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Protein

Mitochondrial glutamate carrier 2

Gene

Slc25a18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-428643 Organic anion transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 2
Short name:
GC-2
Alternative name(s):
Glutamate/H(+) symporter 2
Solute carrier family 25 member 18
Gene namesi
Name:Slc25a18
Synonyms:Gc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919053 Slc25a18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei110 – 128Helical; Name=3Sequence analysisAdd BLAST19
Transmembranei190 – 210Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906221 – 320Mitochondrial glutamate carrier 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DB41
PeptideAtlasiQ9DB41
PRIDEiQ9DB41

PTM databases

iPTMnetiQ9DB41
PhosphoSitePlusiQ9DB41

Expressioni

Gene expression databases

BgeeiENSMUSG00000004902
GenevisibleiQ9DB41 MM

Interactioni

Protein-protein interaction databases

IntActiQ9DB41, 1 interactor
STRINGi10090.ENSMUSP00000108302

Structurei

3D structure databases

ProteinModelPortaliQ9DB41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 97Solcar 1Add BLAST87
Repeati105 – 215Solcar 2Add BLAST111
Repeati224 – 313Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0750 Eukaryota
ENOG410Y240 LUCA
GeneTreeiENSGT00530000062944
HOGENOMiHOG000168308
HOVERGENiHBG039469
InParanoidiQ9DB41
KOiK15107
OMAiMTHQDLS
OrthoDBiEOG091G08GT
PhylomeDBiQ9DB41
TreeFamiTF313209

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DB41-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIACRMSSQD LSISAKLING GIAGLVGVTC VFPIDLAKTR LQNQQGKDVY
60 70 80 90 100
RGMTDCLMKT ARAEGFLGMY RGAAVNLTLV TPEKAIKLAA NDFLRQLLMQ
110 120 130 140 150
DGTQRNLKME MLAGCGAGIC QVVITCPMEM LKIQLQDAGR LAVCHQASAS
160 170 180 190 200
ATPTSRPYST GSTSTHRRPS ATLIARELLR TQGLSGLYRG LGATLLRDIP
210 220 230 240 250
FSIIYFPLFA NLNQLGVSEL TGKASFTHSF VAGCTAGSVA AVAVTPLDVL
260 270 280 290 300
KTRIQTLKKG LGEDTYSGVT DCARKLWTQE GPAAFMKGAG CRALVIAPLF
310 320
GIAQGVYFIG IGERILKCFE
Length:320
Mass (Da):34,166
Last modified:April 8, 2008 - v4
Checksum:i1FC0AD760C44E6FE
GO
Isoform 2 (identifier: Q9DB41-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MIACRMSSQDLSISAKL → TPSSCRTKI

Note: Incomplete sequence.
Show »
Length:312
Mass (Da):33,304
Checksum:i4F01B4FB04F68439
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0222621 – 17MIACR…ISAKL → TPSSCRTKI in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116828 mRNA Translation: AAI16829.2
BC137603 mRNA Translation: AAI37604.1
AK005250 mRNA No translation available.
CCDSiCCDS39614.1 [Q9DB41-1]
RefSeqiNP_001074517.1, NM_001081048.2 [Q9DB41-1]
XP_006506712.1, XM_006506649.3 [Q9DB41-1]
XP_006506713.1, XM_006506650.3 [Q9DB41-1]
UniGeneiMm.425340

Genome annotation databases

EnsembliENSMUST00000112682; ENSMUSP00000108302; ENSMUSG00000004902 [Q9DB41-1]
GeneIDi71803
KEGGimmu:71803
UCSCiuc009dnq.1 mouse [Q9DB41-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGHC2_MOUSE
AccessioniPrimary (citable) accession number: Q9DB41
Secondary accession number(s): B2RPU3, Q14AI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 128 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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