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Protein

Prostamide/prostaglandin F synthase

Gene

Fam213b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of prostaglandin-ethanolamide H2 (prostamide H2) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H2 to prostaglandin F(2alpha).1 Publication

Catalytic activityi

Thioredoxin + prostaglandin H2 = thioredoxin disulfide + prostaglandin F(2-alpha).1 Publication

GO - Molecular functioni

  • antioxidant activity Source: GO_Central
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: UniProtKB
  • prostaglandin-F synthase activity Source: UniProtKB
  • thioredoxin peroxidase activity Source: Reactome

GO - Biological processi

  • prostaglandin biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism
LigandNADP

Enzyme and pathway databases

BRENDAi1.11.1.20 3474

Chemistry databases

SwissLipidsiSLP:000001101

Names & Taxonomyi

Protein namesi
Recommended name:
Prostamide/prostaglandin F synthase (EC:1.11.1.20)
Short name:
Prostamide/PG F synthase
Short name:
Prostamide/PGF synthase
Gene namesi
Name:Fam213b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913719 Fam213b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44C → S: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi47C → S: Decreased enzyme activity to retain 63% of wild type activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846381 – 201Prostamide/prostaglandin F synthaseAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DB60
PaxDbiQ9DB60
PeptideAtlasiQ9DB60
PRIDEiQ9DB60

PTM databases

iPTMnetiQ9DB60
PhosphoSitePlusiQ9DB60

Expressioni

Tissue specificityi

Mainly present in brain and spinal cord. In spinal cord, present in the superficial layer of the dorsal horn, in motor neurons of the ventral horn and in glia of the white matter of the spinal cord. In brain, expressed preferentially in the white matter bundles of the entire CNS of adult with less marked expression in neuronal cell bodies. Colocalizes with MBP in myelin sheaths but not in axons. Localizes to myelin sheaths (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000029059
CleanExiMM_2810405K02RIK
ExpressionAtlasiQ9DB60 baseline and differential
GenevisibleiQ9DB60 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030935

Structurei

3D structure databases

ProteinModelPortaliQ9DB60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4498 Eukaryota
ENOG410YFY9 LUCA
GeneTreeiENSGT00530000063724
HOVERGENiHBG106494
InParanoidiQ9DB60
KOiK15717
OMAiCRWIAQD
OrthoDBiEOG091G0WTG
PhylomeDBiQ9DB60
TreeFamiTF313804

Family and domain databases

InterProiView protein in InterPro
IPR032801 FAM213/AAED1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR28630 PTHR28630, 1 hit
PfamiView protein in Pfam
PF13911 AhpC-TSA_2, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DB60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVVDLGRVG ACVLKHAVTG EAVELRSLWQ EKACVVAGLR RFGCMVCRWI
60 70 80 90 100
AQDLSNLRSI LDQHDVRLVG VGPEALGLQE FLDGGYFSGE LYLDESKQIY
110 120 130 140 150
KELGFKRYNS LSILPAALGK PVRDVASKAK AVGIQGNLSG DLLQSGGLLV
160 170 180 190 200
VSKGGDKVLL HFIQKSPGDY VPQENILQAL GISAEVCSSK PPQCDEEVCG

R
Length:201
Mass (Da):21,670
Last modified:June 1, 2001 - v1
Checksum:i4F392EF111AC6B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005188 mRNA Translation: BAB23870.1
AL607032 Genomic DNA No translation available.
BC030453 mRNA Translation: AAH30453.1
CCDSiCCDS19016.1
RefSeqiNP_079858.2, NM_025582.3
UniGeneiMm.41868

Genome annotation databases

EnsembliENSMUST00000030935; ENSMUSP00000030935; ENSMUSG00000029059
GeneIDi66469
KEGGimmu:66469
UCSCiuc008wch.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPGFS_MOUSE
AccessioniPrimary (citable) accession number: Q9DB60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health