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Protein

AP-1 complex subunit sigma-2

Gene

Ap1s2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).By similarity

GO - Biological processi

  • adipose tissue development Source: MGI
  • fat cell differentiation Source: MGI
  • intracellular protein transport Source: InterPro
  • neuromuscular process controlling balance Source: MGI
  • synaptic vesicle recycling Source: MGI
  • vesicle-mediated transport Source: MGI
  • visual learning Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit sigma-2
Alternative name(s):
Adaptor protein complex AP-1 subunit sigma-1B
Adaptor-related protein complex 1 subunit sigma-1B
Clathrin assembly protein complex 1 sigma-1B small chain
Golgi adaptor HA1/AP1 adaptin sigma-1B subunit
Sigma 1B subunit of AP-1 clathrin
Sigma-adaptin 1B
Sigma1B-adaptin
Gene namesi
Name:Ap1s2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1889383 Ap1s2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938001 – 160AP-1 complex subunit sigma-2Add BLAST160

Proteomic databases

MaxQBiQ9DB50
PRIDEiQ9DB50

PTM databases

iPTMnetiQ9DB50
PhosphoSitePlusiQ9DB50

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000031367
ExpressionAtlasiQ9DB50 baseline and differential
GenevisibleiQ9DB50 MM

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9DB50, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9DB50
SMRiQ9DB50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000062839
HOGENOMiHOG000185227
HOVERGENiHBG050517
InParanoidiQ9DB50
KOiK12394
OMAiLFFVCGI
PhylomeDBiQ9DB50

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DB50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE
60 70 80 90 100
WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL
110 120 130 140 150
DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEDAKEAETP
160
RSVLEEIGLT
Length:160
Mass (Da):18,929
Last modified:June 1, 2001 - v1
Checksum:i31435A74AAF476E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005223 mRNA Translation: BAB23892.1
AK045558 mRNA Translation: BAC32418.1
AK047724 mRNA Translation: BAC33140.1
BX469932 Genomic DNA No translation available.
CCDSiCCDS72465.1
RefSeqiNP_001277307.1, NM_001290378.1
NP_001277308.1, NM_001290379.1
NP_081163.2, NM_026887.3
XP_011246071.1, XM_011247769.2
UniGeneiMm.426783

Genome annotation databases

EnsembliENSMUST00000069041; ENSMUSP00000066185; ENSMUSG00000031367
GeneIDi108012
KEGGimmu:108012
UCSCiuc009uuy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAP1S2_MOUSE
AccessioniPrimary (citable) accession number: Q9DB50
Secondary accession number(s): B1B0F4, Q543R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health