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Protein
Submitted name:

Vascular endothelial growth factor receptor 1

Gene

Flt1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. growth factor binding Source: MGI
  3. identical protein binding Source: MGI
  4. placental growth factor-activated receptor activity Source: MGI
  5. vascular endothelial growth factor-activated receptor activity Source: MGI
  6. VEGF-A-activated receptor activity Source: MGI
  7. VEGF-B-activated receptor activity Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. cell migration Source: MGI
  3. cellular response to vascular endothelial growth factor stimulus Source: MGI
  4. monocyte chemotaxis Source: MGI
  5. patterning of blood vessels Source: MGI
  6. peptidyl-tyrosine phosphorylation Source: MGI
  7. positive regulation of angiogenesis Source: MGI
  8. positive regulation of cell migration Source: MGI
  9. positive regulation of hematopoietic progenitor cell differentiation Source: MGI
  10. positive regulation of MAPK cascade Source: MGI
  11. positive regulation of MAP kinase activity Source: MGI
  12. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  13. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  14. positive regulation of phospholipase C activity Source: MGI
  15. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
  16. protein autophosphorylation Source: MGI
  17. response to hypoxia Source: MGI
  18. sprouting angiogenesis Source: MGI
  19. vascular endothelial growth factor receptor-1 signaling pathway Source: MGI
  20. vascular endothelial growth factor receptor signaling pathway Source: MGI
  21. vascular endothelial growth factor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vascular endothelial growth factor receptor 1Imported
Gene namesi
Name:Flt1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95558. Flt1.

Subcellular locationi

GO - Cellular componenti

  1. focal adhesion Source: MGI
  2. integral component of plasma membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9DAV2.

Expressioni

Gene expression databases

BgeeiQ9DAV2.
ExpressionAtlasiQ9DAV2. baseline and differential.
GenevestigatoriQ9DAV2.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9DAV2.
SMRiQ9DAV2. Positions 32-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118923.
HOGENOMiHOG000114763.
HOVERGENiHBG053003.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR009135. VEGFR1_rcpt.
[Graphical view]
PANTHERiPTHR24416:SF126. PTHR24416:SF126. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF000615. TyrPK_CSF1-R. 1 hit.
PRINTSiPR01833. VEGFRECEPTR1.
SMARTiSM00409. IG. 4 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSCWDTAVL PYALLGCLLL TGYGSGSKLK VPELSLKGTQ HVMQAGQTLF
60 70 80 90 100
LKCRGEAAHS WSLPTTVSQE DKRLSITPPS ACGRDNRQFC STLTLDTAQA
110 120 130 140 150
NHTGLYTCRY LPTSTSKKKK AESSIYIFVS DAGSPFIEMH TDIPKLVHMT
160 170 180 190 200
EGRQLIIPCR VTSPNVTVTL KKFPFDTLTP DGQRITWDSR RGFIIANATY
210 220 230 240 250
KEIGLLNCEA TVNGHLYQTN YLTHRQTNTI LDVQIRPPSP VRLLHGQTLV
260 270 280 290 300
LNCTATTELN TRVQMSWNYP GKATKRASIR QRIDRSHSHN NVFHSVLKIN
310 320 330 340 350
NVESRDKGLY TCRVKSGSSF QSFNTSVHVY EKGFISVKHR KQPVQETTAG
360 370 380 390 400
RRSYRLSMKV KAFPSPEIVW LKDGSPATLK SARYLVHGYS LIIKDVTTED
410 420 430 440 450
AGDYTILLGI KQSRLFKNLT ATLIVNVKPQ IYEKSVSSLP SPPLYPLGSR
460 470 480 490 500
QVLTCTVYGI PRPTITWLWH PCHHNHSKER YDFCTENEES FILDPSSNLG
510 520 530 540 550
NRIESISQRM TVIEGTNKPG ELILLGNQAG CTLLAPYPNY TFNLLSALQS
560
HLWGGTWSPH KCWD
Length:564
Mass (Da):63,247
Last modified:May 31, 2001 - v1
Checksum:iAA102CEF71B677DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122299 Genomic DNA. No translation available.
AC131730 Genomic DNA. No translation available.
AK005502 mRNA. Translation: BAB24084.1.
UniGeneiMm.389712.

Genome annotation databases

EnsembliENSMUST00000031652; ENSMUSP00000031652; ENSMUSG00000029648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122299 Genomic DNA. No translation available.
AC131730 Genomic DNA. No translation available.
AK005502 mRNA. Translation: BAB24084.1.
UniGeneiMm.389712.

3D structure databases

ProteinModelPortaliQ9DAV2.
SMRiQ9DAV2. Positions 32-471.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9DAV2.

Proteomic databases

PRIDEiQ9DAV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031652; ENSMUSP00000031652; ENSMUSG00000029648.

Organism-specific databases

MGIiMGI:95558. Flt1.

Phylogenomic databases

GeneTreeiENSGT00760000118923.
HOGENOMiHOG000114763.
HOVERGENiHBG053003.

Miscellaneous databases

ChiTaRSiFlt1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAV2.
ExpressionAtlasiQ9DAV2. baseline and differential.
GenevestigatoriQ9DAV2.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR009135. VEGFR1_rcpt.
[Graphical view]
PANTHERiPTHR24416:SF126. PTHR24416:SF126. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF000615. TyrPK_CSF1-R. 1 hit.
PRINTSiPR01833. VEGFRECEPTR1.
SMARTiSM00409. IG. 4 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9DAV2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAV2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2001
Last sequence update: May 31, 2001
Last modified: March 31, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.