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Protein

Amyloid protein-binding protein 2

Gene

Appbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name:
APP-BP2
Gene namesi
Name:Appbp2
Synonyms:Kiaa0228
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914134. Appbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Amyloid protein-binding protein 2PRO_0000106260Add
BLAST

Post-translational modificationi

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.By similarity

Proteomic databases

EPDiQ9DAX9.
MaxQBiQ9DAX9.
PaxDbiQ9DAX9.
PeptideAtlasiQ9DAX9.
PRIDEiQ9DAX9.

PTM databases

iPTMnetiQ9DAX9.
PhosphoSiteiQ9DAX9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018481.
GenevisibleiQ9DAX9. MM.

Interactioni

Subunit structurei

Binds APP.By similarity

Protein-protein interaction databases

BioGridi211787. 2 interactions.
STRINGi10090.ENSMUSP00000018625.

Structurei

3D structure databases

ProteinModelPortaliQ9DAX9.
SMRiQ9DAX9. Positions 342-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 8334TPR 1Add
BLAST
Repeati120 – 15334TPR 2Add
BLAST
Repeati206 – 23934TPR 3Add
BLAST
Repeati288 – 32134TPR 4Add
BLAST
Repeati333 – 36735TPR 5Add
BLAST
Repeati429 – 46234TPR 6Add
BLAST
Repeati471 – 50535TPR 7Add
BLAST
Repeati514 – 54734TPR 8Add
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000010722.
HOGENOMiHOG000007799.
HOVERGENiHBG050527.
InParanoidiQ9DAX9.
OMAiHYDEAYR.
OrthoDBiEOG091G057R.
PhylomeDBiQ9DAX9.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ
60 70 80 90 100
GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS
110 120 130 140 150
FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC
160 170 180 190 200
TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG
210 220 230 240 250
QQANRAALYG ELCALLFAKS HYDEAYKWCV EAMKEITAGL PVKVVVDVLR
260 270 280 290 300
QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
310 320 330 340 350
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF
360 370 380 390 400
DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ
410 420 430 440 450
RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE
460 470 480 490 500
MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA
510 520 530 540 550
IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ
560 570 580
YSVTDALEDV SSSPQSTEEV VQSFLMAQNV EGPSC
Length:585
Mass (Da):66,855
Last modified:June 1, 2001 - v1
Checksum:i70779B567F785B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005440 mRNA. Translation: BAB24034.1.
AL596183 Genomic DNA. Translation: CAI24920.1.
BC018442 mRNA. Translation: AAH18442.1.
BC019152 mRNA. Translation: AAH19152.1.
AK122222 mRNA. Translation: BAC65504.1.
CCDSiCCDS25193.1.
RefSeqiNP_080101.1. NM_025825.3.
UniGeneiMm.271997.

Genome annotation databases

EnsembliENSMUST00000018625; ENSMUSP00000018625; ENSMUSG00000018481.
GeneIDi66884.
KEGGimmu:66884.
UCSCiuc007krj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005440 mRNA. Translation: BAB24034.1.
AL596183 Genomic DNA. Translation: CAI24920.1.
BC018442 mRNA. Translation: AAH18442.1.
BC019152 mRNA. Translation: AAH19152.1.
AK122222 mRNA. Translation: BAC65504.1.
CCDSiCCDS25193.1.
RefSeqiNP_080101.1. NM_025825.3.
UniGeneiMm.271997.

3D structure databases

ProteinModelPortaliQ9DAX9.
SMRiQ9DAX9. Positions 342-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211787. 2 interactions.
STRINGi10090.ENSMUSP00000018625.

PTM databases

iPTMnetiQ9DAX9.
PhosphoSiteiQ9DAX9.

Proteomic databases

EPDiQ9DAX9.
MaxQBiQ9DAX9.
PaxDbiQ9DAX9.
PeptideAtlasiQ9DAX9.
PRIDEiQ9DAX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018625; ENSMUSP00000018625; ENSMUSG00000018481.
GeneIDi66884.
KEGGimmu:66884.
UCSCiuc007krj.1. mouse.

Organism-specific databases

CTDi10513.
MGIiMGI:1914134. Appbp2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000010722.
HOGENOMiHOG000007799.
HOVERGENiHBG050527.
InParanoidiQ9DAX9.
OMAiHYDEAYR.
OrthoDBiEOG091G057R.
PhylomeDBiQ9DAX9.
TreeFamiTF314010.

Miscellaneous databases

ChiTaRSiAppbp2. mouse.
PROiQ9DAX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018481.
GenevisibleiQ9DAX9. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAX9
Secondary accession number(s): Q5SX12, Q80U61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.