Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9DAY9

- Q9DAY9_MOUSE

UniProt

Q9DAY9 - Q9DAY9_MOUSE

Protein
Submitted name:

Nucleophosmin

Gene

Npm1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. NF-kappaB binding Source: UniProtKB
    2. protein binding Source: MGI
    3. ribosomal large subunit binding Source: MGI
    4. ribosomal small subunit binding Source: MGI
    5. RNA binding Source: MGI
    6. rRNA binding Source: MGI
    7. unfolded protein binding Source: UniProtKB

    GO - Biological processi

    1. cell aging Source: UniProtKB
    2. cell growth Source: MGI
    3. cell volume homeostasis Source: MGI
    4. centrosome cycle Source: UniProtKB
    5. negative regulation of cell proliferation Source: UniProtKB
    6. negative regulation of mRNA splicing, via spliceosome Source: MGI
    7. nucleocytoplasmic transport Source: MGI
    8. positive regulation of cell proliferation Source: MGI
    9. positive regulation of cellular biosynthetic process Source: MGI
    10. positive regulation of centrosome duplication Source: MGI
    11. positive regulation of protein kinase activity Source: MGI
    12. protein localization Source: MGI
    13. protein oligomerization Source: MGI
    14. regulation of cell cycle Source: MGI
    15. regulation of centrosome duplication Source: MGI
    16. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
    17. ribosomal large subunit biogenesis Source: MGI
    18. ribosomal large subunit export from nucleus Source: MGI
    19. ribosomal small subunit biogenesis Source: MGI
    20. ribosomal small subunit export from nucleus Source: MGI
    21. rRNA export from nucleus Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NucleophosminImported
    Gene namesi
    Name:Npm1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:106184. Npm1.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: MGI
    4. granular component Source: MGI
    5. large ribosomal subunit Source: MGI
    6. nuclear speck Source: MGI
    7. nucleolus Source: MGI
    8. nucleoplasm Source: MGI
    9. nucleus Source: UniProtKB
    10. ribonucleoprotein complex Source: MGI
    11. small ribosomal subunit Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ9DAY9.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00440000034554.
    HOVERGENiHBG001860.
    KOiK11276.

    Family and domain databases

    Gene3Di2.60.120.340. 1 hit.
    InterProiIPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view]
    PANTHERiPTHR22747. PTHR22747. 1 hit.
    SUPFAMiSSF69203. SSF69203. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9DAY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG    50
    AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL 100
    RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK 150
    VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA 200
    KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ 250
    ASIEKAH 257
    Length:257
    Mass (Da):28,385
    Last modified:June 1, 2001 - v1
    Checksum:i68C05DC278172D7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772409 Genomic DNA. No translation available.
    AK005420 mRNA. Translation: BAB24014.1.
    AK088923 mRNA. Translation: BAC40655.1.
    RefSeqiNP_001239190.1. NM_001252261.1.
    XP_006514641.1. XM_006514578.1.
    UniGeneiMm.485384.

    Genome annotation databases

    EnsembliENSMUST00000109354; ENSMUSP00000104978; ENSMUSG00000057113.
    GeneIDi18148.
    KEGGimmu:18148.
    UCSCiuc007ike.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772409 Genomic DNA. No translation available.
    AK005420 mRNA. Translation: BAB24014.1 .
    AK088923 mRNA. Translation: BAC40655.1 .
    RefSeqi NP_001239190.1. NM_001252261.1.
    XP_006514641.1. XM_006514578.1.
    UniGenei Mm.485384.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109354 ; ENSMUSP00000104978 ; ENSMUSG00000057113 .
    GeneIDi 18148.
    KEGGi mmu:18148.
    UCSCi uc007ike.2. mouse.

    Organism-specific databases

    CTDi 4869.
    MGIi MGI:106184. Npm1.

    Phylogenomic databases

    GeneTreei ENSGT00440000034554.
    HOVERGENi HBG001860.
    KOi K11276.

    Miscellaneous databases

    NextBioi 293410.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9DAY9.

    Family and domain databases

    Gene3Di 2.60.120.340. 1 hit.
    InterProi IPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view ]
    PANTHERi PTHR22747. PTHR22747. 1 hit.
    SUPFAMi SSF69203. SSF69203. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: PlacentaImported and ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: PlacentaImported and ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: PlacentaImported and ThymusImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PlacentaImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: PlacentaImported and ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: PlacentaImported and ThymusImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: PlacentaImported and ThymusImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: PlacentaImported and ThymusImported.
    10. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    16. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    17. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQ9DAY9_MOUSE
    AccessioniPrimary (citable) accession number: Q9DAY9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3