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Q9DBB1

- DUS6_MOUSE

UniProt

Q9DBB1 - DUS6_MOUSE

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Protein

Dual specificity protein phosphatase 6

Gene

Dusp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inactivates MAP kinases. Has a specificity for the ERK family (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei293 – 2931Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: Ensembl
  2. phosphoprotein phosphatase activity Source: MGI
  3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  4. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell differentiation Source: Ensembl
  2. dorsal/ventral pattern formation Source: RefGenome
  3. negative regulation of ERK1 and ERK2 cascade Source: RefGenome
  4. negative regulation of protein phosphorylation Source: MGI
  5. positive regulation of apoptotic process Source: RefGenome
  6. protein dephosphorylation Source: MGI
  7. regulation of endodermal cell fate specification Source: RefGenome
  8. regulation of fibroblast growth factor receptor signaling pathway Source: RefGenome
  9. regulation of heart growth Source: MGI
  10. response to drug Source: Ensembl
  11. response to growth factor Source: Ensembl
  12. response to nitrosative stress Source: Ensembl
  13. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_210064. ERKs are inactivated.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 6 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 3
Short name:
MAP kinase phosphatase 3
Short name:
MKP-3
Gene namesi
Name:Dusp6
Synonyms:Mkp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1914853. Dusp6.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Dual specificity protein phosphatase 6PRO_0000094805Add
BLAST

Proteomic databases

MaxQBiQ9DBB1.
PaxDbiQ9DBB1.
PRIDEiQ9DBB1.

PTM databases

PhosphoSiteiQ9DBB1.

Expressioni

Gene expression databases

BgeeiQ9DBB1.
CleanExiMM_DUSP6.
GenevestigatoriQ9DBB1.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk1P630852EBI-7812384,EBI-397697

Protein-protein interaction databases

BioGridi212304. 1 interaction.
IntActiQ9DBB1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9DBB1.
SMRiQ9DBB1. Positions 1-154, 205-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 148119RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini206 – 381176Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118902.
HOVERGENiHBG007347.
InParanoidiQ9DBB1.
KOiK04459.
OMAiSEWNENT.
OrthoDBiEOG793B7W.
PhylomeDBiQ9DBB1.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDTLRPVPF ASEMAICKTV SWLNEQLELG NERLLLMDCR PQELYESSHI
60 70 80 90 100
ESAINVAIPG IMLRRLQKGN LPVRALFTRC EDRDRFTRRC GTDTVVLYDE
110 120 130 140 150
NSSDWNENTG GESVLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFALHCETN
160 170 180 190 200
LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS
210 220 230 240 250
NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA
260 270 280 290 300
GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS
310 320 330 340 350
VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS
360 370 380
SPCDNRVPTP QLYFTTPSNQ NVYQVDSLQS T
Length:381
Mass (Da):42,408
Last modified:June 1, 2001 - v1
Checksum:i7EA1FB154F4AD2DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221W → G in BAB26093. (PubMed:16141072)Curated
Sequence conflicti34 – 341L → F in BAB26093. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005062 mRNA. Translation: BAB23786.1.
AK009131 mRNA. Translation: BAB26093.1.
AK088468 mRNA. Translation: BAC40372.1.
AK088665 mRNA. Translation: BAC40489.1.
AK159146 mRNA. Translation: BAE34853.1.
AK159502 mRNA. Translation: BAE35135.1.
AK159900 mRNA. Translation: BAE35465.1.
BC003869 mRNA. Translation: AAH03869.1.
CCDSiCCDS24147.1.
RefSeqiNP_080544.1. NM_026268.3.
UniGeneiMm.1791.

Genome annotation databases

EnsembliENSMUST00000020118; ENSMUSP00000020118; ENSMUSG00000019960.
GeneIDi67603.
KEGGimmu:67603.
UCSCiuc007gxk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005062 mRNA. Translation: BAB23786.1 .
AK009131 mRNA. Translation: BAB26093.1 .
AK088468 mRNA. Translation: BAC40372.1 .
AK088665 mRNA. Translation: BAC40489.1 .
AK159146 mRNA. Translation: BAE34853.1 .
AK159502 mRNA. Translation: BAE35135.1 .
AK159900 mRNA. Translation: BAE35465.1 .
BC003869 mRNA. Translation: AAH03869.1 .
CCDSi CCDS24147.1.
RefSeqi NP_080544.1. NM_026268.3.
UniGenei Mm.1791.

3D structure databases

ProteinModelPortali Q9DBB1.
SMRi Q9DBB1. Positions 1-154, 205-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212304. 1 interaction.
IntActi Q9DBB1. 1 interaction.

PTM databases

PhosphoSitei Q9DBB1.

Proteomic databases

MaxQBi Q9DBB1.
PaxDbi Q9DBB1.
PRIDEi Q9DBB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020118 ; ENSMUSP00000020118 ; ENSMUSG00000019960 .
GeneIDi 67603.
KEGGi mmu:67603.
UCSCi uc007gxk.2. mouse.

Organism-specific databases

CTDi 1848.
MGIi MGI:1914853. Dusp6.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000118902.
HOVERGENi HBG007347.
InParanoidi Q9DBB1.
KOi K04459.
OMAi SEWNENT.
OrthoDBi EOG793B7W.
PhylomeDBi Q9DBB1.
TreeFami TF105122.

Enzyme and pathway databases

Reactomei REACT_210064. ERKs are inactivated.

Miscellaneous databases

ChiTaRSi Dusp6. mouse.
NextBioi 325017.
PROi Q9DBB1.
SOURCEi Search...

Gene expression databases

Bgeei Q9DBB1.
CleanExi MM_DUSP6.
Genevestigatori Q9DBB1.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Liver, Thymus and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDUS6_MOUSE
AccessioniPrimary (citable) accession number: Q9DBB1
Secondary accession number(s): Q542I5, Q9D7L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3