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Protein

Eukaryotic translation initiation factor 4E type 3

Gene

Eif4e3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1169408. ISG15 antiviral mechanism.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 3
Short name:
eIF-4E type 3
Short name:
eIF-4E3
Short name:
eIF4E type 3
Short name:
eIF4E-3
Gene namesi
Name:Eif4e3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914142. Eif4e3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876981 – 207Eukaryotic translation initiation factor 4E type 3Add BLAST207

Proteomic databases

EPDiQ9DBB5.
MaxQBiQ9DBB5.
PaxDbiQ9DBB5.
PeptideAtlasiQ9DBB5.
PRIDEiQ9DBB5.

2D gel databases

REPRODUCTION-2DPAGEQ9DBB5.

PTM databases

PhosphoSitePlusiQ9DBB5.

Expressioni

Tissue specificityi

Only expressed in heart, skeletal muscle, lung and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000093661.
GenevisibleiQ9DBB5. MM.

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9DBB5. 1 interactor.
MINTiMINT-4127798.
STRINGi10090.ENSMUSP00000032151.

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 15Combined sources4
Turni17 – 20Combined sources4
Beta strandi24 – 27Combined sources4
Beta strandi31 – 41Combined sources11
Helixi49 – 55Combined sources7
Beta strandi57 – 64Combined sources8
Helixi65 – 74Combined sources10
Helixi78 – 80Combined sources3
Beta strandi83 – 93Combined sources11
Helixi97 – 99Combined sources3
Turni101 – 105Combined sources5
Beta strandi107 – 113Combined sources7
Turni115 – 117Combined sources3
Helixi118 – 129Combined sources12
Turni130 – 132Combined sources3
Helixi134 – 137Combined sources4
Beta strandi144 – 151Combined sources8
Beta strandi156 – 163Combined sources8
Helixi165 – 167Combined sources3
Turni168 – 170Combined sources3
Helixi173 – 180Combined sources8
Beta strandi187 – 193Combined sources7
Turni194 – 196Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B6UNMR-A1-207[»]
4B6VNMR-A1-207[»]
ProteinModelPortaliQ9DBB5.
SMRiQ9DBB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 997-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni152 – 1577-methylguanosine-containing mRNA cap bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHHQ. Eukaryota.
COG5053. LUCA.
GeneTreeiENSGT00520000055549.
HOGENOMiHOG000059588.
HOVERGENiHBG107990.
InParanoidiQ9DBB5.
OMAiGTWRLKC.
OrthoDBiEOG091G0ISE.
PhylomeDBiQ9DBB5.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DBB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPPAAAPP GANEPLDKAL SALPPEPGGV PLHSPWTFWL DRSLPGATAA
60 70 80 90 100
ECASNLKKIY TVQTVQIFWS VYNNIPPVTS LPLRCSYHLM RGERRPLWEE
110 120 130 140 150
ESNAKGGVWK MKVPKDSTST VWKELLLATI GEQFTDCAAA DDEIIGVSVS
160 170 180 190 200
VRDREDVVQV WNVNASLVGE ATVLEKIHQL LPHIAFKAVF YKPHEEHHAF

EGGRGKH
Length:207
Mass (Da):22,836
Last modified:June 1, 2001 - v1
Checksum:i0263A317BFD0A4C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122W → G in BAB24928 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY628329 mRNA. Translation: AAT45741.1.
AK005054 mRNA. Translation: BAB23780.1.
AK007268 mRNA. Translation: BAB24928.1.
BC027014 mRNA. Translation: AAH27014.1.
CCDSiCCDS20386.1.
RefSeqiNP_080105.1. NM_025829.4.
UniGeneiMm.32889.

Genome annotation databases

EnsembliENSMUST00000032151; ENSMUSP00000032151; ENSMUSG00000093661.
GeneIDi66892.
KEGGimmu:66892.
UCSCiuc009dbr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY628329 mRNA. Translation: AAT45741.1.
AK005054 mRNA. Translation: BAB23780.1.
AK007268 mRNA. Translation: BAB24928.1.
BC027014 mRNA. Translation: AAH27014.1.
CCDSiCCDS20386.1.
RefSeqiNP_080105.1. NM_025829.4.
UniGeneiMm.32889.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B6UNMR-A1-207[»]
4B6VNMR-A1-207[»]
ProteinModelPortaliQ9DBB5.
SMRiQ9DBB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBB5. 1 interactor.
MINTiMINT-4127798.
STRINGi10090.ENSMUSP00000032151.

PTM databases

PhosphoSitePlusiQ9DBB5.

2D gel databases

REPRODUCTION-2DPAGEQ9DBB5.

Proteomic databases

EPDiQ9DBB5.
MaxQBiQ9DBB5.
PaxDbiQ9DBB5.
PeptideAtlasiQ9DBB5.
PRIDEiQ9DBB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032151; ENSMUSP00000032151; ENSMUSG00000093661.
GeneIDi66892.
KEGGimmu:66892.
UCSCiuc009dbr.1. mouse.

Organism-specific databases

CTDi317649.
MGIiMGI:1914142. Eif4e3.

Phylogenomic databases

eggNOGiENOG410IHHQ. Eukaryota.
COG5053. LUCA.
GeneTreeiENSGT00520000055549.
HOGENOMiHOG000059588.
HOVERGENiHBG107990.
InParanoidiQ9DBB5.
OMAiGTWRLKC.
OrthoDBiEOG091G0ISE.
PhylomeDBiQ9DBB5.

Enzyme and pathway databases

ReactomeiR-MMU-1169408. ISG15 antiviral mechanism.

Miscellaneous databases

PROiQ9DBB5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000093661.
GenevisibleiQ9DBB5. MM.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF4E3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBB5
Secondary accession number(s): Q9D983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.