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Q9DBB8 (DHDH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC=1.3.1.20
Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
EC=1.1.1.179
Dimeric dihydrodiol dehydrogenase
Gene names
Name:Dhdh
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the Gfo/Idh/MocA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
PRO_0000315364

Sites

Site711May play an important role in coenzyme binding By similarity
Site791May play an important role in coenzyme binding By similarity
Site971May play an important role in coenzyme binding By similarity
Site1761May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
Site1801May play an important role in catalytic activity By similarity

Experimental info

Sequence conflict1151S → F in AAI16415. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9DBB8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 24CCCB8DB0423074

FASTA33336,301
        10         20         30         40         50         60 
MALRWGIVSA GLIANDFTTV LSSLPSSEHQ VVAVAARDLN RAEEFAQKFN IPKAYGSYEE 

        70         80         90        100        110        120 
LAKDPNVEVA YIATQHPQHK PAVLLCLAAG KAVLCEKPMG VNAAEVREMV AKARSQGVFL 

       130        140        150        160        170        180 
MEAIWSRFFP AMEALREVLV QGTIGDLRVA RAEFGFDLSH IPRATDWNQA GGGLLDLGIY 

       190        200        210        220        230        240 
CVQFLSMIFG AQKPEKISAV GRIHETGVDD TVSVLLQYPG GVHGSFTCSI SSNLPNTAYV 

       250        260        270        280        290        300 
SGTKGMAQIQ KLWAPTELVV NGERKEFPPP VLGKDYNFVN GSCMLYEANH VRECLRKGLK 

       310        320        330 
ESPVVPLAES ELLAEILEEA RKAIGVTFPQ DKR

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK005050 mRNA. Translation: BAB23776.1.
AK154452 mRNA. Translation: BAE32596.1.
BC116414 mRNA. Translation: AAI16415.1.
IPIIPI00172146.
RefSeqNP_082179.1. NM_027903.3.
UniGeneMm.34208.

3D structure databases

ProteinModelPortalQ9DBB8.
SMRQ9DBB8. Positions 2-331.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1869308.

Proteomic databases

PaxDbQ9DBB8.
PRIDEQ9DBB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000011526; ENSMUSP00000011526; ENSMUSG00000011382.
GeneID71755.
KEGGmmu:71755.
UCSCuc009gvj.1. mouse.

Organism-specific databases

CTD27294.
MGIMGI:1919005. Dhdh.

Phylogenomic databases

eggNOGCOG0673.
GeneTreeENSGT00390000007946.
HOVERGENHBG105348.
InParanoidQ9DBB8.
KOK00078.
OMATKGMAQI.
OrthoDBEOG46144D.

Gene expression databases

ArrayExpressQ9DBB8.
BgeeQ9DBB8.
CleanExMM_DHDH.
GenevestigatorQ9DBB8.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio334417.
SOURCESearch...

Entry information

Entry nameDHDH_MOUSE
AccessionPrimary (citable) accession number: Q9DBB8
Secondary accession number(s): Q14B09
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: May 29, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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