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Protein

Mediator of RNA polymerase II transcription subunit 29

Gene

Med29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 29
Alternative name(s):
Intersex-like protein
Mediator complex subunit 29
Gene namesi
Name:Med29
Synonyms:Ixl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914474 Med29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002880592 – 199Mediator of RNA polymerase II transcription subunit 29Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DB91
MaxQBiQ9DB91
PaxDbiQ9DB91
PeptideAtlasiQ9DB91
PRIDEiQ9DB91

PTM databases

iPTMnetiQ9DB91
PhosphoSitePlusiQ9DB91

Expressioni

Gene expression databases

BgeeiENSMUSG00000003444
CleanExiMM_MED29
GenevisibleiQ9DB91 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer (By similarity).By similarity

Protein-protein interaction databases

BioGridi212029, 1 interactor
DIPiDIP-60702N
IntActiQ9DB91, 4 interactors
MINTiQ9DB91
STRINGi10090.ENSMUSP00000003536

Structurei

3D structure databases

SMRiQ9DB91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 83Gln-richAdd BLAST55

Sequence similaritiesi

Belongs to the Mediator complex subunit 29 family.Curated

Phylogenomic databases

eggNOGiENOG410IXGN Eukaryota
ENOG4111K6Y LUCA
GeneTreeiENSGT00390000007540
HOGENOMiHOG000038041
HOVERGENiHBG060489
InParanoidiQ9DB91
KOiK15142
OMAiCAKDIHN
OrthoDBiEOG091G0S43
PhylomeDBiQ9DB91
TreeFamiTF326632

Family and domain databases

InterProiView protein in InterPro
IPR021018 Mediator_Med29_met
PfamiView protein in Pfam
PF11568 Med29, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DB91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQPQAAA VSSASGVSGP GSAGGPGPQQ QPQPTQLVGS AQSGLLQQQQ
60 70 80 90 100
QDFDPVQRYK MLIPQLKESL QTLMKVAAQN LIQNTNIDNG QKSSDAPLQR
110 120 130 140 150
FDKCLEEFYA LCDQLELCLR LAHECLSQSC DSAKHSPTLV PTATKPDAVQ
160 170 180 190
PDSLPYPQYL AVIKAQITCA KDIHTALLDC ANKVTGKTTA PSTGPGGSL
Length:199
Mass (Da):21,011
Last modified:June 1, 2001 - v1
Checksum:i60C50BE919D5A2C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005112 mRNA Translation: BAB23826.1
BC023192 mRNA Translation: AAH23192.1
BC083314 mRNA Translation: AAH83314.1
CCDSiCCDS21042.1
RefSeqiNP_080318.2, NM_026042.3
UniGeneiMm.41647

Genome annotation databases

EnsembliENSMUST00000003536; ENSMUSP00000003536; ENSMUSG00000003444
GeneIDi67224
KEGGimmu:67224
UCSCiuc009fyt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMED29_MOUSE
AccessioniPrimary (citable) accession number: Q9DB91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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