Q9DB00 (GON4L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GON-4-like protein

Alternative name(s):
GON-4 homolog

Gene names

Name:	Gon4l
Synonyms:	Gon4, Kiaa1606

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2260 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 Myb-like domain. Contains 2 PAH (paired amphipathic helix) domains.
Sequence caution	The sequence AAH16616.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB23992.1 differs from that shown. Reason: Chimeric cDNA. The sequence BAC65813.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2260

2260

GON-4-like protein

PRO_0000197110

Regions

Domain

1648 – 1720

73

PAH 1

Domain

1730 – 1801

72

PAH 2

Domain

2167 – 2220

54

Myb-like

Compositional bias

242 – 248

7

Poly-Lys

Compositional bias

380 – 385

6

Poly-Glu

Compositional bias

450 – 456

7

Poly-Pro

Compositional bias

519 – 578

60

Asp-rich

Compositional bias

622 – 625

4

Poly-Glu

Compositional bias

1476 – 1570

95

Glu-rich

Amino acid modifications

Modified residue

188

1

Phosphoserine By similarity

Modified residue

1998

1

Phosphoserine By similarity

Modified residue

2074

1

Phosphoserine By similarity

Cross-link

536

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict

259

1

P → L in BAC65813. Ref.3

Sequence conflict

734

1

I → V in BAC65813. Ref.3

Sequence conflict

1080

1

A → S in BAC65813. Ref.3

Sequence conflict

1341

1

S → P in BAC65813. Ref.3

Sequence conflict

1354

1

Q → E in BAC65813. Ref.3

Sequence conflict

1364

1

F → L in BAC65813. Ref.3

Sequence conflict

1392

1

S → R in BAC65813. Ref.3

Sequence conflict

1407

1

M → T in BAC65813. Ref.3

Sequence conflict

1438

1

L → P in BAC65813. Ref.3

Sequence conflict

1458

1

A → V in BAC65813. Ref.3

Sequence conflict

2069

1

S → P in BAC65813. Ref.3

Sequence conflict

2069

1

S → P in AAH16616. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

2260

Helix Strand Turn

Details...

Beta strand

2173 – 2175

3

Helix

2177 – 2189

13

Turn

2194 – 2196

3

Helix

2197 – 2204

8

Helix

2209 – 2225

17

Sequences

	Sequence		Length	Mass (Da)
	Q9DB00 [UniParc]. Last modified July 27, 2011. Version 3. Checksum: BB0F605666D642C6	FASTA	2,260	248,742
	10 20 30 40 50 60 MLPCKKRRLS VTESSQQQDD QEGDDLDLEA AVKPDTDQLP DSASESLSWG QSQDSAVCPE 70 80 90 100 110 120 GLSMQDGDDQ LRAEGLSLNS KMLAQHVNLA VLEAVDVAVS QEIPLPSLES SHSLPVHVDK 130 140 150 160 170 180 GRLQVSASKK GKRVVFTPGQ VTREDRGDHP VPEEPPSGEP AEEAKTEGGE LELRSDGEVP 190 200 210 220 230 240 LLSSSSQSAK PGAQPRKSVQ PDGSAFPQDK PLGPLVRQAE EEMEDGGLFI PTEEQDSEES 250 260 270 280 290 300 DKKKKTKKGT KRKRDGKGPE QGTMVYDPKL DDMLDRTLED GAKQHNLTAV NVRNILHEVI 310 320 330 340 350 360 TNEHVVAMMK AAISETEDMP LFEPKMTRSK LKEVVEKGVV IPTWNISPIK KASEIKQPPQ 370 380 390 400 410 420 FVDIHLEEDD SSDEEYSPDE EEEDETAEES LLESDVESTA SSPRGVKRSR LRLSSEVAET 430 440 450 460 470 480 DEESGMLSEV EKAATPALRH ISAEVVPMGP PPPPKPKQSR DSVFMEKLDA VDEELASSPV 490 500 510 520 530 540 CMDSFQPMED SLIAFRTRSK MPLKDVPLGQ LEAELQAPDI TPDMYDPNTA DDEDWKQWLG 550 560 570 580 590 600 GLINDDVENE DEADDDDDPE YNFLEDLDEP DTEDFRTDRA VRITKKEVNG LMEELFETVQ 610 620 630 640 650 660 SVVPSKFQDE MGFSNMEDDG PEEEERATES RPSFNTPQAL RFEEPLANLL NERHRTVKEL 670 680 690 700 710 720 LEQLKMKKPS VRQQPEVEKL KPQEEAAHQT LVLDPAQRSR LQQQMQQHVQ LLTQIYLLTT 730 740 750 760 770 780 SNPNLSSEAS TTRIFLKELG TFAENSIALH QQFNPRFQTL FQPCNWMGAM RLIEDFTQVS 790 800 810 820 830 840 IDCSPHKTAK KTASEFPCLP KQVAWILATN KVFMYPELLP ICSLKANNPR DKTIFTKAED 850 860 870 880 890 900 NLLALGLKHF EGTEFPKPLI SKYLVTCKTA HQLTVRIKNL NLNRAPNNVI KFYKKTKQLP 910 920 930 940 950 960 VLVRCCEEIQ PHQWKPPFEK EEHRLPFWLK ASLQSIQDEL RNISEGATEG GSVTTATESS 970 980 990 1000 1010 1020 TDQHLQKASP ALGDEPQYPL LLPKGVVLKL KPGSKRFSRK AWRQKRPLVQ KPLLIQPSPS 1030 1040 1050 1060 1070 1080 VQPVFNPGKM ATWPTQSEVP PSNTVVQIPH LIQPAAVLQT LPGFPSVGVR GEDGFESPTA 1090 1100 1110 1120 1130 1140 LPAMPCGSEA RTTFPLSETQ SAPPSCSAPK LMLPSLAPSK FRKPYVRRKP TRRKGAKVSP 1150 1160 1170 1180 1190 1200 CVKPAPIIHP TPVIFTVPAT TVKVVSIGGG CNMIQPVSAA VAPSPQTIPI TTLLVNPTTF 1210 1220 1230 1240 1250 1260 PCSLNQPLVA SSISPLIVSS NPLTLPVTSI PEDKAQVKLD VAEGKNAPQN PESKLKPQEL 1270 1280 1290 1300 1310 1320 TPLCTTVFSK EEPKSWHSSA DTGSQEAFSE SSACSWAVVK TESQEGSSEK SACGWTVVKT 1330 1340 1350 1360 1370 1380 EDGGHAVEPL PQNLQDSLSS SSKDLLNMVK MEAQDCMVEI SSNFPKQDIG EEVKEECSME 1390 1400 1410 1420 1430 1440 LDSESPQEKP SSASEMSKQT VLQREDMQAA KSPSVPQDAA AEGRTSSHAS RGLPKSTLSS 1450 1460 1470 1480 1490 1500 MGQGGGLSGP PGKLEDSANA DGQSVGTPAG PDTGGEKDGP EEEEEEDFDD LTQDEEDELS 1510 1520 1530 1540 1550 1560 SASEESVLSV PELQETMEKL TWLASERRMS QEGESEEENS QEENSEPEEE EEEEAEGMET 1570 1580 1590 1600 1610 1620 LQKEDEVNDE AVGDAAKKPP STLASPQTAP EIETSIAPAG ESIKAAGKGR SSHRARNKRG 1630 1640 1650 1660 1670 1680 SRARASKDTS KLLLLYDEDI LDRDPLREQK DLAFAQAYLT RVREALQHTP GKYEDFLQII 1690 1700 1710 1720 1730 1740 YEFESSTQMH SAVDLFKSLQ TLLQDWPQLL KDFAAFLLPE QALSCGLFEE QQAFEKSRKF 1750 1760 1770 1780 1790 1800 LRQLEICFAE NPSHHQKIIK VLQGCADCLP QDIAELKTQM WQLLRGHDHL QDEFSIFFDH 1810 1820 1830 1840 1850 1860 LRPAASRMGD FEEINWTEEK EYEFDGFEEV ILPDVEEDEE PAKVSTASKS KRRKEIGVQH 1870 1880 1890 1900 1910 1920 QDKDTEWPEA AKDCSCSCHE GGPESKLKKS KRRNCHCSSK VCDSKPYKSK EPPELVGSGP 1930 1940 1950 1960 1970 1980 LHEASTVPGS KEAGQGKDML EEEILEEQEN MEVTQSKTAR TTRKGEAPAP GSTIGSTLLC 1990 2000 2010 2020 2030 2040 PAEVTPMELL LEGPALCSAE TPRLPPQTGA VVCSVRRNQA GPEVVSCLST SSLPPEEGED 2050 2060 2070 2080 2090 2100 QRAAANSETI APHREASETE RLPETVEHSA PLPSPVSTRT RDTGRRHICG KAGSQSWLIE 2110 2120 2130 2140 2150 2160 SRAEAEAAHV AAPICEKSSG ARASEAAPKT AREVLAEDSG TQGMGPEGAL PKASEATVCA 2170 2180 2190 2200 2210 2220 NNSKVSSTGE KVVLWTREAD RVILTMCQEQ GAQPHTFSVI SQQLGNKTPV EVSHRFRELM 2230 2240 2250 2260 QLFHTACEAS SEDEDDATST SNADQLSDHG DLLSEEELDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-168. Strain: C57BL/6J. Tissue: Cerebellum.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed: 12693553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-2260. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1531-2260. Strain: FVB/N. Tissue: Mammary gland.
[5]	"Solution structure of mouse hypothetical gene (2610100B20Rik) product homologous to Myb DNA-binding domain." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 2148-2230.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC127377 Genomic DNA. No translation available.
AK005385 mRNA. Translation: BAB23992.1. Different termination.
AK122531 mRNA. Translation: BAC65813.1. Different initiation.
BC016616 mRNA. Translation: AAH16616.1. Different initiation.

