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Q9DBB5 (IF4E3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 4E type 3

Short name=eIF-4E type 3
Short name=eIF-4E3
Short name=eIF4E type 3
Short name=eIF4E-3
Gene names
Name:Eif4e3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity. Ref.1

Subunit structure

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G By similarity. EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3. Ref.1

Tissue specificity

Only expressed in heart, skeletal muscle, lung and spleen. Ref.1

Sequence similarities

Belongs to the eukaryotic initiation factor 4E family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Eukaryotic translation initiation factor 4E type 3
PRO_0000287698

Regions

Region98 – 9927-methylguanosine-containing mRNA cap binding By similarity
Region152 – 15767-methylguanosine-containing mRNA cap binding By similarity

Experimental info

Sequence conflict1221W → G in BAB24928. Ref.2

Secondary structure

.......................................... 207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9DBB5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0263A317BFD0A4C1

FASTA20722,836
        10         20         30         40         50         60 
MALPPAAAPP GANEPLDKAL SALPPEPGGV PLHSPWTFWL DRSLPGATAA ECASNLKKIY 

        70         80         90        100        110        120 
TVQTVQIFWS VYNNIPPVTS LPLRCSYHLM RGERRPLWEE ESNAKGGVWK MKVPKDSTST 

       130        140        150        160        170        180 
VWKELLLATI GEQFTDCAAA DDEIIGVSVS VRDREDVVQV WNVNASLVGE ATVLEKIHQL 

       190        200 
LPHIAFKAVF YKPHEEHHAF EGGRGKH 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of mammalian eIF4E-family members."
Joshi B., Cameron A., Jagus R.
Eur. J. Biochem. 271:2189-2203(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH EIF4G1.
Strain: Czech II.
Tissue: Lung tumor.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY628329 mRNA. Translation: AAT45741.1.
AK005054 mRNA. Translation: BAB23780.1.
AK007268 mRNA. Translation: BAB24928.1.
BC027014 mRNA. Translation: AAH27014.1.
RefSeqNP_080105.1. NM_025829.4.
UniGeneMm.32889.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B6UNMR-A1-207[»]
4B6VNMR-A1-207[»]
ProteinModelPortalQ9DBB5.
SMRQ9DBB5. Positions 16-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9DBB5. 1 interaction.
MINTMINT-4127798.

PTM databases

PhosphoSiteQ9DBB5.

2D gel databases

REPRODUCTION-2DPAGEQ9DBB5.

Proteomic databases

PaxDbQ9DBB5.
PRIDEQ9DBB5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032151; ENSMUSP00000032151; ENSMUSG00000093661.
GeneID66892.
KEGGmmu:66892.
UCSCuc009dbr.1. mouse.

Organism-specific databases

CTD317649.
MGIMGI:1914142. Eif4e3.

Phylogenomic databases

eggNOGCOG5053.
GeneTreeENSGT00520000055549.
HOGENOMHOG000059588.
HOVERGENHBG107990.
InParanoidQ9DBB5.
OMADVVQIWN.
OrthoDBEOG7X6M1B.
PhylomeDBQ9DBB5.

Gene expression databases

BgeeQ9DBB5.
GenevestigatorQ9DBB5.

Family and domain databases

Gene3D3.30.760.10. 1 hit.
InterProIPR023398. TIF_eIF4e-like_dom.
IPR001040. TIF_eIF_4E.
[Graphical view]
PANTHERPTHR11960. PTHR11960. 1 hit.
PfamPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMSSF55418. SSF55418. 1 hit.
ProtoNetSearch...

Other

NextBio322945.
PROQ9DBB5.
SOURCESearch...

Entry information

Entry nameIF4E3_MOUSE
AccessionPrimary (citable) accession number: Q9DBB5
Secondary accession number(s): Q9D983
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot