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Protein

WAP four-disulfide core domain protein 2

Gene

Wfdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Broad range protease inhibitor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI17.004.

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 2
Alternative name(s):
WAP domain-containing protein HE4
Gene namesi
Name:Wfdc2
Synonyms:He4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914951. Wfdc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 174149WAP four-disulfide core domain protein 2PRO_0000041371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 62PROSITE-ProRule annotation
Disulfide bondi45 ↔ 66PROSITE-ProRule annotation
Disulfide bondi49 ↔ 61PROSITE-ProRule annotation
Disulfide bondi55 ↔ 70PROSITE-ProRule annotation
Disulfide bondi132 ↔ 160PROSITE-ProRule annotation
Disulfide bondi143 ↔ 164PROSITE-ProRule annotation
Disulfide bondi147 ↔ 159PROSITE-ProRule annotation
Disulfide bondi153 ↔ 169PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9DAU7.
PaxDbiQ9DAU7.
PeptideAtlasiQ9DAU7.
PRIDEiQ9DAU7.

Expressioni

Gene expression databases

BgeeiQ9DAU7.
CleanExiMM_WFDC2.
ExpressionAtlasiQ9DAU7. baseline and differential.
GenevisibleiQ9DAU7. MM.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked.By similarity

Protein-protein interaction databases

IntActiQ9DAU7. 1 interaction.
MINTiMINT-4140382.
STRINGi10090.ENSMUSP00000017867.

Structurei

3D structure databases

ProteinModelPortaliQ9DAU7.
SMRiQ9DAU7. Positions 31-74, 127-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 7446WAP 1PROSITE-ProRule annotationAdd
BLAST
Domaini125 – 17349WAP 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 WAP domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J36N. Eukaryota.
ENOG41125F3. LUCA.
GeneTreeiENSGT00730000111410.
HOGENOMiHOG000115819.
HOVERGENiHBG018073.
InParanoidiQ9DAU7.
OMAiQCPGLLK.
OrthoDBiEOG7S7SG9.
PhylomeDBiQ9DAU7.

Family and domain databases

Gene3Di4.10.75.10. 2 hits.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 2 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 2 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 2 hits.
PROSITEiPS51390. WAP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DAU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPACRLCLLA AGLLLGLLLF TPISATGTDA EKPGECPQLE PITDCVLECT
60 70 80 90 100
LDKDCADNRK CCQAGCSSVC SKPNGPSEGE LSGTDTKLSE TGTTTQSAGL
110 120 130 140 150
DHTTKPPGGQ VSTKPPAVTR EGLGVREKQG TCPSVDIPKL GLCEDQCQVD
160 170
SQCSGNMKCC RNGCGKMACT TPKF
Length:174
Mass (Da):18,032
Last modified:June 1, 2001 - v1
Checksum:i82484E28ED6F1E20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334269 mRNA. Translation: AAL73189.1.
AK005519 mRNA. Translation: BAB24094.1.
CCDSiCCDS17040.1.
RefSeqiNP_080599.1. NM_026323.2.
UniGeneiMm.27289.

Genome annotation databases

EnsembliENSMUST00000017867; ENSMUSP00000017867; ENSMUSG00000017723.
GeneIDi67701.
KEGGimmu:67701.
UCSCiuc008nve.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334269 mRNA. Translation: AAL73189.1.
AK005519 mRNA. Translation: BAB24094.1.
CCDSiCCDS17040.1.
RefSeqiNP_080599.1. NM_026323.2.
UniGeneiMm.27289.

3D structure databases

ProteinModelPortaliQ9DAU7.
SMRiQ9DAU7. Positions 31-74, 127-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DAU7. 1 interaction.
MINTiMINT-4140382.
STRINGi10090.ENSMUSP00000017867.

Protein family/group databases

MEROPSiI17.004.

Proteomic databases

MaxQBiQ9DAU7.
PaxDbiQ9DAU7.
PeptideAtlasiQ9DAU7.
PRIDEiQ9DAU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017867; ENSMUSP00000017867; ENSMUSG00000017723.
GeneIDi67701.
KEGGimmu:67701.
UCSCiuc008nve.1. mouse.

Organism-specific databases

CTDi10406.
MGIiMGI:1914951. Wfdc2.

Phylogenomic databases

eggNOGiENOG410J36N. Eukaryota.
ENOG41125F3. LUCA.
GeneTreeiENSGT00730000111410.
HOGENOMiHOG000115819.
HOVERGENiHBG018073.
InParanoidiQ9DAU7.
OMAiQCPGLLK.
OrthoDBiEOG7S7SG9.
PhylomeDBiQ9DAU7.

Miscellaneous databases

PROiQ9DAU7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAU7.
CleanExiMM_WFDC2.
ExpressionAtlasiQ9DAU7. baseline and differential.
GenevisibleiQ9DAU7. MM.

Family and domain databases

Gene3Di4.10.75.10. 2 hits.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 2 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 2 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 2 hits.
PROSITEiPS51390. WAP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse HE4."
    Bingle C.D.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiWFDC2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.