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Protein

Protein disulfide-isomerase-like protein of the testis

Gene

Pdilt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable redox-inactive chaperone involved in spermatogenesis.By similarity

GO - Molecular functioni

  • protein disulfide isomerase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein, Isomerase
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein of the testis
Gene namesi
Name:Pdilt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1919080 Pdilt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000032585121 – 588Protein disulfide-isomerase-like protein of the testisAdd BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DAN1
PeptideAtlasiQ9DAN1
PRIDEiQ9DAN1

PTM databases

PhosphoSitePlusiQ9DAN1

Expressioni

Tissue specificityi

Testis-specific (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000030968
CleanExiMM_1700007B13RIK
ExpressionAtlasiQ9DAN1 baseline and differential
GenevisibleiQ9DAN1 MM

Interactioni

Subunit structurei

Homodimer. The homodimer is not disulfide-linked. Interacts with CLGN and ERO1A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Adam3Q622872EBI-15971896,EBI-15971963

Protein-protein interaction databases

DIPiDIP-60024N
IntActiQ9DAN1, 3 interactors
STRINGi10090.ENSMUSP00000033267

Structurei

3D structure databases

ProteinModelPortaliQ9DAN1
SMRiQ9DAN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini385 – 448ThioredoxinPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi585 – 588Prevents secretion from ERPROSITE-ProRule annotation4

Domaini

The thioredoxin domain lacks the conserved redox-active Cys at position 414 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000115479
HOVERGENiHBG108240
InParanoidiQ9DAN1
KOiK20354
OMAiYFRITEV
OrthoDBiEOG091G0B2I
PhylomeDBiQ9DAN1
TreeFamiTF106381

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DAN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLWTPLLL VAACLSEVLG SPEIDTGINI SQPLHILEDH NLMVLTPAGL
60 70 80 90 100
TQTLNETRFL MVIFHNPSLK QSRKLAKELG KAAEIFGKGK NGLGFGKVDI
110 120 130 140 150
TKETELQQEF DITHAPELKL FFEGNRLKPI SCKDVVESTA LVVWLRRQIS
160 170 180 190 200
KKALLFNNSD EVADFVKSRP LVIVGFFQDL EEEVAELFYD TIKDFPELTF
210 220 230 240 250
GAIQIKNSFG RFHVILDSVL VFKKGKIVKR QELINDSTNK DHLNQVIKQQ
260 270 280 290 300
LTGFVIELNP ENKDLIYELN ILNHMLLFIS KSSEPYSTIS RHYRQIAKEF
310 320 330 340 350
QNKILFVLVN ADEPKNKRIF EYFQISRVNV PSVQILNLSS DGRYKMPTDD
360 370 380 390 400
INFESLKKFC NSFLSKTAKK HKASEEIPKY WDQGPVKKLV GKNFNVVVLD
410 420 430 440 450
KEKDVFVMFY APWSEKCRVL LPLLEELGIK YQNHSTVIIA KIDITANDIQ
460 470 480 490 500
LANPEQYPFF RLFPTDSQEA VMYKGEHTMK GFCDFLESHV KVRIEEEDEL
510 520 530 540 550
LYIEQNEEEE VLAEPEIQLI EKLPENPLLK IEDTSKQDRP VKESPVLDSI
560 570 580
RKPEEPERRK ETAEREAAAA QPKEQPKPER KLEVKEEL
Length:588
Mass (Da):67,759
Last modified:March 18, 2008 - v2
Checksum:i1B0A73E5DBDF6187
GO

Sequence cautioni

The sequence BAB24190 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005692 mRNA Translation: BAB24190.1 Different initiation.
CCDSiCCDS52378.1
RefSeqiNP_082219.1, NM_027943.1
XP_006508276.2, XM_006508213.3
XP_006508277.1, XM_006508214.1
UniGeneiMm.84631

Genome annotation databases

EnsembliENSMUST00000033267; ENSMUSP00000033267; ENSMUSG00000030968
GeneIDi71830
KEGGimmu:71830
UCSCiuc009jld.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPDILT_MOUSE
AccessioniPrimary (citable) accession number: Q9DAN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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