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Protein

Zinc finger protein 593

Gene

Znf593

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri61 – 8525C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 593
Alternative name(s):
Zinc finger protein T86
Gene namesi
Name:Znf593
Synonyms:Zfp593
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915290. Zfp593.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Zinc finger protein 593PRO_0000047685Add
BLAST

Proteomic databases

MaxQBiQ9DB42.
PaxDbiQ9DB42.
PRIDEiQ9DB42.

PTM databases

PhosphoSiteiQ9DB42.

Expressioni

Gene expression databases

BgeeiQ9DB42.
CleanExiMM_ZFP593.
GenevisibleiQ9DB42. MM.

Interactioni

Protein-protein interaction databases

BioGridi212620. 2 interactions.
STRINGi10090.ENSMUSP00000030644.

Structurei

3D structure databases

ProteinModelPortaliQ9DB42.
SMRiQ9DB42. Positions 46-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The protein is largely disordered, with the exception of the zinc finger domain.By similarity

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri61 – 8525C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG301714.
GeneTreeiENSGT00390000004173.
HOGENOMiHOG000216641.
HOVERGENiHBG058255.
InParanoidiQ9DB42.
KOiK14821.
OMAiWKTKRRT.
OrthoDBiEOG7KSXBJ.
PhylomeDBiQ9DB42.
TreeFamiTF315114.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DB42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRSRRTGAH RAHSLARQMK AKKRRPDLDE IHRELRPQGL PRPKPEPDAE
60 70 80 90 100
PDPDLPGGGL HRCLACARYF IDSANLKTHF RSKDHKKRLK QLSVEPYSQE
110 120 130
EAERAAGMGS YVQPQRLGVP TEVSTDIPEM DTST
Length:134
Mass (Da):15,147
Last modified:July 28, 2009 - v2
Checksum:i62D0A3C01FD3FB70
GO

Sequence cautioni

The sequence AAH03465.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB23902.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471P → R in AAH03465 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005247 mRNA. Translation: BAB23902.1. Different initiation.
AK133585 mRNA. Translation: BAE21733.1.
AL627314 Genomic DNA. Translation: CAM21943.1.
BC003465 mRNA. Translation: AAH03465.1. Different initiation.
CCDSiCCDS51325.1.
RefSeqiNP_077177.2. NM_024215.2.
UniGeneiMm.300404.

Genome annotation databases

EnsembliENSMUST00000030644; ENSMUSP00000030644; ENSMUSG00000028840.
GeneIDi68040.
KEGGimmu:68040.
UCSCiuc008vej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005247 mRNA. Translation: BAB23902.1. Different initiation.
AK133585 mRNA. Translation: BAE21733.1.
AL627314 Genomic DNA. Translation: CAM21943.1.
BC003465 mRNA. Translation: AAH03465.1. Different initiation.
CCDSiCCDS51325.1.
RefSeqiNP_077177.2. NM_024215.2.
UniGeneiMm.300404.

3D structure databases

ProteinModelPortaliQ9DB42.
SMRiQ9DB42. Positions 46-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212620. 2 interactions.
STRINGi10090.ENSMUSP00000030644.

PTM databases

PhosphoSiteiQ9DB42.

Proteomic databases

MaxQBiQ9DB42.
PaxDbiQ9DB42.
PRIDEiQ9DB42.

Protocols and materials databases

DNASUi68040.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030644; ENSMUSP00000030644; ENSMUSG00000028840.
GeneIDi68040.
KEGGimmu:68040.
UCSCiuc008vej.1. mouse.

Organism-specific databases

CTDi68040.
MGIiMGI:1915290. Zfp593.

Phylogenomic databases

eggNOGiNOG301714.
GeneTreeiENSGT00390000004173.
HOGENOMiHOG000216641.
HOVERGENiHBG058255.
InParanoidiQ9DB42.
KOiK14821.
OMAiWKTKRRT.
OrthoDBiEOG7KSXBJ.
PhylomeDBiQ9DB42.
TreeFamiTF315114.

Miscellaneous databases

NextBioi326280.
PROiQ9DB42.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DB42.
CleanExiMM_ZFP593.
GenevisibleiQ9DB42. MM.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Pituitary.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiZN593_MOUSE
AccessioniPrimary (citable) accession number: Q9DB42
Secondary accession number(s): Q3UZX2, Q99J54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 28, 2009
Last modified: June 24, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.