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Q9DAS9

- GBG12_MOUSE

UniProt

Q9DAS9 - GBG12_MOUSE

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Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene
Gng12
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. PDZ domain binding Source: MGI
  2. phosphate ion binding Source: Ensembl
  3. signal transducer activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
  2. cerebral cortex development Source: Ensembl
  3. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene namesi
Name:Gng12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1336171. Gng12.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 6968Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
PRO_0000012669Add
BLAST
Propeptidei70 – 723Removed in mature form By similarity
PRO_0000012670

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei26 – 261Phosphoserine1 Publication
Modified residuei69 – 691Cysteine methyl ester By similarity
Lipidationi69 – 691S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ9DAS9.
PaxDbiQ9DAS9.
PRIDEiQ9DAS9.

PTM databases

PhosphoSiteiQ9DAS9.

Expressioni

Gene expression databases

BgeeiQ9DAS9.
GenevestigatoriQ9DAS9.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi199985. 1 interaction.
IntActiQ9DAS9. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9DAS9.
SMRiQ9DAS9. Positions 10-53.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG265454.
GeneTreeiENSGT00740000115214.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ9DAS9.
KOiK04347.
OMAiDKKTCTI.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9DAS9.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DAS9-1 [UniParc]FASTAAdd to Basket

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MSSKTASTNS IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD   50
PLLMGIPTSE NPFKDKKTCI IL 72
Length:72
Mass (Da):7,997
Last modified:January 23, 2007 - v3
Checksum:iA4D56F3BD697E7B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005561 mRNA. Translation: BAB24121.1.
AK033422 mRNA. Translation: BAC28280.1.
AK148765 mRNA. Translation: BAE28660.1.
AK159872 mRNA. Translation: BAE35445.1.
AK162342 mRNA. Translation: BAE36863.1.
AK166035 mRNA. Translation: BAE38536.1.
AK166299 mRNA. Translation: BAE38688.1.
BC040685 mRNA. Translation: AAH40685.1.
CCDSiCCDS39502.1.
RefSeqiNP_001171027.1. NM_001177556.1.
NP_001171028.1. NM_001177557.1.
NP_001171029.1. NM_001177558.1.
NP_001171030.1. NM_001177559.1.
NP_001171031.1. NM_001177560.1.
NP_079554.1. NM_025278.5.
XP_006505605.1. XM_006505542.1.
UniGeneiMm.234342.

Genome annotation databases

EnsembliENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402.
ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402.
ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402.
ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402.
ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402.
ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402.
ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402.
GeneIDi14701.
KEGGimmu:14701.
UCSCiuc009cew.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005561 mRNA. Translation: BAB24121.1 .
AK033422 mRNA. Translation: BAC28280.1 .
AK148765 mRNA. Translation: BAE28660.1 .
AK159872 mRNA. Translation: BAE35445.1 .
AK162342 mRNA. Translation: BAE36863.1 .
AK166035 mRNA. Translation: BAE38536.1 .
AK166299 mRNA. Translation: BAE38688.1 .
BC040685 mRNA. Translation: AAH40685.1 .
CCDSi CCDS39502.1.
RefSeqi NP_001171027.1. NM_001177556.1.
NP_001171028.1. NM_001177557.1.
NP_001171029.1. NM_001177558.1.
NP_001171030.1. NM_001177559.1.
NP_001171031.1. NM_001177560.1.
NP_079554.1. NM_025278.5.
XP_006505605.1. XM_006505542.1.
UniGenei Mm.234342.

3D structure databases

ProteinModelPortali Q9DAS9.
SMRi Q9DAS9. Positions 10-53.
ModBasei Search...

Protein-protein interaction databases

BioGridi 199985. 1 interaction.
IntActi Q9DAS9. 3 interactions.

PTM databases

PhosphoSitei Q9DAS9.

Proteomic databases

MaxQBi Q9DAS9.
PaxDbi Q9DAS9.
PRIDEi Q9DAS9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043148 ; ENSMUSP00000046557 ; ENSMUSG00000036402 .
ENSMUST00000114222 ; ENSMUSP00000109860 ; ENSMUSG00000036402 .
ENSMUST00000114224 ; ENSMUSP00000109862 ; ENSMUSG00000036402 .
ENSMUST00000114225 ; ENSMUSP00000109863 ; ENSMUSG00000036402 .
ENSMUST00000114226 ; ENSMUSP00000109864 ; ENSMUSG00000036402 .
ENSMUST00000114227 ; ENSMUSP00000109865 ; ENSMUSG00000036402 .
ENSMUST00000114228 ; ENSMUSP00000109866 ; ENSMUSG00000036402 .
GeneIDi 14701.
KEGGi mmu:14701.
UCSCi uc009cew.2. mouse.

Organism-specific databases

CTDi 55970.
MGIi MGI:1336171. Gng12.

Phylogenomic databases

eggNOGi NOG265454.
GeneTreei ENSGT00740000115214.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi Q9DAS9.
KOi K04347.
OMAi DKKTCTI.
OrthoDBi EOG7H1JP7.
PhylomeDBi Q9DAS9.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

ChiTaRSi GNG12. mouse.
NextBioi 286667.
PROi Q9DAS9.
SOURCEi Search...

Gene expression databases

Bgeei Q9DAS9.
Genevestigatori Q9DAS9.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum, Colon, Lung, Mammary gland, Placenta and Sympathetic ganglion.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGBG12_MOUSE
AccessioniPrimary (citable) accession number: Q9DAS9
Secondary accession number(s): Q544P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi