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Protein

Zinc finger protein 580

Gene

Znf580

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O2-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processChemotaxis, Inflammatory response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 580
Gene namesi
Name:Znf580
Synonyms:Zfp580
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916242. Zfp580.

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalized with SMAD2 in the nucleus.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476721 – 172Zinc finger protein 580Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9DB38.
PaxDbiQ9DB38.
PRIDEiQ9DB38.

PTM databases

iPTMnetiQ9DB38.
PhosphoSitePlusiQ9DB38.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055633.
CleanExiMM_ZFP580.
ExpressionAtlasiQ9DB38. baseline and differential.
GenevisibleiQ9DB38. MM.

Interactioni

Subunit structurei

Interacts with SMAD2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065861.

Structurei

3D structure databases

ProteinModelPortaliQ9DB38.
SMRiQ9DB38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 88Pro-richAdd BLAST84

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139391.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9DB38.
OrthoDBiEOG091G0STS.
PhylomeDBiQ9DB38.
TreeFamiTF338348.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9DB38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLPPRPPH PRSSSPEVMD PPPPKTPPFP KAEGPSSTSS SVAGPRPPRL
60 70 80 90 100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE ATPGEPGPRK GYSCPECARV
110 120 130 140 150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH
160 170
TCPLCPRRFQ DAAELAQHVR LH
Length:172
Mass (Da):18,837
Last modified:June 1, 2001 - v1
Checksum:i885238D4EB35CCAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005257 mRNA. Translation: BAB23910.1.
BC066001 mRNA. Translation: AAH66001.1.
CCDSiCCDS51982.1.
RefSeqiNP_081176.1. NM_026900.1.
UniGeneiMm.41484.

Genome annotation databases

EnsembliENSMUST00000069324; ENSMUSP00000065861; ENSMUSG00000055633.
GeneIDi68992.
KEGGimmu:68992.
UCSCiuc009ezp.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiZN580_MOUSE
AccessioniPrimary (citable) accession number: Q9DB38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot