Q9DB28 (POP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P/MRP protein subunit POP5
EC=3.1.26.5

Gene names

Name:

Pop5

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
Sequence caution	The sequence BAB28294.1 differs from that shown. Reason: Frameshift at position 44.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tRNA processing Inferred from direct assay. Source: MGI
Cellular component	nucleolar ribonuclease P complex Inferred from direct assay. Source: MGI
Molecular function	ribonuclease P activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Ribonuclease P/MRP protein subunit POP5		PRO_0000239008
Experimental info
	Sequence conflict	2	1	V → R in BAB28751. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9DB28 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 8334DECD7665A48D	FASTA	169	19,285
	10 20 30 40 50 60 MVRFKHRYLL CELVSEDARC RLSLDDRVLG GLVRDTIARV HGAFGAAACS VGFAVRYLNA 70 80 90 100 110 120 YTGVVLLRCR KDFYQLVWSA LPFITYLENK GHRYPCFFNT LHVGGTIRTC QKFLIQYNRR 130 140 150 160 QLLILLQNCT DEGEREAIKK SVSRSCLLDR EPVEELSDSA GEEVAEAME

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum and Embryo.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK005290 mRNA. Translation: BAB23935.1. AK012523 mRNA. Translation: BAB28294.1. Frameshift. AK013257 mRNA. Translation: BAB28751.1. BC022670 mRNA. Translation: AAH22670.1.
IPI	IPI00756093.
RefSeq	NP_080674.1. NM_026398.4.
UniGene	Mm.24636.
3D structure databases
ProteinModelPortal	Q9DB28.
SMR	Q9DB28. Positions 1-120.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9DB28.
PTM databases
PhosphoSite	Q9DB28.
Proteomic databases
PRIDE	Q9DB28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000081497; ENSMUSP00000080215; ENSMUSG00000060152. ENSMUST00000135455; ENSMUSP00000118408; ENSMUSG00000060152.
GeneID	117109.
KEGG	mmu:117109.
UCSC	uc008zdi.1. mouse.
Organism-specific databases
CTD	51367.
MGI	MGI:2151221. Pop5.
Phylogenomic databases
eggNOG	roNOG16661.
GeneTree	ENSGT00390000012331.
HOGENOM	HBG713344.
HOVERGEN	HBG082157.
InParanoid	Q9DB28.
OMA	CEVVSDD.
OrthoDB	EOG49W2GX.
Gene expression databases
ArrayExpress	Q9DB28.
Bgee	Q9DB28.
Genevestigator	Q9DB28.
GermOnline	ENSMUSG00000060152. Mus musculus.
Family and domain databases
InterPro	IPR016819. RNase_P/MRP_POP5. IPR002759. RNase_P/MRP_subunit. [Graphical view]
KO	K03537.
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
PIRSF	PIRSF023803. Ribonuclease_P_prd. 1 hit.
ProtoNet	Search...
Other
NextBio	369498.
SOURCE	Search...

Entry information

Entry name

POP5_MOUSE

Accession

Primary (citable) accession number: Q9DB28
Secondary accession number(s): Q9CSC3, Q9CSL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	June 1, 2001
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program