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Q9DAW6

- PRP4_MOUSE

UniProt

Q9DAW6 - PRP4_MOUSE

Protein

U4/U6 small nuclear ribonucleoprotein Prp4

Gene

Prpf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome By similarity.By similarity

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U4/U6 small nuclear ribonucleoprotein Prp4
    Alternative name(s):
    U4/U6 snRNP 60 kDa protein
    WD splicing factor Prp4
    Gene namesi
    Name:Prpf4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1917302. Prpf4.

    Subcellular locationi

    Nucleus speckle By similarity
    Note: Colocalizes with spliceosomal snRNPs.By similarity

    GO - Cellular componenti

    1. Cajal body Source: Ensembl
    2. nuclear speck Source: UniProtKB-SubCell
    3. spliceosomal complex Source: UniProtKB-KW
    4. U4/U6 snRNP Source: Ensembl

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521U4/U6 small nuclear ribonucleoprotein Prp4PRO_0000051150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9DAW6.
    PaxDbiQ9DAW6.
    PRIDEiQ9DAW6.

    PTM databases

    PhosphoSiteiQ9DAW6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9DAW6.
    BgeeiQ9DAW6.
    CleanExiMM_PRPF4.
    GenevestigatoriQ9DAW6.

    Interactioni

    Subunit structurei

    Interacts directly with PRPF18, PPIH and PRPF3. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi213838. 1 interaction.
    IntActiQ9DAW6. 1 interaction.
    MINTiMINT-4127974.
    STRINGi10090.ENSMUSP00000081572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DAW6.
    SMRiQ9DAW6. Positions 106-136, 238-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati228 – 26740WD 1Add
    BLAST
    Repeati270 – 31748WD 2Add
    BLAST
    Repeati320 – 35940WD 3Add
    BLAST
    Repeati362 – 40140WD 4Add
    BLAST
    Repeati404 – 44340WD 5Add
    BLAST
    Repeati446 – 48641WD 6Add
    BLAST
    Repeati489 – 52133WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00740000115057.
    HOGENOMiHOG000157615.
    HOVERGENiHBG030892.
    InParanoidiQ9DAW6.
    KOiK12662.
    OMAiHPSRQAY.
    OrthoDBiEOG7P5T0Z.
    PhylomeDBiQ9DAW6.
    TreeFamiTF314922.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR027106. Prp4.
    IPR014906. PRP4-like.
    IPR003648. SFM.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR19846. PTHR19846. 1 hit.
    PfamiPF08799. PRP4. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00500. SFM. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DAW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSRASSTT TKTKAPDDLV APVVKKPHIY YGSLEEKERE RLAKGESGIL    50
    GKEGLKAGIE AGNINITSGE VFEIEEHISE RQAEVLAEFE RRKRARQINV 100
    STDDSEVKAC LRALGEPITL FGEGPAERRE RLRNILSVVG TDALKKTKKD 150
    DEKSKKSKEE YQQTWYHEGP NSLKVARLWI ANYSLPRAMK RLEEARLHKE 200
    IPETTRTSQM QELHKSLRSL NNFCSQIGDD RPISYCHFSP NSKMLATACW 250
    SGLCKLWSVP DCSLLHTLRG HNTNVGAIVF HPKSTVSLDQ KDVNLASCAA 300
    DGSVKLWSLD SDEPVADIEG HTVRVARVMW HPSGRFLGTT CYDRSWRLWD 350
    LEAQEEILHQ EGHSMGVYDI AFHQDGSLAG TGGLDAFGRV WDLRTGRCIM 400
    FLEGHLKEIY GINFSPNGYH IATGSGDNTC KVWDLRQRRC VYTIPAHQNL 450
    VTGVKFEPIH GDFLLTGAYD NTAKIWTHPG WSPLKTLAGH EGKVMGLDIS 500
    SDGQLIATCS YDRTFKLWMA E 521
    Length:521
    Mass (Da):58,370
    Last modified:June 1, 2001 - v1
    Checksum:iCDE80E76D591CC89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005464 mRNA. Translation: BAB24055.1.
    AK089838 mRNA. Translation: BAC40976.1.
    AK166912 mRNA. Translation: BAE39112.1.
    AK167216 mRNA. Translation: BAE39342.1.
    AK169532 mRNA. Translation: BAE41214.1.
    BC106089 mRNA. Translation: AAI06090.1.
    CCDSiCCDS18239.1.
    RefSeqiNP_081573.1. NM_027297.3.
    UniGeneiMm.30660.

    Genome annotation databases

    EnsembliENSMUST00000084524; ENSMUSP00000081572; ENSMUSG00000066148.
    GeneIDi70052.
    KEGGimmu:70052.
    UCSCiuc008ter.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005464 mRNA. Translation: BAB24055.1 .
    AK089838 mRNA. Translation: BAC40976.1 .
    AK166912 mRNA. Translation: BAE39112.1 .
    AK167216 mRNA. Translation: BAE39342.1 .
    AK169532 mRNA. Translation: BAE41214.1 .
    BC106089 mRNA. Translation: AAI06090.1 .
    CCDSi CCDS18239.1.
    RefSeqi NP_081573.1. NM_027297.3.
    UniGenei Mm.30660.

    3D structure databases

    ProteinModelPortali Q9DAW6.
    SMRi Q9DAW6. Positions 106-136, 238-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 213838. 1 interaction.
    IntActi Q9DAW6. 1 interaction.
    MINTi MINT-4127974.
    STRINGi 10090.ENSMUSP00000081572.

    PTM databases

    PhosphoSitei Q9DAW6.

    Proteomic databases

    MaxQBi Q9DAW6.
    PaxDbi Q9DAW6.
    PRIDEi Q9DAW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084524 ; ENSMUSP00000081572 ; ENSMUSG00000066148 .
    GeneIDi 70052.
    KEGGi mmu:70052.
    UCSCi uc008ter.1. mouse.

    Organism-specific databases

    CTDi 9128.
    MGIi MGI:1917302. Prpf4.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00740000115057.
    HOGENOMi HOG000157615.
    HOVERGENi HBG030892.
    InParanoidi Q9DAW6.
    KOi K12662.
    OMAi HPSRQAY.
    OrthoDBi EOG7P5T0Z.
    PhylomeDBi Q9DAW6.
    TreeFami TF314922.

    Miscellaneous databases

    ChiTaRSi PRPF4. mouse.
    NextBioi 330897.
    PROi Q9DAW6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DAW6.
    Bgeei Q9DAW6.
    CleanExi MM_PRPF4.
    Genevestigatori Q9DAW6.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR027106. Prp4.
    IPR014906. PRP4-like.
    IPR003648. SFM.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR19846. PTHR19846. 1 hit.
    Pfami PF08799. PRP4. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00500. SFM. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Placenta, Spleen and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiPRP4_MOUSE
    AccessioniPrimary (citable) accession number: Q9DAW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3