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Q9DB28

- POP5_MOUSE

UniProt

Q9DB28 - POP5_MOUSE

Protein

Ribonuclease P/MRP protein subunit POP5

Gene

Pop5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease MRP activity Source: MGI
    2. ribonuclease P activity Source: MGI

    GO - Biological processi

    1. RNA phosphodiester bond hydrolysis Source: GOC
    2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    3. rRNA processing Source: MGI
    4. tRNA processing Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P/MRP protein subunit POP5 (EC:3.1.26.5)
    Gene namesi
    Name:Pop5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2151221. Pop5.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolar ribonuclease P complex Source: MGI
    2. ribonuclease MRP complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169Ribonuclease P/MRP protein subunit POP5PRO_0000239008Add
    BLAST

    Proteomic databases

    PRIDEiQ9DB28.

    PTM databases

    PhosphoSiteiQ9DB28.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9DB28.
    BgeeiQ9DB28.
    GenevestigatoriQ9DB28.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DB28.
    SMRiQ9DB28. Positions 1-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG284693.
    GeneTreeiENSGT00390000012331.
    HOGENOMiHOG000293345.
    HOVERGENiHBG082157.
    InParanoidiQ9DB28.
    KOiK03537.
    OMAiCEVVSDD.
    OrthoDBiEOG7GTT69.
    PhylomeDBiQ9DB28.
    TreeFamiTF317496.

    Family and domain databases

    InterProiIPR016819. RNase_P/MRP_POP5.
    IPR002759. RNase_P/MRP_subunit.
    [Graphical view]
    PfamiPF01900. RNase_P_Rpp14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF023803. Ribonuclease_P_prd. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9DB28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRFKHRYLL CELVSEDARC RLSLDDRVLG GLVRDTIARV HGAFGAAACS    50
    VGFAVRYLNA YTGVVLLRCR KDFYQLVWSA LPFITYLENK GHRYPCFFNT 100
    LHVGGTIRTC QKFLIQYNRR QLLILLQNCT DEGEREAIKK SVSRSCLLDR 150
    EPVEELSDSA GEEVAEAME 169
    Length:169
    Mass (Da):19,285
    Last modified:June 1, 2001 - v1
    Checksum:i8334DECD7665A48D
    GO

    Sequence cautioni

    The sequence BAB28294.1 differs from that shown. Reason: Frameshift at position 44.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21V → R in BAB28751. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005290 mRNA. Translation: BAB23935.1.
    AK012523 mRNA. Translation: BAB28294.1. Frameshift.
    AK013257 mRNA. Translation: BAB28751.1.
    BC022670 mRNA. Translation: AAH22670.1.
    CCDSiCCDS19583.1.
    RefSeqiNP_080674.1. NM_026398.4.
    UniGeneiMm.24636.

    Genome annotation databases

    EnsembliENSMUST00000081497; ENSMUSP00000080215; ENSMUSG00000060152.
    ENSMUST00000135455; ENSMUSP00000118408; ENSMUSG00000060152.
    GeneIDi117109.
    KEGGimmu:117109.
    UCSCiuc008zdi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005290 mRNA. Translation: BAB23935.1 .
    AK012523 mRNA. Translation: BAB28294.1 . Frameshift.
    AK013257 mRNA. Translation: BAB28751.1 .
    BC022670 mRNA. Translation: AAH22670.1 .
    CCDSi CCDS19583.1.
    RefSeqi NP_080674.1. NM_026398.4.
    UniGenei Mm.24636.

    3D structure databases

    ProteinModelPortali Q9DB28.
    SMRi Q9DB28. Positions 1-120.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9DB28.

    Proteomic databases

    PRIDEi Q9DB28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081497 ; ENSMUSP00000080215 ; ENSMUSG00000060152 .
    ENSMUST00000135455 ; ENSMUSP00000118408 ; ENSMUSG00000060152 .
    GeneIDi 117109.
    KEGGi mmu:117109.
    UCSCi uc008zdi.1. mouse.

    Organism-specific databases

    CTDi 51367.
    MGIi MGI:2151221. Pop5.

    Phylogenomic databases

    eggNOGi NOG284693.
    GeneTreei ENSGT00390000012331.
    HOGENOMi HOG000293345.
    HOVERGENi HBG082157.
    InParanoidi Q9DB28.
    KOi K03537.
    OMAi CEVVSDD.
    OrthoDBi EOG7GTT69.
    PhylomeDBi Q9DB28.
    TreeFami TF317496.

    Miscellaneous databases

    ChiTaRSi POP5. mouse.
    NextBioi 369498.
    PROi Q9DB28.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DB28.
    Bgeei Q9DB28.
    Genevestigatori Q9DB28.

    Family and domain databases

    InterProi IPR016819. RNase_P/MRP_POP5.
    IPR002759. RNase_P/MRP_subunit.
    [Graphical view ]
    Pfami PF01900. RNase_P_Rpp14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF023803. Ribonuclease_P_prd. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiPOP5_MOUSE
    AccessioniPrimary (citable) accession number: Q9DB28
    Secondary accession number(s): Q9CSC3, Q9CSL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3