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Protein

Calcium-binding protein 39-like

Gene

Cab39l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39-like
Alternative name(s):
MO25beta
Mo25-like protein
Gene namesi
Name:Cab39l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914081. Cab39l.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098271 – 337Calcium-binding protein 39-likeAdd BLAST337

Proteomic databases

EPDiQ9DB16.
PaxDbiQ9DB16.
PeptideAtlasiQ9DB16.
PRIDEiQ9DB16.

PTM databases

iPTMnetiQ9DB16.
PhosphoSitePlusiQ9DB16.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021981.
CleanExiMM_CAB39L.
GenevisibleiQ9DB16. MM.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022553.

Structurei

3D structure databases

ProteinModelPortaliQ9DB16.
SMRiQ9DB16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiKOG1566. Eukaryota.
ENOG410XP4S. LUCA.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9DB16.
KOiK08272.
OMAiKEPHTET.
OrthoDBiEOG091G0DTL.
PhylomeDBiQ9DB16.
TreeFamiTF314910.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiView protein in Pfam
PF08569. Mo25. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DB16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK
60 70 80 90 100
EILCGTNDKE PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI
110 120 130 140 150
FNNILRRQIG TRCPTVEYIS SHPHILFMLL KGYEAPQIAL RCGIMLRECI
160 170 180 190 200
RHEPLAKIIL FSNQFRDFFK YVELSTFDIA SDAFATFKDL LTRHKVLVAD
210 220 230 240 250
FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH NFTIMTKYIS
260 270 280 290 300
KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK
310 320 330
LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKAAP
Length:337
Mass (Da):39,106
Last modified:August 16, 2004 - v3
Checksum:iC62B5B58095A98C8
GO
Isoform 2 (identifier: Q9DB16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     279-296: VFVASPHKTQPIVEILLK → NSVFITNRIHGLKRWLSS
     297-337: Missing.

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):34,336
Checksum:i5580784D1DC91AD1
GO

Sequence cautioni

The sequence AAH16128 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45S → P in BAB23953 (PubMed:16141072).Curated1
Sequence conflicti232L → R in AAH16546 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007417279 – 296VFVAS…EILLK → NSVFITNRIHGLKRWLSS in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_007418297 – 337Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005323 mRNA. Translation: BAB23953.2.
AK030474 mRNA. Translation: BAC26978.1.
AK053642 mRNA. Translation: BAC35457.1.
AK076758 mRNA. Translation: BAC36470.1.
AK076867 mRNA. Translation: BAC36513.1.
BC016128 mRNA. Translation: AAH16128.1. Different initiation.
BC016546 mRNA. Translation: AAH16546.2.
CCDSiCCDS27171.1. [Q9DB16-1]
RefSeqiNP_081184.3. NM_026908.3. [Q9DB16-1]
XP_006519557.1. XM_006519494.2. [Q9DB16-1]
XP_006519558.1. XM_006519495.2. [Q9DB16-1]
XP_017171665.1. XM_017316176.1. [Q9DB16-1]
UniGeneiMm.179091.

Genome annotation databases

EnsembliENSMUST00000022553; ENSMUSP00000022553; ENSMUSG00000021981. [Q9DB16-1]
ENSMUST00000225595; ENSMUSP00000153643; ENSMUSG00000021981. [Q9DB16-2]
GeneIDi69008.
KEGGimmu:69008.
UCSCiuc007uek.1. mouse. [Q9DB16-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCB39L_MOUSE
AccessioniPrimary (citable) accession number: Q9DB16
Secondary accession number(s): Q8BG52, Q91WB8, Q91YL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families