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Q9DB42

- ZN593_MOUSE

UniProt

Q9DB42 - ZN593_MOUSE

Protein

Zinc finger protein 593

Gene

Znf593

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri61 – 8525C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 593
    Alternative name(s):
    Zinc finger protein T86
    Gene namesi
    Name:Znf593
    Synonyms:Zfp593
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1915290. Zfp593.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134Zinc finger protein 593PRO_0000047685Add
    BLAST

    Proteomic databases

    PaxDbiQ9DB42.
    PRIDEiQ9DB42.

    PTM databases

    PhosphoSiteiQ9DB42.

    Expressioni

    Gene expression databases

    BgeeiQ9DB42.
    CleanExiMM_ZFP593.
    GenevestigatoriQ9DB42.

    Interactioni

    Protein-protein interaction databases

    BioGridi212620. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DB42.
    SMRiQ9DB42. Positions 46-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The protein is largely disordered, with the exception of the zinc finger domain.By similarity

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri61 – 8525C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG301714.
    GeneTreeiENSGT00390000004173.
    HOGENOMiHOG000216641.
    HOVERGENiHBG058255.
    InParanoidiQ3UZX2.
    KOiK14821.
    OMAiRTKDLDQ.
    OrthoDBiEOG7KSXBJ.
    PhylomeDBiQ9DB42.
    TreeFamiTF315114.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    [Graphical view]
    PfamiPF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DB42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRSRRTGAH RAHSLARQMK AKKRRPDLDE IHRELRPQGL PRPKPEPDAE    50
    PDPDLPGGGL HRCLACARYF IDSANLKTHF RSKDHKKRLK QLSVEPYSQE 100
    EAERAAGMGS YVQPQRLGVP TEVSTDIPEM DTST 134
    Length:134
    Mass (Da):15,147
    Last modified:July 28, 2009 - v2
    Checksum:i62D0A3C01FD3FB70
    GO

    Sequence cautioni

    The sequence AAH03465.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB23902.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471P → R in AAH03465. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005247 mRNA. Translation: BAB23902.1. Different initiation.
    AK133585 mRNA. Translation: BAE21733.1.
    AL627314 Genomic DNA. Translation: CAM21943.1.
    BC003465 mRNA. Translation: AAH03465.1. Different initiation.
    CCDSiCCDS51325.1.
    RefSeqiNP_077177.2. NM_024215.2.
    UniGeneiMm.300404.

    Genome annotation databases

    EnsembliENSMUST00000030644; ENSMUSP00000030644; ENSMUSG00000028840.
    GeneIDi68040.
    KEGGimmu:68040.
    UCSCiuc008vej.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005247 mRNA. Translation: BAB23902.1 . Different initiation.
    AK133585 mRNA. Translation: BAE21733.1 .
    AL627314 Genomic DNA. Translation: CAM21943.1 .
    BC003465 mRNA. Translation: AAH03465.1 . Different initiation.
    CCDSi CCDS51325.1.
    RefSeqi NP_077177.2. NM_024215.2.
    UniGenei Mm.300404.

    3D structure databases

    ProteinModelPortali Q9DB42.
    SMRi Q9DB42. Positions 46-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212620. 2 interactions.

    PTM databases

    PhosphoSitei Q9DB42.

    Proteomic databases

    PaxDbi Q9DB42.
    PRIDEi Q9DB42.

    Protocols and materials databases

    DNASUi 68040.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030644 ; ENSMUSP00000030644 ; ENSMUSG00000028840 .
    GeneIDi 68040.
    KEGGi mmu:68040.
    UCSCi uc008vej.1. mouse.

    Organism-specific databases

    CTDi 68040.
    MGIi MGI:1915290. Zfp593.

    Phylogenomic databases

    eggNOGi NOG301714.
    GeneTreei ENSGT00390000004173.
    HOGENOMi HOG000216641.
    HOVERGENi HBG058255.
    InParanoidi Q3UZX2.
    KOi K14821.
    OMAi RTKDLDQ.
    OrthoDBi EOG7KSXBJ.
    PhylomeDBi Q9DB42.
    TreeFami TF315114.

    Miscellaneous databases

    NextBioi 326280.
    PROi Q9DB42.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DB42.
    CleanExi MM_ZFP593.
    Genevestigatori Q9DB42.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    [Graphical view ]
    Pfami PF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Pituitary.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiZN593_MOUSE
    AccessioniPrimary (citable) accession number: Q9DB42
    Secondary accession number(s): Q3UZX2, Q99J54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3