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Q9DBB5

- IF4E3_MOUSE

UniProt

Q9DBB5 - IF4E3_MOUSE

Protein

Eukaryotic translation initiation factor 4E type 3

Gene

Eif4e3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.1 Publication

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of translation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis, Translation regulation

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198533. ISG15 antiviral mechanism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 4E type 3
    Short name:
    eIF-4E type 3
    Short name:
    eIF-4E3
    Short name:
    eIF4E type 3
    Short name:
    eIF4E-3
    Gene namesi
    Name:Eif4e3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1914142. Eif4e3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. mRNA cap binding complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Eukaryotic translation initiation factor 4E type 3PRO_0000287698Add
    BLAST

    Proteomic databases

    MaxQBiQ9DBB5.
    PaxDbiQ9DBB5.
    PRIDEiQ9DBB5.

    2D gel databases

    REPRODUCTION-2DPAGEQ9DBB5.

    PTM databases

    PhosphoSiteiQ9DBB5.

    Expressioni

    Tissue specificityi

    Only expressed in heart, skeletal muscle, lung and spleen.1 Publication

    Gene expression databases

    BgeeiQ9DBB5.
    GenevestigatoriQ9DBB5.

    Interactioni

    Subunit structurei

    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G By similarity. EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ9DBB5. 1 interaction.
    MINTiMINT-4127798.

    Structurei

    Secondary structure

    1
    207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi12 – 154
    Turni17 – 204
    Beta strandi24 – 274
    Beta strandi31 – 4111
    Helixi49 – 557
    Beta strandi57 – 648
    Helixi65 – 7410
    Helixi78 – 803
    Beta strandi83 – 9311
    Helixi97 – 993
    Turni101 – 1055
    Beta strandi107 – 1137
    Turni115 – 1173
    Helixi118 – 12912
    Turni130 – 1323
    Helixi134 – 1374
    Beta strandi144 – 1518
    Beta strandi156 – 1638
    Helixi165 – 1673
    Turni168 – 1703
    Helixi173 – 1808
    Beta strandi187 – 1937
    Turni194 – 1963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4B6UNMR-A1-207[»]
    4B6VNMR-A1-207[»]
    ProteinModelPortaliQ9DBB5.
    SMRiQ9DBB5. Positions 16-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni98 – 9927-methylguanosine-containing mRNA cap bindingBy similarity
    Regioni152 – 15767-methylguanosine-containing mRNA cap bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5053.
    GeneTreeiENSGT00520000055549.
    HOGENOMiHOG000059588.
    HOVERGENiHBG107990.
    InParanoidiQ9DBB5.
    OMAiRVYNNIP.
    OrthoDBiEOG7X6M1B.
    PhylomeDBiQ9DBB5.

    Family and domain databases

    Gene3Di3.30.760.10. 1 hit.
    InterProiIPR023398. TIF_eIF4e-like_dom.
    IPR001040. TIF_eIF_4E.
    [Graphical view]
    PANTHERiPTHR11960. PTHR11960. 1 hit.
    PfamiPF01652. IF4E. 1 hit.
    [Graphical view]
    SUPFAMiSSF55418. SSF55418. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9DBB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPPAAAPP GANEPLDKAL SALPPEPGGV PLHSPWTFWL DRSLPGATAA    50
    ECASNLKKIY TVQTVQIFWS VYNNIPPVTS LPLRCSYHLM RGERRPLWEE 100
    ESNAKGGVWK MKVPKDSTST VWKELLLATI GEQFTDCAAA DDEIIGVSVS 150
    VRDREDVVQV WNVNASLVGE ATVLEKIHQL LPHIAFKAVF YKPHEEHHAF 200
    EGGRGKH 207
    Length:207
    Mass (Da):22,836
    Last modified:June 1, 2001 - v1
    Checksum:i0263A317BFD0A4C1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221W → G in BAB24928. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY628329 mRNA. Translation: AAT45741.1.
    AK005054 mRNA. Translation: BAB23780.1.
    AK007268 mRNA. Translation: BAB24928.1.
    BC027014 mRNA. Translation: AAH27014.1.
    CCDSiCCDS20386.1.
    RefSeqiNP_080105.1. NM_025829.4.
    UniGeneiMm.32889.

    Genome annotation databases

    EnsembliENSMUST00000032151; ENSMUSP00000032151; ENSMUSG00000093661.
    GeneIDi66892.
    KEGGimmu:66892.
    UCSCiuc009dbr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY628329 mRNA. Translation: AAT45741.1 .
    AK005054 mRNA. Translation: BAB23780.1 .
    AK007268 mRNA. Translation: BAB24928.1 .
    BC027014 mRNA. Translation: AAH27014.1 .
    CCDSi CCDS20386.1.
    RefSeqi NP_080105.1. NM_025829.4.
    UniGenei Mm.32889.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4B6U NMR - A 1-207 [» ]
    4B6V NMR - A 1-207 [» ]
    ProteinModelPortali Q9DBB5.
    SMRi Q9DBB5. Positions 16-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DBB5. 1 interaction.
    MINTi MINT-4127798.

    PTM databases

    PhosphoSitei Q9DBB5.

    2D gel databases

    REPRODUCTION-2DPAGE Q9DBB5.

    Proteomic databases

    MaxQBi Q9DBB5.
    PaxDbi Q9DBB5.
    PRIDEi Q9DBB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032151 ; ENSMUSP00000032151 ; ENSMUSG00000093661 .
    GeneIDi 66892.
    KEGGi mmu:66892.
    UCSCi uc009dbr.1. mouse.

    Organism-specific databases

    CTDi 317649.
    MGIi MGI:1914142. Eif4e3.

    Phylogenomic databases

    eggNOGi COG5053.
    GeneTreei ENSGT00520000055549.
    HOGENOMi HOG000059588.
    HOVERGENi HBG107990.
    InParanoidi Q9DBB5.
    OMAi RVYNNIP.
    OrthoDBi EOG7X6M1B.
    PhylomeDBi Q9DBB5.

    Enzyme and pathway databases

    Reactomei REACT_198533. ISG15 antiviral mechanism.

    Miscellaneous databases

    NextBioi 322945.
    PROi Q9DBB5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DBB5.
    Genevestigatori Q9DBB5.

    Family and domain databases

    Gene3Di 3.30.760.10. 1 hit.
    InterProi IPR023398. TIF_eIF4e-like_dom.
    IPR001040. TIF_eIF_4E.
    [Graphical view ]
    PANTHERi PTHR11960. PTHR11960. 1 hit.
    Pfami PF01652. IF4E. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55418. SSF55418. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of mammalian eIF4E-family members."
      Joshi B., Cameron A., Jagus R.
      Eur. J. Biochem. 271:2189-2203(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH EIF4G1.
      Strain: Czech II.
      Tissue: Lung tumor.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiIF4E3_MOUSE
    AccessioniPrimary (citable) accession number: Q9DBB5
    Secondary accession number(s): Q9D983
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3