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Protein

Protein SMG9

Gene

Smg9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Nonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SMG9
Alternative name(s):
Protein smg-9 homolog
Gene namesi
Name:Smg9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919247. Smg9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 520519Protein SMG9PRO_0000289164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei32 – 321PhosphoserineCombined sources
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei451 – 4511PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by SMG1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DB90.
MaxQBiQ9DB90.
PaxDbiQ9DB90.
PeptideAtlasiQ9DB90.
PRIDEiQ9DB90.

PTM databases

iPTMnetiQ9DB90.
PhosphoSiteiQ9DB90.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002210.
CleanExiMM_1500002O20RIK.
ExpressionAtlasiQ9DB90. baseline and differential.
GenevisibleiQ9DB90. MM.

Interactioni

Subunit structurei

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002280.

Structurei

3D structure databases

ProteinModelPortaliQ9DB90.
SMRiQ9DB90. Positions 206-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi71 – 13363Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SMG9 family.Curated

Phylogenomic databases

eggNOGiKOG4181. Eukaryota.
ENOG410XSTF. LUCA.
GeneTreeiENSGT00390000003568.
HOGENOMiHOG000006915.
InParanoidiQ9DB90.
KOiK18735.
OMAiNSTKFEY.
OrthoDBiEOG091G0F37.
PhylomeDBiQ9DB90.
TreeFamiTF319763.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR019354. Smg8/Smg9.
[Graphical view]
PfamiPF10220. DUF2146. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DB90-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESGHSQPG LYGIERRRRW KEPGSSGPQN LSGPGGRERD YIAPWERERR
60 70 80 90 100
DGSEDPSTNV MQKTPIILSK PPAERSKQPP PSTAPAAPPA PAPLEKPIVL
110 120 130 140 150
MKPREEGKGP VAGTGASTPE GTAPPPPTAP APPKGEKEGQ RPTQPVYQIQ
160 170 180 190 200
NRGMGTAAPT AMDPVVGQAK LLPPERMKHS IKLVDDQMNW CDSAIEYLLD
210 220 230 240 250
QTDVLVVGVL GLQGTGKSMV MSLLSANTPE EDQRAYVFRA QSAEMKERGG
260 270 280 290 300
NQTSGIDFFI TQERIVFLDT QPILSPSILD HLINNDRKLP PEYNLPHTYV
310 320 330 340 350
EMQSLQIAAF LFTVCHVVIV VQDWFTDLSL YRFLQTAEMV KPSTPSPSHE
360 370 380 390 400
SSSSAGSDEG TEYYPHLVFL QNKARREDFC PRKLRQMHLM IDQLMAHSHL
410 420 430 440 450
RYKGTLSMLQ CNVFPGLPPD FLDAEVNLFL VPFMDSEAEN ENPPRAGPGS
460 470 480 490 500
SPLFSLLPGY RGHPSFQSLV SKLRSQVMSM ARPQLSHTIL TEKNWFHYAA
510 520
RIWDGVKKSS ALAEYSRLLA
Length:520
Mass (Da):57,621
Last modified:June 1, 2001 - v1
Checksum:i98947051F376BB34
GO
Isoform 2 (identifier: Q9DB90-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-520: Missing.

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):25,085
Checksum:i2A183328679D560F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti492 – 4921E → G in BAC30328 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei235 – 520286Missing in isoform 2. 1 PublicationVSP_025947Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005126 mRNA. Translation: BAB23829.1.
AK039368 mRNA. Translation: BAC30328.1.
AK141576 mRNA. Translation: BAE24745.1.
AK161454 mRNA. Translation: BAE36406.1.
AK169651 mRNA. Translation: BAE41275.1.
BC034211 mRNA. Translation: AAH34211.1.
CCDSiCCDS20949.1. [Q9DB90-1]
RefSeqiNP_082323.1. NM_028047.2. [Q9DB90-1]
XP_006540440.1. XM_006540377.1. [Q9DB90-1]
UniGeneiMm.150977.

Genome annotation databases

EnsembliENSMUST00000002280; ENSMUSP00000002280; ENSMUSG00000002210. [Q9DB90-1]
GeneIDi71997.
KEGGimmu:71997.
UCSCiuc009fpm.1. mouse. [Q9DB90-2]
uc009fpn.1. mouse. [Q9DB90-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005126 mRNA. Translation: BAB23829.1.
AK039368 mRNA. Translation: BAC30328.1.
AK141576 mRNA. Translation: BAE24745.1.
AK161454 mRNA. Translation: BAE36406.1.
AK169651 mRNA. Translation: BAE41275.1.
BC034211 mRNA. Translation: AAH34211.1.
CCDSiCCDS20949.1. [Q9DB90-1]
RefSeqiNP_082323.1. NM_028047.2. [Q9DB90-1]
XP_006540440.1. XM_006540377.1. [Q9DB90-1]
UniGeneiMm.150977.

3D structure databases

ProteinModelPortaliQ9DB90.
SMRiQ9DB90. Positions 206-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002280.

PTM databases

iPTMnetiQ9DB90.
PhosphoSiteiQ9DB90.

Proteomic databases

EPDiQ9DB90.
MaxQBiQ9DB90.
PaxDbiQ9DB90.
PeptideAtlasiQ9DB90.
PRIDEiQ9DB90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002280; ENSMUSP00000002280; ENSMUSG00000002210. [Q9DB90-1]
GeneIDi71997.
KEGGimmu:71997.
UCSCiuc009fpm.1. mouse. [Q9DB90-2]
uc009fpn.1. mouse. [Q9DB90-1]

Organism-specific databases

CTDi56006.
MGIiMGI:1919247. Smg9.

Phylogenomic databases

eggNOGiKOG4181. Eukaryota.
ENOG410XSTF. LUCA.
GeneTreeiENSGT00390000003568.
HOGENOMiHOG000006915.
InParanoidiQ9DB90.
KOiK18735.
OMAiNSTKFEY.
OrthoDBiEOG091G0F37.
PhylomeDBiQ9DB90.
TreeFamiTF319763.

Enzyme and pathway databases

ReactomeiR-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ9DB90.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002210.
CleanExiMM_1500002O20RIK.
ExpressionAtlasiQ9DB90. baseline and differential.
GenevisibleiQ9DB90. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR019354. Smg8/Smg9.
[Graphical view]
PfamiPF10220. DUF2146. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMG9_MOUSE
AccessioniPrimary (citable) accession number: Q9DB90
Secondary accession number(s): Q3TTB9, Q8BYJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.