 200 210 220 230 240 CVQFLSMIFG AQKPEKISAV GRIHETGVDD TVSVLLQYPG GVHGSFTCSI SSNLPNTAYV 250 260 270 280 290 300 SGTKGMAQIQ KLWAPTELVV NGERKEFPPP VLGKDYNFVN GSCMLYEANH VRECLRKGLK 310 320 330 ESPVVPLAES ELLAEILEEA RKAIGVTFPQ DKR

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK005050 mRNA. Translation: BAB23776.1. AK154452 mRNA. Translation: BAE32596.1. BC116414 mRNA. Translation: AAI16415.1.
IPI	IPI00172146.
RefSeq	NP_082179.1.
UniGene	Mm.34208 Mm.439742
3D structure databases
SMR	Q9DBB8. Positions 2-331.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9DBB8.
Proteomic databases
PRIDE	Q9DBB8.
Genome annotation databases
Ensembl	ENSMUST00000011526; ENSMUSP00000011526; ENSMUSG00000011382; Mus musculus. [Genome view]
GeneID	71755.
KEGG	mmu:71755.
UCSC	uc009gvj.1. mouse.
Organism-specific databases
CTD	71755.
MGI	MGI:1919005. Dhdh.
Phylogenomic databases
HOVERGEN	Q9DBB8.
InParanoid	Q9DBB8.
OMA	DSHAQYA.
OrthoDB	EOG9NZXD5.
PhylomeDB	Q9DBB8.
Enzyme and pathway databases
BRENDA	1.1.1.179. 244. 1.3.1.20. 244.
Gene expression databases
ArrayExpress	Q9DBB8.
Bgee	Q9DBB8.
CleanEx	MM_DHDH.
Genevestigator	Q9DBB8.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	334417.
SOURCE	Search...

Entry information

Entry name

DHDH_MOUSE

Accession

Primary (citable) accession number: Q9DBB8
Secondary accession number(s): Q14B09

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 1, 2001
Last modified:	January 19, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)