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Q9DAN1

- PDILT_MOUSE

UniProt

Q9DAN1 - PDILT_MOUSE

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Protein
Protein disulfide-isomerase-like protein of the testis
Gene
Pdilt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable redox-inactive chaperone involved in spermatogenesis By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. protein disulfide isomerase activity Source: MGI

GO - Biological processi

  1. cell migration Source: MGI
  2. cell redox homeostasis Source: InterPro
  3. multicellular organismal development Source: UniProtKB-KW
  4. protein folding Source: GOC
  5. spermatid development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Developmental protein, Isomerase

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein of the testis
Gene namesi
Name:Pdilt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1919080. Pdilt.

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 588568Protein disulfide-isomerase-like protein of the testis
PRO_0000325851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DAN1.
PRIDEiQ9DAN1.

PTM databases

PhosphoSiteiQ9DAN1.

Expressioni

Tissue specificityi

Testis-specific (at protein level).2 Publications

Gene expression databases

BgeeiQ9DAN1.
CleanExiMM_1700007B13RIK.
GenevestigatoriQ9DAN1.

Interactioni

Subunit structurei

Homodimer. The homodimer is not disulfide-linked. Interacts with CLGN and ERO1L By similarity.

Protein-protein interaction databases

DIPiDIP-60024N.
STRINGi10090.ENSMUSP00000033267.

Structurei

3D structure databases

ProteinModelPortaliQ9DAN1.
SMRiQ9DAN1. Positions 30-488.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini385 – 44864Thioredoxin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi585 – 5884Prevents secretion from ER Reviewed prediction

Domaini

The thioredoxin domain lacks the conserved redox-active Cys at position 414 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00740000115202.
HOGENOMiHOG000115479.
HOVERGENiHBG108240.
InParanoidiQ9DAN1.
OMAiQKAFLFN.
OrthoDBiEOG7VHSX1.
PhylomeDBiQ9DAN1.
TreeFamiTF106381.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DAN1-1 [UniParc]FASTAAdd to Basket

« Hide

MELLWTPLLL VAACLSEVLG SPEIDTGINI SQPLHILEDH NLMVLTPAGL    50
TQTLNETRFL MVIFHNPSLK QSRKLAKELG KAAEIFGKGK NGLGFGKVDI 100
TKETELQQEF DITHAPELKL FFEGNRLKPI SCKDVVESTA LVVWLRRQIS 150
KKALLFNNSD EVADFVKSRP LVIVGFFQDL EEEVAELFYD TIKDFPELTF 200
GAIQIKNSFG RFHVILDSVL VFKKGKIVKR QELINDSTNK DHLNQVIKQQ 250
LTGFVIELNP ENKDLIYELN ILNHMLLFIS KSSEPYSTIS RHYRQIAKEF 300
QNKILFVLVN ADEPKNKRIF EYFQISRVNV PSVQILNLSS DGRYKMPTDD 350
INFESLKKFC NSFLSKTAKK HKASEEIPKY WDQGPVKKLV GKNFNVVVLD 400
KEKDVFVMFY APWSEKCRVL LPLLEELGIK YQNHSTVIIA KIDITANDIQ 450
LANPEQYPFF RLFPTDSQEA VMYKGEHTMK GFCDFLESHV KVRIEEEDEL 500
LYIEQNEEEE VLAEPEIQLI EKLPENPLLK IEDTSKQDRP VKESPVLDSI 550
RKPEEPERRK ETAEREAAAA QPKEQPKPER KLEVKEEL 588
Length:588
Mass (Da):67,759
Last modified:March 18, 2008 - v2
Checksum:i1B0A73E5DBDF6187
GO

Sequence cautioni

The sequence BAB24190.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005692 mRNA. Translation: BAB24190.1. Different initiation.
CCDSiCCDS52378.1.
RefSeqiNP_082219.1. NM_027943.1.
XP_006508277.1. XM_006508214.1.
UniGeneiMm.84631.

Genome annotation databases

EnsembliENSMUST00000033267; ENSMUSP00000033267; ENSMUSG00000030968.
GeneIDi71830.
KEGGimmu:71830.
UCSCiuc009jld.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005692 mRNA. Translation: BAB24190.1 . Different initiation.
CCDSi CCDS52378.1.
RefSeqi NP_082219.1. NM_027943.1.
XP_006508277.1. XM_006508214.1.
UniGenei Mm.84631.

3D structure databases

ProteinModelPortali Q9DAN1.
SMRi Q9DAN1. Positions 30-488.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60024N.
STRINGi 10090.ENSMUSP00000033267.

PTM databases

PhosphoSitei Q9DAN1.

Proteomic databases

PaxDbi Q9DAN1.
PRIDEi Q9DAN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033267 ; ENSMUSP00000033267 ; ENSMUSG00000030968 .
GeneIDi 71830.
KEGGi mmu:71830.
UCSCi uc009jld.1. mouse.

Organism-specific databases

CTDi 204474.
MGIi MGI:1919080. Pdilt.

Phylogenomic databases

eggNOGi COG0526.
GeneTreei ENSGT00740000115202.
HOGENOMi HOG000115479.
HOVERGENi HBG108240.
InParanoidi Q9DAN1.
OMAi QKAFLFN.
OrthoDBi EOG7VHSX1.
PhylomeDBi Q9DAN1.
TreeFami TF106381.

Miscellaneous databases

NextBioi 334632.
PROi Q9DAN1.
SOURCEi Search...

Gene expression databases

Bgeei Q9DAN1.
CleanExi MM_1700007B13RIK.
Genevestigatori Q9DAN1.

Family and domain databases

Gene3Di 3.40.30.10. 4 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum."
    van Lith M., Hartigan N., Hatch J., Benham A.M.
    J. Biol. Chem. 280:1376-1383(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. "A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells."
    van Lith M., Karala A.R., Bown D., Gatehouse J.A., Ruddock L.W., Saunders P.T.K., Benham A.M.
    Mol. Biol. Cell 18:2795-2804(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPDILT_MOUSE
AccessioniPrimary (citable) accession number: Q9DAN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi