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UniProtKB - Q9DAS9 (GBG12_MOUSE)

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

Gng12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene namesi
Name:Gng12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1336171. Gng12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000126692 – 69Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Add BLAST68
PropeptideiPRO_000001267070 – 72Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei10PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei42PhosphotyrosineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei69Cysteine methyl esterBy similarity1
Lipidationi69S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9DAS9.
MaxQBiQ9DAS9.
PaxDbiQ9DAS9.
PeptideAtlasiQ9DAS9.
PRIDEiQ9DAS9.
TopDownProteomicsiQ9DAS9.

PTM databases

iPTMnetiQ9DAS9.
PhosphoSitePlusiQ9DAS9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036402.
ExpressionAtlasiQ9DAS9. baseline and differential.
GenevisibleiQ9DAS9. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi199985. 1 interactor.
IntActiQ9DAS9. 4 interactors.
STRINGi10090.ENSMUSP00000046557.

Structurei

3D structure databases

ProteinModelPortaliQ9DAS9.
SMRiQ9DAS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ9DAS9.
KOiK04347.
OrthoDBiEOG091G17J0.
PhylomeDBiQ9DAS9.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
PRINTSiPR00321. GPROTEING.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DAS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKTASTNS IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD 
        60         70 
PLLMGIPTSE NPFKDKKTCI IL
Length:72
Mass (Da):7,997
Last modified:January 23, 2007 - v3
Checksum:iA4D56F3BD697E7B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005561 mRNA. Translation: BAB24121.1.
AK033422 mRNA. Translation: BAC28280.1.
AK148765 mRNA. Translation: BAE28660.1.
AK159872 mRNA. Translation: BAE35445.1.
AK162342 mRNA. Translation: BAE36863.1.
AK166035 mRNA. Translation: BAE38536.1.
AK166299 mRNA. Translation: BAE38688.1.
BC040685 mRNA. Translation: AAH40685.1.
CCDSiCCDS39502.1.
RefSeqiNP_001171027.1. NM_001177556.1.
NP_001171028.1. NM_001177557.1.
NP_001171029.1. NM_001177558.1.
NP_001171030.1. NM_001177559.1.
NP_001171031.1. NM_001177560.1.
NP_079554.1. NM_025278.5.
XP_006505605.1. XM_006505542.3.
UniGeneiMm.234342.

Genome annotation databases

EnsembliENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402.
ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402.
ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402.
ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402.
ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402.
ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402.
ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402.
GeneIDi14701.
KEGGimmu:14701.
UCSCiuc009cew.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGBG12_MOUSE
AccessioniPrimary (citable) accession number: Q9DAS9
Secondary accession number(s): Q544P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families