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Q9DAW6

- PRP4_MOUSE

UniProt

Q9DAW6 - PRP4_MOUSE

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Protein

U4/U6 small nuclear ribonucleoprotein Prp4

Gene
Prpf4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome By similarity.

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6 small nuclear ribonucleoprotein Prp4
Alternative name(s):
U4/U6 snRNP 60 kDa protein
WD splicing factor Prp4
Gene namesi
Name:Prpf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1917302. Prpf4.

Subcellular locationi

Nucleus speckle By similarity
Note: Colocalizes with spliceosomal snRNPs By similarity.

GO - Cellular componenti

  1. Cajal body Source: Ensembl
  2. nuclear speck Source: UniProtKB-SubCell
  3. spliceosomal complex Source: UniProtKB-KW
  4. U4/U6 snRNP Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521U4/U6 small nuclear ribonucleoprotein Prp4PRO_0000051150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9DAW6.
PaxDbiQ9DAW6.
PRIDEiQ9DAW6.

PTM databases

PhosphoSiteiQ9DAW6.

Expressioni

Gene expression databases

ArrayExpressiQ9DAW6.
BgeeiQ9DAW6.
CleanExiMM_PRPF4.
GenevestigatoriQ9DAW6.

Interactioni

Subunit structurei

Interacts directly with PRPF18, PPIH and PRPF3. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.

Protein-protein interaction databases

BioGridi213838. 1 interaction.
IntActiQ9DAW6. 1 interaction.
MINTiMINT-4127974.
STRINGi10090.ENSMUSP00000081572.

Structurei

3D structure databases

ProteinModelPortaliQ9DAW6.
SMRiQ9DAW6. Positions 106-136, 238-519.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati228 – 26740WD 1Add
BLAST
Repeati270 – 31748WD 2Add
BLAST
Repeati320 – 35940WD 3Add
BLAST
Repeati362 – 40140WD 4Add
BLAST
Repeati404 – 44340WD 5Add
BLAST
Repeati446 – 48641WD 6Add
BLAST
Repeati489 – 52133WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00740000115057.
HOGENOMiHOG000157615.
HOVERGENiHBG030892.
InParanoidiQ9DAW6.
KOiK12662.
OMAiHPSRQAY.
OrthoDBiEOG7P5T0Z.
PhylomeDBiQ9DAW6.
TreeFamiTF314922.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR027106. Prp4.
IPR014906. PRP4-like.
IPR003648. SFM.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19846. PTHR19846. 1 hit.
PfamiPF08799. PRP4. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00500. SFM. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAW6-1 [UniParc]FASTAAdd to Basket

« Hide

MASSRASSTT TKTKAPDDLV APVVKKPHIY YGSLEEKERE RLAKGESGIL    50
GKEGLKAGIE AGNINITSGE VFEIEEHISE RQAEVLAEFE RRKRARQINV 100
STDDSEVKAC LRALGEPITL FGEGPAERRE RLRNILSVVG TDALKKTKKD 150
DEKSKKSKEE YQQTWYHEGP NSLKVARLWI ANYSLPRAMK RLEEARLHKE 200
IPETTRTSQM QELHKSLRSL NNFCSQIGDD RPISYCHFSP NSKMLATACW 250
SGLCKLWSVP DCSLLHTLRG HNTNVGAIVF HPKSTVSLDQ KDVNLASCAA 300
DGSVKLWSLD SDEPVADIEG HTVRVARVMW HPSGRFLGTT CYDRSWRLWD 350
LEAQEEILHQ EGHSMGVYDI AFHQDGSLAG TGGLDAFGRV WDLRTGRCIM 400
FLEGHLKEIY GINFSPNGYH IATGSGDNTC KVWDLRQRRC VYTIPAHQNL 450
VTGVKFEPIH GDFLLTGAYD NTAKIWTHPG WSPLKTLAGH EGKVMGLDIS 500
SDGQLIATCS YDRTFKLWMA E 521
Length:521
Mass (Da):58,370
Last modified:June 1, 2001 - v1
Checksum:iCDE80E76D591CC89
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005464 mRNA. Translation: BAB24055.1.
AK089838 mRNA. Translation: BAC40976.1.
AK166912 mRNA. Translation: BAE39112.1.
AK167216 mRNA. Translation: BAE39342.1.
AK169532 mRNA. Translation: BAE41214.1.
BC106089 mRNA. Translation: AAI06090.1.
CCDSiCCDS18239.1.
RefSeqiNP_081573.1. NM_027297.3.
UniGeneiMm.30660.

Genome annotation databases

EnsembliENSMUST00000084524; ENSMUSP00000081572; ENSMUSG00000066148.
GeneIDi70052.
KEGGimmu:70052.
UCSCiuc008ter.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005464 mRNA. Translation: BAB24055.1 .
AK089838 mRNA. Translation: BAC40976.1 .
AK166912 mRNA. Translation: BAE39112.1 .
AK167216 mRNA. Translation: BAE39342.1 .
AK169532 mRNA. Translation: BAE41214.1 .
BC106089 mRNA. Translation: AAI06090.1 .
CCDSi CCDS18239.1.
RefSeqi NP_081573.1. NM_027297.3.
UniGenei Mm.30660.

3D structure databases

ProteinModelPortali Q9DAW6.
SMRi Q9DAW6. Positions 106-136, 238-519.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 213838. 1 interaction.
IntActi Q9DAW6. 1 interaction.
MINTi MINT-4127974.
STRINGi 10090.ENSMUSP00000081572.

PTM databases

PhosphoSitei Q9DAW6.

Proteomic databases

MaxQBi Q9DAW6.
PaxDbi Q9DAW6.
PRIDEi Q9DAW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084524 ; ENSMUSP00000081572 ; ENSMUSG00000066148 .
GeneIDi 70052.
KEGGi mmu:70052.
UCSCi uc008ter.1. mouse.

Organism-specific databases

CTDi 9128.
MGIi MGI:1917302. Prpf4.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00740000115057.
HOGENOMi HOG000157615.
HOVERGENi HBG030892.
InParanoidi Q9DAW6.
KOi K12662.
OMAi HPSRQAY.
OrthoDBi EOG7P5T0Z.
PhylomeDBi Q9DAW6.
TreeFami TF314922.

Miscellaneous databases

ChiTaRSi PRPF4. mouse.
NextBioi 330897.
PROi Q9DAW6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9DAW6.
Bgeei Q9DAW6.
CleanExi MM_PRPF4.
Genevestigatori Q9DAW6.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR027106. Prp4.
IPR014906. PRP4-like.
IPR003648. SFM.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR19846. PTHR19846. 1 hit.
Pfami PF08799. PRP4. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00500. SFM. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Placenta, Spleen and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPRP4_MOUSE
AccessioniPrimary (citable) accession number: Q9DAW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi