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Q9DAY9

- Q9DAY9_MOUSE

UniProt

Q9DAY9 - Q9DAY9_MOUSE

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Protein
Submitted name: Nucleophosmin
Gene
Npm1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. NF-kappaB binding Source: UniProtKB
  2. RNA binding Source: MGI
  3. protein binding Source: MGI
  4. rRNA binding Source: MGI
  5. ribosomal large subunit binding Source: MGI
  6. ribosomal small subunit binding Source: MGI
  7. unfolded protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell aging Source: UniProtKB
  2. cell growth Source: MGI
  3. cell volume homeostasis Source: MGI
  4. centrosome cycle Source: UniProtKB
  5. negative regulation of cell proliferation Source: UniProtKB
  6. negative regulation of mRNA splicing, via spliceosome Source: MGI
  7. nucleocytoplasmic transport Source: MGI
  8. positive regulation of cell proliferation Source: MGI
  9. positive regulation of cellular biosynthetic process Source: MGI
  10. positive regulation of centrosome duplication Source: MGI
  11. positive regulation of protein kinase activity Source: MGI
  12. protein localization Source: MGI
  13. protein oligomerization Source: MGI
  14. rRNA export from nucleus Source: MGI
  15. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  16. regulation of cell cycle Source: MGI
  17. regulation of centrosome duplication Source: MGI
  18. ribosomal large subunit biogenesis Source: MGI
  19. ribosomal large subunit export from nucleus Source: MGI
  20. ribosomal small subunit biogenesis Source: MGI
  21. ribosomal small subunit export from nucleus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NucleophosminImported
Gene namesi
Name:Npm1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:106184. Npm1.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: MGI
  4. granular component Source: MGI
  5. large ribosomal subunit Source: MGI
  6. nuclear speck Source: MGI
  7. nucleolus Source: MGI
  8. nucleoplasm Source: MGI
  9. nucleus Source: UniProtKB
  10. ribonucleoprotein complex Source: MGI
  11. small ribosomal subunit Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9DAY9.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00440000034554.
HOVERGENiHBG001860.
KOiK11276.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DAY9-1 [UniParc]FASTAAdd to Basket

« Hide

MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG    50
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL 100
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK 150
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA 200
KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ 250
ASIEKAH 257
Length:257
Mass (Da):28,385
Last modified:June 1, 2001 - v1
Checksum:i68C05DC278172D7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772409 Genomic DNA. No translation available.
AK005420 mRNA. Translation: BAB24014.1.
AK088923 mRNA. Translation: BAC40655.1.
RefSeqiNP_001239190.1. NM_001252261.1.
XP_006514641.1. XM_006514578.1.
UniGeneiMm.485384.

Genome annotation databases

EnsembliENSMUST00000109354; ENSMUSP00000104978; ENSMUSG00000057113.
GeneIDi18148.
KEGGimmu:18148.
UCSCiuc007ike.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772409 Genomic DNA. No translation available.
AK005420 mRNA. Translation: BAB24014.1 .
AK088923 mRNA. Translation: BAC40655.1 .
RefSeqi NP_001239190.1. NM_001252261.1.
XP_006514641.1. XM_006514578.1.
UniGenei Mm.485384.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109354 ; ENSMUSP00000104978 ; ENSMUSG00000057113 .
GeneIDi 18148.
KEGGi mmu:18148.
UCSCi uc007ike.2. mouse.

Organism-specific databases

CTDi 4869.
MGIi MGI:106184. Npm1.

Phylogenomic databases

GeneTreei ENSGT00440000034554.
HOVERGENi HBG001860.
KOi K11276.

Miscellaneous databases

NextBioi 293410.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9DAY9.

Family and domain databases

Gene3Di 2.60.120.340. 1 hit.
InterProi IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view ]
PANTHERi PTHR22747. PTHR22747. 1 hit.
SUPFAMi SSF69203. SSF69203. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: PlacentaImported and ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: PlacentaImported and ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: PlacentaImported and ThymusImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: PlacentaImported and ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: PlacentaImported and ThymusImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: ThymusImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: PlacentaImported and ThymusImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: PlacentaImported and ThymusImported.
  10. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  16. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  17. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ9DAY9_MOUSE
AccessioniPrimary (citable) accession number: Q9DAY9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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