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Q9DB42

- ZN593_MOUSE

UniProt

Q9DB42 - ZN593_MOUSE

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Protein

Zinc finger protein 593

Gene
Znf593, Zfp593
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri61 – 8525C2H2-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 593
Alternative name(s):
Zinc finger protein T86
Gene namesi
Name:Znf593
Synonyms:Zfp593
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1915290. Zfp593.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Zinc finger protein 593PRO_0000047685Add
BLAST

Proteomic databases

PaxDbiQ9DB42.
PRIDEiQ9DB42.

PTM databases

PhosphoSiteiQ9DB42.

Expressioni

Gene expression databases

BgeeiQ9DB42.
CleanExiMM_ZFP593.
GenevestigatoriQ9DB42.

Interactioni

Protein-protein interaction databases

BioGridi212620. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9DB42.
SMRiQ9DB42. Positions 46-112.

Family & Domainsi

Domaini

The protein is largely disordered, with the exception of the zinc finger domain By similarity.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG301714.
GeneTreeiENSGT00390000004173.
HOGENOMiHOG000216641.
HOVERGENiHBG058255.
InParanoidiQ3UZX2.
KOiK14821.
OMAiRTKDLDQ.
OrthoDBiEOG7KSXBJ.
PhylomeDBiQ9DB42.
TreeFamiTF315114.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DB42-1 [UniParc]FASTAAdd to Basket

« Hide

MGRSRRTGAH RAHSLARQMK AKKRRPDLDE IHRELRPQGL PRPKPEPDAE    50
PDPDLPGGGL HRCLACARYF IDSANLKTHF RSKDHKKRLK QLSVEPYSQE 100
EAERAAGMGS YVQPQRLGVP TEVSTDIPEM DTST 134
Length:134
Mass (Da):15,147
Last modified:July 28, 2009 - v2
Checksum:i62D0A3C01FD3FB70
GO

Sequence cautioni

The sequence AAH03465.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB23902.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471P → R in AAH03465. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005247 mRNA. Translation: BAB23902.1. Different initiation.
AK133585 mRNA. Translation: BAE21733.1.
AL627314 Genomic DNA. Translation: CAM21943.1.
BC003465 mRNA. Translation: AAH03465.1. Different initiation.
CCDSiCCDS51325.1.
RefSeqiNP_077177.2. NM_024215.2.
UniGeneiMm.300404.

Genome annotation databases

EnsembliENSMUST00000030644; ENSMUSP00000030644; ENSMUSG00000028840.
GeneIDi68040.
KEGGimmu:68040.
UCSCiuc008vej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005247 mRNA. Translation: BAB23902.1 . Different initiation.
AK133585 mRNA. Translation: BAE21733.1 .
AL627314 Genomic DNA. Translation: CAM21943.1 .
BC003465 mRNA. Translation: AAH03465.1 . Different initiation.
CCDSi CCDS51325.1.
RefSeqi NP_077177.2. NM_024215.2.
UniGenei Mm.300404.

3D structure databases

ProteinModelPortali Q9DB42.
SMRi Q9DB42. Positions 46-112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212620. 2 interactions.

PTM databases

PhosphoSitei Q9DB42.

Proteomic databases

PaxDbi Q9DB42.
PRIDEi Q9DB42.

Protocols and materials databases

DNASUi 68040.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030644 ; ENSMUSP00000030644 ; ENSMUSG00000028840 .
GeneIDi 68040.
KEGGi mmu:68040.
UCSCi uc008vej.1. mouse.

Organism-specific databases

CTDi 68040.
MGIi MGI:1915290. Zfp593.

Phylogenomic databases

eggNOGi NOG301714.
GeneTreei ENSGT00390000004173.
HOGENOMi HOG000216641.
HOVERGENi HBG058255.
InParanoidi Q3UZX2.
KOi K14821.
OMAi RTKDLDQ.
OrthoDBi EOG7KSXBJ.
PhylomeDBi Q9DB42.
TreeFami TF315114.

Miscellaneous databases

NextBioi 326280.
PROi Q9DB42.
SOURCEi Search...

Gene expression databases

Bgeei Q9DB42.
CleanExi MM_ZFP593.
Genevestigatori Q9DB42.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
[Graphical view ]
Pfami PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Pituitary.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiZN593_MOUSE
AccessioniPrimary (citable) accession number: Q9DB42
Secondary accession number(s): Q3UZX2, Q99J54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 28, 2009
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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