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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

Gng12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. PDZ domain binding Source: MGI
  2. phosphate ion binding Source: Ensembl
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. cerebral cortex development Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: InterPro
  3. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene namesi
Name:Gng12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1336171. Gng12.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. actin filament Source: Ensembl
  2. extracellular vesicular exosome Source: MGI
  3. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6968Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12PRO_0000012669Add
BLAST
Propeptidei70 – 723Removed in mature formBy similarityPRO_0000012670

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei26 – 261Phosphoserine1 Publication
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei69 – 691Cysteine methyl esterBy similarity
Lipidationi69 – 691S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ9DAS9.
PaxDbiQ9DAS9.
PRIDEiQ9DAS9.

PTM databases

PhosphoSiteiQ9DAS9.

Expressioni

Gene expression databases

BgeeiQ9DAS9.
GenevestigatoriQ9DAS9.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi199985. 1 interaction.
IntActiQ9DAS9. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9DAS9.
SMRiQ9DAS9. Positions 10-53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG265454.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ9DAS9.
KOiK04347.
OMAiQEDCLLV.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9DAS9.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DAS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKTASTNS IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD
60 70
PLLMGIPTSE NPFKDKKTCI IL
Length:72
Mass (Da):7,997
Last modified:January 23, 2007 - v3
Checksum:iA4D56F3BD697E7B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005561 mRNA. Translation: BAB24121.1.
AK033422 mRNA. Translation: BAC28280.1.
AK148765 mRNA. Translation: BAE28660.1.
AK159872 mRNA. Translation: BAE35445.1.
AK162342 mRNA. Translation: BAE36863.1.
AK166035 mRNA. Translation: BAE38536.1.
AK166299 mRNA. Translation: BAE38688.1.
BC040685 mRNA. Translation: AAH40685.1.
CCDSiCCDS39502.1.
RefSeqiNP_001171027.1. NM_001177556.1.
NP_001171028.1. NM_001177557.1.
NP_001171029.1. NM_001177558.1.
NP_001171030.1. NM_001177559.1.
NP_001171031.1. NM_001177560.1.
NP_079554.1. NM_025278.5.
XP_006505605.1. XM_006505542.1.
UniGeneiMm.234342.

Genome annotation databases

EnsembliENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402.
ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402.
ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402.
ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402.
ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402.
ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402.
ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402.
GeneIDi14701.
KEGGimmu:14701.
UCSCiuc009cew.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005561 mRNA. Translation: BAB24121.1.
AK033422 mRNA. Translation: BAC28280.1.
AK148765 mRNA. Translation: BAE28660.1.
AK159872 mRNA. Translation: BAE35445.1.
AK162342 mRNA. Translation: BAE36863.1.
AK166035 mRNA. Translation: BAE38536.1.
AK166299 mRNA. Translation: BAE38688.1.
BC040685 mRNA. Translation: AAH40685.1.
CCDSiCCDS39502.1.
RefSeqiNP_001171027.1. NM_001177556.1.
NP_001171028.1. NM_001177557.1.
NP_001171029.1. NM_001177558.1.
NP_001171030.1. NM_001177559.1.
NP_001171031.1. NM_001177560.1.
NP_079554.1. NM_025278.5.
XP_006505605.1. XM_006505542.1.
UniGeneiMm.234342.

3D structure databases

ProteinModelPortaliQ9DAS9.
SMRiQ9DAS9. Positions 10-53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199985. 1 interaction.
IntActiQ9DAS9. 3 interactions.

PTM databases

PhosphoSiteiQ9DAS9.

Proteomic databases

MaxQBiQ9DAS9.
PaxDbiQ9DAS9.
PRIDEiQ9DAS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402.
ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402.
ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402.
ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402.
ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402.
ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402.
ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402.
GeneIDi14701.
KEGGimmu:14701.
UCSCiuc009cew.2. mouse.

Organism-specific databases

CTDi55970.
MGIiMGI:1336171. Gng12.

Phylogenomic databases

eggNOGiNOG265454.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ9DAS9.
KOiK04347.
OMAiQEDCLLV.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9DAS9.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

ChiTaRSiGng12. mouse.
NextBioi286667.
PROiQ9DAS9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DAS9.
GenevestigatoriQ9DAS9.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum, Colon, Lung, Mammary gland, Placenta and Sympathetic ganglion.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGBG12_MOUSE
AccessioniPrimary (citable) accession number: Q9DAS9
Secondary accession number(s): Q544P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.