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Q9DAS9

- GBG12_MOUSE

UniProt

Q9DAS9 - GBG12_MOUSE

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

Gng12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. PDZ domain binding Source: MGI
    2. phosphate ion binding Source: Ensembl
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. cerebral cortex development Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: InterPro
    3. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
    Gene namesi
    Name:Gng12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1336171. Gng12.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 6968Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12PRO_0000012669Add
    BLAST
    Propeptidei70 – 723Removed in mature formBy similarityPRO_0000012670

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei26 – 261Phosphoserine1 Publication
    Modified residuei69 – 691Cysteine methyl esterBy similarity
    Lipidationi69 – 691S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ9DAS9.
    PaxDbiQ9DAS9.
    PRIDEiQ9DAS9.

    PTM databases

    PhosphoSiteiQ9DAS9.

    Expressioni

    Gene expression databases

    BgeeiQ9DAS9.
    GenevestigatoriQ9DAS9.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    BioGridi199985. 1 interaction.
    IntActiQ9DAS9. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DAS9.
    SMRiQ9DAS9. Positions 10-53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG265454.
    GeneTreeiENSGT00740000115214.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiQ9DAS9.
    KOiK04347.
    OMAiDKKTCTI.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiQ9DAS9.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DAS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKTASTNS IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD   50
    PLLMGIPTSE NPFKDKKTCI IL 72
    Length:72
    Mass (Da):7,997
    Last modified:January 23, 2007 - v3
    Checksum:iA4D56F3BD697E7B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005561 mRNA. Translation: BAB24121.1.
    AK033422 mRNA. Translation: BAC28280.1.
    AK148765 mRNA. Translation: BAE28660.1.
    AK159872 mRNA. Translation: BAE35445.1.
    AK162342 mRNA. Translation: BAE36863.1.
    AK166035 mRNA. Translation: BAE38536.1.
    AK166299 mRNA. Translation: BAE38688.1.
    BC040685 mRNA. Translation: AAH40685.1.
    CCDSiCCDS39502.1.
    RefSeqiNP_001171027.1. NM_001177556.1.
    NP_001171028.1. NM_001177557.1.
    NP_001171029.1. NM_001177558.1.
    NP_001171030.1. NM_001177559.1.
    NP_001171031.1. NM_001177560.1.
    NP_079554.1. NM_025278.5.
    XP_006505605.1. XM_006505542.1.
    UniGeneiMm.234342.

    Genome annotation databases

    EnsembliENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402.
    ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402.
    ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402.
    ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402.
    ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402.
    ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402.
    ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402.
    GeneIDi14701.
    KEGGimmu:14701.
    UCSCiuc009cew.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005561 mRNA. Translation: BAB24121.1 .
    AK033422 mRNA. Translation: BAC28280.1 .
    AK148765 mRNA. Translation: BAE28660.1 .
    AK159872 mRNA. Translation: BAE35445.1 .
    AK162342 mRNA. Translation: BAE36863.1 .
    AK166035 mRNA. Translation: BAE38536.1 .
    AK166299 mRNA. Translation: BAE38688.1 .
    BC040685 mRNA. Translation: AAH40685.1 .
    CCDSi CCDS39502.1.
    RefSeqi NP_001171027.1. NM_001177556.1.
    NP_001171028.1. NM_001177557.1.
    NP_001171029.1. NM_001177558.1.
    NP_001171030.1. NM_001177559.1.
    NP_001171031.1. NM_001177560.1.
    NP_079554.1. NM_025278.5.
    XP_006505605.1. XM_006505542.1.
    UniGenei Mm.234342.

    3D structure databases

    ProteinModelPortali Q9DAS9.
    SMRi Q9DAS9. Positions 10-53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199985. 1 interaction.
    IntActi Q9DAS9. 3 interactions.

    PTM databases

    PhosphoSitei Q9DAS9.

    Proteomic databases

    MaxQBi Q9DAS9.
    PaxDbi Q9DAS9.
    PRIDEi Q9DAS9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043148 ; ENSMUSP00000046557 ; ENSMUSG00000036402 .
    ENSMUST00000114222 ; ENSMUSP00000109860 ; ENSMUSG00000036402 .
    ENSMUST00000114224 ; ENSMUSP00000109862 ; ENSMUSG00000036402 .
    ENSMUST00000114225 ; ENSMUSP00000109863 ; ENSMUSG00000036402 .
    ENSMUST00000114226 ; ENSMUSP00000109864 ; ENSMUSG00000036402 .
    ENSMUST00000114227 ; ENSMUSP00000109865 ; ENSMUSG00000036402 .
    ENSMUST00000114228 ; ENSMUSP00000109866 ; ENSMUSG00000036402 .
    GeneIDi 14701.
    KEGGi mmu:14701.
    UCSCi uc009cew.2. mouse.

    Organism-specific databases

    CTDi 55970.
    MGIi MGI:1336171. Gng12.

    Phylogenomic databases

    eggNOGi NOG265454.
    GeneTreei ENSGT00740000115214.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi Q9DAS9.
    KOi K04347.
    OMAi DKKTCTI.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi Q9DAS9.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    ChiTaRSi GNG12. mouse.
    NextBioi 286667.
    PROi Q9DAS9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DAS9.
    Genevestigatori Q9DAS9.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum, Colon, Lung, Mammary gland, Placenta and Sympathetic ganglion.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary gland.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGBG12_MOUSE
    AccessioniPrimary (citable) accession number: Q9DAS9
    Secondary accession number(s): Q544P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3