Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Protein delta homolog 1

Gene

Dlk1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • embryonic skeletal system development Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI
  • post-embryonic development Source: MGI
  • regulation of gene expression Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein delta homolog 1Imported
Gene namesi
Name:Dlk1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:94900. Dlk1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei214 – 23522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 290267Sequence analysisPRO_5005942758Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063104.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 5534EGF-likeInterPro annotationAdd
BLAST
Domaini59 – 8628EGF-likeInterPro annotationAdd
BLAST
Domaini88 – 12538EGF-likeInterPro annotationAdd
BLAST
Domaini127 – 16842EGF-likeInterPro annotationAdd
BLAST
Domaini172 – 20837EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410XP6K. LUCA.
KOG1217. Eukaryota.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000072581.
HOVERGENiHBG007065.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DAU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIATGALLRV LLLLLAFGHS TYGAECDPPC DPQYGFCEAD NVCRCHVGWE
60 70 80 90 100
GPLCDKCVTA PGCVNGVCKE PWQCICKDGW DGKFCEIDVR ACTSTPCANN
110 120 130 140 150
GTCVDLEKGQ YECSCTPGFS GKDCQHKAGP CVINGSPCQH GGACVDDEGQ
160 170 180 190 200
ASHASCLCPP GFSGNFCEIV AATNSCTPNP CENDGVCTDI GGDFRCRCPA
210 220 230 240 250
GFVDKTCSRP AICFTILGVL TSLVVLGTVA IVFLNKCETW VSNLRYNHML
260 270 280 290
RKKKNLLLQY NSGEELAVNI IFPEKIDMTT FNKEAGDEEI
Length:290
Mass (Da):31,117
Last modified:June 1, 2001 - v1
Checksum:iEED42925D5AA267E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC165954 Genomic DNA. No translation available.
AK005522 mRNA. Translation: BAB24096.1.
RefSeqiNP_001177632.1. NM_001190703.1.
UniGeneiMm.157069.

Genome annotation databases

EnsembliENSMUST00000109843; ENSMUSP00000105469; ENSMUSG00000040856.
GeneIDi13386.
KEGGimmu:13386.
UCSCiuc007pan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC165954 Genomic DNA. No translation available.
AK005522 mRNA. Translation: BAB24096.1.
RefSeqiNP_001177632.1. NM_001190703.1.
UniGeneiMm.157069.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109843; ENSMUSP00000105469; ENSMUSG00000040856.
GeneIDi13386.
KEGGimmu:13386.
UCSCiuc007pan.2. mouse.

Organism-specific databases

CTDi8788.
MGIiMGI:94900. Dlk1.

Phylogenomic databases

eggNOGiENOG410XP6K. LUCA.
KOG1217. Eukaryota.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000072581.
HOVERGENiHBG007065.

Miscellaneous databases

NextBioi283744.
SOURCEiSearch...

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PlacentaImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9DAU5_MOUSE
AccessioniPrimary (citable) accession number: Q9DAU5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 20, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.