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Protein

Isoamyl acetate-hydrolyzing esterase 1 homolog

Gene

Iah1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable lipase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei24NucleophileBy similarity1
Binding sitei56Substrate; via amide nitrogenBy similarity1
Binding sitei89SubstrateBy similarity1
Active sitei197By similarity1
Active sitei200By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Isoamyl acetate-hydrolyzing esterase 1 homolog (EC:3.1.-.-)
Gene namesi
Name:Iah1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1914982. Iah1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157241 – 249Isoamyl acetate-hydrolyzing esterase 1 homologAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-succinyllysineCombined sources1

Proteomic databases

EPDiQ9DB29.
MaxQBiQ9DB29.
PaxDbiQ9DB29.
PeptideAtlasiQ9DB29.
PRIDEiQ9DB29.

2D gel databases

REPRODUCTION-2DPAGEIPI00119004.

PTM databases

iPTMnetiQ9DB29.
PhosphoSitePlusiQ9DB29.
SwissPalmiQ9DB29.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062054.
GenevisibleiQ9DB29. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9DB29. 2 interactors.
MINTiMINT-1869552.
STRINGi10090.ENSMUSP00000076090.

Structurei

3D structure databases

ProteinModelPortaliQ9DB29.
SMRiQ9DB29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3035. Eukaryota.
COG2755. LUCA.
GeneTreeiENSGT00390000008069.
HOGENOMiHOG000214294.
HOVERGENiHBG105140.
InParanoidiQ9DB29.
OMAiWEKECII.
OrthoDBiEOG091G0I3Q.
PhylomeDBiQ9DB29.
TreeFamiTF328918.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DB29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCERAASG SALLWPRVLL FGDSITQFSF QQGGWGSLLA DRLVRKCDVL
60 70 80 90 100
NRGFSGYNTR WAKIILPRLI RKGPGMENPV AVTIFFGAND SSLKDENPKQ
110 120 130 140 150
HVPLDEYSAN LRDMVQYLRS VDVPRERVIL ITPPPLCEAA WEKECVLKGC
160 170 180 190 200
KLNRLNSVVG EYANACLQVA RDCGTDVLDL WTLMQKDSQD FSSYLSDGLH
210 220 230 240
LSPMGNEFLF LNLCPLLDKK VSSLPWLLPY WKDVEEAKPE LSLLGDGDY
Length:249
Mass (Da):27,974
Last modified:June 1, 2001 - v1
Checksum:i45E9C8FE068F8423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005287 mRNA. Translation: BAB23934.1.
BC060949 mRNA. Translation: AAH60949.1.
BC087901 mRNA. Translation: AAH87901.1.
CCDSiCCDS25835.1.
RefSeqiNP_080623.2. NM_026347.3.
UniGeneiMm.335830.

Genome annotation databases

EnsembliENSMUST00000076813; ENSMUSP00000076090; ENSMUSG00000062054.
GeneIDi67732.
KEGGimmu:67732.
UCSCiuc007nds.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005287 mRNA. Translation: BAB23934.1.
BC060949 mRNA. Translation: AAH60949.1.
BC087901 mRNA. Translation: AAH87901.1.
CCDSiCCDS25835.1.
RefSeqiNP_080623.2. NM_026347.3.
UniGeneiMm.335830.

3D structure databases

ProteinModelPortaliQ9DB29.
SMRiQ9DB29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DB29. 2 interactors.
MINTiMINT-1869552.
STRINGi10090.ENSMUSP00000076090.

PTM databases

iPTMnetiQ9DB29.
PhosphoSitePlusiQ9DB29.
SwissPalmiQ9DB29.

2D gel databases

REPRODUCTION-2DPAGEIPI00119004.

Proteomic databases

EPDiQ9DB29.
MaxQBiQ9DB29.
PaxDbiQ9DB29.
PeptideAtlasiQ9DB29.
PRIDEiQ9DB29.

Protocols and materials databases

DNASUi67732.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076813; ENSMUSP00000076090; ENSMUSG00000062054.
GeneIDi67732.
KEGGimmu:67732.
UCSCiuc007nds.1. mouse.

Organism-specific databases

CTDi285148.
MGIiMGI:1914982. Iah1.

Phylogenomic databases

eggNOGiKOG3035. Eukaryota.
COG2755. LUCA.
GeneTreeiENSGT00390000008069.
HOGENOMiHOG000214294.
HOVERGENiHBG105140.
InParanoidiQ9DB29.
OMAiWEKECII.
OrthoDBiEOG091G0I3Q.
PhylomeDBiQ9DB29.
TreeFamiTF328918.

Miscellaneous databases

PROiQ9DB29.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062054.
GenevisibleiQ9DB29. MM.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIAH1_MOUSE
AccessioniPrimary (citable) accession number: Q9DB29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.