Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospholipid phosphatase 2

Gene

Plpp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) (By similarity).By similarity

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

  • lipid phosphatase activity Source: GO_Central
  • phosphatidate phosphatase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 2By similarity (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphohydrolase 2
PAP2-gamma
Short name:
PAP2-G
Phosphatidate phosphohydrolase type 2c
Phosphatidic acid phosphatase 2c
Short name:
PAP-2c
Short name:
PAP2c
Gene namesi
Name:Plpp2By similarity
Synonyms:Lpp2, Ppap2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1354945. Plpp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Phospholipid phosphatase 2PRO_0000220910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9DAX2.
PaxDbiQ9DAX2.
PRIDEiQ9DAX2.

PTM databases

iPTMnetiQ9DAX2.
PhosphoSiteiQ9DAX2.

Expressioni

Tissue specificityi

Expressed at high levels in lung, liver and kidney; at low levels in heart and brain, and was not detected in skeletal muscle.

Gene expression databases

BgeeiQ9DAX2.
CleanExiMM_PPAP2C.
ExpressionAtlasiQ9DAX2. baseline and differential.
GenevisibleiQ9DAX2. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9DAX2. 1 interaction.
STRINGi10090.ENSMUSP00000069670.

Structurei

3D structure databases

ProteinModelPortaliQ9DAX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOVERGENiHBG002048.
InParanoidiQ9DAX2.
KOiK01080.
OMAiVACLTVR.
OrthoDBiEOG7C5M9Q.
PhylomeDBiQ9DAX2.
TreeFamiTF316040.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028674. LPP2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF25. PTHR10165:SF25. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DAX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERRWVFVLL DVLCVLVASL PFIILTLVNA PYKRGFYCGD DSIRYPYRPD
60 70 80 90 100
TITHGLMAGV IITATVILVS LGEAYLVYTD RLYSRSNFNN YVAAIYKVLG
110 120 130 140 150
TFLFGAAVSQ SLTDLAKYMI GRLRPSFLAV CDPDWSQVNC SGYVQLEVCR
160 170 180 190 200
GSPANVTEAR LSFYSGHSSF GMYCMLFLAL YVQARLCWKW ARLLRPTVQF
210 220 230 240 250
FLVAFAIYVG YTRVSDHKHH WSDVLVGLLQ GALVACLTVR YVSDFFKSRP
260 270
PQPCQEDEVP ERKPSLSLTL TLGDRP
Length:276
Mass (Da):31,193
Last modified:June 1, 2001 - v1
Checksum:i978A83D4681113D2
GO
Isoform 2 (identifier: Q9DAX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-250: RYVSDFFKSRP → SPTCLTHRLCF
     251-276: Missing.

Show »
Length:250
Mass (Da):28,181
Checksum:iD2FFB4C25244781E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei240 – 25011RYVSDFFKSRP → SPTCLTHRLCF in isoform 2. 1 PublicationVSP_009654Add
BLAST
Alternative sequencei251 – 27626Missing in isoform 2. 1 PublicationVSP_009655Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123611 mRNA. Translation: AAD24061.1.
AK005452 mRNA. Translation: BAB24045.1.
AK049581 mRNA. Translation: BAC33824.1.
BC010332 mRNA. Translation: AAH10332.1.
CCDSiCCDS35966.1. [Q9DAX2-1]
RefSeqiNP_001289318.1. NM_001302389.1.
NP_001289319.1. NM_001302390.1.
NP_001289371.1. NM_001302442.1.
NP_056632.2. NM_015817.3. [Q9DAX2-1]
UniGeneiMm.28873.

Genome annotation databases

EnsembliENSMUST00000063879; ENSMUSP00000069670; ENSMUSG00000052151. [Q9DAX2-1]
GeneIDi50784.
KEGGimmu:50784.
UCSCiuc007fyq.2. mouse. [Q9DAX2-1]
uc007fyt.1. mouse. [Q9DAX2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123611 mRNA. Translation: AAD24061.1.
AK005452 mRNA. Translation: BAB24045.1.
AK049581 mRNA. Translation: BAC33824.1.
BC010332 mRNA. Translation: AAH10332.1.
CCDSiCCDS35966.1. [Q9DAX2-1]
RefSeqiNP_001289318.1. NM_001302389.1.
NP_001289319.1. NM_001302390.1.
NP_001289371.1. NM_001302442.1.
NP_056632.2. NM_015817.3. [Q9DAX2-1]
UniGeneiMm.28873.

3D structure databases

ProteinModelPortaliQ9DAX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DAX2. 1 interaction.
STRINGi10090.ENSMUSP00000069670.

PTM databases

iPTMnetiQ9DAX2.
PhosphoSiteiQ9DAX2.

Proteomic databases

MaxQBiQ9DAX2.
PaxDbiQ9DAX2.
PRIDEiQ9DAX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063879; ENSMUSP00000069670; ENSMUSG00000052151. [Q9DAX2-1]
GeneIDi50784.
KEGGimmu:50784.
UCSCiuc007fyq.2. mouse. [Q9DAX2-1]
uc007fyt.1. mouse. [Q9DAX2-2]

Organism-specific databases

CTDi8612.
MGIiMGI:1354945. Plpp2.

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOVERGENiHBG002048.
InParanoidiQ9DAX2.
KOiK01080.
OMAiVACLTVR.
OrthoDBiEOG7C5M9Q.
PhylomeDBiQ9DAX2.
TreeFamiTF316040.

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiPpap2c. mouse.
PROiQ9DAX2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAX2.
CleanExiMM_PPAP2C.
ExpressionAtlasiQ9DAX2. baseline and differential.
GenevisibleiQ9DAX2. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028674. LPP2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF25. PTHR10165:SF25. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases."
    Zhang N., Copeland N.G., Gilbert D.J., Jenkins N.A., Gridley T.
    Genomics 63:142-144(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo and Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary tumor.
  4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-155.
    Tissue: Myoblast.

Entry informationi

Entry nameiPLPP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAX2
Secondary accession number(s): Q9WUA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.