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Q9DBB5

- IF4E3_MOUSE

UniProt

Q9DBB5 - IF4E3_MOUSE

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Protein
Eukaryotic translation initiation factor 4E type 3
Gene
Eif4e3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.1 Publication

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_198533. ISG15 antiviral mechanism.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 3
Short name:
eIF-4E type 3
Short name:
eIF-4E3
Short name:
eIF4E type 3
Short name:
eIF4E-3
Gene namesi
Name:Eif4e3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1914142. Eif4e3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. mRNA cap binding complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Eukaryotic translation initiation factor 4E type 3
PRO_0000287698Add
BLAST

Proteomic databases

MaxQBiQ9DBB5.
PaxDbiQ9DBB5.
PRIDEiQ9DBB5.

2D gel databases

REPRODUCTION-2DPAGEQ9DBB5.

PTM databases

PhosphoSiteiQ9DBB5.

Expressioni

Tissue specificityi

Only expressed in heart, skeletal muscle, lung and spleen.1 Publication

Gene expression databases

BgeeiQ9DBB5.
GenevestigatoriQ9DBB5.

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G By similarity. EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3.1 Publication

Protein-protein interaction databases

IntActiQ9DBB5. 1 interaction.
MINTiMINT-4127798.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 154
Turni17 – 204
Beta strandi24 – 274
Beta strandi31 – 4111
Helixi49 – 557
Beta strandi57 – 648
Helixi65 – 7410
Helixi78 – 803
Beta strandi83 – 9311
Helixi97 – 993
Turni101 – 1055
Beta strandi107 – 1137
Turni115 – 1173
Helixi118 – 12912
Turni130 – 1323
Helixi134 – 1374
Beta strandi144 – 1518
Beta strandi156 – 1638
Helixi165 – 1673
Turni168 – 1703
Helixi173 – 1808
Beta strandi187 – 1937
Turni194 – 1963

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B6UNMR-A1-207[»]
4B6VNMR-A1-207[»]
ProteinModelPortaliQ9DBB5.
SMRiQ9DBB5. Positions 16-207.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 9927-methylguanosine-containing mRNA cap binding By similarity
Regioni152 – 15767-methylguanosine-containing mRNA cap binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5053.
GeneTreeiENSGT00520000055549.
HOGENOMiHOG000059588.
HOVERGENiHBG107990.
InParanoidiQ9DBB5.
OMAiRVYNNIP.
OrthoDBiEOG7X6M1B.
PhylomeDBiQ9DBB5.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like_dom.
IPR001040. TIF_eIF_4E.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DBB5-1 [UniParc]FASTAAdd to Basket

« Hide

MALPPAAAPP GANEPLDKAL SALPPEPGGV PLHSPWTFWL DRSLPGATAA    50
ECASNLKKIY TVQTVQIFWS VYNNIPPVTS LPLRCSYHLM RGERRPLWEE 100
ESNAKGGVWK MKVPKDSTST VWKELLLATI GEQFTDCAAA DDEIIGVSVS 150
VRDREDVVQV WNVNASLVGE ATVLEKIHQL LPHIAFKAVF YKPHEEHHAF 200
EGGRGKH 207
Length:207
Mass (Da):22,836
Last modified:June 1, 2001 - v1
Checksum:i0263A317BFD0A4C1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221W → G in BAB24928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY628329 mRNA. Translation: AAT45741.1.
AK005054 mRNA. Translation: BAB23780.1.
AK007268 mRNA. Translation: BAB24928.1.
BC027014 mRNA. Translation: AAH27014.1.
CCDSiCCDS20386.1.
RefSeqiNP_080105.1. NM_025829.4.
UniGeneiMm.32889.

Genome annotation databases

EnsembliENSMUST00000032151; ENSMUSP00000032151; ENSMUSG00000093661.
GeneIDi66892.
KEGGimmu:66892.
UCSCiuc009dbr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY628329 mRNA. Translation: AAT45741.1 .
AK005054 mRNA. Translation: BAB23780.1 .
AK007268 mRNA. Translation: BAB24928.1 .
BC027014 mRNA. Translation: AAH27014.1 .
CCDSi CCDS20386.1.
RefSeqi NP_080105.1. NM_025829.4.
UniGenei Mm.32889.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B6U NMR - A 1-207 [» ]
4B6V NMR - A 1-207 [» ]
ProteinModelPortali Q9DBB5.
SMRi Q9DBB5. Positions 16-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DBB5. 1 interaction.
MINTi MINT-4127798.

PTM databases

PhosphoSitei Q9DBB5.

2D gel databases

REPRODUCTION-2DPAGE Q9DBB5.

Proteomic databases

MaxQBi Q9DBB5.
PaxDbi Q9DBB5.
PRIDEi Q9DBB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032151 ; ENSMUSP00000032151 ; ENSMUSG00000093661 .
GeneIDi 66892.
KEGGi mmu:66892.
UCSCi uc009dbr.1. mouse.

Organism-specific databases

CTDi 317649.
MGIi MGI:1914142. Eif4e3.

Phylogenomic databases

eggNOGi COG5053.
GeneTreei ENSGT00520000055549.
HOGENOMi HOG000059588.
HOVERGENi HBG107990.
InParanoidi Q9DBB5.
OMAi RVYNNIP.
OrthoDBi EOG7X6M1B.
PhylomeDBi Q9DBB5.

Enzyme and pathway databases

Reactomei REACT_198533. ISG15 antiviral mechanism.

Miscellaneous databases

NextBioi 322945.
PROi Q9DBB5.
SOURCEi Search...

Gene expression databases

Bgeei Q9DBB5.
Genevestigatori Q9DBB5.

Family and domain databases

Gene3Di 3.30.760.10. 1 hit.
InterProi IPR023398. TIF_eIF4e-like_dom.
IPR001040. TIF_eIF_4E.
[Graphical view ]
PANTHERi PTHR11960. PTHR11960. 1 hit.
Pfami PF01652. IF4E. 1 hit.
[Graphical view ]
SUPFAMi SSF55418. SSF55418. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of mammalian eIF4E-family members."
    Joshi B., Cameron A., Jagus R.
    Eur. J. Biochem. 271:2189-2203(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH EIF4G1.
    Strain: Czech II.
    Tissue: Lung tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiIF4E3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBB5
Secondary accession number(s): Q9D983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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