Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amyloid protein-binding protein 2

Gene

Appbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name:
APP-BP2
Gene namesi
Name:Appbp2
Synonyms:Kiaa0228
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914134 Appbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001062601 – 585Amyloid protein-binding protein 2Add BLAST585

Post-translational modificationi

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.By similarity

Proteomic databases

EPDiQ9DAX9
MaxQBiQ9DAX9
PaxDbiQ9DAX9
PeptideAtlasiQ9DAX9
PRIDEiQ9DAX9

PTM databases

iPTMnetiQ9DAX9
PhosphoSitePlusiQ9DAX9

Expressioni

Gene expression databases

BgeeiENSMUSG00000018481
GenevisibleiQ9DAX9 MM

Interactioni

Subunit structurei

Binds APP.By similarity

Protein-protein interaction databases

BioGridi211787, 3 interactors
STRINGi10090.ENSMUSP00000018625

Structurei

3D structure databases

ProteinModelPortaliQ9DAX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 83TPR 1Add BLAST34
Repeati120 – 153TPR 2Add BLAST34
Repeati206 – 239TPR 3Add BLAST34
Repeati288 – 321TPR 4Add BLAST34
Repeati333 – 367TPR 5Add BLAST35
Repeati429 – 462TPR 6Add BLAST34
Repeati471 – 505TPR 7Add BLAST35
Repeati514 – 547TPR 8Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000010722
HOGENOMiHOG000007799
HOVERGENiHBG050527
InParanoidiQ9DAX9
OMAiSVAIYQT
OrthoDBiEOG091G057R
PhylomeDBiQ9DAX9
TreeFamiTF314010

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DAX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ
60 70 80 90 100
GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS
110 120 130 140 150
FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC
160 170 180 190 200
TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG
210 220 230 240 250
QQANRAALYG ELCALLFAKS HYDEAYKWCV EAMKEITAGL PVKVVVDVLR
260 270 280 290 300
QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
310 320 330 340 350
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF
360 370 380 390 400
DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ
410 420 430 440 450
RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE
460 470 480 490 500
MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA
510 520 530 540 550
IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ
560 570 580
YSVTDALEDV SSSPQSTEEV VQSFLMAQNV EGPSC
Length:585
Mass (Da):66,855
Last modified:June 1, 2001 - v1
Checksum:i70779B567F785B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005440 mRNA Translation: BAB24034.1
AL596183 Genomic DNA No translation available.
BC018442 mRNA Translation: AAH18442.1
BC019152 mRNA Translation: AAH19152.1
AK122222 mRNA Translation: BAC65504.1
CCDSiCCDS25193.1
RefSeqiNP_080101.1, NM_025825.3
UniGeneiMm.271997

Genome annotation databases

EnsembliENSMUST00000018625; ENSMUSP00000018625; ENSMUSG00000018481
GeneIDi66884
KEGGimmu:66884
UCSCiuc007krj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAPBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAX9
Secondary accession number(s): Q5SX12, Q80U61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health