IPI

IPI00854904.

UniGene

Mm.126870.
Mm.482358.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UG2	NMR	-	A	2148-2228	[»]

ProteinModelPortal

Q9DB00.

SMR

Q9DB00. Positions 2140-2229.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9DB00.

PTM databases

PhosphoSite

Q9DB00.

Proteomic databases

PRIDE

Q9DB00.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000090942; ENSMUSP00000088461; ENSMUSG00000054199.

UCSC

uc008pwv.2. mouse.

Organism-specific databases

MGI

MGI:1917579. Gon4l.

Rouge

Search...

Phylogenomic databases

GeneTree

ENSGT00390000016256.

HOVERGEN

HBG081563.

Gene expression databases

ArrayExpress

Q9DB00.

Bgee

Q9DB00.

Genevestigator

Q9DB00.

GermOnline

ENSMUSG00000054199. Mus musculus.

Family and domain databases

InterPro

IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
IPR017877. MYB-like.
IPR003822. PAH.
IPR001005. SANT_DNA-bd.
[Graphical view]

Gene3D

G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
G3DSA:1.20.1160.11. PAH. 1 hit.

Pfam

PF02671. PAH. 1 hit.
[Graphical view]

SMART

SM00717. SANT. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.
SSF47762. PAH. 2 hits.

PROSITE

PS50090. MYB_LIKE. 1 hit.
PS51477. PAH. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

SOURCE

Search...

Entry information

Entry name

GON4L_MOUSE

Accession

Primary (citable) accession number: Q9DB00
Secondary accession number(s): E9Q5N3, Q80TB4, Q91YI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 27, 2011
Last modified:	November 16, 2011
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program