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Protein

Calponin-3

Gene

Cnn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-3
Alternative name(s):
Calponin, acidic isoform
Gene namesi
Name:Cnn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919244. Cnn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047771 – 330Calponin-3Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei158N6-methyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ9DAW9.
MaxQBiQ9DAW9.
PaxDbiQ9DAW9.
PeptideAtlasiQ9DAW9.
PRIDEiQ9DAW9.

PTM databases

iPTMnetiQ9DAW9.
PhosphoSitePlusiQ9DAW9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053931.
CleanExiMM_CNN3.
ExpressionAtlasiQ9DAW9. baseline and differential.
GenevisibleiQ9DAW9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215081. 4 interactors.
IntActiQ9DAW9. 4 interactors.
MINTiMINT-217278.
STRINGi10090.ENSMUSP00000029773.

Structurei

3D structure databases

ProteinModelPortaliQ9DAW9.
SMRiQ9DAW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 129CHPROSITE-ProRule annotationAdd BLAST104
Repeati164 – 189Calponin-like 1Add BLAST26
Repeati204 – 229Calponin-like 2Add BLAST26
Repeati243 – 268Calponin-like 3Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi290 – 330Asp/Glu-rich (acidic)Add BLAST41

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 3 calponin-like repeats.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ9DAW9.
OMAiDDYPREY.
OrthoDBiEOG091G0LY2.
PhylomeDBiQ9DAW9.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHFNKGPSY GLSAEVKNKI ASKYDQQAEE DLRNWIEEVT GLGIGTNFQL
60 70 80 90 100
GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP
110 120 130 140 150
HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDI GVKYAEKQTR
160 170 180 190 200
RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD
210 220 230 240 250
QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN STISLQMGTN
260 270 280 290 300
KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
310 320 330
QAEYPDEYHG EYPDDYPREY QYGDDQGIDY
Length:330
Mass (Da):36,429
Last modified:June 1, 2001 - v1
Checksum:iFF448A33F29B2C90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005460 mRNA. Translation: BAB24051.1.
AK051628 mRNA. Translation: BAC34697.1.
AK159555 mRNA. Translation: BAE35180.1.
AK159871 mRNA. Translation: BAE35444.1.
AK166578 mRNA. Translation: BAE38867.1.
AK167201 mRNA. Translation: BAE39329.1.
AK167613 mRNA. Translation: BAE39666.1.
AK169021 mRNA. Translation: BAE40817.1.
AK169098 mRNA. Translation: BAE40881.1.
AK169410 mRNA. Translation: BAE41156.1.
BC055711 mRNA. Translation: AAH55711.1.
BC085268 mRNA. Translation: AAH85268.1.
CCDSiCCDS17802.1.
RefSeqiNP_082320.1. NM_028044.2.
UniGeneiMm.275555.

Genome annotation databases

EnsembliENSMUST00000029773; ENSMUSP00000029773; ENSMUSG00000053931.
GeneIDi71994.
KEGGimmu:71994.
UCSCiuc008rdy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005460 mRNA. Translation: BAB24051.1.
AK051628 mRNA. Translation: BAC34697.1.
AK159555 mRNA. Translation: BAE35180.1.
AK159871 mRNA. Translation: BAE35444.1.
AK166578 mRNA. Translation: BAE38867.1.
AK167201 mRNA. Translation: BAE39329.1.
AK167613 mRNA. Translation: BAE39666.1.
AK169021 mRNA. Translation: BAE40817.1.
AK169098 mRNA. Translation: BAE40881.1.
AK169410 mRNA. Translation: BAE41156.1.
BC055711 mRNA. Translation: AAH55711.1.
BC085268 mRNA. Translation: AAH85268.1.
CCDSiCCDS17802.1.
RefSeqiNP_082320.1. NM_028044.2.
UniGeneiMm.275555.

3D structure databases

ProteinModelPortaliQ9DAW9.
SMRiQ9DAW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215081. 4 interactors.
IntActiQ9DAW9. 4 interactors.
MINTiMINT-217278.
STRINGi10090.ENSMUSP00000029773.

PTM databases

iPTMnetiQ9DAW9.
PhosphoSitePlusiQ9DAW9.

Proteomic databases

EPDiQ9DAW9.
MaxQBiQ9DAW9.
PaxDbiQ9DAW9.
PeptideAtlasiQ9DAW9.
PRIDEiQ9DAW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029773; ENSMUSP00000029773; ENSMUSG00000053931.
GeneIDi71994.
KEGGimmu:71994.
UCSCiuc008rdy.1. mouse.

Organism-specific databases

CTDi1266.
MGIiMGI:1919244. Cnn3.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ9DAW9.
OMAiDDYPREY.
OrthoDBiEOG091G0LY2.
PhylomeDBiQ9DAW9.
TreeFamiTF313921.

Miscellaneous databases

ChiTaRSiCnn3. mouse.
PROiQ9DAW9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053931.
CleanExiMM_CNN3.
ExpressionAtlasiQ9DAW9. baseline and differential.
GenevisibleiQ9DAW9. MM.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNN3_MOUSE
AccessioniPrimary (citable) accession number: Q9DAW9
Secondary accession number(s): Q3TW23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.