Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9DBA9 (TF2H1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor IIH subunit 1
Alternative name(s):
Basic transcription factor 2 62 kDa subunit
Short name=BTF2 p62
General transcription factor IIH polypeptide 1
TFIIH basal transcription factor complex p62 subunit
Gene names
Name:Gtf2h1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

Subunit structure

One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with PUF60 By similarity.

Subcellular location

Nucleus.

Sequence similarities

Contains 2 BSD domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547General transcription factor IIH subunit 1
PRO_0000119246

Regions

Domain99 – 15456BSD 1
Domain179 – 23153BSD 2

Amino acid modifications

Modified residue2391N6-acetyllysine Ref.3

Experimental info

Sequence conflict1371I → F in BAB23789. Ref.2
Sequence conflict2081E → G in BAB23789. Ref.2
Sequence conflict2811S → G in BAB23789. Ref.2
Sequence conflict5371T → A in BAB23789. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9DBA9 [UniParc].

Last modified October 18, 2001. Version 2.
Checksum: 0167316D11F87969

FASTA54761,851
        10         20         30         40         50         60 
MATSSEEVLL IVKKVRQKKQ DGALYLMAER IAWAPEGKDR FTISHMYADI KCQKISPEGK 

        70         80         90        100        110        120 
AKIQLQLVLH AGDTTNFHFS NESTAVKERD AVKDLLQQLL PKFKRKANKE LEEKNRMLQE 

       130        140        150        160        170        180 
DPVLFQLYKD LVVSQVISAE EFWANRLNVN ATDSSTSSHK QDVGISAAFL ADVRPQTDGC 

       190        200        210        220        230        240 
NGLRYNLTSD IIESIFRTYP AVKMKYAETV PHNMTEKEFW TRFFQSHYFH RDRLNTGSKD 

       250        260        270        280        290        300 
LFAECAKIDE KGLKTMVSLG VKNPMLDLTS LEDKPLDEGY SISSVPSTSN SKSIKENSNA 

       310        320        330        340        350        360 
AIIKRFNHHS AMVLAAGLRK QQAQNGQNGE PSSVDGNSGD TDCFQPAVKR AKLQESIEYE 

       370        380        390        400        410        420 
DLGNNNSVKT IALNLKKSDR YYHGPTPIQS LQYATSQDII NSFQSIRQEM EAYTPKLTQV 

       430        440        450        460        470        480 
LSSSAASSTI TALSPGGALM QGGTQQAVNQ MVPNDIQSEL KHLYVAVGEL LRHFWSCFPV 

       490        500        510        520        530        540 
NTPFLEEKVV KMKSNLERFQ VTKLCPFQEK IRRQYLSTNL VSHIEEMLQT AYNKLHTWQS 


RRLMKKT 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization and promoter characterization of the mouse and human genes encoding p62 subunit of the transcription/DNA repair factor TFIIH."
Perez C., Auriol J., Seroz T., Egly J.-M.
Gene 213:73-82(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Teratocarcinoma.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ002366 mRNA. Translation: CAA05340.1.
AK005065 mRNA. Translation: BAB23789.1.
CCDSCCDS21287.1.
RefSeqNP_001278004.1. NM_001291075.1.
NP_032212.3. NM_008186.4.
UniGeneMm.22700.

3D structure databases

ProteinModelPortalQ9DBA9.
SMRQ9DBA9. Positions 1-155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200111. 3 interactions.
IntActQ9DBA9. 1 interaction.
STRING10090.ENSMUSP00000103271.

PTM databases

PhosphoSiteQ9DBA9.

Proteomic databases

PaxDbQ9DBA9.
PRIDEQ9DBA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID14884.
KEGGmmu:14884.

Organism-specific databases

CTD2965.
MGIMGI:1277216. Gtf2h1.

Phylogenomic databases

eggNOGNOG315835.
HOGENOMHOG000006589.
HOVERGENHBG060375.
InParanoidQ9DBA9.
KOK03141.
PhylomeDBQ9DBA9.

Gene expression databases

CleanExMM_GTF2H1.
GenevestigatorQ9DBA9.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR005607. BSD.
IPR011993. PH_like_dom.
IPR027079. Tfb1/p62.
IPR013876. TFIIH_BTF_p62_N.
[Graphical view]
PANTHERPTHR12856. PTHR12856. 1 hit.
PfamPF03909. BSD. 2 hits.
PF08567. TFIIH_BTF_p62_N. 1 hit.
[Graphical view]
SMARTSM00751. BSD. 2 hits.
[Graphical view]
PROSITEPS50858. BSD. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGTF2H1. mouse.
NextBio287163.
PROQ9DBA9.
SOURCESearch...

Entry information

Entry nameTF2H1_MOUSE
AccessionPrimary (citable) accession number: Q9DBA9
Secondary accession number(s): O35637
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot