ID   ZN593_MOUSE             Reviewed;         134 AA.
AC   Q9DB42; Q3UZX2; Q99J54;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   27-MAR-2024, entry version 157.
DE   RecName: Full=Zinc finger protein 593;
DE   AltName: Full=Zinc finger protein T86;
GN   Name=Znf593; Synonyms=Zfp593;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum, and Pituitary;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver, Lung, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Involved in pre-60S ribosomal particles maturation by
CC       promoting the nuclear export of the 60S ribosome. Negatively modulates
CC       the DNA binding activity of Oct-2 and therefore its transcriptional
CC       regulatory activity. {ECO:0000250|UniProtKB:O00488}.
CC   -!- SUBUNIT: Associates with pre-60S ribosomal particles.
CC       {ECO:0000250|UniProtKB:O00488}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:O00488}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q08004}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:Q08004}.
CC   -!- DOMAIN: The protein is largely disordered, with the exception of the
CC       zinc finger domain. {ECO:0000250|UniProtKB:O00488}.
CC   -!- SIMILARITY: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH03465.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB23902.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK005247; BAB23902.1; ALT_INIT; mRNA.
DR   EMBL; AK133585; BAE21733.1; -; mRNA.
DR   EMBL; AL627314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC003465; AAH03465.1; ALT_INIT; mRNA.
DR   CCDS; CCDS51325.1; -.
DR   RefSeq; NP_077177.2; NM_024215.2.
DR   AlphaFoldDB; Q9DB42; -.
DR   SMR; Q9DB42; -.
DR   BioGRID; 212620; 3.
DR   IntAct; Q9DB42; 2.
DR   STRING; 10090.ENSMUSP00000030644; -.
DR   iPTMnet; Q9DB42; -.
DR   PhosphoSitePlus; Q9DB42; -.
DR   SwissPalm; Q9DB42; -.
DR   EPD; Q9DB42; -.
DR   jPOST; Q9DB42; -.
DR   MaxQB; Q9DB42; -.
DR   PaxDb; 10090-ENSMUSP00000030644; -.
DR   PeptideAtlas; Q9DB42; -.
DR   ProteomicsDB; 299591; -.
DR   Pumba; Q9DB42; -.
DR   Antibodypedia; 30564; 77 antibodies from 19 providers.
DR   DNASU; 68040; -.
DR   Ensembl; ENSMUST00000030644.8; ENSMUSP00000030644.8; ENSMUSG00000028840.11.
DR   GeneID; 68040; -.
DR   KEGG; mmu:68040; -.
DR   UCSC; uc008vej.1; mouse.
DR   AGR; MGI:1915290; -.
DR   CTD; 68040; -.
DR   MGI; MGI:1915290; Zfp593.
DR   VEuPathDB; HostDB:ENSMUSG00000028840; -.
DR   eggNOG; KOG3408; Eukaryota.
DR   GeneTree; ENSGT00390000004173; -.
DR   HOGENOM; CLU_117291_1_2_1; -.
DR   InParanoid; Q9DB42; -.
DR   OMA; MKDHFRS; -.
DR   OrthoDB; 230013at2759; -.
DR   PhylomeDB; Q9DB42; -.
DR   TreeFam; TF315114; -.
DR   BioGRID-ORCS; 68040; 7 hits in 77 CRISPR screens.
DR   PRO; PR:Q9DB42; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q9DB42; Protein.
DR   Bgee; ENSMUSG00000028840; Expressed in paneth cell and 228 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1990275; F:preribosome binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR022755; Znf_C2H2_jaz.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR46095; ZINC FINGER PROTEIN 593; 1.
DR   PANTHER; PTHR46095:SF1; ZINC FINGER PROTEIN 593; 1.
DR   Pfam; PF12171; zf-C2H2_jaz; 1.
DR   SMART; SM00451; ZnF_U1; 1.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
DR   Genevisible; Q9DB42; MM.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Ribosome biogenesis; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..134
FT                   /note="Zinc finger protein 593"
FT                   /id="PRO_0000047685"
FT   ZN_FING         61..85
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        47
FT                   /note="P -> R (in Ref. 3; AAH03465)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   134 AA;  15147 MW;  62D0A3C01FD3FB70 CRC64;
     MGRSRRTGAH RAHSLARQMK AKKRRPDLDE IHRELRPQGL PRPKPEPDAE PDPDLPGGGL
     HRCLACARYF IDSANLKTHF RSKDHKKRLK QLSVEPYSQE EAERAAGMGS YVQPQRLGVP
     TEVSTDIPEM DTST
//