Q9DBB8 (DHDH_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase EC=1.3.1.20 Alternative name(s): D-xylose 1-dehydrogenase D-xylose-NADP dehydrogenase EC=1.1.1.179 Dimeric dihydrodiol dehydrogenase | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus![]() |
Protein attributes
| Sequence length | 333 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the Gfo/Idh/MocA family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | D-xylose catabolic process Inferred from direct assay PubMed 6753830. Source: MGI |
| Molecular_function | D-xylose 1-dehydrogenase (NADP+) activity Inferred from direct assay PubMed 6753830. Source: MGI trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 333 | 333 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | PRO_0000315364 | |||||
Sites | |||||||||
| Site | 71 | 1 | May play an important role in coenzyme binding By similarity | ||||||
| Site | 79 | 1 | May play an important role in coenzyme binding By similarity | ||||||
| Site | 97 | 1 | May play an important role in coenzyme binding By similarity | ||||||
| Site | 176 | 1 | May play an important role for the adaptation of the alcohol substrate into the binding site By similarity | ||||||
| Site | 180 | 1 | May play an important role in catalytic activity By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 115 | 1 | S → F in AAI16415. Ref.2 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Liver. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK005050 mRNA. Translation: BAB23776.1. AK154452 mRNA. Translation: BAE32596.1. BC116414 mRNA. Translation: AAI16415.1. |
| IPI | IPI00172146. |
| RefSeq | NP_082179.1. NM_027903.3. |
| UniGene | Mm.34208. |
3D structure databases | |
| ProteinModelPortal | Q9DBB8. |
| SMR | Q9DBB8. Positions 2-331. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-1869308. |
Proteomic databases | |
| PaxDb | Q9DBB8. |
| PRIDE | Q9DBB8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000011526; ENSMUSP00000011526; ENSMUSG00000011382. |
| GeneID | 71755. |
| KEGG | mmu:71755. |
| UCSC | uc009gvj.1. mouse. |
Organism-specific databases | |
| CTD | 27294. |
| MGI | MGI:1919005. Dhdh. |
Phylogenomic databases | |
| eggNOG | COG0673. |
| GeneTree | ENSGT00390000007946. |
| HOVERGEN | HBG105348. |
| InParanoid | Q9DBB8. |
| KO | K00078. |
| OMA | TKGMAQI. |
| OrthoDB | EOG46144D. |
Gene expression databases | |
| ArrayExpress | Q9DBB8. |
| Bgee | Q9DBB8. |
| CleanEx | MM_DHDH. |
| Genevestigator | Q9DBB8. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view] |
| Pfam | PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 334417. |
| SOURCE | Search... |
Entry information
| Entry name | DHDH_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9DBB8 Secondary accession number(s): Q14B09 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
