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Protein

Phytanoyl-CoA dioxygenase domain-containing protein 1

Gene

Phyhd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity).By similarity

Cofactori

Fe cationBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021Alpha-ketoglutarateBy similarity
Binding sitei141 – 1411Alpha-ketoglutarateBy similarity
Metal bindingi156 – 1561IronBy similarity
Metal bindingi158 – 1581IronBy similarity
Binding sitei174 – 1741Alpha-ketoglutarateBy similarity
Metal bindingi246 – 2461IronBy similarity
Binding sitei248 – 2481Alpha-ketoglutarateBy similarity
Binding sitei257 – 2571Alpha-ketoglutarateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC:1.-.-.-)
Gene namesi
Name:Phyhd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3612860. Phyhd1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Phytanoyl-CoA dioxygenase domain-containing protein 1PRO_0000313634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DB26.
PaxDbiQ9DB26.
PRIDEiQ9DB26.

PTM databases

iPTMnetiQ9DB26.
PhosphoSiteiQ9DB26.
SwissPalmiQ9DB26.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079484.
ExpressionAtlasiQ9DB26. baseline and differential.
GenevisibleiQ9DB26. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9DB26. 2 interactions.
MINTiMINT-4128063.
STRINGi10090.ENSMUSP00000088663.

Structurei

3D structure databases

ProteinModelPortaliQ9DB26.
SMRiQ9DB26. Positions 2-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni156 – 1583Alpha-ketoglutarate bindingBy similarity

Sequence similaritiesi

Belongs to the PhyH family. PHYHD1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3290. Eukaryota.
ENOG410XUSH. LUCA.
GeneTreeiENSGT00390000006287.
HOGENOMiHOG000185005.
HOVERGENiHBG054973.
InParanoidiQ9DB26.
PhylomeDBiQ9DB26.
TreeFamiTF300011.

Family and domain databases

InterProiIPR008775. Phytyl_CoA_dOase.
[Graphical view]
PfamiPF05721. PhyH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DB26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLSPSQLK KFQEDGFLLL EGFFTADECV AMQQRIGEIV AEMDVPLHCR
60 70 80 90 100
TEFSTQEDEQ LQTQGKTDYF LSSGDKIRFF FEKGVFDEKG NFLVPPEKSI
110 120 130 140 150
NKIGHALHAH DPVFRSITHS PKVQALVRSL GLQMPVVVQS MYIFKQPHFG
160 170 180 190 200
GEVSPHQDAT FLYTEPLGRV LGLWIAMEDA MLENGCLWFI PGSHTRGVSR
210 220 230 240 250
RMIRAPSDSG PGTSFLGSDP AWASNLFVPL PVRRGGLVLI HGEVVHKSEQ
260 270 280 290
NHSDHSRQAY TVHLMEAAGT VWSPGNWLQP TPELPFPPLY S
Length:291
Mass (Da):32,517
Last modified:January 15, 2008 - v2
Checksum:i7CA9823E4E6BF8B3
GO

Sequence cautioni

The sequence AAI32272 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI32274 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB23937 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE23715 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005293 mRNA. Translation: BAB23937.1. Different initiation.
AK138607 mRNA. Translation: BAE23715.1. Different initiation.
AL845258, AL954388 Genomic DNA. Translation: CAM20569.2.
AL845258, AL954388 Genomic DNA. Translation: CAM20572.1.
AL954388, AL845258 Genomic DNA. Translation: CAM23174.2.
AL954388, AL845258 Genomic DNA. Translation: CAM23177.1.
BC039982 mRNA. Translation: AAH39982.1.
BC132271 mRNA. Translation: AAI32272.1. Different initiation.
BC132273 mRNA. Translation: AAI32274.1. Different initiation.
CCDSiCCDS57163.1.
RefSeqiNP_001239497.1. NM_001252568.2.
NP_001239499.1. NM_001252570.1.
NP_001268758.1. NM_001281829.1.
NP_758471.1. NM_172267.4.
UniGeneiMm.297949.

Genome annotation databases

EnsembliENSMUST00000113645; ENSMUSP00000109275; ENSMUSG00000079484.
ENSMUST00000154647; ENSMUSP00000121371; ENSMUSG00000079484.
GeneIDi227696.
KEGGimmu:227696.
UCSCiuc008jbv.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005293 mRNA. Translation: BAB23937.1. Different initiation.
AK138607 mRNA. Translation: BAE23715.1. Different initiation.
AL845258, AL954388 Genomic DNA. Translation: CAM20569.2.
AL845258, AL954388 Genomic DNA. Translation: CAM20572.1.
AL954388, AL845258 Genomic DNA. Translation: CAM23174.2.
AL954388, AL845258 Genomic DNA. Translation: CAM23177.1.
BC039982 mRNA. Translation: AAH39982.1.
BC132271 mRNA. Translation: AAI32272.1. Different initiation.
BC132273 mRNA. Translation: AAI32274.1. Different initiation.
CCDSiCCDS57163.1.
RefSeqiNP_001239497.1. NM_001252568.2.
NP_001239499.1. NM_001252570.1.
NP_001268758.1. NM_001281829.1.
NP_758471.1. NM_172267.4.
UniGeneiMm.297949.

3D structure databases

ProteinModelPortaliQ9DB26.
SMRiQ9DB26. Positions 2-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DB26. 2 interactions.
MINTiMINT-4128063.
STRINGi10090.ENSMUSP00000088663.

PTM databases

iPTMnetiQ9DB26.
PhosphoSiteiQ9DB26.
SwissPalmiQ9DB26.

Proteomic databases

MaxQBiQ9DB26.
PaxDbiQ9DB26.
PRIDEiQ9DB26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113645; ENSMUSP00000109275; ENSMUSG00000079484.
ENSMUST00000154647; ENSMUSP00000121371; ENSMUSG00000079484.
GeneIDi227696.
KEGGimmu:227696.
UCSCiuc008jbv.3. mouse.

Organism-specific databases

CTDi254295.
MGIiMGI:3612860. Phyhd1.

Phylogenomic databases

eggNOGiKOG3290. Eukaryota.
ENOG410XUSH. LUCA.
GeneTreeiENSGT00390000006287.
HOGENOMiHOG000185005.
HOVERGENiHBG054973.
InParanoidiQ9DB26.
PhylomeDBiQ9DB26.
TreeFamiTF300011.

Miscellaneous databases

PROiQ9DB26.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079484.
ExpressionAtlasiQ9DB26. baseline and differential.
GenevisibleiQ9DB26. MM.

Family and domain databases

InterProiIPR008775. Phytyl_CoA_dOase.
[Graphical view]
PfamiPF05721. PhyH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHYD1_MOUSE
AccessioniPrimary (citable) accession number: Q9DB26
Secondary accession number(s): A2AQZ4, Q80V68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.