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Q9DAS9 (GBG12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene names
Name:Gng12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 6968Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
PRO_0000012669
Propeptide70 – 723Removed in mature form By similarity
PRO_0000012670

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue261Phosphoserine Ref.3
Modified residue691Cysteine methyl ester By similarity
Lipidation691S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9DAS9 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: A4D56F3BD697E7B4

FASTA727,997
        10         20         30         40         50         60 
MSSKTASTNS IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD PLLMGIPTSE 

        70 
NPFKDKKTCI IL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cecum, Colon, Lung, Mammary gland, Placenta and Sympathetic ganglion.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary gland.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK005561 mRNA. Translation: BAB24121.1.
AK033422 mRNA. Translation: BAC28280.1.
AK148765 mRNA. Translation: BAE28660.1.
AK159872 mRNA. Translation: BAE35445.1.
AK162342 mRNA. Translation: BAE36863.1.
AK166035 mRNA. Translation: BAE38536.1.
AK166299 mRNA. Translation: BAE38688.1.
BC040685 mRNA. Translation: AAH40685.1.
RefSeqNP_001171027.1. NM_001177556.1.
NP_001171028.1. NM_001177557.1.
NP_001171029.1. NM_001177558.1.
NP_001171030.1. NM_001177559.1.
NP_001171031.1. NM_001177560.1.
NP_079554.1. NM_025278.5.
XP_006505605.1. XM_006505542.1.
UniGeneMm.234342.

3D structure databases

ProteinModelPortalQ9DAS9.
SMRQ9DAS9. Positions 10-53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199985. 1 interaction.
IntActQ9DAS9. 3 interactions.

PTM databases

PhosphoSiteQ9DAS9.

Proteomic databases

PaxDbQ9DAS9.
PRIDEQ9DAS9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402.
ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402.
ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402.
ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402.
ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402.
ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402.
ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402.
GeneID14701.
KEGGmmu:14701.
UCSCuc009cew.2. mouse.

Organism-specific databases

CTD55970.
MGIMGI:1336171. Gng12.

Phylogenomic databases

eggNOGNOG265454.
GeneTreeENSGT00740000115214.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidQ9DAS9.
KOK04347.
OMAYITEHEQ.
OrthoDBEOG7H1JP7.
PhylomeDBQ9DAS9.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeQ9DAS9.
GenevestigatorQ9DAS9.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGNG12. mouse.
NextBio286667.
PROQ9DAS9.
SOURCESearch...

Entry information

Entry nameGBG12_MOUSE
AccessionPrimary (citable) accession number: Q9DAS9
Secondary accession number(s): Q544P3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot