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Protein

Hydroxyacylglutathione hydrolase-like protein

Gene

Haghl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolase acting on ester bonds.Curated

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Zinc 1By similarity
Metal bindingi56 – 561Zinc 1By similarity
Metal bindingi58 – 581Zinc 2By similarity
Metal bindingi59 – 591Zinc 2By similarity
Metal bindingi110 – 1101Zinc 1By similarity
Metal bindingi134 – 1341Zinc 1By similarity
Metal bindingi134 – 1341Zinc 2By similarity
Metal bindingi173 – 1731Zinc 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacylglutathione hydrolase-like protein (EC:3.1.2.-)
Gene namesi
Name:Haghl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1919877. Haghl.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Hydroxyacylglutathione hydrolase-like proteinPRO_0000313602Add
BLAST

Proteomic databases

MaxQBiQ9DB32.
PaxDbiQ9DB32.
PRIDEiQ9DB32.

PTM databases

PhosphoSiteiQ9DB32.

Expressioni

Gene expression databases

BgeeiQ9DB32.
CleanExiMM_HAGHL.
ExpressionAtlasiQ9DB32. baseline and differential.
GenevisibleiQ9DB32. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9DB32. 1 interaction.
MINTiMINT-4128083.
STRINGi10090.ENSMUSP00000077091.

Structurei

3D structure databases

ProteinModelPortaliQ9DB32.
SMRiQ9DB32. Positions 1-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0813. Eukaryota.
COG0491. LUCA.
GeneTreeiENSGT00530000063033.
HOGENOMiHOG000058041.
HOVERGENiHBG001152.
InParanoidiQ9DB32.
KOiK01069.
OMAiHARGNAE.
OrthoDBiEOG789CBX.
PhylomeDBiQ9DB32.
TreeFamiTF105273.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01374. Glyoxalase_2.
InterProiIPR032282. HAGH_C.
IPR017782. Hydroxyacylglutathione_Hdrlase.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF16123. HAGH_C. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR03413. GSH_gloB. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DB32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVKVIPVLE DNYMYLIIEE HTREAVAIDV AVAERLLEIA GREGVSLTMV
60 70 80 90 100
LSTHHHWDHT RGNAELAHIL PGLAVLGADE RICALTRRLE HGEGLQFGAI
110 120 130 140 150
HVRCLLTPGH TSGHMSYFLW EDDCPDSPAL FSGDALSVAG CGWHLEDTAQ
160 170 180 190 200
QMYQSLAKTL GTLPPETKVF CGHEHTLSNL EFAQKVEPCN EHVQAKLSWA
210 220 230 240 250
QERDDEDIPT VPSTLGEELM YNPFLRVTED AVRAFTGQVA PAQVLEALCR
260 270 280
ERARFQPAVE PPQPQVRALL ALQWGLLSTH QKK
Length:283
Mass (Da):31,490
Last modified:June 1, 2001 - v1
Checksum:i366329A46EF0C441
GO
Isoform 2 (identifier: Q9DB32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-240: EDAVRAFTGQVA → QLQPRRLSSHCL
     241-283: Missing.

Show »
Length:240
Mass (Da):26,806
Checksum:i17C84D63DB5D65EE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei229 – 24012EDAVR…TGQVA → QLQPRRLSSHCL in isoform 2. 1 PublicationVSP_030057Add
BLAST
Alternative sequencei241 – 28343Missing in isoform 2. 1 PublicationVSP_030058Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005274 mRNA. Translation: BAB23924.1.
AK047517 mRNA. Translation: BAC33079.1.
BC030466 mRNA. Translation: AAH30466.1.
BC083322 mRNA. Translation: AAH83322.1.
CCDSiCCDS28527.1. [Q9DB32-1]
CCDS70773.1. [Q9DB32-2]
RefSeqiNP_001258362.1. NM_001271433.1. [Q9DB32-1]
NP_001258364.1. NM_001271435.1. [Q9DB32-2]
NP_081173.1. NM_026897.3. [Q9DB32-1]
UniGeneiMm.29230.

Genome annotation databases

EnsembliENSMUST00000077938; ENSMUSP00000077091; ENSMUSG00000061046. [Q9DB32-1]
ENSMUST00000140738; ENSMUSP00000116841; ENSMUSG00000061046. [Q9DB32-2]
ENSMUST00000150324; ENSMUSP00000119647; ENSMUSG00000061046. [Q9DB32-1]
GeneIDi68977.
KEGGimmu:68977.
UCSCiuc008bbr.2. mouse. [Q9DB32-1]
uc033hby.1. mouse. [Q9DB32-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005274 mRNA. Translation: BAB23924.1.
AK047517 mRNA. Translation: BAC33079.1.
BC030466 mRNA. Translation: AAH30466.1.
BC083322 mRNA. Translation: AAH83322.1.
CCDSiCCDS28527.1. [Q9DB32-1]
CCDS70773.1. [Q9DB32-2]
RefSeqiNP_001258362.1. NM_001271433.1. [Q9DB32-1]
NP_001258364.1. NM_001271435.1. [Q9DB32-2]
NP_081173.1. NM_026897.3. [Q9DB32-1]
UniGeneiMm.29230.

3D structure databases

ProteinModelPortaliQ9DB32.
SMRiQ9DB32. Positions 1-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DB32. 1 interaction.
MINTiMINT-4128083.
STRINGi10090.ENSMUSP00000077091.

PTM databases

PhosphoSiteiQ9DB32.

Proteomic databases

MaxQBiQ9DB32.
PaxDbiQ9DB32.
PRIDEiQ9DB32.

Protocols and materials databases

DNASUi68977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077938; ENSMUSP00000077091; ENSMUSG00000061046. [Q9DB32-1]
ENSMUST00000140738; ENSMUSP00000116841; ENSMUSG00000061046. [Q9DB32-2]
ENSMUST00000150324; ENSMUSP00000119647; ENSMUSG00000061046. [Q9DB32-1]
GeneIDi68977.
KEGGimmu:68977.
UCSCiuc008bbr.2. mouse. [Q9DB32-1]
uc033hby.1. mouse. [Q9DB32-2]

Organism-specific databases

CTDi84264.
MGIiMGI:1919877. Haghl.

Phylogenomic databases

eggNOGiKOG0813. Eukaryota.
COG0491. LUCA.
GeneTreeiENSGT00530000063033.
HOGENOMiHOG000058041.
HOVERGENiHBG001152.
InParanoidiQ9DB32.
KOiK01069.
OMAiHARGNAE.
OrthoDBiEOG789CBX.
PhylomeDBiQ9DB32.
TreeFamiTF105273.

Miscellaneous databases

ChiTaRSiHaghl. mouse.
PROiQ9DB32.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DB32.
CleanExiMM_HAGHL.
ExpressionAtlasiQ9DB32. baseline and differential.
GenevisibleiQ9DB32. MM.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01374. Glyoxalase_2.
InterProiIPR032282. HAGH_C.
IPR017782. Hydroxyacylglutathione_Hdrlase.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF16123. HAGH_C. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR03413. GSH_gloB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiHAGHL_MOUSE
AccessioniPrimary (citable) accession number: Q9DB32
Secondary accession number(s): Q8C8C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.